Disease activity in COPD: time to make imaging biomarkers a PET project? | European Respiratory Society

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TABLE 1

PET, CT and MRI: summary for potential COPD biomarkers

Modality	Type	Measurement	Potential biomarker of	Radiation	Cost	Time
PET	Functional ¹⁸F-FDG	Lung FDG uptake Large vessel FDG uptake	Pulmonary inflammation Risk of cardiovascular events	+++	++	+++
CT	Structural Insp only	Lung density Airway structure Vascular pruning	Emphysema, AECOPD risk, FEV₁ decline COPD risk, FEV₁ decline Mortality risk	+	+	+
	Functional Insp/Exp	Low density on exp Deformation on image registration	Small airways disease/gas trapping Biomechanics	++	+	+
MRI	Functional ³He/¹²⁹Xe	Ventilation defect percent Dissolved phase	Ventilation heterogeneity Gas exchange	−	+++	+

PET: positron emission tomography; CT: computed tomography; MRI: magnetic resonance imaging; Exp: expiratory; Insp: inspiratory; FDG: fluorodeoxyglucose; FEV₁: forced expiratory volume in 1 s; AECOPD: acute exacerbation of COPD.

Vol 7 Issue 3 Table of Contents

ERJ Open Research: 7 (3)

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