ERJ Open Research: 7 (2)

01 April 2021; volume 7, issue 2

Editorials

Open Access
COVID-19 controversy: when to intubate?
Alyn H Morice

ERJ Open Res 7: 00185-2021; DOI: 10.1183/23120541.00185-2021 Published 6 April 2021
Open Access
The benefits of pulmonary rehabilitation in patients with COVID-19
Zhen-feng He, Nan-shan Zhong, Wei-jie Guan

ERJ Open Res 7: 00212-2021; DOI: 10.1183/23120541.00212-2021 Published 31 May 2021
Open Access
Lung volume reduction in real clinical practice
Jorine E. Hartman, Dirk-Jan Slebos

ERJ Open Res 7: 00258-2021; DOI: 10.1183/23120541.00258-2021 Published 7 June 2021

Reviews

Open Access
Targeted therapy in eosinophilic chronic obstructive pulmonary disease
Mathieu Fieldes, Chloé Bourguignon, Said Assou, Amel Nasri, Aurélie Fort, Isabelle Vachier, John De Vos, Engi Ahmed, Arnaud Bourdin

ERJ Open Res 7: 00437-2020; DOI: 10.1183/23120541.00437-2020 Published 12 April 2021
Open Access
SHARP: enabling generation of real-world evidence on a pan-European scale to improve the lives of individuals with severe asthma
Job J.M.H. van Bragt, Susanne Hansen, Ratko Djukanovic, Elisabeth H.D. Bel, Anneke ten Brinke, Scott S. Wagers, Anke H. Maitland-van der Zee, Celeste Porsbjerg

ERJ Open Res 7: 00064-2021; DOI: 10.1183/23120541.00064-2021 Published 19 April 2021
Open Access
Nontuberculous mycobacterial pulmonary disease: an integrated approach beyond antibiotics
Paola Faverio, Federica De Giacomi, Bruno Dino Bodini, Anna Stainer, Alessia Fumagalli, Francesco Bini, Fabrizio Luppi, Stefano Aliberti

ERJ Open Res 7: 00574-2020; DOI: 10.1183/23120541.00574-2020 Published 24 May 2021
Open Access
Safety data in randomised real-world evidence studies: Salford Lung Study learnings
Catherine Harvey, Ashley Woodcock, Jørgen Vestbo, Courtney Crim, Lucy Frith, Nawar Diar Bakerly, John P. New, Claire Williams, Hanaa Elkhenini, Nasir Majeed, Glenn Cardwell, Susan Collier, Loretta Jacques, Joanne Fletcher

ERJ Open Res 7: 00966-2020; DOI: 10.1183/23120541.00966-2020 Published 31 May 2021
Open Access
Identification and treatment of T2-low asthma in the era of biologics
Chris Kyriakopoulos, Athena Gogali, Konstantinos Bartziokas, Konstantinos Kostikas

ERJ Open Res 7: 00309-2020; DOI: 10.1183/23120541.00309-2020 Published 7 June 2021
Open Access
Endothelial dysfunction in COPD: a systematic review and meta-analysis of studies using different functional assessment methods
Marieta P. Theodorakopoulou, Maria Eleni Alexandrou, Dimitra Rafailia Bakaloudi, Georgia Pitsiou, Ioannis Stanopoulos, Theodoros Kontakiotis, Afroditi K. Boutou

ERJ Open Res 7: 00983-2020; DOI: 10.1183/23120541.00983-2020 Published 28 June 2021

Congress Highlights

Open Access
ERS International Congress 2020: highlights from the Respiratory Infections assembly
Stefan Frent, Cristina Calarasu, Kseniia Suska, Kateryna Gashynova, Holly Keir

ERJ Open Res 7: 00091-2021; DOI: 10.1183/23120541.00091-2021 Published 19 April 2021
Open Access
ERS International Congress 2020: highlights from the Clinical Techniques, Imaging and Endoscopy assembly
Pia Iben Pietersen, Bibi Klap, Nicole Hersch, Christian B. Laursen, Simon Walsh, Jouke Annema, Daniela Gompelmann

ERJ Open Res 7: 00118-2021; DOI: 10.1183/23120541.00118-2021 Published 31 May 2021

Study protocols

Open Access
BronchUK: protocol for an observational cohort study and biobank in bronchiectasis
Anthony De Soyza, Philip Mawson, Adam T. Hill, Stuart Elborn, Judy M. Bradley, Charles S. Haworth, R. Andres Floto, Robert Wilson, Michael R. Loebinger, Mary Carroll, Megan Crichton, James D. Chalmers, Anita Sullivan, Jeremy Brown, John R. Hurst, Jamie Duckers, Martin Kelly, John Steer, Tim Gatheral, Paul P. Walker, Craig Winstanley, Alistair McGuire, David Denning, Richard McNally

ERJ Open Res 7: 00775-2020; DOI: 10.1183/23120541.00775-2020 Published 19 April 2021
Open Access
Design and rationale of a randomised, double-blind trial of the efficacy and safety of pirfenidone in patients with fibrotic hypersensitivity pneumonitis
Evans R. Fernández Pérez, James L. Crooks, Jeffrey J. Swigris, Joshua J. Solomon, Michael P. Mohning, Tristan J. Huie, Matthew Koslow, David A. Lynch, Steve D. Groshong, Kaitlin Fier

ERJ Open Res 7: 00054-2021; DOI: 10.1183/23120541.00054-2021 Published 7 June 2021
Open Access
Study design of a randomised, placebo-controlled trial of nintedanib in children and adolescents with fibrosing interstitial lung disease
Robin Deterding, Matthias Griese, Gail Deutsch, David Warburton, Emily M. DeBoer, Steven Cunningham, Annick Clement, Nicolaus Schwerk, Kevin R. Flaherty, Kevin K. Brown, Florian Voss, Ulrike Schmid, Rozsa Schlenker-Herceg, Daniela Verri, Mihaela Dumistracel, Marilisa Schiwek, Susanne Stowasser, Kay Tetzlaff, Emmanuelle Clerisme-Beaty, Lisa R. Young

ERJ Open Res 7: 00805-2020; DOI: 10.1183/23120541.00805-2020 Published 21 June 2021

Original articles

COVID-19
- Open Access
  A randomised trial of Mycobacterium w in critically ill patients with COVID-19: ARMY-1
  Inderpaul Singh Sehgal, Randeep Guleria, Sarman Singh, Mohammad Sabah Siddiqui, Ritesh Agarwal
  
  ERJ Open Res 7: 00059-2021; DOI: 10.1183/23120541.00059-2021 Published 12 April 2021
- Open Access
  Nicotine upregulates ACE2 expression and increases competence for SARS-CoV-2 in human pneumocytes
  Fabrizio Maggi, Alfredo Rosellini, Pietro Giorgio Spezia, Daniele Focosi, Lisa Macera, Michele Lai, Mauro Pistello, Antonio de Iure, Carlo Tomino, Stefano Bonassi, Patrizia Russo
  
  ERJ Open Res 7: 00713-2020; DOI: 10.1183/23120541.00713-2020 Published 12 April 2021
- Open Access
  Recovery from COVID-19: a sprint or marathon? 6-month follow-up data from online long COVID-19 support group members
  Anouk W. Vaes, Yvonne M.J. Goërtz, Maarten Van Herck, Felipe V.C. Machado, Roy Meys, Jeannet M. Delbressine, Sarah Houben-Wilke, Swetlana Gaffron, Dieter Maier, Chris Burtin, Rein Posthuma, Nicole P.H. van Loon, Frits M.E. Franssen, Bita Hajian, Sami O. Simons, Job F.M. van Boven, Frederikus A. Klok, Bart Spaetgens, Claire M.H. Pinxt, Limmie Y.L. Liu, Geertjan Wesseling, Yvonne Spies, Herman Vijlbrief, Alex J. van ’t Hul, Daisy J.A. Janssen, Martijn A. Spruit
  
  ERJ Open Res 7: 00141-2021; DOI: 10.1183/23120541.00141-2021 Published 24 May 2021
- Open Access
  Benefits of pulmonary rehabilitation in COVID-19: a prospective observational cohort study
  Rainer Gloeckl, Daniela Leitl, Inga Jarosch, Tessa Schneeberger, Christoph Nell, Nikola Stenzel, Claus F. Vogelmeier, Klaus Kenn, Andreas R. Koczulla
  
  ERJ Open Res 7: 00108-2021; DOI: 10.1183/23120541.00108-2021 Published 31 May 2021
- Open Access
  The protective effect of SARS-CoV-2 antibodies in Scottish healthcare workers
  Hani Abo-Leyah, Stephanie Gallant, Diane Cassidy, Yan Hui Giam, Justin Killick, Beth Marshall, Gordon Hay, Caroline Snowdon, Eleanor J. Hothersall, Thomas Pembridge, Rachel Strachan, Natalie Gallant, Benjamin J. Parcell, Jacob George, Elizabeth Furrie, James D. Chalmers
  
  ERJ Open Res 7: 00080-2021; DOI: 10.1183/23120541.00080-2021 Published 7 June 2021
Critical care
- Open Access
  Critical care outcomes in patients with pre-existing pulmonary hypertension: insights from the ASPIRE registry
  Kris Bauchmuller, Robin Condliffe, Jennifer Southern, Catherine Billings, Athanasios Charalampopoulos, Charlie A. Elliot, Abdul Hameed, David G. Kiely, Ian Sabroe, A.A. Roger Thompson, Ajay Raithatha, Gary H. Mills
  
  ERJ Open Res 7: 00046-2021; DOI: 10.1183/23120541.00046-2021 Published 6 April 2021
Noninvasive ventilation
- Open Access
  REINVENT: ERS International survey on REstrictive thoracic diseases IN long term home noninvasive VENTilation
  Paola Pierucci, Claudia Crimi, Annalisa Carlucci, Giovanna E. Carpagnano, Jean-Paul Janssens, Manel Lujan, Alberto Noto, Peter J. Wijkstra, Wolfram Windisch, Raffaele Scala
  
  ERJ Open Res 7: 00911-2020; DOI: 10.1183/23120541.00911-2020 Published 19 April 2021
COPD
- Open Access
  Dyspnoea and symptom burden in mild–moderate COPD: the Canadian Cohort Obstructive Lung Disease Study
  Mathew Cherian, Dennis Jensen, Wan C. Tan, Sara Mursleen, Emma C. Goodall, Gilbert A. Nadeau, Amnah M. Awan, Darcy D. Marciniuk, Brandie L. Walker, Shawn D. Aaron, Denis E. O'Donnell, Kenneth R. Chapman, François Maltais, Paul Hernandez, Don D. Sin, Andrea Benedetti, Jean Bourbeau
  
  ERJ Open Res 7: 00960-2020; DOI: 10.1183/23120541.00960-2020 Published 19 April 2021
- Open Access
  Energy expenditure and physical activity in COPD by doubly labelled water method and an accelerometer
  Hideaki Sato, Hidetoshi Nakamura, Yuki Nishida, Toru Shirahata, Sanehiro Yogi, Tomoe Akagami, Machika Soma, Kaiji Inoue, Mamoru Niitsu, Tomohiko Mio, Tatsuyuki Miyashita, Makoto Nagata, Satoshi Nakae, Yosuke Yamada, Shigeho Tanaka, Fuminori Katsukawa
  
  ERJ Open Res 7: 00407-2020; DOI: 10.1183/23120541.00407-2020 Published 4 May 2021
- Open Access
  Pleiotropic associations of heterozygosity for the SERPINA1 Z allele in the UK Biobank
  Katherine A. Fawcett, Kijoung Song, Guoqing Qian, Aliki-Eleni Farmaki, Richard Packer, Catherine John, Nick Shrine, Raquel Granell, Sue Ring, Nicholas J. Timpson, Laura M. Yerges-Armstrong, Richard Eastell, Louise V. Wain, Robert A. Scott, Martin D. Tobin, Ian P. Hall
  
  ERJ Open Res 7: 00049-2021; DOI: 10.1183/23120541.00049-2021 Published 10 May 2021
- Open Access
  Airflow limitation and tongue microbiota in community-dwelling elderly individuals
  Toru Takeshita, Koichiro Matsumoto, Michiko Furuta, Satoru Fukuyama, Kenji Takeuchi, Hiroaki Ogata, Mikari Asakawa, Shinya Kageyama, Jun Hata, Toshiharu Ninomiya, Hiromasa Inoue, Yoshihisa Yamashita
  
  ERJ Open Res 7: 00616-2020; DOI: 10.1183/23120541.00616-2020 Published 24 May 2021
- Open Access
  Treatable traits in an English cohort: prevalence and predictors of future decline in lung function and quality of life in COPD
  Muhammad Rehan Sarwar, Vanessa Marie McDonald, Michael John Abramson, Eldho Paul, Johnson George
  
  ERJ Open Res 7: 00934-2020; DOI: 10.1183/23120541.00934-2020 Published 31 May 2021
- Open Access
  Lung volume reduction in emphysema: a pragmatic prospective cohort study
  Christophe Dooms, Astrid Blondeel, Laurens J. Ceulemans, Johan Coolen, Stephanie Everaerts, Heleen Demeyer, Thierry Troosters, Geert Verleden, Dirk Van Raemdonck, Wim Janssens
  
  ERJ Open Res 7: 00877-2020; DOI: 10.1183/23120541.00877-2020 Published 31 May 2021
- Open Access
  Increased myofibroblasts in the small airways, and relationship to remodelling and functional changes in smokers and COPD patients: potential role of epithelial–mesenchymal transition
  Mathew Suji Eapen, Wenying Lu, Tillie L. Hackett, Gurpreet Kaur Singhera, Malik Q. Mahmood, Ashutosh Hardikar, Chris Ward, Eugene Haydn Walters, Sukhwinder Singh Sohal
  
  ERJ Open Res 7: 00876-2020; DOI: 10.1183/23120541.00876-2020 Published 7 June 2021
- Open Access
  INTREPID: single- versus multiple-inhaler triple therapy for COPD in usual clinical practice
  David M.G. Halpin, Sally Worsley, Afisi S. Ismaila, Kai-Michael Beeh, Dawn Midwinter, Janwillem W.H. Kocks, Elaine Irving, Jose M. Marin, Neil Martin, Maggie Tabberer, Neil G. Snowise, Chris Compton
  
  ERJ Open Res 7: 00950-2020; DOI: 10.1183/23120541.00950-2020 Published 7 June 2021
- Open Access
  Swallowing dysfunction in patients hospitalised due to a COPD exacerbation
  Margareta Gonzalez Lindh, Christer Janson, Monica Blom Johansson, Mimmi Jonsson, Emma Mälberg, Elina Allansson, Cecilia Holm, Margareta Jennische, Hirsch Koyi
  
  ERJ Open Res 7: 00173-2021; DOI: 10.1183/23120541.00173-2021 Published 7 June 2021
- Open Access
  Effect of β-blockers on the risk of COPD exacerbations according to indication of use: the Rotterdam Study
  Leila Karimi, Lies Lahousse, Phebe De Nocker, Bruno H. Stricker, Guy G. Brusselle, Katia M.C. Verhamme
  
  ERJ Open Res 7: 00624-2020; DOI: 10.1183/23120541.00624-2020 Published 28 June 2021
Asthma
- Open Access
  Asthma in South African adolescents: a time trend and risk factor analysis over two decades
  Cynthia B. Baard, Zoe Franckling-Smith, Jacinta Munro, Lesley Workman, Heather J. Zar
  
  ERJ Open Res 7: 00576-2020; DOI: 10.1183/23120541.00576-2020 Published 6 April 2021
- Open Access
  Patients' experiences of asthma exacerbation and management: a qualitative study of severe asthma
  Woo-Jung Song, Ha-Kyeong Won, Suh Young Lee, Han-Ki Park, You Sook Cho, Kian Fan Chung, Liam G. Heaney, Woo Joung Joung
  
  ERJ Open Res 7: 00528-2020; DOI: 10.1183/23120541.00528-2020 Published 6 April 2021
- Open Access
  “It's like being on a roller coaster”: the burden of caring for people with severe asthma
  Eleanor C. Majellano, Vanessa L. Clark, Juliet M. Foster, Peter G. Gibson, Vanessa M. McDonald
  
  ERJ Open Res 7: 00812-2020; DOI: 10.1183/23120541.00812-2020 Published 12 April 2021
- Open Access
  Comparison of inhalation technique with the Diskus and Autohaler in asthmatic children at home
  Annelies van der Kolk, Natasja Lammers, Marjolein Brusse-Keizer, Job van der Palen, Joyce Faber, Reina Spenkelink-Visser, Bernard J. Thio
  
  ERJ Open Res 7: 00215-2019; DOI: 10.1183/23120541.00215-2019 Published 19 April 2021
- You have accessRestricted access
  Anxiety disorders and asthma among adolescents in Uganda: role of early-life exposures
  Harriet Mpairwe, Richard Stephen Mpango, Wilber Sembajjwe, Emily L. Webb, Alison M. Elliott, Neil Pearce, Eugene Kinyanda
  
  ERJ Open Res 7: 00749-2020; DOI: 10.1183/23120541.00749-2020 Published 19 April 2021
- Open Access
  Lung function improvements following inhaled indacaterol/glycopyrronium/mometasone furoate are independent of dosing time in asthma patients: a randomised trial
  Jutta Beier, Henrik Watz, Zuzana Diamant, Jens M. Hohlfeld, Dave Singh, Pascale Pinot, Ieuan Jones, Hanns-Christian Tillmann
  
  ERJ Open Res 7: 00425-2020; DOI: 10.1183/23120541.00425-2020 Published 19 April 2021
- Open Access
  COL4A3 expression in asthmatic epithelium depends on intronic methylation and ZNF263 binding
  Sai Sneha Priya Nemani, Cornelis Joseph Vermeulen, Martin Pech, Alen Faiz, Brian George G. Oliver, Maarten van den Berge, Janette Kay Burgess, Matthias V. Kopp, Markus Weckmann
  
  ERJ Open Res 7: 00802-2020; DOI: 10.1183/23120541.00802-2020 Published 7 June 2021
- Open Access
  Acute and durable effect of inhaled hypertonic saline on mucociliary clearance in adult asthma
  William D. Bennett, Allison Burbank, Martha Almond, Jihong Wu, Agathe Ceppe, Michelle Hernandez, Richard C. Boucher, David B. Peden
  
  ERJ Open Res 7: 00062-2021; DOI: 10.1183/23120541.00062-2021 Published 7 June 2021
Asthma and allergy
- Open Access
  Contributions of asthma, rhinitis and IgE to exhaled nitric oxide in adolescents
  Bess M. Flashner, Sheryl L. Rifas-Shiman, Emily Oken, Carlos A. Camargo, Thomas A.E. Platts-Mills, Lisa Workman, Augusto A. Litonjua, Diane R. Gold, Mary B. Rice
  
  ERJ Open Res 7: 00945-2020; DOI: 10.1183/23120541.00945-2020 Published 19 April 2021
Allergy
- Open Access
  Effect of fexofenadine hydrochloride on allergic rhinitis aggravated by air pollutants
  Anne K. Ellis, Margarita Murrieta-Aguttes, Sandy Furey, Pascaline Picard, Christopher Carlsten
  
  ERJ Open Res 7: 00806-2020; DOI: 10.1183/23120541.00806-2020 Published 6 April 2021
- You have accessRestricted access
  Nasal upregulation of CST1 in dog-sensitised children with severe allergic airway disease
  Ulrika Käck, Elisabet Einarsdottir, Marianne van Hage, Anna Asarnoj, Anna James, Anna Nopp, Kaarel Krjutškov, Shintaro Katayama, Juha Kere, Gunnar Lilja, Cilla Söderhäll, Jon R. Konradsen
  
  ERJ Open Res 7: 00917-2020; DOI: 10.1183/23120541.00917-2020 Published 19 April 2021
Altitude
- Open Access
  Pulmonary haemodynamic response to exercise in highlanders versus lowlanders
  Silvia Ulrich, Stéphanie Saxer, Michael Furian, Patrick R. Bader, Paula Appenzeller, Philipp M. Scheiwiller, Maamed Mademilov, Ulan Sheraliev, Felix Tanner, Talantbek M. Sooronbaev, Konrad E. Bloch, Mona Lichtblau
  
  ERJ Open Res 7: 00937-2020; DOI: 10.1183/23120541.00937-2020 Published 6 April 2021
Dyspnoea
- Open Access
  Validity and reliability of the Multidimensional Dyspnoea Profile in older adults
  Eralda Hegendörfer, Alexander Doukhopelnikoff, Jean-Marie Degryse
  
  ERJ Open Res 7: 00606-2020; DOI: 10.1183/23120541.00606-2020 Published 12 April 2021
- Open Access
  A common model for the breathlessness experience across cardiorespiratory disease
  Sarah L. Finnegan, Kyle T.S. Pattinson, Josefin Sundh, Magnus Sköld, Christer Janson, Anders Blomberg, Jacob Sandberg, Magnus Ekström
  
  ERJ Open Res 7: 00818-2020; DOI: 10.1183/23120541.00818-2020 Published 28 June 2021
Lung function
- Open Access
  The differing physiology of nitrogen and tracer gas multiple-breath washout techniques
  Dominic Sandhu, Grant A.D. Ritchie, Peter A. Robbins
  
  ERJ Open Res 7: 00858-2020; DOI: 10.1183/23120541.00858-2020 Published 19 April 2021
- Open Access
  Classifying signals from a wearable accelerometer device to measure respiratory rate
  Gordon B. Drummond, Darius Fischer, Margaret Lees, Andrew Bates, Janek Mann, D.K. Arvind
  
  ERJ Open Res 7: 00681-2020; DOI: 10.1183/23120541.00681-2020 Published 26 April 2021
- Open Access
  Reference equations for tidal breathing parameters using structured light plethysmography
  Shayan Motamedi-Fakhr, Richard Iles, Nicki Barker, John Alexander, Brendan G. Cooper
  
  ERJ Open Res 7: 00050-2021; DOI: 10.1183/23120541.00050-2021 Published 7 June 2021
Cystic fibrosis
- Open Access
  Cystic fibrosis airway microbiota associated with outcomes of nontuberculous mycobacterial infection
  Lindsay J. Caverly, Madsen Zimbric, Michelle Azar, Kristopher Opron, John J. LiPuma
  
  ERJ Open Res 7: 00578-2020; DOI: 10.1183/23120541.00578-2020 Published 19 April 2021
- Open Access
  Lumacaftor/ivacaftor changes the lung microbiome and metabolome in cystic fibrosis patients
  Anne H. Neerincx, Katrine Whiteson, Joann L. Phan, Paul Brinkman, Mahmoud I. Abdel-Aziz, Els J.M. Weersink, Josje Altenburg, Christof J. Majoor, Anke H. Maitland-van der Zee, Lieuwe D.J. Bos
  
  ERJ Open Res 7: 00731-2020; DOI: 10.1183/23120541.00731-2020 Published 19 April 2021
- Open Access
  Achromobacter xylosoxidans airway infection is associated with lung disease severity in children with cystic fibrosis
  Charlotte Marsac, Laura Berdah, Guillaume Thouvenin, Isabelle Sermet-Gaudelus, Harriet Corvol
  
  ERJ Open Res 7: 00076-2021; DOI: 10.1183/23120541.00076-2021 Published 31 May 2021
Pulmonary vascular disease
- Open Access
  Rapid prediction of adverse outcomes for acute normotensive pulmonary embolism: derivation of the Calgary Acute Pulmonary Embolism score
  Kevin Solverson, Christopher Humphreys, Zhiying Liang, Graeme Prosperi-Porta, James E. Andruchow, Paul Boiteau, Andre Ferland, Eric Herget, Doug Helmersen, Jason Weatherald
  
  ERJ Open Res 7: 00879-2020; DOI: 10.1183/23120541.00879-2020 Published 19 April 2021
- Open Access
  Prognostic value of right atrial dilation in patients with pulmonary embolism
  Markus H. Lerchbaumer, Matthias Ebner, Christian O. Ritter, Laura Steimke, Nina I.J. Rogge, Carmen Sentler, Aaron Thielmann, Lukas Hobohm, Karsten Keller, Joachim Lotz, Gerd Hasenfuß, Rolf Wachter, Bernd Hamm, Stavros V. Konstantinides, Galit Aviram, Mareike Lankeit
  
  ERJ Open Res 7: 00414-2020; DOI: 10.1183/23120541.00414-2020 Published 24 May 2021
- Open Access
  Predicting mortality during long-term follow-up in pulmonary arterial hypertension
  David Kylhammar, Clara Hjalmarsson, Roger Hesselstrand, Kjell Jansson, Mohammad Kavianipour, Barbro Kjellström, Magnus Nisell, Stefan Söderberg, Göran Rådegran
  
  ERJ Open Res 7: 00837-2020; DOI: 10.1183/23120541.00837-2020 Published 31 May 2021
- Open Access
  The isobaric pulmonary arterial compliance in pulmonary hypertension
  Denis Chemla, Emmanuelle Berthelot, Jason Weatherald, Edmund M. T. Lau, Laurent Savale, Antoine Beurnier, David Montani, Olivier Sitbon, Pierre Attal, David Boulate, Patrick Assayag, Marc Humbert, Philippe Hervé
  
  ERJ Open Res 7: 00941-2020; DOI: 10.1183/23120541.00941-2020 Published 31 May 2021
Sleep
- Open Access
  Sleep apnoea and incident malignancy in type 2 diabetes
  Sarah Driendl, Michael Arzt, Claudia S. Zimmermann, Bettina Jung, Tobias Pukrop, Carsten A. Böger, Sebastian Haferkamp, Florian Zeman, Iris M. Heid, Stefan Stadler
  
  ERJ Open Res 7: 00036-2021; DOI: 10.1183/23120541.00036-2021 Published 4 May 2021
- Open Access
  Participation in physical activity is associated with reduced nocturnal hypoxaemia in males
  David Stevens, Sarah Appleton, Yohannes Melaku, Sean Martin, Robert Adams, Gary Wittert
  
  ERJ Open Res 7: 00852-2020; DOI: 10.1183/23120541.00852-2020 Published 24 May 2021
Cough
- Open Access
  Prevalence, incidence and characteristics of chronic cough among adults from the Canadian Longitudinal Study on Aging
  Imran Satia, Alexandra J. Mayhew, Nazmul Sohel, Om Kurmi, Kieran J. Killian, Paul M. O'Byrne, Parminder Raina
  
  ERJ Open Res 7: 00160-2021; DOI: 10.1183/23120541.00160-2021 Published 4 May 2021
Interstitial lung disease
- Open Access
  Idiopathic pulmonary fibrosis cluster analysis highlights diagnostic delay and cardiovascular comorbidity association with outcome
  Jaume Bordas-Martínez, Ricard Gavaldà, Jessica G. Shull, Vanesa Vicens-Zygmunt, Lurdes Planas-Cerezales, Guadalupe Bermudo-Peloche, Salud Santos, Neus Salord, Carmen Monasterio, Maria Molina-Molina, Guillermo Suarez-Cuartin
  
  ERJ Open Res 7: 00897-2020; DOI: 10.1183/23120541.00897-2020 Published 10 May 2021
- You have accessRestricted access
  Type 2 diabetes risk in sarcoidosis patients untreated and treated with corticosteroids
  Joshua P. Entrop, Susanna Kullberg, Johan Grunewald, Anders Eklund, Kerstin Brismar, Elizabeth V. Arkema
  
  ERJ Open Res 7: 00028-2021; DOI: 10.1183/23120541.00028-2021 Published 24 May 2021
- You have accessRestricted access
  The Living with Pulmonary Fibrosis questionnaire in progressive fibrosing interstitial lung disease
  Jeffrey Swigris, Katelyn Cutts, Natalia Male, Michael Baldwin, Klaus B. Rohr, Donald M. Bushnell
  
  ERJ Open Res 7: 00145-2020; DOI: 10.1183/23120541.00145-2020 Published 24 May 2021
- Open Access
  Telomere shortening and DNA damage in culprit cells of different types of progressive fibrosing interstitial lung disease
  Aernoud A. van Batenburg, Karin M. Kazemier, Matthijs F.M. van Oosterhout, Joanne J. van der Vis, Jan C. Grutters, Roel Goldschmeding, Coline H.M. van Moorsel
  
  ERJ Open Res 7: 00691-2020; DOI: 10.1183/23120541.00691-2020 Published 31 May 2021
- Open Access
  Transition of patients with interstitial lung disease from paediatric to adult care
  Václav Koucký, Petr Pohunek, Martina Vašáková, Andrew Bush
  
  ERJ Open Res 7: 00964-2020; DOI: 10.1183/23120541.00964-2020 Published 7 June 2021
- Open Access
  Spectrum of childhood interstitial and diffuse lung diseases at a tertiary hospital in Egypt
  Salma G. Abdelhady, Eman M. Fouda, Malak A. Shaheen, Faten A. Ghazal, Ahmed M. Mostafa, Ahmed M. Osman, Andrew G. Nicholson, Heba M. Hamza
  
  ERJ Open Res 7: 00880-2020; DOI: 10.1183/23120541.00880-2020 Published 7 June 2021
- Open Access
  Anti-HSP47 siRNA lipid nanoparticle ND-L02-s0201 reverses interstitial pulmonary fibrosis in preclinical rat models
  Yun Liu, Jian Liu, Alistair Quimbo, Fengcheng Xia, Jiping Yao, Jean-Pierre Clamme, Sonya Zabludoff, Jun Zhang, Wenbin Ying
  
  ERJ Open Res 7: 00733-2020; DOI: 10.1183/23120541.00733-2020 Published 7 June 2021
- Open Access
  Endobronchial autologous bone marrow–mesenchymal stromal cells in idiopathic pulmonary fibrosis: a phase I trial
  Arantza Campo, José María González-Ruiz, Enrique Andreu, Ana B. Alcaide, María M. Ocón, Juan De-Torres, Jesús Pueyo, Rosa Cordovilla, Eva Villaron, Fermín Sanchez-Guijo, Miguel Barrueco, Jorge Nuñez-Córdoba, Felipe Prósper, Javier J. Zulueta
  
  ERJ Open Res 7: 00773-2020; DOI: 10.1183/23120541.00773-2020 Published 28 June 2021
- Open Access
  Body mass index and in-hospital mortality in patients with acute exacerbation of idiopathic pulmonary fibrosis
  Nobuyasu Awano, Taisuke Jo, Hideo Yasunaga, Minoru Inomata, Naoyuki Kuse, Mari Tone, Kojiro Morita, Hiroki Matsui, Kiyohide Fushimi, Takahide Nagase, Takehiro Izumo
  
  ERJ Open Res 7: 00037-2021; DOI: 10.1183/23120541.00037-2021 Published 28 June 2021
Respiratory infections
- Open Access
  Influence of age, sex and respiratory viruses on the rates of emergency department visits and hospitalisations with respiratory tract infections, asthma and COPD
  Imran Satia, Adil Adatia, Ruth P. Cusack, Justina M. Greene, Paul M. O'Byrne, Kieran J. Killian, Neil Johnston
  
  ERJ Open Res 7: 00053-2021; DOI: 10.1183/23120541.00053-2021 Published 24 May 2021
- Open Access
  Microbial and clinical factors are related to recurrence of symptoms after childhood lower respiratory tract infection
  Emma M. de Koff, Wing Ho Man, Marlies A. van Houten, Arine M. Vlieger, Mei Ling J.N. Chu, Elisabeth A.M. Sanders, Debby Bogaert
  
  ERJ Open Res 7: 00939-2020; DOI: 10.1183/23120541.00939-2020 Published 28 June 2021
Lung cancer
- Open Access
  Excess mortality and undertreatment in elderly lung cancer patients: treatment nihilism in the modern era?
  Jonathan Pham, Matthew Conron, Gavin Wright, Paul Mitchell, David Ball, Jennifer Philip, Margaret Brand, John Zalcberg, Rob G. Stirling
  
  ERJ Open Res 7: 00393-2020; DOI: 10.1183/23120541.00393-2020 Published 24 May 2021
Bronchiectasis
- Open Access
  Home-based pulmonary rehabilitation in people with bronchiectasis: a randomised controlled trial
  Anderson José, Anne E. Holland, Jessyca P.R. Selman, Cristiane Oliveira de Camargo, Diogo Simões Fonseca, Rodrigo A. Athanazio, Samia Z. Rached, Alberto Cukier, Rafael Stelmach, Simone Dal Corso
  
  ERJ Open Res 7: 00021-2021; DOI: 10.1183/23120541.00021-2021 Published 31 May 2021
Bronchoscopy
- Open Access
  A randomised study of comfort during bronchoscopy comparing conscious sedation and anaesthetist-controlled general anaesthesia, including the utility of bispectral index monitoring
  Thomas R. Skinner, Joseph Churton, Timothy P. Edwards, Farzad Bashirzadeh, Christopher Zappala, Justin T. Hundloe, Hau Tan, Andrew J. Pattison, Maryann Todman, Gunter F. Hartel, David I. Fielding
  
  ERJ Open Res 7: 00895-2020; DOI: 10.1183/23120541.00895-2020 Published 31 May 2021
Paediatric pulmonology
- Open Access
  Phagocyte extracellular traps in children with neutrophilic airway inflammation
  Paul T. King, Lovisa Dousha, Nadeene Clarke, Jennifer Schaefer, Rosemary Carzino, Roleen Sharma, Ken L. Wan, Aveena Anantharajah, Kim O'Sullivan, Zhong X. Lu, Stephen R. Holdsworth, Sarath Ranganathan, Philip G. Bardin, David S. Armstrong
  
  ERJ Open Res 7: 00883-2020; DOI: 10.1183/23120541.00883-2020 Published 21 June 2021
EILO
- Open Access
  Characteristics and impact of exercise-induced laryngeal obstruction: an international perspective
  Emil S. Walsted, Bamidele Famokunwa, Louise Andersen, Sune L. Rubak, Frederik Buchvald, Lars Pedersen, James Dodd, Vibeke Backer, Kim G. Nielsen, Andrew Getzin, James H. Hull
  
  ERJ Open Res 7: 00195-2021; DOI: 10.1183/23120541.00195-2021 Published 28 June 2021

Original research letters

Open Access
Pneumatocoeles after bronchoscopic lung volume reduction with valves
Francois Lestelle, Romane Fumat, Alain Didier, Samia Collot, Thomas Egenod, Guillaume Faviez, Christophe Hermant, Gavin Plat, Nicolas Guibert

ERJ Open Res 7: 00747-2020; DOI: 10.1183/23120541.00747-2020 Published 6 April 2021
Open Access
Analysis of pathological changes in the epithelium in COVID-19 patient airways
Wenguang Yin, Weitao Cao, Guangde Zhou, Lifei Wang, Jing Sun, Airu Zhu, Zhongfang Wang, Yumin Zhou, Xiaoqing Liu, Yimin Li, Nanshan Zhong, Jincun Zhao, Lei Liu, Pixin Ran

ERJ Open Res 7: 00690-2020; DOI: 10.1183/23120541.00690-2020 Published 6 April 2021
Open Access
High-dose glucocorticoid treatment of near-fatal bocavirus lung infection results in rapid recovery
Matthias Obenaus, Oliver Schildgen, Dirk Schürmann, Ann-Christin von Brünneck, Martin Janz, Ulrich Keller, Bernhard Gebauer, Johannes Schilling, Stefan Schwartz, Benedikt Weissbrich, Thomas Schneider, Jörg Hofmann, Stephan Mathas

ERJ Open Res 7: 00060-2021; DOI: 10.1183/23120541.00060-2021 Published 12 April 2021
Open Access
Effect of ACE1 polymorphism rs1799752 on protein levels of ACE2, the SARS-CoV-2 entry receptor, in alveolar lung epithelium
Merel Jacobs, Lies Lahousse, Hannelore P. Van Eeckhoutte, Sara R.A. Wijnant, Joris R. Delanghe, Guy G. Brusselle, Ken R. Bracke

ERJ Open Res 7: 00940-2020; DOI: 10.1183/23120541.00940-2020 Published 19 April 2021
Open Access
Home parasternal electromyography tracks patient-reported and physiological measures of recovery from severe COPD exacerbation
Rebecca Francesca D'Cruz, Eui-Sik Suh, Georgios Kaltsakas, Amy Dewar, Neeraj Mukesh Shah, Rita Priori, Abdel Douiri, Louise Rose, Nicholas Hart, Patrick Brian Murphy

ERJ Open Res 7: 00709-2020; DOI: 10.1183/23120541.00709-2020 Published 26 April 2021
Open Access
Detection of Cutibacterium acnes in granulomas of patients with either hypersensitivity pneumonitis or vasculitis reveals that its presence is not unique for sarcoidosis
Els Beijer, Kees Seldenrijk, Bob Meek, Jan Damen, Marian J.R. Quanjel, Jan C. Grutters, Marcel Veltkamp

ERJ Open Res 7: 00930-2020; DOI: 10.1183/23120541.00930-2020 Published 4 May 2021
Open Access
Home-based pulmonary rehabilitation: an implementation study using the RE-AIM framework
Janet Bondarenko, Chloe Babic, Angela T. Burge, Anne E. Holland

ERJ Open Res 7: 00469-2020; DOI: 10.1183/23120541.00469-2020 Published 10 May 2021
Open Access
Sputum production in chronic cough increases the probability of asthma: a cross-sectional questionnaire study
Heikki O. Koskela, Anne M. Lätti

ERJ Open Res 7: 00086-2021; DOI: 10.1183/23120541.00086-2021 Published 24 May 2021
Open Access
Would it have happened without Christmas? Thoracic emphysema and allergic bronchopulmonary aspergillosis in a juvenile cystic fibrosis patient with the G551D mutation receiving ivacaftor
Jochen G. Mainz, Nina Erdmann, Franziska Duckstein, Carlos Zagoya

ERJ Open Res 7: 00758-2020; DOI: 10.1183/23120541.00758-2020 Published 24 May 2021
Open Access
Airway smooth muscle cells from severe asthma patients with fixed airflow obstruction are responsive to steroid and bronchodilator treatment in vitro
Sandra Rutting, Dia Xenaki, Karosham D. Reddy, Melissa Baraket, David G. Chapman, Gregory G. King, Brian G. Oliver, Katrina O. Tonga

ERJ Open Res 7: 00117-2021; DOI: 10.1183/23120541.00117-2021 Published 31 May 2021
Open Access
A review of physiotherapy practice for people with bronchiectasis
Annemarie L. Lee, Susy Baenziger, Amanda Louey, Sophie Jennings, Peter Solin, Ryan Hoy

ERJ Open Res 7: 00569-2020; DOI: 10.1183/23120541.00569-2020 Published 7 June 2021
Open Access
Nasal airway epithelial repair after very preterm birth
Jessica Hillas, Denby J. Evans, Sherlynn Ang, Thomas Iosifidis, Luke W. Garratt, Naomi Hemy, Elizabeth Kicic-Starcevich, Shannon J. Simpson, Anthony Kicic

ERJ Open Res 7: 00913-2020; DOI: 10.1183/23120541.00913-2020 Published 7 June 2021
Open Access
Comparison of genome-wide gene expression profiling by RNA Sequencing versus microarray in bronchial biopsies of COPD patients before and after inhaled corticosteroid treatment: does it provide new insights?
Benedikt Ditz, Jeunard G. Boekhoudt, Hananeh Aliee, Fabian J. Theis, Martijn Nawijn, Corry-Anke Brandsma, Pieter S. Hiemstra, Wim Timens, Gaik W. Tew, Michele A. Grimbaldeston, Margaret Neighbors, Victor Guryev, Maarten van den Berge, Alen Faiz

ERJ Open Res 7: 00104-2021; DOI: 10.1183/23120541.00104-2021 Published 21 June 2021
Open Access
Pattern of cancer patient referral and organisational model of an interventional pulmonology programme during the COVID-19 pandemic
Rocco Trisolini, Daniele Magnini, Vanina Livi, Fausto Leoncini, Lucia M. Porro, Maria C. Flore, Daniela Paioli, Giovanni Sotgiu

ERJ Open Res 7: 00152-2021; DOI: 10.1183/23120541.00152-2021 Published 21 June 2021
Open Access
Microparticles in COVID-19 as a link between lung injury extension and thrombosis
Olivier Morel, Benjamin Marchandot, Laurence Jesel, Laurent Sattler, Antonin Trimaille, Anais Curtiaud, Mickael Ohana, Samira Fafi-Kremer, Valerie Schini-Kerth, Lelia Grunebaum, Jean-Marie Freyssinet

ERJ Open Res 7: 00954-2020; DOI: 10.1183/23120541.00954-2020 Published 21 June 2021
Open Access
Single-nucleotide polymorphism rs2070600 regulates AGER splicing and the sputum levels of the COPD biomarker soluble receptor for advanced glycation end-products
Alen Faiz, Senani N.H. Rathnayake, Nick H.T. ten Hacken, Victor Guryev, Maarten van den Berge, Simon D. Pouwels

ERJ Open Res 7: 00947-2020; DOI: 10.1183/23120541.00947-2020 Published 28 June 2021

Correspondence

Open Access
Confocal laser endomicroscopy to guide sampling of a pure ground-glass opacity
Thibault Viatgé, Thomas Villeneuve, Dominique D'Aure, Julien Mazières, Gavin Plat, Christophe Hermant, Nicolas Guibert

ERJ Open Res 7: 00910-2020; DOI: 10.1183/23120541.00910-2020 Published 6 April 2021
Open Access
Conservative management of COVID-19 associated hypoxaemia
Wolfram Windisch, Stefan Kluge, Martin Bachmann, Carl-Peter Criée, Steffen Weber-Carstens, Michael Westhoff, Christian Karagiannidis, Tobias Welte

ERJ Open Res 7: 00113-2021; DOI: 10.1183/23120541.00113-2021 Published 6 April 2021
Open Access
Conservative management of COVID-19 associated hypoxaemia
Thomas Voshaar, Patrick Stais, Dieter Köhler, Dominic Dellweg

ERJ Open Res 7: 00134-2021; DOI: 10.1183/23120541.00134-2021 Published 6 April 2021
Open Access
Is it feasible to collect exhaled breath condensate in COVID-19 patients undergoing noninvasive ventilatory support?
Paola Pierucci, Rosanna Vaschetto, Giovanna E. Carpagnano

ERJ Open Res 7: 00071-2021; DOI: 10.1183/23120541.00071-2021 Published 24 May 2021
Open Access
Conservative management of COVID-19 associated hypoxaemia
Alexander Supady, Philipp M. Lepper, Hendrik Bracht, Onnen Moerer, Ralf M. Muellenbach, Guido Michels, Mascha O. Fiedler, Armin Kalenka, Matthias Kochanek, Haitham Mutlak, Guy Danziger, Sebastian Muenz, Dirk Lunz, Sabrina Hoersch, Dawid Staudacher, Tobias Wengenmayer, Viviane Zotzmann

ERJ Open Res 7: 00204-2021; DOI: 10.1183/23120541.00204-2021 Published 21 June 2021
Open Access
Conservative management of COVID-19 associated hypoxaemia
Thomas Voshaar, Patrick Stais, Dieter Köhler, Dominic Dellweg

ERJ Open Res 7: 00292-2021; DOI: 10.1183/23120541.00292-2021 Published 21 June 2021

Author correction

Open Access
“Expression of endocannabinoid system components in human airway epithelial cells: impact of sex and chronic respiratory disease status”. Matthew F. Fantauzzi, Jennifer A. Aguiar, Benjamin J-M. Tremblay, Michael J. Mansfield, Toyoshi Yanagihara, Abiram Chandiramohan, Spencer Revill, Min Hyung Ryu, Chris Carlsten, Kjetil Ask, Martin Stämpfli, Andrew C. Doxey and Jeremy A. Hirota. ERJ Open Res 2020; 6: 00128-2020.
ERJ Open Res 7: 50128-2020; DOI: 10.1183/23120541.50128-2020 Published 31 May 2021

Erratum

Open Access
“Lung volume reduction in emphysema: a pragmatic prospective cohort study”. Christophe Dooms, Astrid Blondeel, Laurens J. Ceulemans, Johan Coolen, Stephanie Everaerts, Heleen Demeyer, Thierry Troosters Geert Verleden, Dirk Van Raemdonck and Wim Janssens. ERJ Open Res 2021; 7: 00877-2020
ERJ Open Res 7: 50877-2020; DOI: 10.1183/23120541.50877-2020 Published 21 June 2021

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Table of Contents

Editorials

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Congress Highlights

Study protocols

Original articles

COVID-19

Critical care

Noninvasive ventilation

COPD

Asthma

Asthma and allergy

Allergy

Altitude

Dyspnoea

Lung function

Cystic fibrosis

Pulmonary vascular disease

Sleep

Cough

Interstitial lung disease

Respiratory infections

Lung cancer

Bronchiectasis

Bronchoscopy

Paediatric pulmonology

EILO

Original research letters

Correspondence

Author correction

Erratum

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