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Effect of ACE1 polymorphism rs1799752 on protein levels of ACE2, the SARS-CoV-2 entry receptor, in alveolar lung epithelium

Merel Jacobs, Lies Lahousse, Hannelore P. Van Eeckhoutte, Sara R.A. Wijnant, Joris R. Delanghe, Guy G. Brusselle, Ken R. Bracke
ERJ Open Research 2021 7: 00940-2020; DOI: 10.1183/23120541.00940-2020
Merel Jacobs
1Laboratory for Translational Research in Obstructive Pulmonary Diseases, Dept of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium
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  • ORCID record for Merel Jacobs
Lies Lahousse
2Dept of Bioanalysis, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium
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  • ORCID record for Lies Lahousse
Hannelore P. Van Eeckhoutte
1Laboratory for Translational Research in Obstructive Pulmonary Diseases, Dept of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium
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Sara R.A. Wijnant
1Laboratory for Translational Research in Obstructive Pulmonary Diseases, Dept of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium
2Dept of Bioanalysis, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium
3Dept of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
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Joris R. Delanghe
4Laboratory of Clinical Chemistry, Dept of Diagnostic Sciences, Ghent University, Ghent, Belgium
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Guy G. Brusselle
1Laboratory for Translational Research in Obstructive Pulmonary Diseases, Dept of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium
3Dept of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
5Dept of Respiratory Diseases, Erasmus Medical Center, Rotterdam, The Netherlands
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Ken R. Bracke
1Laboratory for Translational Research in Obstructive Pulmonary Diseases, Dept of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium
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  • For correspondence: ken.bracke@UGent.be
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Article Information

vol. 7 no. 2
DOI 
https://doi.org/10.1183/23120541.00940-2020

Published By 
European Respiratory Society
Online ISSN 
2312-0541
History 
  • Received December 15, 2020
  • Accepted February 13, 2021
  • Published online April 19, 2021.

Article Versions

  • previous version (February 25, 2021 - 09:16).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright ©The authors 2021 This version is distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0. For commercial reproduction rights and permissions contact permissions@ersnet.org

Author Information

  1. Merel Jacobs1,
  2. Lies Lahousse2,
  3. Hannelore P. Van Eeckhoutte1,
  4. Sara R.A. Wijnant1,2,3,
  5. Joris R. Delanghe4,
  6. Guy G. Brusselle1,3,5 and
  7. Ken R. Bracke1⇑
  1. 1Laboratory for Translational Research in Obstructive Pulmonary Diseases, Dept of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium
  2. 2Dept of Bioanalysis, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium
  3. 3Dept of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
  4. 4Laboratory of Clinical Chemistry, Dept of Diagnostic Sciences, Ghent University, Ghent, Belgium
  5. 5Dept of Respiratory Diseases, Erasmus Medical Center, Rotterdam, The Netherlands
  1. Ken R. Bracke, Dept of Respiratory Medicine, Ghent University Hospital, Corneel Heymanslaan 10, 9000 Ghent, Belgium. E-mail: ken.bracke{at}UGent.be
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Funding

  • Fonds Wetenschappelijk Onderzoek

    G052518N; G0G2318N
  • Concerted Research Action of the Ghent University

    BOF/GOA 01G00819

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Effect of ACE1 polymorphism rs1799752 on protein levels of ACE2, the SARS-CoV-2 entry receptor, in alveolar lung epithelium
Merel Jacobs, Lies Lahousse, Hannelore P. Van Eeckhoutte, Sara R.A. Wijnant, Joris R. Delanghe, Guy G. Brusselle, Ken R. Bracke
ERJ Open Research Apr 2021, 7 (2) 00940-2020; DOI: 10.1183/23120541.00940-2020

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Effect of ACE1 polymorphism rs1799752 on protein levels of ACE2, the SARS-CoV-2 entry receptor, in alveolar lung epithelium
Merel Jacobs, Lies Lahousse, Hannelore P. Van Eeckhoutte, Sara R.A. Wijnant, Joris R. Delanghe, Guy G. Brusselle, Ken R. Bracke
ERJ Open Research Apr 2021, 7 (2) 00940-2020; DOI: 10.1183/23120541.00940-2020
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