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Controlled versus free breathing for multiple-breath nitrogen washout in asthma

Blake M. Handley, Jack Bozier, Edward Jeagal, Sandra Rutting, Robin E. Schoeffel, Paul D. Robinson, Gregory G. King, Stephen Milne, Cindy Thamrin
ERJ Open Research 2021 7: 00487-2021; DOI: 10.1183/23120541.00487-2021
Blake M. Handley
1Woolcock Institute of Medical Research, University of Sydney, Glebe, NSW, Australia
2Dept of Respiratory Medicine, Royal North Shore Hospital, St Leonards, NSW, Australia
6These first authors contributed equally
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Jack Bozier
1Woolcock Institute of Medical Research, University of Sydney, Glebe, NSW, Australia
2Dept of Respiratory Medicine, Royal North Shore Hospital, St Leonards, NSW, Australia
6These first authors contributed equally
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Edward Jeagal
1Woolcock Institute of Medical Research, University of Sydney, Glebe, NSW, Australia
3University of Technology Sydney, School of Life Sciences, Sydney, NSW, Australia
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Sandra Rutting
1Woolcock Institute of Medical Research, University of Sydney, Glebe, NSW, Australia
2Dept of Respiratory Medicine, Royal North Shore Hospital, St Leonards, NSW, Australia
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  • ORCID record for Sandra Rutting
Robin E. Schoeffel
2Dept of Respiratory Medicine, Royal North Shore Hospital, St Leonards, NSW, Australia
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Paul D. Robinson
1Woolcock Institute of Medical Research, University of Sydney, Glebe, NSW, Australia
4Dept of Respiratory Medicine, The Children's Hospital at Westmead, Westmead, NSW, Australia
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Gregory G. King
1Woolcock Institute of Medical Research, University of Sydney, Glebe, NSW, Australia
2Dept of Respiratory Medicine, Royal North Shore Hospital, St Leonards, NSW, Australia
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Stephen Milne
1Woolcock Institute of Medical Research, University of Sydney, Glebe, NSW, Australia
5Centre for Heart Lung Innovation, St Paul's Hospital and Division of Respiratory Medicine, University of British Columbia, Vancouver, BC, Canada
7These senior authors contributed equally
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Cindy Thamrin
1Woolcock Institute of Medical Research, University of Sydney, Glebe, NSW, Australia
7These senior authors contributed equally
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  • ORCID record for Cindy Thamrin
  • For correspondence: cindy.thamrin@woolcock.org.au
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    FIGURE 1

    Differences between controlled (CB) and free breathing (FB) protocols, and associated factors. a) Functional residual capacity (FRC), showing no significant differences between the two protocols (mean difference (95% limits of agreement) −0.019 (−0.364–0.327) L, p=0.64) and no proportional bias (p=0.81), with b) between-protocol differences in FRC related to body mass index (BMI) (p=0.036). c) Lung clearance index (LCI), showing significant differences (0.235 (−0.578–1.048), p=0.020) but no proportional bias (p=0.179) between protocols. d) Conductive ventilation heterogeneity (Scond), showing no significant differences between protocols (−0.0020 (−0.034–0.030) L−1, p=0.59) and no proportional bias (p=0.203). e) Acinar ventilation heterogeneity (Sacin) was significantly different between protocols (0.0215 (−0.044–0.087) L−1, p=0.01) with a significant proportional bias (p=0.018), and f) between-protocol differences in Sacin were not predicted by between-protocol differences in tidal volume (VTFB−VTCB) (p=0.98) or respiratory rate (p=0.38, data not shown).

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Controlled versus free breathing for multiple-breath nitrogen washout in asthma
Blake M. Handley, Jack Bozier, Edward Jeagal, Sandra Rutting, Robin E. Schoeffel, Paul D. Robinson, Gregory G. King, Stephen Milne, Cindy Thamrin
ERJ Open Research Oct 2021, 7 (4) 00487-2021; DOI: 10.1183/23120541.00487-2021

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Controlled versus free breathing for multiple-breath nitrogen washout in asthma
Blake M. Handley, Jack Bozier, Edward Jeagal, Sandra Rutting, Robin E. Schoeffel, Paul D. Robinson, Gregory G. King, Stephen Milne, Cindy Thamrin
ERJ Open Research Oct 2021, 7 (4) 00487-2021; DOI: 10.1183/23120541.00487-2021
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