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Reduced neutrophil elastase inhibitor elafin and elevated transforming growth factor-β1 are linked to inflammatory response in sputum of cystic fibrosis patients with Pseudomonas aeruginosa

Jan C. Thomassen, Tobias Trojan, Maxine Walz, Christina Vohlen, Gregor Fink, Ernst Rietschel, Miguel A. Alejandre Alcazar, Silke van Koningsbruggen-Rietschel
ERJ Open Research 2021 7: 00636-2020; DOI: 10.1183/23120541.00636-2020
Jan C. Thomassen
1CF Center, Children's Hospital, Faculty of Medicine, University of Cologne, Cologne, Germany
2Translational Experimental Pediatrics – Experimental Pulmonology, Children's Hospital, Faculty of Medicine, University of Cologne, Cologne, Germany
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  • For correspondence: Jan.thomassen@uk-koeln.de
Tobias Trojan
1CF Center, Children's Hospital, Faculty of Medicine, University of Cologne, Cologne, Germany
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Maxine Walz
1CF Center, Children's Hospital, Faculty of Medicine, University of Cologne, Cologne, Germany
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Christina Vohlen
2Translational Experimental Pediatrics – Experimental Pulmonology, Children's Hospital, Faculty of Medicine, University of Cologne, Cologne, Germany
3Center of Molecular Medicine Cologne, Faculty of Medicine, University of Cologne, Cologne, Germany
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Gregor Fink
2Translational Experimental Pediatrics – Experimental Pulmonology, Children's Hospital, Faculty of Medicine, University of Cologne, Cologne, Germany
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Ernst Rietschel
1CF Center, Children's Hospital, Faculty of Medicine, University of Cologne, Cologne, Germany
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Miguel A. Alejandre Alcazar
1CF Center, Children's Hospital, Faculty of Medicine, University of Cologne, Cologne, Germany
2Translational Experimental Pediatrics – Experimental Pulmonology, Children's Hospital, Faculty of Medicine, University of Cologne, Cologne, Germany
3Center of Molecular Medicine Cologne, Faculty of Medicine, University of Cologne, Cologne, Germany
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Silke van Koningsbruggen-Rietschel
1CF Center, Children's Hospital, Faculty of Medicine, University of Cologne, Cologne, Germany
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Article Information

vol. 7 no. 3
DOI 
https://doi.org/10.1183/23120541.00636-2020

Published By 
European Respiratory Society
Online ISSN 
2312-0541
History 
  • Received September 2, 2020
  • Accepted April 19, 2021
  • Published online July 19, 2021.

Article Versions

  • previous version (May 21, 2021 - 02:16).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright ©The authors 2021 This version is distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0. For commercial reproduction rights and permissions contact permissions@ersnet.org

Author Information

  1. Jan C. Thomassen1,2⇑,
  2. Tobias Trojan1,
  3. Maxine Walz1,
  4. Christina Vohlen2,3,
  5. Gregor Fink2,
  6. Ernst Rietschel1,
  7. Miguel A. Alejandre Alcazar1,2,3 and
  8. Silke van Koningsbruggen-Rietschel1
  1. 1CF Center, Children's Hospital, Faculty of Medicine, University of Cologne, Cologne, Germany
  2. 2Translational Experimental Pediatrics – Experimental Pulmonology, Children's Hospital, Faculty of Medicine, University of Cologne, Cologne, Germany
  3. 3Center of Molecular Medicine Cologne, Faculty of Medicine, University of Cologne, Cologne, Germany
  1. Corresponding author: Jan C. Thomassen (Jan.thomassen{at}uk-koeln.de)
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Vol 7 Issue 3 Table of Contents
ERJ Open Research: 7 (3)
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Reduced neutrophil elastase inhibitor elafin and elevated transforming growth factor-β1 are linked to inflammatory response in sputum of cystic fibrosis patients with Pseudomonas aeruginosa
Jan C. Thomassen, Tobias Trojan, Maxine Walz, Christina Vohlen, Gregor Fink, Ernst Rietschel, Miguel A. Alejandre Alcazar, Silke van Koningsbruggen-Rietschel
ERJ Open Research Jul 2021, 7 (3) 00636-2020; DOI: 10.1183/23120541.00636-2020

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Reduced neutrophil elastase inhibitor elafin and elevated transforming growth factor-β1 are linked to inflammatory response in sputum of cystic fibrosis patients with Pseudomonas aeruginosa
Jan C. Thomassen, Tobias Trojan, Maxine Walz, Christina Vohlen, Gregor Fink, Ernst Rietschel, Miguel A. Alejandre Alcazar, Silke van Koningsbruggen-Rietschel
ERJ Open Research Jul 2021, 7 (3) 00636-2020; DOI: 10.1183/23120541.00636-2020
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Subjects

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