Figures
- FIGURE 1
Flow chart depicting numbers of different samples and corresponding diagnostic procedures. PD-L1: programmed cell death protein ligand 1; SCLC: small cell lung cancer; IHC: immunohistochemistry; ICC: immunocytochemistry.
- FIGURE 2
Proposed clinical algorithm for programmed cell death protein ligand 1 (PD-L1) testing in nonsmall cell lung cancer (NSCLC) patients with pleural effusion (PE).
Tables
- TABLE 1
Anthropometric data and smoking status of 50 patients included
Sex Female 17 (34%) Male 33 (66%) Age years 72.5 (62.8–76.3) Body mass index kg·m−2 25.7 (23.2–28.5) Smoking status Never-smoker 7 (14%) Ex-smoker 28 (56%) Current smoker 15 (30%) Data are presented as n (%) or median (interquartile range).
- TABLE 2
Summary of malignancy and programmed cell death protein ligand 1 (PD-L1) status
Pleural effusion n Pleural biopsy n Cases 50 50 Malignancy (+/−/○) 36/7/7 40/10/0 PD-L1 ≥1% of tumour cells (+/−/nd) 19/6/25 21/14/15 PD-L1 ≥50% of tumour cells (+/−/nd) 13/12/25 8/27/15 +: positive; −: negative; ○: inconclusive; nd: not done.
- TABLE 3
Programmed cell death protein ligand 1 (PD-L1) detection in pleural effusion based on all cases with successful PD-L1 analysis. Cross-classification of pleura biopsy and pleura effusion analysis results concerning PD-L1 detection
PD-L1 expression ≥50% of tumour cells defined as positive PD-L1 expression ≥1% of tumour cells defined as positive Pleural biopsy Total Pleural biopsy Total Positive Negative Positive Negative Pleural effusion Positive 5 6 11 12 4 16 Negative 0 10 10 2 3 5 Total 5 16 21 14 7 21 - TABLE 4
Programmed cell death protein ligand 1 (PD-L1) detection in pleural effusion based on all cases with successful PD-L1 analysis. Sensitivity, specificity, positive predictive value, negative predictive value, positive likelihood ratio, negative likelihood ratio
Parameter PD-L1 expression ≥50% of tumour cells defined as positive PD-L1 expression ≥1% of tumour cells defined as positive Estimate 95% CI Estimate 95% CI Sensitivity % 100 46–100 86 56–97 Specificity % 63 36–84 43 12–80 Positive predictive value % 45 18–75 75 47–92 Negative predictive value % 100 66–100 60 17–93 Positive likelihood ratio 2.67 1.42–5.02 1.50 0.76–2.95 Negative likelihood ratio 0.00 Not defined 0.33 0.07–1.56
Supplementary Material
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Table S1 00787-2020.TABLES1
Table S2 00787-2020.TABLES2
Table S3 00787-2020.TABLES3
