Figures
- FIGURE 1
Sputum procalcitonin levels in patients with bronchiectasis at visit 1 and 2.
- FIGURE 2
Induced sputum procalcitonin and bacteria cultural results at visit 1. Negative indicates sputum bacteria culture negative, and positive indicates sputum bacteria culture positive.
Tables
- TABLE 1
Baseline characteristics of participants
Characteristic Bronchiectasis group Healthy group Subjects (n) 30 15 Age (years) 67±11 43±11 Gender (female) 21 (70%) 10 (67%) Ethnic origin (%) European 19 (63%) 12 (80%) Pacific 6 (20%) 0 (0%) Maori 4 (13%) 1 (7%) Other 1 (4%) 2 (13%) Spirometry FEV1 (L) 1.87±0.62 3.31±0.89 FEV1 % pred 73.7±16.8 98.6±11.7 FVC (L) 2.71±0.89 4.06±1.05 FVC % pred 79.7±12.5 98.7±11.5 FEV1/FVC (%) 69.7±10.3 75.2±21.0 C-reactive protein (mg·L−1) 2.8 (2.0–3.9)¶ 1.6 (1.0–2.4)¶ ESR (mm·h−1) 22.7 (17.7–29.1)¶ 8.8 (6.4–12.0)¶ Radiological severity# 3 (2–4)+ N/A BSI severity score N/A Mild 10 Moderate 13 Severe 7 Data are n (%) or mean±sd, unless otherwise stated. FEV1: forced expiratory volume in 1 s; FVC: forced vital capacity; ESR: erythrocyte sedimentation rate; BSI: Bronchiectasis Severity Index (range 0–24). ¶: geometric mean (95% CI); #: median (IQR); +: number of lobes with bronchiectasis.
- TABLE 2
Sputum procalcitonin levels
Spontaneous Induced p-value Participants with bronchiectasis Visit one 0.001¶ Median (IQR) 1.7 (1.1–4.0) 1.3 (0.5–2.0) Geometric mean (95% CI) 1.8 (1.2–2.7) 1.1 (0.7–1.8) Visit two Median (IQR) 2.4 (0.6–3.7) 1.2 (0.7–2.4) Geometric mean (95% CI) 1.5 (1.0–2.5) 1.2 (0.8–1.6) Healthy participants Visit one Median (IQR) 0.5 (0.2–1.2) Geometric mean (95% CI) 0.5 (0.3–0.9) Procalcitonin concentration ratio between patients with bronchiectasis and healthy participants (95% CI) 2.3 (1.2–4.4)#
3.6 (1.5–8.6)+0.02# (0.006)+ ¶: comparison of spontaneous sputum and induced sputum results in the bronchiectasis group using repeated measures ANOVA that pooled visit 1 and visit 2 data; #: comparison of bronchiectasis and healthy groups using mixed-effect repeated measures ANOVA that pooled visit 1 and visit 2 measurements of patients with bronchiectasis without adjusting for age and gender; +: adjusted for age and gender.
