Skip to main content

Main menu

  • Home
  • Current issue
  • Early View
  • Archive
  • Authors/reviewers
    • Instructions for authors
    • Submit a manuscript
    • COVID-19 submission information
    • Institutional open access agreements
    • Peer reviewer login
  • Alerts
  • Subscriptions
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

User menu

  • Log in
  • Subscribe
  • Contact Us
  • My Cart

Search

  • Advanced search
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

Login

European Respiratory Society

Advanced Search

  • Home
  • Current issue
  • Early View
  • Archive
  • Authors/reviewers
    • Instructions for authors
    • Submit a manuscript
    • COVID-19 submission information
    • Institutional open access agreements
    • Peer reviewer login
  • Alerts
  • Subscriptions

Impact of prior smoking exposure and COPD comorbidity on treatment response to monoclonal antibodies in patients with severe asthma

Heba Morobeid, Carmen Pizarro, Leonie Biener, Gudrun Ulrich-Merzenich, Daniel Kütting, Georg Nickenig, Dirk Skowasch
ERJ Open Research 2021 7: 00190-2021; DOI: 10.1183/23120541.00190-2021
Heba Morobeid
1Dept of Internal Medicine II – Pneumology/Cardiology, University Hospital Bonn, Bonn, Germany
4These authors contributed equally
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Carmen Pizarro
1Dept of Internal Medicine II – Pneumology/Cardiology, University Hospital Bonn, Bonn, Germany
4These authors contributed equally
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Leonie Biener
1Dept of Internal Medicine II – Pneumology/Cardiology, University Hospital Bonn, Bonn, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Leonie Biener
Gudrun Ulrich-Merzenich
2Dept of Internal Medicine III – Oncology, University Hospital Bonn, Bonn, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Daniel Kütting
3Dept of Radiology, University Hospital Bonn, Bonn, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Georg Nickenig
1Dept of Internal Medicine II – Pneumology/Cardiology, University Hospital Bonn, Bonn, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Dirk Skowasch
1Dept of Internal Medicine II – Pneumology/Cardiology, University Hospital Bonn, Bonn, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: Dirk.Skowasch@ukbonn.de
  • Article
  • Figures & Data
  • Info & Metrics
  • PDF
Loading

Tables

  • TABLE 1

    Patient characteristics and response to antibody therapy

    AllEx-smokersNonsmokersp-value
    Patients15848 (30)110 (70)
    Females102 (65)21 (44)81 (74)0.010*
    Age, years53.4±14.6758.88±11.4051.07±15.330.002*
    BMI, kg·m−228.56±6.4128.90±4.8928.41±6.990.060
    Duration of the disease, years26.47±16.3324.42±18.6526.94±15.300.045*
    Smoking pack-years21.70±18.0727.98±17.44.94±1.83<0.001*
    Comorbidities
     COPD36 (33)24 (50)12 (11)<0.001*
     Emphysema19 (12)10 (21)9 (8)0.017*
     Allergy92 (84)27 (56)66 (60)0.331
     Atopic dermatitis18 (16)3 (6)15 (14)0.095
     Chronic sinusitis/nasal polyps70 (64)17 (35)53 (48)0.078
     Obstructive sleep apnoea16 (15)8 (17)8 (7)0.287
     Gastro-oesophageal reflux11 (10)3 (6)8 (7)0.891
     Obesity#17 (15)3 (6)14 (13)0.107
    ACT score
     At baseline12.87±5.4510.78±4.0212.11±4.760.353
     At follow-up16.50±5.8816.13±6.0316.66±5.830.568
     Δ pre- to post-treatment4.07±5.714.60±6.083.83±5.550.423
    FEV1, L
     At baseline1.97±0.801.66±0.602.10±0.840.007*
     At follow-up2.11±0.771.86±0.682.21±0.800.263
     Δ pre- to post-treatment0.14±0.420.21±0.360.12±0.460.538
    Exacerbation rate
     At baseline4.08±4.164.90±4.053.73±4.170.598
     At follow-up0.22±0.630.25±0.940.21±0.430.240
     Δ pre- to post-treatment−3.89±4.12−4.79±4.14−3.49±4.060.518
    Regular oral corticosteroid dose, mg·day−1
     At baseline7.15± 8.328.33±7.456.62±8.670.700
     At follow-up2.35±4.763.50±5.481.84±4.330.170
     Δ pre- to post-treatment−3.91±8.74−3.79±10.35−3.97±7.970.200

    Data are presented as n, n (%) or mean±sd, unless otherwise stated. BMI: body mass index; ACT: Asthma Control Test; FEV1: forced expiratory volume in 1 s. #: BMI >30 kg·m−2. *: significant p-value, p<0.05.

    PreviousNext
    Back to top
    Vol 7 Issue 3 Table of Contents
    ERJ Open Research: 7 (3)
    • Table of Contents
    • Index by author
    Email

    Thank you for your interest in spreading the word on European Respiratory Society .

    NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

    Enter multiple addresses on separate lines or separate them with commas.
    Impact of prior smoking exposure and COPD comorbidity on treatment response to monoclonal antibodies in patients with severe asthma
    (Your Name) has sent you a message from European Respiratory Society
    (Your Name) thought you would like to see the European Respiratory Society web site.
    CAPTCHA
    This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
    Print
    Citation Tools
    Impact of prior smoking exposure and COPD comorbidity on treatment response to monoclonal antibodies in patients with severe asthma
    Heba Morobeid, Carmen Pizarro, Leonie Biener, Gudrun Ulrich-Merzenich, Daniel Kütting, Georg Nickenig, Dirk Skowasch
    ERJ Open Research Jul 2021, 7 (3) 00190-2021; DOI: 10.1183/23120541.00190-2021

    Citation Manager Formats

    • BibTeX
    • Bookends
    • EasyBib
    • EndNote (tagged)
    • EndNote 8 (xml)
    • Medlars
    • Mendeley
    • Papers
    • RefWorks Tagged
    • Ref Manager
    • RIS
    • Zotero
    Share
    Impact of prior smoking exposure and COPD comorbidity on treatment response to monoclonal antibodies in patients with severe asthma
    Heba Morobeid, Carmen Pizarro, Leonie Biener, Gudrun Ulrich-Merzenich, Daniel Kütting, Georg Nickenig, Dirk Skowasch
    ERJ Open Research Jul 2021, 7 (3) 00190-2021; DOI: 10.1183/23120541.00190-2021
    Reddit logo Technorati logo Twitter logo Connotea logo Facebook logo Mendeley logo
    Full Text (PDF)

    Jump To

    • Article
      • Abstract
      • Acknowledgements
      • Footnotes
      • References
    • Figures & Data
    • Info & Metrics
    • PDF

    Subjects

    • Asthma and allergy
    • COPD and smoking
    • Tweet Widget
    • Facebook Like
    • Google Plus One

    More in this TOC Section

    • A 3D-engineered silicone stent
    • Obesity does not modify effect of CPAP on insulin resistance
    • Asthma prevalence and medication dispensation
    Show more Research letters

    Related Articles

    Navigate

    • Home
    • Current issue
    • Archive

    About ERJ Open Research

    • Editorial board
    • Journal information
    • Press
    • Permissions and reprints
    • Advertising

    The European Respiratory Society

    • Society home
    • myERS
    • Privacy policy
    • Accessibility

    ERS publications

    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS books online
    • ERS Bookshop

    Help

    • Feedback

    For authors

    • Instructions for authors
    • Publication ethics and malpractice
    • Submit a manuscript

    For readers

    • Alerts
    • Subjects
    • RSS

    Subscriptions

    • Accessing the ERS publications

    Contact us

    European Respiratory Society
    442 Glossop Road
    Sheffield S10 2PX
    United Kingdom
    Tel: +44 114 2672860
    Email: journals@ersnet.org

    ISSN

    Online ISSN: 2312-0541

    Copyright © 2023 by the European Respiratory Society