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Prevalence, incidence and characteristics of chronic cough among adults from the Canadian Longitudinal Study on Aging

Imran Satia, Alexandra J. Mayhew, Nazmul Sohel, Om Kurmi, Kieran J. Killian, Paul M. O'Byrne, Parminder Raina
ERJ Open Research 2021 7: 00160-2021; DOI: 10.1183/23120541.00160-2021
Imran Satia
1Dept of Medicine, McMaster University, Hamilton, ON, Canada
2Firestone Institute for Respiratory Health, St Joseph's Healthcare, Hamilton, ON, Canada
3Dept of Health Research Methods, Evidence, and Impact, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada
4McMaster Institute for Research on Aging, McMaster University, Hamilton, ON, Canada
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  • ORCID record for Imran Satia
  • For correspondence: satiai@mcmaster.ca
Alexandra J. Mayhew
3Dept of Health Research Methods, Evidence, and Impact, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada
4McMaster Institute for Research on Aging, McMaster University, Hamilton, ON, Canada
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Nazmul Sohel
3Dept of Health Research Methods, Evidence, and Impact, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada
4McMaster Institute for Research on Aging, McMaster University, Hamilton, ON, Canada
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Om Kurmi
1Dept of Medicine, McMaster University, Hamilton, ON, Canada
2Firestone Institute for Respiratory Health, St Joseph's Healthcare, Hamilton, ON, Canada
3Dept of Health Research Methods, Evidence, and Impact, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada
5Faculty of Health and Life Sciences, Coventry University, Coventry, UK
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  • ORCID record for Om Kurmi
Kieran J. Killian
1Dept of Medicine, McMaster University, Hamilton, ON, Canada
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Paul M. O'Byrne
1Dept of Medicine, McMaster University, Hamilton, ON, Canada
2Firestone Institute for Respiratory Health, St Joseph's Healthcare, Hamilton, ON, Canada
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Parminder Raina
3Dept of Health Research Methods, Evidence, and Impact, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada
4McMaster Institute for Research on Aging, McMaster University, Hamilton, ON, Canada
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  • FIGURE 1
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    FIGURE 1

    Prevalence of chronic cough based on age, sex and smoking status at baseline.

  • FIGURE 2
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    FIGURE 2

    The associations of symptoms, lung function, airflow obstruction and airways diseases on the prevalence of chronic cough at baseline. Data are presented as mean (95% CI). FEV1: forced expiratory volume in 1 s; CAO: chronic airflow obstruction; LLN: lower limit of normal; SOB: shortness of breath.

  • FIGURE 3
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    FIGURE 3

    Adjusted (age, sex, smoking) incidence rates of chronic cough for respiratory symptoms, airways diseases, lung function and airflow obstruction. Data are presented as mean (95% CI). FEV1: forced expiratory volume in 1 s; CAO: chronic airflow obstruction; LLN: lower limit of normal; SOB: shortness of breath.

  • FIGURE 4
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    FIGURE 4

    Adjusted (age, sex, smoking) incidence rates of chronic cough in the presence of other medical comorbidities. Data are presented as mean (95% CI). AMI: acute myocardial infarction; CHF: congestive heart failure; GI: gastrointestinal.

Tables

  • Figures
  • TABLE 1

    Demographics of chronic cough at baseline#

    No chronic coughChronic cough
    Subjects25 2334739
    Age years59.2±0.0461.5±0.18
    Sex
     Male12 18484.8±0.37252615.2±0.37
     Female13 04987.3±0.31221312.7±0.31
    BMI kg·m−225 13927.7±0.04470128.6±0.11
     Underweight <2017180.4±3.244219.6±3.24
     Normal 20–25764488.0±0.41119012.0±0.41
     Overweight 25–3010 22186.7±0.37181513.3±0.37
     Obese >30710383.0±0.49165417.0±0.49
    Smoking status
     Never13 72989.1±0.30195310.9±0.30
     Former975586.5±0.38180313.5±0.38
     Current160565.8±1.1795334.2±1.17
    Smoking packs per year24 9526.7±0.10468013.2±0.35
    Provinces
     Alberta244585.7±0.7649314.3±0.76
     British Columbia514784.2±0.51107515.8±0.51
     Manitoba254882.9±0.7555217.1±0.75
     Newfoundland and Labrador188086.0±0.8033114.0±0.80
     Nova Scotia254784.7±0.7051115.3±0.70
     Ontario532084.2±0.49108715.8±0.49
     Quebec534689.6±0.4269010.4±0.42
    Ethnicity
     White only22 94886.0±0.25435914.0±0.25
     Black only18694.5±1.58175.5±1.58
     Asian (East and West)35591.7±1.87318.3±1.87
     South Asian24592.0±1.84258.0±1.84
     Arab7993.0±3.1587.0±3.15
     Others121383.2±1.2225416.8±1.22
    Country of birth
     Canada20 57985.5±0.27398014.5±0.27
     USA56886.4±1.4811613.6±1.48
     South, Central America and Caribbean37892.0±1.49418.0±1.49
     Europe/Oceania284686.6±0.6952213.4±0.69
     Africa25792.3±1.71277.7±1.71
     Asia60193.2±1.22526.8±1.22

    Data are presented as n, mean±se or %±se. BMI: body mass index. #: n=29 972.

    • TABLE 2

      Incidence of chronic cough at follow-up 1 based on age, sex, smoking status and body mass index (BMI) (unadjusted and adjusted)

      Incidence rate per 100 person-years
      UnadjustedAdjusted with age, sex and smoking
      Age years
       45–542.60 (2.33–2.86)3.58 (3.20–3.96)
       55–643.55 (3.28–3.82)4.54 (4.17–4.92)
       65–744.20 (3.86–4.54)5.32 (4.89–5.75)
       75–854.50 (4.05–4.95)5.70 (5.17–6.23)
      Sex
       Male3.61 (3.37–3.85)5.09 (4.72–5.45)
       Female3.06 (2.85–3.27)4.48 (4.13–4.83)
      Smoking
       Nonsmoker2.86 (2.66–3.06)3.37 (3.15–3.58)
       Former3.50 (3.25–3.76)3.80 (3.53–4.06)
       Current6.53 (5.65–7.42)7.20 (6.31–8.08)
      BMI
       Underweight5.03 (1.83–8.23)5.99 (5.97–6.01)
       Normal2.53 (2.29–2.77)4.09 (4.07–4.11)
       Overweight3.41 (3.16–3.67)4.80 (4.78–4.82)
       Obese4.14 (3.81–4.47)5.60 (5.55–5.65)

      Data are presented as mean (95% CI).

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      Prevalence, incidence and characteristics of chronic cough among adults from the Canadian Longitudinal Study on Aging
      Imran Satia, Alexandra J. Mayhew, Nazmul Sohel, Om Kurmi, Kieran J. Killian, Paul M. O'Byrne, Parminder Raina
      ERJ Open Research Apr 2021, 7 (2) 00160-2021; DOI: 10.1183/23120541.00160-2021

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      Prevalence, incidence and characteristics of chronic cough among adults from the Canadian Longitudinal Study on Aging
      Imran Satia, Alexandra J. Mayhew, Nazmul Sohel, Om Kurmi, Kieran J. Killian, Paul M. O'Byrne, Parminder Raina
      ERJ Open Research Apr 2021, 7 (2) 00160-2021; DOI: 10.1183/23120541.00160-2021
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