Animal studies | | | | |
Oestradiol | In vivo | CFTR-deficient mouse model (CFTRtm1UNC) |
| [48] |
Ex vivo | CFTR-deficient mouse model (CFTRtm1UNC) |
Increased IL-23 and IL-17 expression in BAL and lung tissue post P. aeruginosa infection
Increased P. aeruginosa load
Decreased antimicrobial peptide, lactoferrin
| [46] |
Human studies | | | | |
Pre-clinical studies | | | | |
Oestradiol | In vitro | Human CF bronchial epithelial cell line (CFBE41o-) |
| [47] |
In vitro | Human CF bronchial epithelial cell line (CuFi-1) |
| [40] |
In vitro | Human CF bronchial epithelial cell lines (CFBE41o- and IB3-1) |
| [66] |
| In vitro | Primary human CF bronchial epithelium (HBECs) |
| [36] |
Tamoxifen | In vitro | Human CF bronchial epithelial cell lines (CFBE41o- and IB3-1) |
| [66] |
Tamoxifen and ICI182780 | In vitro | Human CF bronchial epithelial cell line (CuFi-1) |
| [40] |
In vitro | Primary human CF bronchial epithelium (HBECs) |
| [36] |
Clinical studies | | | | |
Ivacaftor | Retrospective case control | 144 (77 males; 67 females) |
Decreased PEx rates in females to a greater extent than males and to a rate similar to that of males post-IVA
Greater improvement in sweat chloride in females compared to males 3 months post-IVA
No significant sex-related differences in changes in FEV1 or BMI post-IVA
| [67] |
OCP | Retrospective | 77 (36 on OCP) |
| [49] |
Retrospective | 114 (57 on OCP) |
| [61] |
Prospective cohort | 23 (13 on OCP) |
| [62] |
Prospective cohort | 23 (13 on OCP) |
| [31] |