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Pilot study on nocturnal monitoring of crackles in children with pneumonia

Wilfried Nikolaizik, Lisa Wuensch, Monika Bauck, Volker Gross, Keywan Sohrabi, Andreas Weissflog, Olaf Hildebrandt, Ulrich Koehler, Stefanie Weber
ERJ Open Research 2021 7: 00284-2021; DOI: 10.1183/23120541.00284-2021
Wilfried Nikolaizik
1Dept of Pediatric Pulmonology, Children's Hospital, Philipps-University, Marburg, Germany
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Lisa Wuensch
1Dept of Pediatric Pulmonology, Children's Hospital, Philipps-University, Marburg, Germany
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Monika Bauck
1Dept of Pediatric Pulmonology, Children's Hospital, Philipps-University, Marburg, Germany
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Volker Gross
2Faculty of Health Sciences, University of Applied Sciences, Giessen, Germany
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Keywan Sohrabi
2Faculty of Health Sciences, University of Applied Sciences, Giessen, Germany
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Andreas Weissflog
3Thora Tech GmbH, Giessen, Germany
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Olaf Hildebrandt
4Division of Respiratory and Critical Care Medicine, Philipps-University, Marburg, Germany
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Ulrich Koehler
4Division of Respiratory and Critical Care Medicine, Philipps-University, Marburg, Germany
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Stefanie Weber
1Dept of Pediatric Pulmonology, Children's Hospital, Philipps-University, Marburg, Germany
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  • For correspondence: wilfried_nikolaizik@hotmail.com
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  • FIGURE 1
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    FIGURE 1

    Screenshot of the nocturnal lung sound recording of a 3.8-year-old boy with left-sided paracardial infiltrates on the chest radiograph. Microbiological assessment revealed infection with Mycoplasma pneumonia. The leukocyte count was 10.4 G·L−1, the C-reactive protein level <5 mg·L−1. The graphical user interface consists of a context menu and operating elements in the upper part. The event charts represent an overview of the breath rate in blue, cough events in green, wheezing in red, other sounds in orange and comments in black. Single recording periods can be selected and evaluated with the help of the scroll bar of the corresponding time period shown in grey below. The volume level of the outer microphone is shown in the next bar. The next three segment charts below display the recorded sound spectrum over a 30-second time period separated for trachea, left lung and right lung followed by another segment chart for the recorded events below.

    The spectrogram at time epoch 210 (23:45:00–23:45:30 h) is showing fine crackles (high-frequency sharp peaks) and coarse crackles (peaks of slightly lower frequency and slightly longer duration) on the chart of the left lung but not on the charts of the right lung or trachea.

  • FIGURE 2
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    FIGURE 2

    Number of epochs with crackles overnight. The number of the 960 recorded epochs (30 s) per patient overnight showing fine and coarse crackles (mean and single patients’ results, n=30).

  • FIGURE 3
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    FIGURE 3

    Distribution of fine and coarse crackle epochs overnight.

Tables

  • Figures
  • TABLE 1

    Localisation of crackles

    PatientClassical auscultationRadiological changesTotal crackle epochsFine crackle epochsCoarse crackle epochs
    LeftRightLeftRightLeftRight
    1LeftLeft15051404550515955889
    2No cracklesLeft+right14531407631527822880
    3RightRight9391007315345624662
    4n.d.Right417582119180298402
    5No cracklesRight723674271205452469
    6LeftLeft>right1075735467240608495
    7No cracklesRight840655318258522397
    8LeftRight>left255785127300128485
    9No cracklesLeft+right12381246527491711755
    10LeftLeft>right1171799581291590508
    11n.d.Right991874283270708604
    12LeftLeft15541205699392855813
    13No cracklesRight8711114333280538834
    14LeftLeft>right929951187297742654
    15Left+rightLeft10061065197144809921
    16No cracklesLeft>right1017777318106699671
    17Left+rightLeft+right10731096185165888931
    18Left+rightLeft+right10613144643260882
    19RightRight628893182261446632
    20Left+rightRight11591052396244763808
    21RightRight8271019221313606706
    22RightLeft+right669764123174546590
    23Right>leftLeft+right11461318283479863839
    24Right>leftRight76484751068974
    25Left+rightRight83137219729634343
    26No cracklesLeft5754667536500430
    27No cracklesLeft+right1843518216633
    28RightRight4224037784345319
    29LeftLeft2812264220239206
    30Left+rightRight10411134219369822765
    Mean±sd856.3±379.4848.5±375.4268.7±185.9248.6±154.5587.6±237.0599.9±248.3

    n.d.: localisation not documented.

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    Pilot study on nocturnal monitoring of crackles in children with pneumonia
    Wilfried Nikolaizik, Lisa Wuensch, Monika Bauck, Volker Gross, Keywan Sohrabi, Andreas Weissflog, Olaf Hildebrandt, Ulrich Koehler, Stefanie Weber
    ERJ Open Research Oct 2021, 7 (4) 00284-2021; DOI: 10.1183/23120541.00284-2021

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    Pilot study on nocturnal monitoring of crackles in children with pneumonia
    Wilfried Nikolaizik, Lisa Wuensch, Monika Bauck, Volker Gross, Keywan Sohrabi, Andreas Weissflog, Olaf Hildebrandt, Ulrich Koehler, Stefanie Weber
    ERJ Open Research Oct 2021, 7 (4) 00284-2021; DOI: 10.1183/23120541.00284-2021
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