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Home parasternal electromyography tracks patient-reported and physiological measures of recovery from severe COPD exacerbation

Rebecca Francesca D'Cruz, Eui-Sik Suh, Georgios Kaltsakas, Amy Dewar, Neeraj Mukesh Shah, Rita Priori, Abdel Douiri, Louise Rose, Nicholas Hart, Patrick Brian Murphy
ERJ Open Research 2021 7: 00709-2020; DOI: 10.1183/23120541.00709-2020
Rebecca Francesca D'Cruz
1Lane Fox Clinical Respiratory Physiology Research Unit, Guy's and St Thomas’ NHS Foundation Trust, London, UK
2Centre for Human and Applied Physiological Sciences, King's College London, London, UK
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  • ORCID record for Rebecca Francesca D'Cruz
Eui-Sik Suh
1Lane Fox Clinical Respiratory Physiology Research Unit, Guy's and St Thomas’ NHS Foundation Trust, London, UK
3Faculty of Life Sciences and Medicine, King's College London, London, UK
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Georgios Kaltsakas
1Lane Fox Clinical Respiratory Physiology Research Unit, Guy's and St Thomas’ NHS Foundation Trust, London, UK
2Centre for Human and Applied Physiological Sciences, King's College London, London, UK
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Amy Dewar
4Dept of Respiratory Medicine, Guy's and St Thomas’ NHS Foundation Trust, London, UK
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Neeraj Mukesh Shah
1Lane Fox Clinical Respiratory Physiology Research Unit, Guy's and St Thomas’ NHS Foundation Trust, London, UK
2Centre for Human and Applied Physiological Sciences, King's College London, London, UK
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Rita Priori
5Philips Research, Eindhoven, The Netherlands
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Abdel Douiri
6School of Population Health and Environmental Sciences, King's College London, London, UK
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Louise Rose
1Lane Fox Clinical Respiratory Physiology Research Unit, Guy's and St Thomas’ NHS Foundation Trust, London, UK
7Florence Nightingale Faculty of Nursing, Midwifery and Palliative Care, King's College London, London, UK
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  • ORCID record for Louise Rose
Nicholas Hart
1Lane Fox Clinical Respiratory Physiology Research Unit, Guy's and St Thomas’ NHS Foundation Trust, London, UK
2Centre for Human and Applied Physiological Sciences, King's College London, London, UK
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Patrick Brian Murphy
1Lane Fox Clinical Respiratory Physiology Research Unit, Guy's and St Thomas’ NHS Foundation Trust, London, UK
2Centre for Human and Applied Physiological Sciences, King's College London, London, UK
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  • For correspondence: patrick.murphy@gstt.nhs.uk
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    FIGURE 1

    a) Daily measurements of neural respiratory drive index (NRDI) and Exacerbations of Chronic Pulmonary Disease Tool (EXACT) score, respiratory rate (fR) and peripheral oxygen saturation (SpO2) at admission (A), discharge (D) and at home for 30-days post-discharge or until hospital readmission (1–30 days) for each patient (1–12). Dashed lines indicate the day of EXACT-defined recovery, if reached (9-point reduction from peak score sustained for 7 days [9]), dotted lines indicate a day of healthcare utilisation, with light grey bars representing hospital readmission (subjects 1–3) and dark grey bars representing non-readmission re-exacerbation (subjects 4–5). b) Trajectory of patient-reported and physiological outcomes in non-readmitted patients (n=9). Data are presented as mean±sem, unless otherwise stated. Bold type represents statistical significance. bpm: breaths per min; mBorg: modified Borg scale for breathlessness; CAT: COPD Assessment Test; HR: heart rate; FEV1: forced expiratory volume in 1 s; FVC: forced vital capacity; IC: inspiratory capacity; EMGpara%max: normalised mean parasternal electromyography. #: repeated-measures ANOVA; ¶: n=6; +: n=1 unable to perform pre-discharge spirometry due to breathlessness. *: p<0.05 compared to admission, post hoc comparisons with Bonferroni correction were performed if a significant f ratio was obtained by one-way repeated-measures ANOVA across all time points.

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ERJ Open Research: 7 (2)
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Home parasternal electromyography tracks patient-reported and physiological measures of recovery from severe COPD exacerbation
Rebecca Francesca D'Cruz, Eui-Sik Suh, Georgios Kaltsakas, Amy Dewar, Neeraj Mukesh Shah, Rita Priori, Abdel Douiri, Louise Rose, Nicholas Hart, Patrick Brian Murphy
ERJ Open Research Apr 2021, 7 (2) 00709-2020; DOI: 10.1183/23120541.00709-2020

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Home parasternal electromyography tracks patient-reported and physiological measures of recovery from severe COPD exacerbation
Rebecca Francesca D'Cruz, Eui-Sik Suh, Georgios Kaltsakas, Amy Dewar, Neeraj Mukesh Shah, Rita Priori, Abdel Douiri, Louise Rose, Nicholas Hart, Patrick Brian Murphy
ERJ Open Research Apr 2021, 7 (2) 00709-2020; DOI: 10.1183/23120541.00709-2020
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