Figures
- FIGURE 1
a) Reliability: Bland–Altman plot for total AWESCORES (n=20, 1 month apart, clinical stability). Solid line represents mean change in AWESCORE; dashed line represents the limits of agreement (1.96×sd of the mean change in AWESCORE). b) Reliability: Bland–Altman plot for total AWESCORES (n=40). Solid line represents mean change in AWESCORE; dashed line represents the limits of agreement (1.96×sd of the mean change in AWESCORE).
Tables
- TABLE 1
Participant characteristics for each study component
Clinical status Combined Feasibility and known-groups validity# Concurrent validity¶ and reliability+ Reliability§ Responsivenessƒ Stable Exacerbation Stable Combined Stable Exacerbation Stable Exacerbation n 246 183 63 20 40 27 13 60 60 Male sex n 129 100 29 12 19 13 6 28 28 Age years (mean±sd) 31±10 33±11 33±10 33±10 32±9 33±10 33±10 - FEV1 % predicted (mean±sd) 64±23 54±20 54±19 54±19 57±22 53±18 55±17 42±16 #: participants in outpatient clinic, completed AWESCORE once (clinically stable OR exacerbation). ¶: participants in outpatient clinic, completed AWESCORE and CFQ-R once (clinically stable). +: participants in outpatient clinic, completed AWESCORE twice 1 month apart (clinically stable). §: participants in outpatient clinic, completed AWESCORE twice at one visit (clinically stable) OR inpatient admission, completed AWESCORE twice within 24 h (exacerbation). ƒ: participants in outpatient clinic, completed AWESCORE once (clinically stable) and inpatient admission, completed AWESCORE once (exacerbation).
- TABLE 2
Known-groups validity: domain AWESCORES for clinically stable participants and participants with an acute exacerbation
Domain AWESCORES Clinical stability# Acute exacerbation¶ Mann–Whitney U-test Cough 7 (6–8) 4 (3–4) <0.001 Sputum 7 (6–8) 4 (3–5) <0.001 Energy 7 (6–8) 4 (3–5) <0.001 Exercise 7 (5–8) 4 (3–6) <0.001 Appetite 8 (7–10) 5 (4–7) <0.001 Weight 8 (7–9) 5 (4–8) <0.001 Mood 8 (7–9) 5 (4–7) <0.001 Anxiety 8 (6–9) 6 (4–8) <0.001 Sleep 7 (6–8) 4 (3–6) <0.001 General health 7 (6–8) 5 (3–6) <0.001 Data are median (IQR), p<0.001. #: n=183. ¶: n=63.
- TABLE 3
Reliability: AWESCORES at times A and B (n=40)
AWESCORES Time A Time B Wilcoxon signed rank test ICC (95% CI) domains Z p-value Cough 5 (4–7) 5 (4–7) −0.202 0.84 0.910 (0.836–0.951) Sputum 6 (4–7) 5 (4–7) −0.922 0.36 0.900 (0.820–0.946) Energy 5 (3–8) 5 (4–7) −0.347 0.73 0.937 (0.885–0.966) Exercise 6 (4–8) 5 (4–8) −0.447 0.65 0.959 (0.924–0.978) Appetite 7 (5–9) 7 (4–9) −1.495 0.14 0.937 (0.884–0.966) Weight 7 (4–8) 7 (4–9) −0.229 0.82 0.972 (0.947–0.985) Mood 7 (5–8) 7 (5–8) −0.865 0.39 0.874 (0.775–0.931) Anxiety 7 (5–9) 7 (4–9) −0.420 0.67 0.906 (0.830–0.949) Sleep 7 (4–8) 7 (4–8) −0.193 0.85 0.950 (0.907–0.973) General health Mean±sd: 6±2 Mean±sd: 6±2 Mean difference# −0.225 (95% CI −0.409 to −0.041) 0.956 (0.918–0.976) Data are median (IQR) except where indicated. ICC: intraclass coefficient; sd: standard deviation. #: t-test as data normally distributed; p<0.05.
- TABLE 4
Responsiveness: domain AWESCORES for participants (n=60) in clinical stability and during an acute exacerbation
Domain AWESCORES Clinical stability Acute exacerbation Wilcoxon signed rank test Z p-value Cough 7 (6–8) 4 (3–5) −6.526 <0.001 Sputum 7 (6–8) 4 (3–5) −6.454 <0.001 Energy 8 (6–9) 4 (3–5) −6.499 <0.001 Exercise 7 (6–9) 3 (2–5) −6.609 <0.001 Appetite 8 (8–9) 5 (3–7) −6.073 <0.001 Weight 8 (7–9) 6 (4–8) −5.616 <0.001 Mood 8 (8–9) 5 (4–7) −6.203 <0.001 Anxiety 9 (7–10) 7 (5–8) −4.735 <0.001 Sleep 8 (6–8) 4 (3–6) −5.766 <0.001 General health 7 (7–8) 5 (3–6) −6.481 <0.001 Data are median (IQR); p<0.05.
Supplementary Material
Please note: supplementary material is not edited by the Editorial Office, and is uploaded as it has been supplied by the author.
Supplementary material 00120-2021.supplement
