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Vaping-induced metabolomic signatures in the circulation of mice are driven by device type, e-liquid, exposure duration and sex

Alexander Moshensky, Mulong Du, John Shin, Ira Advani, Deepti Gunge, Denzil Mathew, Rita Alkolla, Ashley Du, Christian Javier, Lauren Ma, Albert Tran, Nicholas Nguyen, Jarod Olay, Sedtavut Nilaad, Jeffrey Ding, Mahan Najhawan, Jeramie D. Watrous, Christine M. Bojanowksi, Mohit Jain, David C. Christiani, Laura E. Crotty Alexander
ERJ Open Research 2021 7: 00229-2021; DOI: 10.1183/23120541.00229-2021
Alexander Moshensky
1Pulmonary Critical Care Section, VA San Diego Healthcare System, La Jolla, CA, USA
2Division of Pulmonary, Critical Care and Sleep Medicine, Dept of Medicine, University of California San Diego (UCSD), La Jolla, CA, USA
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Mulong Du
3Dept of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA
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John Shin
1Pulmonary Critical Care Section, VA San Diego Healthcare System, La Jolla, CA, USA
2Division of Pulmonary, Critical Care and Sleep Medicine, Dept of Medicine, University of California San Diego (UCSD), La Jolla, CA, USA
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Ira Advani
1Pulmonary Critical Care Section, VA San Diego Healthcare System, La Jolla, CA, USA
2Division of Pulmonary, Critical Care and Sleep Medicine, Dept of Medicine, University of California San Diego (UCSD), La Jolla, CA, USA
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Deepti Gunge
1Pulmonary Critical Care Section, VA San Diego Healthcare System, La Jolla, CA, USA
2Division of Pulmonary, Critical Care and Sleep Medicine, Dept of Medicine, University of California San Diego (UCSD), La Jolla, CA, USA
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Denzil Mathew
1Pulmonary Critical Care Section, VA San Diego Healthcare System, La Jolla, CA, USA
2Division of Pulmonary, Critical Care and Sleep Medicine, Dept of Medicine, University of California San Diego (UCSD), La Jolla, CA, USA
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Rita Alkolla
1Pulmonary Critical Care Section, VA San Diego Healthcare System, La Jolla, CA, USA
2Division of Pulmonary, Critical Care and Sleep Medicine, Dept of Medicine, University of California San Diego (UCSD), La Jolla, CA, USA
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Ashley Du
1Pulmonary Critical Care Section, VA San Diego Healthcare System, La Jolla, CA, USA
2Division of Pulmonary, Critical Care and Sleep Medicine, Dept of Medicine, University of California San Diego (UCSD), La Jolla, CA, USA
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Christian Javier
1Pulmonary Critical Care Section, VA San Diego Healthcare System, La Jolla, CA, USA
2Division of Pulmonary, Critical Care and Sleep Medicine, Dept of Medicine, University of California San Diego (UCSD), La Jolla, CA, USA
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Lauren Ma
1Pulmonary Critical Care Section, VA San Diego Healthcare System, La Jolla, CA, USA
2Division of Pulmonary, Critical Care and Sleep Medicine, Dept of Medicine, University of California San Diego (UCSD), La Jolla, CA, USA
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Albert Tran
1Pulmonary Critical Care Section, VA San Diego Healthcare System, La Jolla, CA, USA
2Division of Pulmonary, Critical Care and Sleep Medicine, Dept of Medicine, University of California San Diego (UCSD), La Jolla, CA, USA
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Nicholas Nguyen
1Pulmonary Critical Care Section, VA San Diego Healthcare System, La Jolla, CA, USA
2Division of Pulmonary, Critical Care and Sleep Medicine, Dept of Medicine, University of California San Diego (UCSD), La Jolla, CA, USA
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Jarod Olay
1Pulmonary Critical Care Section, VA San Diego Healthcare System, La Jolla, CA, USA
2Division of Pulmonary, Critical Care and Sleep Medicine, Dept of Medicine, University of California San Diego (UCSD), La Jolla, CA, USA
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Sedtavut Nilaad
1Pulmonary Critical Care Section, VA San Diego Healthcare System, La Jolla, CA, USA
2Division of Pulmonary, Critical Care and Sleep Medicine, Dept of Medicine, University of California San Diego (UCSD), La Jolla, CA, USA
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Jeffrey Ding
4Depts of Medicine and Pharmacology, UCSD, La Jolla, CA, USA
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Mahan Najhawan
4Depts of Medicine and Pharmacology, UCSD, La Jolla, CA, USA
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  • ORCID record for Mahan Najhawan
Jeramie D. Watrous
4Depts of Medicine and Pharmacology, UCSD, La Jolla, CA, USA
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Christine M. Bojanowksi
1Pulmonary Critical Care Section, VA San Diego Healthcare System, La Jolla, CA, USA
2Division of Pulmonary, Critical Care and Sleep Medicine, Dept of Medicine, University of California San Diego (UCSD), La Jolla, CA, USA
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Mohit Jain
4Depts of Medicine and Pharmacology, UCSD, La Jolla, CA, USA
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David C. Christiani
3Dept of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA
5Division of Pulmonary and Critical Care Medicine, Dept of Medicine, Massachusetts General Hospital, Boston, MA, USA
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Laura E. Crotty Alexander
1Pulmonary Critical Care Section, VA San Diego Healthcare System, La Jolla, CA, USA
2Division of Pulmonary, Critical Care and Sleep Medicine, Dept of Medicine, University of California San Diego (UCSD), La Jolla, CA, USA
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  • For correspondence: lca@ucsd.edu
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Article Information

vol. 7 no. 3
DOI 
https://doi.org/10.1183/23120541.00229-2021

Published By 
European Respiratory Society
Online ISSN 
2312-0541
History 
  • Received April 1, 2021
  • Accepted April 24, 2021
  • Published online July 12, 2021.

Article Versions

  • previous version (June 17, 2021 - 07:22).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright ©The authors 2021 This version is distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0.

Author Information

  1. Alexander Moshensky1,2,
  2. Mulong Du3,
  3. John Shin1,2,
  4. Ira Advani1,2,
  5. Deepti Gunge1,2,
  6. Denzil Mathew1,2,
  7. Rita Alkolla1,2,
  8. Ashley Du1,2,
  9. Christian Javier1,2,
  10. Lauren Ma1,2,
  11. Albert Tran1,2,
  12. Nicholas Nguyen1,2,
  13. Jarod Olay1,2,
  14. Sedtavut Nilaad1,2,
  15. Jeffrey Ding4,
  16. Mahan Najhawan4,
  17. Jeramie D. Watrous4,
  18. Christine M. Bojanowksi1,2,
  19. Mohit Jain4,
  20. David C. Christiani3,5 and
  21. Laura E. Crotty Alexander1,2⇑
  1. 1Pulmonary Critical Care Section, VA San Diego Healthcare System, La Jolla, CA, USA
  2. 2Division of Pulmonary, Critical Care and Sleep Medicine, Dept of Medicine, University of California San Diego (UCSD), La Jolla, CA, USA
  3. 3Dept of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA
  4. 4Depts of Medicine and Pharmacology, UCSD, La Jolla, CA, USA
  5. 5Division of Pulmonary and Critical Care Medicine, Dept of Medicine, Massachusetts General Hospital, Boston, MA, USA
  1. Laura E. Crotty Alexander (lca{at}ucsd.edu)
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Funding

  • Health Services Research and Development

    1I01BX004767
  • American Thoracic Society

    Foundation Award for Outstanding Early Career Inve
  • American Heart Association

    16BGIA27790079
  • Tobacco-Related Disease Research Program

    24FT-0010; 24RT-0032; 26IP-0040; T30IP0965
  • National Heart, Lung, and Blood Institute

    K01DK116917; P30DK063491; P30ES000002; P42ES010337; R01ES027595; R01HL147326; S10OD020025; U01CA209414

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Vaping-induced metabolomic signatures in the circulation of mice are driven by device type, e-liquid, exposure duration and sex
Alexander Moshensky, Mulong Du, John Shin, Ira Advani, Deepti Gunge, Denzil Mathew, Rita Alkolla, Ashley Du, Christian Javier, Lauren Ma, Albert Tran, Nicholas Nguyen, Jarod Olay, Sedtavut Nilaad, Jeffrey Ding, Mahan Najhawan, Jeramie D. Watrous, Christine M. Bojanowksi, Mohit Jain, David C. Christiani, Laura E. Crotty Alexander
ERJ Open Research Jul 2021, 7 (3) 00229-2021; DOI: 10.1183/23120541.00229-2021

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Vaping-induced metabolomic signatures in the circulation of mice are driven by device type, e-liquid, exposure duration and sex
Alexander Moshensky, Mulong Du, John Shin, Ira Advani, Deepti Gunge, Denzil Mathew, Rita Alkolla, Ashley Du, Christian Javier, Lauren Ma, Albert Tran, Nicholas Nguyen, Jarod Olay, Sedtavut Nilaad, Jeffrey Ding, Mahan Najhawan, Jeramie D. Watrous, Christine M. Bojanowksi, Mohit Jain, David C. Christiani, Laura E. Crotty Alexander
ERJ Open Research Jul 2021, 7 (3) 00229-2021; DOI: 10.1183/23120541.00229-2021
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