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Challenging the obesity paradox: extreme obesity and COPD mortality in the SUMMIT trial

Emily P. Brigham, Julie A. Anderson, Robert D. Brook, Peter M.A. Calverley, Bartolome R. Celli, Nicholas J. Cowans, Courtney Crim, James E. Diserens, Fernando J. Martinez, Meredith C. McCormack, David E. Newby, Julie Yates, Jorgen Vestbo, Tianshi David Wu, Robert A. Wise
ERJ Open Research 2021 7: 00902-2020; DOI: 10.1183/23120541.00902-2020
Emily P. Brigham
1Division of Pulmonary and Critical Care Medicine, Johns Hopkins Medicine, Baltimore, MD, USA
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  • For correspondence: ebrigham@jhmi.edu
Julie A. Anderson
2Research and Development, GlaxoSmithKline, Stockley Park, UK
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Robert D. Brook
3Division of Cardiovascular Diseases, Wayne State University, Detroit, MI, USA
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Peter M.A. Calverley
4Dept of Medicine, Clinical Sciences Centre, University of Liverpool, University Hospital Aintree, Liverpool, UK
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Bartolome R. Celli
5Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
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  • ORCID record for Bartolome R. Celli
Nicholas J. Cowans
6Statistics and Programming, Veramed Ltd, Twickenham, UK
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Courtney Crim
7Research and Development, GlaxoSmithKline, Research Triangle Park, NC, USA
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James E. Diserens
6Statistics and Programming, Veramed Ltd, Twickenham, UK
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Fernando J. Martinez
8Division of Pulmonary and Critical Care Medicine, Weill Cornell Medicine, New York, NY, USA
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Meredith C. McCormack
1Division of Pulmonary and Critical Care Medicine, Johns Hopkins Medicine, Baltimore, MD, USA
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David E. Newby
9Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK
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Julie Yates
7Research and Development, GlaxoSmithKline, Research Triangle Park, NC, USA
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Jorgen Vestbo
10Division of Infection, Immunity and Respiratory Medicine, Manchester Academic Health Sciences Centre, The University of Manchester and Manchester University NHS Foundation Trust, Manchester, UK
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Tianshi David Wu
11Section of Pulmonary, Critical Care, and Sleep Medicine, Baylor College of Medicine, Houston, TX, USA
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Robert A. Wise
1Division of Pulmonary and Critical Care Medicine, Johns Hopkins Medicine, Baltimore, MD, USA
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Article Information

vol. 7 no. 3
DOI 
https://doi.org/10.1183/23120541.00902-2020

Published By 
European Respiratory Society
Online ISSN 
2312-0541
History 
  • Received December 2, 2020
  • Accepted May 1, 2021
  • Published online July 26, 2021.

Article Versions

  • previous version (June 17, 2021 - 07:22).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright ©The authors 2021 This version is distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0. For commercial reproduction rights and permissions contact permissions@ersnet.org

Author Information

  1. Emily P. Brigham1⇑,
  2. Julie A. Anderson2,
  3. Robert D. Brook3,
  4. Peter M.A. Calverley4,
  5. Bartolome R. Celli5,
  6. Nicholas J. Cowans6,
  7. Courtney Crim7,
  8. James E. Diserens6,
  9. Fernando J. Martinez8,
  10. Meredith C. McCormack1,
  11. David E. Newby9,
  12. Julie Yates7,
  13. Jorgen Vestbo10,
  14. Tianshi David Wu11 and
  15. Robert A. Wise1
  1. 1Division of Pulmonary and Critical Care Medicine, Johns Hopkins Medicine, Baltimore, MD, USA
  2. 2Research and Development, GlaxoSmithKline, Stockley Park, UK
  3. 3Division of Cardiovascular Diseases, Wayne State University, Detroit, MI, USA
  4. 4Dept of Medicine, Clinical Sciences Centre, University of Liverpool, University Hospital Aintree, Liverpool, UK
  5. 5Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
  6. 6Statistics and Programming, Veramed Ltd, Twickenham, UK
  7. 7Research and Development, GlaxoSmithKline, Research Triangle Park, NC, USA
  8. 8Division of Pulmonary and Critical Care Medicine, Weill Cornell Medicine, New York, NY, USA
  9. 9Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK
  10. 10Division of Infection, Immunity and Respiratory Medicine, Manchester Academic Health Sciences Centre, The University of Manchester and Manchester University NHS Foundation Trust, Manchester, UK
  11. 11Section of Pulmonary, Critical Care, and Sleep Medicine, Baylor College of Medicine, Houston, TX, USA
  1. Corresponding author: Emily P. Brigham (ebrigham{at}jhmi.edu)
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Funding

  • GlaxoSmithKline

    clinicaltrials.gov ID NCT01313676

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Challenging the obesity paradox: extreme obesity and COPD mortality in the SUMMIT trial
Emily P. Brigham, Julie A. Anderson, Robert D. Brook, Peter M.A. Calverley, Bartolome R. Celli, Nicholas J. Cowans, Courtney Crim, James E. Diserens, Fernando J. Martinez, Meredith C. McCormack, David E. Newby, Julie Yates, Jorgen Vestbo, Tianshi David Wu, Robert A. Wise
ERJ Open Research Jul 2021, 7 (3) 00902-2020; DOI: 10.1183/23120541.00902-2020

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Challenging the obesity paradox: extreme obesity and COPD mortality in the SUMMIT trial
Emily P. Brigham, Julie A. Anderson, Robert D. Brook, Peter M.A. Calverley, Bartolome R. Celli, Nicholas J. Cowans, Courtney Crim, James E. Diserens, Fernando J. Martinez, Meredith C. McCormack, David E. Newby, Julie Yates, Jorgen Vestbo, Tianshi David Wu, Robert A. Wise
ERJ Open Research Jul 2021, 7 (3) 00902-2020; DOI: 10.1183/23120541.00902-2020
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