Tables
- TABLE 1
Genotype data of patients with community-acquired pneumonia (CAP)
Patients n Genotype frequencies (%) p-value
OR (95% CI)Genotype comparisons Allele comparisons CC CT TT Recessive model: CC versus TC+TT Additive model rs4957796 CAP 960 29 (52.7) 243 (46.8) 688 (49.8) 0.583 0.51 0.502 Control 996 26 (47.3) 276 (53.2) 694 (50.2) 1.16 (0.68–1.99) 0.94 (0.80–1.12) 0.94 (0.80–1.12) Dead 28 days 57 2 (6.9) 11 (4.5) 44 (6.4) 0.688 0.44 0.446 Alive 28 days 903 27 (93.1) 232 (95.5) 644 (93.6) 1.18 (0.27–5.09) 0.81 (0.47–1.40) 0.81 (0.46–1.41) Dead 90 days 76 2 (6.9) 15 (6.2) 59 (8.6) 1.000 0.26 0.262 Alive 90 days 884 27 (93.1) 228 (93.8) 629 (91.4) 0.86 (0.20–3.68) 0.76 (0.47–1.24) 0.75 (0.46–1.24) ARDS 64 3 (10.3) 15 (6.2) 46 (6.7) 0.435 0.82 0.814 No ARDS 896 26 (89.7) 228 (93.8) 642 (93.3) 1.65 (0.48–5.59) 1.06 (0.66–1.70) 1.06 (0.65–1.72) SS/SSh 313 14 (48.3) 79 (32.5) 220 (32.0) 0.068 0.25 0.235 No SS/SSh 647 15 (51.7) 164 (67.5) 468 (68.0) 1.97 (0.94–4.14) 1.16 (0.90–1.50) 1.17 (0.90–1.51) Sepsis 765 27 (93.1) 192 (79.0) 546 (79.4) 0.041 0.34 0.338 No sepsis 195 2 (6.9) 51 (21.0) 142 (20.6) 3.53 (0.83–15.00) 1.16 (0.85–1.58) 1.17 (0.85–1.60) ICU 338 9 (31.0) 82 (33.7) 247 (35.9) 0.633 0.44 0.432 No ICU 622 20 (69.0) 161 (66.3) 441 (64.1) 0.82 (0.37–1.83) 0.90 (0.70–1.17) 0.90 (0.69–1.17) ICU dead 28 days# 44 1 (11.1) 6 (7.3) 37 (15.0) 1.000 0.093 0.106 ICU alive 28 days# 294 8 (88.9) 76 (92.7) 210 (85.0) 0.81 (0.10–6.81) 0.55 (0.26–1.16) 0.54 (0.25–1.15) ICU dead 90 days# 62 1 (11.1) 10 (12.2) 51 (20.6) 1.000 0.068 0.076 ICU alive 90 days# 276 8 (88.9) 72 (87.8) 196 (79.4) 0.55 (0.07–4.47) 0.57 (0.31–1.08) 0.57 (0.30–1.07) rs62375529 CAP 960 23 (45.1) 214 (48.2) 723 (49.5) 0.564 0.47 0.462 Controls 996 28 (54.9) 230 (51.8) 738 (50.5) 0.85 (0.49–1.48) 0.94 (0.79–1.12) 0.93 (0.78–1.12) Dead 28 days 57 4 (17.4) 8 (3.7) 45 (6.2) 0.042 0.88 0.874 Alive 28 days 903 19 (82.6) 206 (96.3) 678 (93.8) 3.51 (1.15–10.7) 1.04 (0.61–1.78) 1.05 (0.61–1.80) Dead 90 days 76 4 (17.4) 11 (5.1) 61 (8.4) 0.101 0.70 0.696 Alive 90 days 884 19 (82.6) 203 (94.9) 662 (91.6) 2.53 (0.84–7.63) 0.91 (0.56–1.48) 0.91 (0.55–1.49) ARDS 64 2 (8.7) 13 (6.1) 49 (6.8) 0.662 0.93 0.929 No ARDS 896 21 (91.3) 201 (93.9) 674 (93.2) 1.34 (0.31–5.86) 0.98 (0.58–1.54) 0.98 (0.58–1.66) SS/SSh 313 14 (60.9) 66 (30.8) 233 (32.2) 0.003¶ 0.2 0.189 No SS/SSh 647 9 (39.1) 148 (69.2) 490 (67.8) 3.32 (1.42–7.76) 1.19 (0.91–1.56) 1.20 (0.91–1.58) Sepsis 765 22 (95.7) 165 (77.1) 578 (79.9) 0.025 0.77 0.764 No sepsis 195 1 (4.3) 49 (22.9) 145 (20.1) 5.74 (0.77–42.90) 1.05 (0.76–1.45) 1.05 (0.76–1.46) ICU 338 9 (39.1) 68 (31.8) 261 (36.1) 0.690 0.45 0.439 No ICU 622 14 (60.9) 146 (68.2) 462 (63.9) 1.19 (0.51–2.77) 0.90 (0.69–1.18) 0.90 (0.68–1.18) ICU dead 28 days 44 2 (22.2) 5 (7.4) 37 (14.2) 0.331 0.46 0.451 ICU alive 28 days 224 7 (77.8) 63 (92.6) 224 (85.8) 1.95 (0.39–9.71) 0.77 (0.38–1.56) 0.76 (0.36–1.57) ICU dead 90 days 62 2 (22.2) 8 (11.8) 52 (19.9) 0.672 0.27 0.260 ICU alive 90 days 276 7 (77.8) 60 (88.2) 209 (80.1) 1.28 (0.26–6.32) 0.71 (0.38–1.33) 0.69 (0.36–1.32) Bivariate and multivariate analyses were performed using SPSS (version 15.0; SPSS, Inc., Chicago, IL, USA). The mean±sd age of the patients and controls was 61.8±17.7 and 44.3±19.3 years, respectively; 620 (66%) patients and 435 controls (52%) were male. Genotype distribution of both single-nucleotide polymorphisms did not differ significantly under conditions of Hardy–Weinberg equilibrium in the control group (p=0.444 for rs4957796, p=0.746 for rs62375529). Data are presented as n (%), unless otherwise stated. ARDS: acute respiratory distress syndrome; SS/SSh: severe sepsis/septic shock; ICU: intensive care unit; ICU dead 28/90 days: patients admitted to the ICU who died at 28/90 days; ICU alive 28/90 days: patients admitted to the ICU who survived at 28/90 days #: p-value for the bivariate comparison calculated with the Chi-squared test. ¶: after adjustment for age, sex, comorbidities and admitting hospital, the rs62375529 FER variant remains significantly associated with severe sepsis risk (OR=5.17; 95% CI 1.963–13.68, p=0.001), p-value for the multivariate analysis calculated with binary logistic regression.
