Skip to main content

Main menu

  • Home
  • Current issue
  • Early View
  • Archive
  • Authors/reviewers
    • Instructions for authors
    • Submit a manuscript
    • COVID-19 submission information
    • Institutional open access agreements
    • Peer reviewer login
  • Alerts
  • Subscriptions
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

User menu

  • Log in
  • Subscribe
  • Contact Us
  • My Cart

Search

  • Advanced search
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

Login

European Respiratory Society

Advanced Search

  • Home
  • Current issue
  • Early View
  • Archive
  • Authors/reviewers
    • Instructions for authors
    • Submit a manuscript
    • COVID-19 submission information
    • Institutional open access agreements
    • Peer reviewer login
  • Alerts
  • Subscriptions

Short-term effects of menthol on walking dyspnoea in patients with COPD: a randomised, single blinded, cross-over study

Guillaume Prieur, Marc Beaumont, Mathieu Delorme, Yann Combret, Clement Medrinal, Roger Hilfiker, Tristan Bonnevie, Francis-Edouard Gravier, Pauline Smondack, Bouchra Lamia, Gregory Reychler
ERJ Open Research 2021 7: 00450-2021; DOI: 10.1183/23120541.00450-2021
Guillaume Prieur
1Institut de Recherche Expérimentale et Clinique (IREC), Pôle de Pneumologie, ORL and Dermatologie, Groupe de Recherche en Kinésithérapie Respiratoire, Université Catholique de Louvain, Brussels, Belgium
2Normandie Univ, UNIROUEN, EA3830-GRHV, Institute for Research and Innovation in Biomedicine (IRIB), Rouen, France
3Groupe Hospitalier du Havre, Pulmonology Dept and Pulmonary Rehabilitation Dept, Montivilliers, France
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: gprieur.kine@gmail.com
Marc Beaumont
4Pulmonary Rehabilitation Dept, CH des Pays de Morlaix, Kersaint Gilly, Morlaix, France
5EA3878 (GETBO) CIC INSERM 1412, European University of Occidental Brittany, Brest, France
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Mathieu Delorme
6Université Paris-Saclay, UVSQ, ERPHAN, Versailles, France
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Mathieu Delorme
Yann Combret
1Institut de Recherche Expérimentale et Clinique (IREC), Pôle de Pneumologie, ORL and Dermatologie, Groupe de Recherche en Kinésithérapie Respiratoire, Université Catholique de Louvain, Brussels, Belgium
3Groupe Hospitalier du Havre, Pulmonology Dept and Pulmonary Rehabilitation Dept, Montivilliers, France
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Yann Combret
Clement Medrinal
3Groupe Hospitalier du Havre, Pulmonology Dept and Pulmonary Rehabilitation Dept, Montivilliers, France
6Université Paris-Saclay, UVSQ, ERPHAN, Versailles, France
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Roger Hilfiker
7University of Applied Sciences and Arts Western Switzerland Valais (HES-SO Valais-Wallis), Physiotherapy, Sierre, Switzerland
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Roger Hilfiker
Tristan Bonnevie
2Normandie Univ, UNIROUEN, EA3830-GRHV, Institute for Research and Innovation in Biomedicine (IRIB), Rouen, France
8ADIR Association, Rouen University Hospital, Rouen, France
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Tristan Bonnevie
Francis-Edouard Gravier
2Normandie Univ, UNIROUEN, EA3830-GRHV, Institute for Research and Innovation in Biomedicine (IRIB), Rouen, France
8ADIR Association, Rouen University Hospital, Rouen, France
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Francis-Edouard Gravier
Pauline Smondack
8ADIR Association, Rouen University Hospital, Rouen, France
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Bouchra Lamia
2Normandie Univ, UNIROUEN, EA3830-GRHV, Institute for Research and Innovation in Biomedicine (IRIB), Rouen, France
3Groupe Hospitalier du Havre, Pulmonology Dept and Pulmonary Rehabilitation Dept, Montivilliers, France
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Gregory Reychler
1Institut de Recherche Expérimentale et Clinique (IREC), Pôle de Pneumologie, ORL and Dermatologie, Groupe de Recherche en Kinésithérapie Respiratoire, Université Catholique de Louvain, Brussels, Belgium
9Service de Pneumologie, Cliniques Universitaires Saint-Luc, Brussels, Belgium
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Gregory Reychler
  • Article
  • Figures & Data
  • Info & Metrics
  • PDF
Loading

Tables

  • TABLE 1

    Effects of menthol gum versus control gum on dyspnoea and physiological variables at the end of exercise

    VariablesMentholControlCondition effect
    BaselineEnd-exerciseBaselineEnd-exerciseAdjusted mean difference#p-value
    Dyspnoea, mBorg0.9±14.4±1.6***1±1.04.7±1.7***−0.3 (−0.5–−0.0)0.058
    Leg discomfort, mBorg0.6±1.12.8±2.1***0.6±12.9±2.3***−0.0 (−0.3–0.2)0.807
    SpO2, %92.6±3.785.7±7***92.6±3.386.3±6.2***−0.4 (−1.0–0.3)0.255
    Lowest SpO2, %82.7±7.383.1±6.6−0.4 (−1.2–0.3)0.263
    Heart rate, beats per min91.4±17.8115.3±15.2***92.3±17.5114.5.9±15.7***4.4 (−1.2–9.9)0.124
    Respiratory rate, cycles per min18.6±4.624.1±9.5***19±5.224.1±5.9 ***0.3 (−2.1–2.6)0.827
    Tidal volume, L0.8±0.31.1±0.5 ***0.8±0.41.1±0.5***0.0 (−0.0–0.1)0.172
    Minute ventilation, L·min−113.9±5.125.6±9.3***14.7±5.625.8±9***−0.1 (−1.5–1.3)0.924
    Inspiratory capacity, L1.8±0.61.7±0.6**1.9±0.71.8±0.7−0.0 (−0.2–0.1)0.449
    6MWD, m461.1±124.2458.7±124.92.6 (−4.1–9.4)0.447
    6MWD, % pred73.1±20.772.8±20.70.37 (−0.76–1.5)0.495

    Continuous data are presented as mean±sd and as mean (95% CI) for the difference between the two conditions. Mean differences were calculated using a mixed model adjusted for baseline values, and the sequence (order of conditions) was used to assess the carry-over effect, with participants as random effects. Within-condition changes (before-after test) were compared using a paired t-test. *: p<0.05; **: p<0.01; and ***: p<0.001 for before–after analysis of a condition. mBorg: modified Borg scale from 0 to 10 (0: no fatigue or dyspnoea, 10: maximal fatigue or dyspnoea). For leg discomfort, there was evidence for a period or cross-over effect (p=0.050), this result should be taken with caution. There was no evidence of a period or cross-over effect on the other outcomes. SpO2: oxygen saturation measured by pulse oximetry; 6MWD: 6-min walking distance. #: difference for menthol − control.

    PreviousNext
    Back to top
    Vol 7 Issue 4 Table of Contents
    ERJ Open Research: 7 (4)
    • Table of Contents
    • Index by author
    Email

    Thank you for your interest in spreading the word on European Respiratory Society .

    NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

    Enter multiple addresses on separate lines or separate them with commas.
    Short-term effects of menthol on walking dyspnoea in patients with COPD: a randomised, single blinded, cross-over study
    (Your Name) has sent you a message from European Respiratory Society
    (Your Name) thought you would like to see the European Respiratory Society web site.
    CAPTCHA
    This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
    Print
    Citation Tools
    Short-term effects of menthol on walking dyspnoea in patients with COPD: a randomised, single blinded, cross-over study
    Guillaume Prieur, Marc Beaumont, Mathieu Delorme, Yann Combret, Clement Medrinal, Roger Hilfiker, Tristan Bonnevie, Francis-Edouard Gravier, Pauline Smondack, Bouchra Lamia, Gregory Reychler
    ERJ Open Research Oct 2021, 7 (4) 00450-2021; DOI: 10.1183/23120541.00450-2021

    Citation Manager Formats

    • BibTeX
    • Bookends
    • EasyBib
    • EndNote (tagged)
    • EndNote 8 (xml)
    • Medlars
    • Mendeley
    • Papers
    • RefWorks Tagged
    • Ref Manager
    • RIS
    • Zotero
    Share
    Short-term effects of menthol on walking dyspnoea in patients with COPD: a randomised, single blinded, cross-over study
    Guillaume Prieur, Marc Beaumont, Mathieu Delorme, Yann Combret, Clement Medrinal, Roger Hilfiker, Tristan Bonnevie, Francis-Edouard Gravier, Pauline Smondack, Bouchra Lamia, Gregory Reychler
    ERJ Open Research Oct 2021, 7 (4) 00450-2021; DOI: 10.1183/23120541.00450-2021
    del.icio.us logo Digg logo Reddit logo Technorati logo Twitter logo CiteULike logo Connotea logo Facebook logo Google logo Mendeley logo
    Full Text (PDF)

    Jump To

    • Article
      • Abstract
      • Acknowledgements
      • Footnotes
      • References
    • Figures & Data
    • Info & Metrics
    • PDF

    Subjects

    • COPD and smoking
    • Pulmonary pharmacology and therapeutics
    • Tweet Widget
    • Facebook Like
    • Google Plus One

    More in this TOC Section

    • COVID-19 in patients with pulmonary alveolar proteinosis
    • Fatigue and signs of sleep apnoea after COVID-19
    • Increased PAR1 autoantibodies and severe COVID-19
    Show more Research letters

    Related Articles

    Navigate

    • Home
    • Current issue
    • Archive

    About ERJ Open Research

    • Editorial board
    • Journal information
    • Press
    • Permissions and reprints
    • Advertising

    The European Respiratory Society

    • Society home
    • myERS
    • Privacy policy
    • Accessibility

    ERS publications

    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS books online
    • ERS Bookshop

    Help

    • Feedback

    For authors

    • Instructions for authors
    • Publication ethics and malpractice
    • Submit a manuscript

    For readers

    • Alerts
    • Subjects
    • RSS

    Subscriptions

    • Accessing the ERS publications

    Contact us

    European Respiratory Society
    442 Glossop Road
    Sheffield S10 2PX
    United Kingdom
    Tel: +44 114 2672860
    Email: journals@ersnet.org

    ISSN

    Online ISSN: 2312-0541

    Copyright © 2023 by the European Respiratory Society