ERJ Open Research: 8 (1)

01 January 2022; volume 8, issue 1

Editorials

Open Access
European Respiratory Society clinical practice guidelines: methodological guidance
Blin Nagavci, Thomy Tonia, Nicolas Roche, Celine Genton, Valerie Vaccaro, Marc Humbert, Christopher Brightling, Carlos Robalo Cordeiro, Andrew Bush

ERJ Open Res 8: 00655-2021; DOI: 10.1183/23120541.00655-2021 Published 24 January 2022

Reviews

Open Access
Communicating with patients with idiopathic pulmonary fibrosis: can we do it better?
Marlies S. Wijsenbeek, Francesco Bonella, Leticia Orsatti, Anne-Marie Russell, Claudia Valenzuela, Wim A. Wuyts, Walter F. Baile

ERJ Open Res 8: 00422-2021; DOI: 10.1183/23120541.00422-2021 Published 24 January 2022
Open Access
Physiotherapy for large airway collapse: an ABC approach
Lizzie J.F. Grillo, Georgie M. Housley, Sidhu Gangadharan, Adnan Majid, James H. Hull

ERJ Open Res 8: 00510-2021; DOI: 10.1183/23120541.00510-2021 Published 7 February 2022
Open Access
International consensus on lung function testing during the COVID-19 pandemic and beyond
Aisling McGowan, Pierantonio Laveneziana, Sam Bayat, Nicole Beydon, P.W. Boros, Felip Burgos, Matjaž Fležar, Monika Franczuk, Maria-Alejandra Galarza, Adrian H. Kendrick, Enrico Lombardi, Jellien Makonga-Braaksma, Meredith C. McCormack, Laurent Plantier, Sanja Stanojevic, Irene Steenbruggen, Bruce Thompson, Allan L. Coates, Jack Wanger, Donald W. Cockcroft, Bruce Culver, Karl Sylvester, Frans De Jongh

ERJ Open Res 8: 00602-2021; DOI: 10.1183/23120541.00602-2021 Published 7 March 2022
Open Access
COPD mortality and exacerbations in the placebo group of clinical trials over two decades: a systematic review and meta-regression
Stefan Andreas, Christian Röver, Judith Heinz, Christian Taube, Tim Friede

ERJ Open Res 8: 00261-2021; DOI: 10.1183/23120541.00261-2021 Published 7 March 2022
Open Access
Mortality and survival in idiopathic pulmonary fibrosis: a systematic review and meta-analysis
Qiang Zheng, Ingrid A. Cox, Julie A. Campbell, Qing Xia, Petr Otahal, Barbara de Graaff, Tamera J. Corte, Alan K.Y. Teoh, E. Haydn Walters, Andrew J. Palmer

ERJ Open Res 8: 00591-2021; DOI: 10.1183/23120541.00591-2021 Published 14 March 2022
Open Access
Physical activity end-points in trials of chronic respiratory diseases: summary of evidence
Cassie Rist, Niklas Karlsson, Sofia Necander, Carla A. Da Silva

ERJ Open Res 8: 00541-2021; DOI: 10.1183/23120541.00541-2021 Published 14 March 2022
Open Access
Use of single-inhaler triple therapy in the management of obstructive airway disease: Indian medical experts’ review
Raja Dhar, Deepak Talwar, Sundeep Salvi, B.V. Muralimohan, Sagar Panchal, Saiprasad Patil, Sagar Bhagat, Nishtha Khatri, Hanmant Barkate

ERJ Open Res 8: 00556-2021; DOI: 10.1183/23120541.00556-2021 Published 28 March 2022

Study protocols

Open Access
Hypnosis for the management of COPD-related anxiety and dyspnoea in pulmonary rehabilitation: rationale and design for a cluster-randomised, active-control trial (HYPNOBPCO_2)
Hernán Anlló,, Bertrand Herer, Agathe Delignières, Adelina Ghergan, Yolaine Bocahu, Isabelle Segundo, Cécile Moulin, François Larue

ERJ Open Res 8: 00565-2021; DOI: 10.1183/23120541.00565-2021 Published 7 February 2022

Original research articles

COPD
- Open Access
  Changes in health-related quality of life as a marker in the prognosis in COPD patients
  Cristóbal Esteban, Inmaculada Arostegui, Amaia Aramburu, Javier Moraza, Myriam Aburto, Susana Aizpiri, Leyre Chasco, José M. Quintana
  
  ERJ Open Res 8: 00181-2021; DOI: 10.1183/23120541.00181-2021 Published 12 January 2022
- Open Access
  Evaluation of spirometry-gated computed tomography to measure lung volumes in emphysema patients
  Jens T. Bakker, Karin Klooster, Jan Bouwman, Gert Jan Pelgrim, Rozemarijn Vliegenthart, Dirk-Jan Slebos
  
  ERJ Open Res 8: 00492-2021; DOI: 10.1183/23120541.00492-2021 Published 24 January 2022
- Open Access
  Predicting in-hospital death in pneumonic COPD exacerbation via BAP-65, CURB-65 and machine learning
  Akihiro Shiroshita, Yuya Kimura, Hiroshi Shiba, Chigusa Shirakawa, Kenya Sato, Shinya Matsushita, Keisuke Tomii, Yuki Kataoka
  
  ERJ Open Res 8: 00452-2021; DOI: 10.1183/23120541.00452-2021 Published 24 January 2022
- Open Access
  Blood eosinophils to guide inhaled maintenance therapy in a primary care COPD population
  Helen F. Ashdown, Margaret Smith, Emily McFadden, Ian D. Pavord, Chris C. Butler, Mona Bafadhel
  
  ERJ Open Res 8: 00606-2021; DOI: 10.1183/23120541.00606-2021 Published 7 February 2022
- Open Access
  Is single-inhaler triple therapy for COPD cost-effective in the UK? The IMPACT trial
  Alan Martin, Dhvani Shah, Kerigo Ndirangu, Glenn A. Anley, Gabriel Okorogheye, Melanie Schroeder, Nancy Risebrough, Afisi S. Ismaila
  
  ERJ Open Res 8: 00333-2021; DOI: 10.1183/23120541.00333-2021 Published 21 February 2022
- Open Access
  The impact of personal and outdoor temperature exposure during cold and warm seasons on lung function and respiratory symptoms in COPD
  Charlotte Scheerens, Lina Nurhussien, Amro Aglan, Andrew J. Synn, Brent A. Coull, Petros Koutrakis, Mary B. Rice
  
  ERJ Open Res 8: 00574-2021; DOI: 10.1183/23120541.00574-2021 Published 14 March 2022
Asthma
- Open Access
  Health outcomes after stopping long-term mepolizumab in severe eosinophilic asthma: COMET
  Mark C. Liu, Elisabeth H. Bel, Oliver Kornmann, Wendy C. Moore, Norihiro Kaneko, Steven G. Smith, Neil Martin, Robert G. Price, Steven W. Yancey, Marc Humbert
  
  ERJ Open Res 8: 00419-2021; DOI: 10.1183/23120541.00419-2021 Published 12 January 2022
- Open Access
  Vitamin D supplementation in childhood asthma: a systematic review and meta-analysis of randomised controlled trials
  Jogender Kumar, Prawin Kumar, Jagdish Prasad Goyal, Chirag Thakur, Puja Choudhary, Jitendra Meena, Jaykaran Charan, Kuldeep Singh, Atul Gupta
  
  ERJ Open Res 8: 00662-2021; DOI: 10.1183/23120541.00662-2021 Published 7 February 2022
- Open Access
  Mucosal cryobiopsies: a new method for studying airway pathology in asthma
  Morten Hvidtfeldt, Asger Sverrild, Alexis Pulga, Laurits Frøssing, Alexander Silberbrandt, Caroline Sanden, Carl Magnus Clausson, Daisy Bornesund, Jonas Erjefält, Celeste Porsbjerg
  
  ERJ Open Res 8: 00666-2021; DOI: 10.1183/23120541.00666-2021 Published 24 March 2022
- Open Access
  Characterisation of lung function trajectories and associated early-life predictors in an Australian birth cohort study
  Francesca Sanna, Francesca Locatelli, Peter D. Sly, Elisha White, David Blake, Jane Heyworth, Graham L. Hall, Rachel E. Foong
  
  ERJ Open Res 8: 00072-2022; DOI: 10.1183/23120541.00072-2022 Published 24 March 2022
- Open Access
  Inhaled anti-asthma therapies following hormone therapy in women: a nationwide cohort study
  Erik Soeren Halvard Hansen, Kristian Aasbjerg, Amalie Lykkemark Moeller, Amani Meaidi, Elisabeth Juul Gade, Christian Torp-Pedersen, Vibeke Backer
  
  ERJ Open Res 8: 00611-2021; DOI: 10.1183/23120541.00611-2021 Published 24 March 2022
- Open Access
  Is overreliance on short-acting β₂-agonists associated with health risks in the older asthma population?
  Teresa To, Jingqin Zhu, Emilie Terebessy, Kimball Zhang, Andrea S. Gershon, Christopher Licskai
  
  ERJ Open Res 8: 00032-2022; DOI: 10.1183/23120541.00032-2022 Published 28 March 2022
COPD and asthma
- Open Access
  Sarcopenia, systemic immune-inflammation index and all-cause mortality in middle-aged and older people with COPD and asthma: a population-based study
  Elizabeth Benz, Sara R.A. Wijnant, Katerina Trajanoska, Johnmary T. Arinze, Emmely W. de Roos, Maria de Ridder, Ross Williams, Frank van Rooij, Katia M.C. Verhamme, M. Arfan Ikram, Bruno H. Stricker, Fernando Rivadeneira, Lies Lahousse, Guy G. Brusselle
  
  ERJ Open Res 8: 00628-2021; DOI: 10.1183/23120541.00628-2021 Published 12 January 2022
COPD and pulmonary hypertension
- Open Access
  Treatment of pulmonary hypertension associated with COPD: a systematic review
  Ragdah Arif, Arjun Pandey, Ying Zhao, Kyle Arsenault-Mehta, Danya Khoujah, Sanjay Mehta
  
  ERJ Open Res 8: 00348-2021; DOI: 10.1183/23120541.00348-2021 Published 21 February 2022
COVID-19
- Open Access
  Physiological effects and subjective tolerability of prone positioning in COVID-19 and healthy hypoxic challenge
  Akhilesh Jha, Fangyue Chen, Sam Mann, Ravi Shah, Randa Abu-Youssef, Holly Pavey, Helen Lin-Jia-Qi, Josh Cara, Daniel Cunningham, Kate Fitzpatrick, Celine Goh, Renee Ma, Souradip Mookerjee, Vaitehi Nageshwaran, Timothy Old, Catherine Oxley, Louise Jordon, Mayurun Selvan, Anna Wood, Andrew Ying, Chen Zhang, Dariusz Wozniak, Iain Goodhart, Frances Early, Marie Fisk, Jonathan Fuld
  
  ERJ Open Res 8: 00524-2021; DOI: 10.1183/23120541.00524-2021 Published 7 February 2022
- Open Access
  Clinical characteristics, risk factors and outcomes in patients with severe COVID-19 registered in the International Severe Acute Respiratory and Emerging Infection Consortium WHO clinical characterisation protocol: a prospective, multinational, multicentre, observational study
  Luis Felipe Reyes, Srinivas Murthy, Esteban Garcia-Gallo, Mike Irvine, Laura Merson, Ignacio Martin-Loeches, Jordi Rello, Fabio S. Taccone, Robert A. Fowler, Annemarie B. Docherty, Christiana Kartsonaki, Irene Aragao, Peter W. Barrett, Abigail Beane, Aidan Burrell, Matthew Pellan Cheng, Michael D. Christian, Jose Pedro Cidade, Barbara Wanjiru Citarella, Christl A. Donnelly, Susana M. Fernandes, Craig French, Rashan Haniffa, Ewen M. Harrison, Antonia Ying Wai Ho, Mark Joseph, Irfan Khan, Michelle E. Kho, Anders Benjamin Kildal, Demetrios Kutsogiannis, François Lamontagne, Todd C. Lee, Gianluigi Li Bassi, Jose Wagner Lopez Revilla, Catherine Marquis, Jonathan Millar, Raul Neto, Alistair Nichol, Rachael Parke, Rui Pereira, Sergio Poli, Pedro Povoa, Kollengode Ramanathan, Oleksa Rewa, Jordi Riera, Sally Shrapnel, Maria Joao Silva, Andrew Udy, Timothy Uyeki, Steve A. Webb, Evert-Jan Wils, Amanda Rojek, Piero L. Olliaro, ISARIC Clinical Characterisation Group
  
  ERJ Open Res 8: 00552-2021; DOI: 10.1183/23120541.00552-2021 Published 14 February 2022
- Open Access
  “You can do it yourself and you can do it at your convenience”: internet accessibility and willingness of people with chronic breathlessness to use an internet-based breathlessness self-management intervention during the COVID-19 pandemic
  Charles C. Reilly, Katherine Bristowe, Anna Roach, Matthew Maddocks, Irene J. Higginson
  
  ERJ Open Res 8: 00557-2021; DOI: 10.1183/23120541.00557-2021 Published 21 February 2022
- Open Access
  Azithromycin for treatment of hospitalised COVID-19 patients: a randomised, multicentre, open-label clinical trial (DAWn-AZITHRO)
  Iwein Gyselinck, Laurens Liesenborghs, Ann Belmans, Matthias M. Engelen, Albrecht Betrains, Quentin Van Thillo, Pham Anh Hong Nguyen, Pieter Goeminne, Ann-Catherine Soenen, Nikolaas De Maeyer, Charles Pilette, Emmanuelle Papleux, Eef Vanderhelst, Aurélie Derweduwen, Patrick Alexander, Bernard Bouckaert, Jean-Benoît Martinot, Lynn Decoster, Kurt Vandeurzen, Rob Schildermans, Peter Verhamme, Wim Janssens, Robin Vos
  
  ERJ Open Res 8: 00610-2021; DOI: 10.1183/23120541.00610-2021 Published 28 February 2022
- Open Access
  New domiciliary supplemental oxygen therapy after hospitalisation for COVID-19 in metropolitan Chicago
  Malvika Kaul, Preeti Gupta, Salil Kalra, Jessica Gardner, Howard S. Gordon, Israel Rubinstein
  
  ERJ Open Res 8: 00577-2021; DOI: 10.1183/23120541.00577-2021 Published 24 March 2022
Respiratory infections
- Open Access
  Community-acquired pneumonia subgroups and differential response to corticosteroids: a secondary analysis of controlled studies
  Esther Wittermans, Philip A. van der Zee, Hongchao Qi, Ewoudt M.W. van de Garde, Claudine A. Blum, Mirjam Christ-Crain, Diederik Gommers, Jan C. Grutters, G. Paul Voorn, Willem Jan W. Bos, Henrik Endeman
  
  ERJ Open Res 8: 00489-2021; DOI: 10.1183/23120541.00489-2021 Published 12 January 2022
- Open Access
  The impact of long-term azithromycin on antibiotic resistance in HIV-associated chronic lung disease
  Regina E. Abotsi, Mark P. Nicol, Grace McHugh, Victoria Simms, Andrea M. Rehman, Charmaine Barthus, Lucky G. Ngwira, Brenda Kwambana-Adams, Robert S. Heyderman, Jon Ø. Odland, Rashida A. Ferrand, Felix S. Dube
  
  ERJ Open Res 8: 00491-2021; DOI: 10.1183/23120541.00491-2021 Published 7 February 2022
- Open Access
  An international survey on the use of intrapleural tissue plasminogen activator/DNase therapy for pleural infection
  Estee P.M. Lau, Matin Eshraghi, Kirstie Dootson, Cindy Yeoh, Wint Ywe Phu, Y.C. Gary Lee, Natalia D. Popowicz
  
  ERJ Open Res 8: 00590-2021; DOI: 10.1183/23120541.00590-2021 Published 7 February 2022
- Open Access
  Breath octane and acetaldehyde as markers for acute respiratory distress syndrome in invasively ventilated patients suspected to have ventilator-associated pneumonia
  Nanon F.L. Heijnen, Laura A. Hagens, Frederik-Jan van Schooten, Lieuwe D.J. Bos, Iwan C.C. van der Horst, Alex Mommers, Marcus J. Schultz, Marry R. Smit, Dennis C.J.J. Bergmans, Agnieszka Smolinska, Ronny M. Schnabel
  
  ERJ Open Res 8: 00624-2021; DOI: 10.1183/23120541.00624-2021 Published 24 March 2022
Tuberculosis
- Open Access
  Programme costs of longer and shorter tuberculosis drug regimens and drug import: a modelling study for Karakalpakstan, Uzbekistan
  Stefan Kohler, Norman Sitali, Jay Achar, Nicolas Paul
  
  ERJ Open Res 8: 00622-2021; DOI: 10.1183/23120541.00622-2021 Published 24 March 2022
Cough
- Open Access
  Chronic cough in Germany: results from a general-population survey
  J. Christian Virchow, Vicky W. Li, Eileen Fonseca, Helena Salmen, Ashley Martin, Joanne Brady, Christina Jannowitz, Jonathan Schelfhout
  
  ERJ Open Res 8: 00420-2021; DOI: 10.1183/23120541.00420-2021 Published 12 January 2022
- Open Access
  Assessing cough symptom severity in refractory or unexplained chronic cough: findings from patient focus groups and an international expert panel
  Elena Kum, Gordon H. Guyatt, Caroline Munoz, Suzanne Beaudin, Shelly-Anne Li, Rayid Abdulqawi, Huda Badri, Louis-Philippe Boulet, Ruchong Chen, Peter Dicpinigaitis, Lieven Dupont, Stephen K. Field, Cynthia L. French, Peter G. Gibson, Richard S. Irwin, Paul Marsden, Lorcan McGarvey, Jaclyn A. Smith, Woo-Jung Song, Paul M. O'Byrne, Imran Satia
  
  ERJ Open Res 8: 00667-2021; DOI: 10.1183/23120541.00667-2021 Published 14 March 2022
- Open Access
  A double-blind randomised placebo-controlled trial investigating the effects of lesogaberan on the objective cough frequency and capsaicin-evoked coughs in patients with refractory chronic cough
  Huda Badri, Carmen Gibbard, Dimitra Denton, Imran Satia, Bashar Al-Sheklly, Rachel J. Dockry, Kimberley Holt, Kevin McGuiness, Sam Treadway, Peter Whorwell, Lesley Houghton, Augustine Lee, K. Jane Escott, Theresa Lee, Greame Wilkinson, Alison Holt, Brendan J. Canning, Jacky A. Smith
  
  ERJ Open Res 8: 00546-2021; DOI: 10.1183/23120541.00546-2021 Published 14 March 2022
Aspiration
- Open Access
  Different clinical symptom patterns in patients with reflux micro-aspiration
  Oleksandr Khoma, Jin-soo Park, Felix Michael Lee, Hans Van der Wall, Gregory L. Falk
  
  ERJ Open Res 8: 00508-2021; DOI: 10.1183/23120541.00508-2021 Published 24 January 2022
Interstitial lung disease
- Open Access
  Epidemiology of interstitial lung diseases and their progressive-fibrosing behaviour in six European countries
  Ole Hilberg, Anna-Maria Hoffmann-Vold, Vanessa Smith, Demosthenes Bouros, Maritta Kilpeläinen, Julien Guiot, Antonio Morais, Susana Clemente, Zoe Daniil, Despina Papakosta, Havard Fretheim, Sofia Neves, Tiago M. Alfaro, Katerina M. Antoniou, Neus Valveny, Guus Asijee, Stéphane Soulard, Wim Wuyts, the PERSEIDS study group , Guy Brusselle, Vassilios Tzilas, Argyris Tzouvelekis, Evangelos Bouros, Katariina Perkonoja, Monique Henket, Marie-Pierre Cunin, Raquel Rosa, Teresa Martín, Joana Branco, Maria Alvarenga, Ilias Dimeas, Theodora Simopoulou, Evangelia Fouka, Ioanna Tsiouprou, Athanasios Zaharias, Sergio Campainha, Carla Nogueira, Sara Freitas, Vânia Fernandes, Carolina Cabo, Irini Vasarmidi
  
  ERJ Open Res 8: 00597-2021; DOI: 10.1183/23120541.00597-2021 Published 24 January 2022
- Open Access
  Monogenic gene variants in lung transplant recipients with usual interstitial pneumonia
  Christoffer Stark, Juha W. Koskenvuo, Antti Nykänen, Eija H. Seppälä, Samuel Myllykangas, Karl Lemström, Peter Raivio
  
  ERJ Open Res 8: 00583-2021; DOI: 10.1183/23120541.00583-2021 Published 24 January 2022
- Open Access
  Evidence for shared genetic risk factors between lymphangioleiomyomatosis and pulmonary function
  Xavier Farré, Roderic Espín, Alexandra Baiges, Eline Blommaert, Wonji Kim, Krinio Giannikou, Carmen Herranz, Antonio Román, Berta Sáez, Álvaro Casanova, Julio Ancochea, Claudia Valenzuela, Piedad Ussetti, Rosalía Laporta, José A. Rodríguez-Portal, Coline H.M. van Moorsel, Joanne J. van der Vis, Marian J.R. Quanjel, Mireia Tena-Garitaonaindia, Fermín Sánchez de Medina, Francesca Mateo, María Molina-Molina, Sungho Won, David J. Kwiatkowski, Rafael de Cid, Miquel Angel Pujana
  
  ERJ Open Res 8: 00375-2021; DOI: 10.1183/23120541.00375-2021 Published 24 January 2022
- Open Access
  Antigen avoidance and outcome of nonfibrotic and fibrotic hypersensitivity pneumonitis
  Takashi Nishida, Eriko Kawate, Takashi Ishiguro, Tetsu Kanauchi, Yoshihiko Shimizu, Noboru Takayanagi
  
  ERJ Open Res 8: 00474-2021; DOI: 10.1183/23120541.00474-2021 Published 7 February 2022
- Open Access
  Autoantibodies are present in the bronchoalveolar lavage but not circulation in patients with fibrotic interstitial lung disease
  Karim Boustani, Poonam Ghai, Rachele Invernizzi, Richard J. Hewitt, Toby M. Maher, Quan-Zhen Li, Philip L. Molyneaux, James A. Harker
  
  ERJ Open Res 8: 00481-2021; DOI: 10.1183/23120541.00481-2021 Published 14 February 2022
- Open Access
  Nutritional assessment in idiopathic pulmonary fibrosis: a prospective multicentre study
  Paola Faverio, Alessia Fumagalli, Sara Conti, Fabiana Madotto, Francesco Bini, Sergio Harari, Michele Mondoni, Tiberio Oggionni, Emanuela Barisione, Paolo Ceruti, Maria Chiara Papetti, Bruno Dino Bodini, Antonella Caminati, Angela Valentino, Stefano Centanni, Donatella Noè, Matteo Della Zoppa, Silvia Crotti, Marco Grosso, Samir Giuseppe Sukkar, Denise Modina, Marco Andreoli, Roberta Nicali, Giulia Suigo, Federica De Giacomi, Sara Busnelli, Elena Cattaneo, Lorenzo Giovanni Mantovani, Giancarlo Cesana, Alberto Pesci, Fabrizio Luppi
  
  ERJ Open Res 8: 00443-2021; DOI: 10.1183/23120541.00443-2021 Published 7 March 2022
- Open Access
  Autoimmune pulmonary alveolar proteinosis in children
  Matthias Griese, Panagiota Panagiotou, Effrosyni D. Manali, Mirjam Stahl, Nicolaus Schwerk, Vanessa Costa, Konstantinos Douros, Maria Kallieri, Ruth Maria Urbantat, Horst von Bernuth, Lykourgos Kolilekas, Lurdes Morais, Ana Ramos, Kerstin Landwehr, Katrin Knoflach, Florian Gothe, Karl Reiter, Vassiliki Papaevangelou, Athanasios G. Kaditis, Christina Kanaka-Gantenbein, Spyros A. Papiris
  
  ERJ Open Res 8: 00701-2021; DOI: 10.1183/23120541.00701-2021 Published 24 March 2022
- Open Access
  Vascular remodelling in idiopathic pulmonary fibrosis patients and its detrimental effect on lung physiology: potential role of endothelial-to-mesenchymal transition
  Archana Vijay Gaikwad, Wenying Lu, Surajit Dey, Prem Bhattarai, Collin Chia, Josie Larby, Greg Haug, Stephen Myers, Jade Jaffar, Glen Westall, Gurpreet Kaur Singhera, Tillie-Louise Hackett, James Markos, Mathew Suji Eapen, Sukhwinder Singh Sohal
  
  ERJ Open Res 8: 00571-2021; DOI: 10.1183/23120541.00571-2021 Published 24 March 2022
Dyspnoea
- Open Access
  Agreement of the modified Medical Research Council and New York Heart Association scales for assessing the impact of self-rated breathlessness in cardiopulmonary disease
  Zainab Ahmadi, Helena Igelström, Jacob Sandberg, Josefin Sundh, Magnus Sköld, Christer Janson, Anders Blomberg, Hans Bornefalk, Anna Bornefalk-Hermansson, Magnus Ekström
  
  ERJ Open Res 8: 00460-2021; DOI: 10.1183/23120541.00460-2021 Published 24 January 2022
- Open Access
  Prevalence and severity of differing dimensions of breathlessness among elderly males in the population
  Max Olsson, David C. Currow, Miriam J. Johnson, Jacob Sandberg, Gunnar Engström, Magnus Ekström
  
  ERJ Open Res 8: 00553-2021; DOI: 10.1183/23120541.00553-2021 Published 7 February 2022
Lung cancer
- Open Access
  Transthoracic lung biopsy for pulmonary nodules ≤20 mm in routine clinical care
  Emilie Lissavalid, Antoine Khalil, Ghassen Soussi, Marie-Pierre Debray, Alice Guyard, Vincent Bunel, Raphael Borie, Pierre Mordant, Aurélie Cazes, Gérard Zalcman, Valérie Gounant
  
  ERJ Open Res 8: 00562-2021; DOI: 10.1183/23120541.00562-2021 Published 24 January 2022
Pulmonary pharmacology
- Open Access
  NSAID-exacerbated respiratory disease: a population study
  Heidi Andersén, Pinja Ilmarinen, Jasmin Honkamäki, Leena E. Tuomisto, Hanna Hisinger-Mölkänen, Helena Backman, Bo Lundbäck, Eva Rönmark, Tari Haahtela, Anssi Sovijärvi, Lauri Lehtimäki, Päivi Piirilä, Hannu Kankaanranta
  
  ERJ Open Res 8: 00462-2021; DOI: 10.1183/23120541.00462-2021 Published 24 January 2022
Pulmonary vascular disease
- Open Access
  Computed tomography lung parenchymal descriptions in routine radiological reporting have diagnostic and prognostic utility in patients with idiopathic pulmonary arterial hypertension and pulmonary hypertension associated with lung disease
  Krit Dwivedi, Robin Condliffe, Michael Sharkey, Robert Lewis, Samer Alabed, Smitha Rajaram, Catherine Hill, Laura Saunders, Peter Metherall, Faisal Alandejani, Dheyaa Alkhanfar, Jim M. Wild, Haiping Lu, David G. Kiely, Andrew J. Swift
  
  ERJ Open Res 8: 00549-2021; DOI: 10.1183/23120541.00549-2021 Published 24 January 2022
- Open Access
  Self-help cognitive behavioural therapy for anxiety in pulmonary hypertension: pilot randomised controlled trial
  Gregg H. Rawlings, Nigel Beail, Iain Armstrong, Andrew R. Thompson
  
  ERJ Open Res 8: 00526-2021; DOI: 10.1183/23120541.00526-2021 Published 7 March 2022
Sleep
- Open Access
  Association between depression and sleep apnoea: a Mendelian randomisation study
  Gui Chen, Junyang Xie, Weixing Liu, Tianhao Liang, Xiao Liao, Wenjing Liao, Lijuan Song, Xiaowen Zhang
  
  ERJ Open Res 8: 00394-2021; DOI: 10.1183/23120541.00394-2021 Published 7 February 2022
Breath analysis
- Open Access
  Simultaneous measurement of inhaled air and exhaled breath by double multicapillary column ion-mobility spectrometry, a new method for breath analysis: results of a feasibility study
  Michael Westhoff, Maren Friedrich, Jörg I. Baumbach
  
  ERJ Open Res 8: 00493-2021; DOI: 10.1183/23120541.00493-2021 Published 14 February 2022
ARDS
- Open Access
  Breath analysis for detection and trajectory monitoring of acute respiratory distress syndrome in swine
  Ruchi Sharma, Menglian Zhou, Mohamad Hakam Tiba, Brendan M. McCracken, Robert P. Dickson, Christopher E. Gillies, Michael W. Sjoding, Jean A. Nemzek, Kevin R. Ward, Kathleen A. Stringer, Xudong Fan
  
  ERJ Open Res 8: 00154-2021; DOI: 10.1183/23120541.00154-2021 Published 14 February 2022
Bronchiectasis
- Open Access
  Outcomes and survival following lung transplantation in non-cystic fibrosis bronchiectasis
  Frederick Jung, Leonard Riley, Jorge Lascano
  
  ERJ Open Res 8: 00607-2021; DOI: 10.1183/23120541.00607-2021 Published 14 February 2022
- Open Access
  Comparative safety of inhaled corticosteroids and macrolides in Medicare enrolees with bronchiectasis
  Emily Henkle, Charles L. Daley, Jeffrey R. Curtis, Benjamin Chan, Timothy R. Aksamit, Kevin L. Winthrop
  
  ERJ Open Res 8: 00786-2020; DOI: 10.1183/23120541.00786-2020 Published 7 March 2022
- Open Access
  Comparison of different sets of immunological tests to identify treatable immunodeficiencies in adult bronchiectasis patients
  Stefano Aliberti, Francesco Amati, Andrea Gramegna, Barbara Vigone, Martina Oriano, Giovanni Sotgiu, Marco Mantero, Edoardo Simonetta, Laura Saderi, Anna Stainer, Serena Tammaro, Paola Marchisio, Eva Polverino, James D. Chalmers, Francesco Blasi
  
  ERJ Open Res 8: 00388-2021; DOI: 10.1183/23120541.00388-2021 Published 28 March 2022
Lung imaging
- Open Access
  Characterisation of hemidiaphragm dysfunction using dynamic chest radiography: a pilot study
  Thomas Simon FitzMaurice, Caroline McCann, Dilip S. Nazareth, Martin J. Walshaw
  
  ERJ Open Res 8: 00343-2021; DOI: 10.1183/23120541.00343-2021 Published 21 February 2022
Arterial blood gases
- Open Access
  Arterial blood gas analysis: as safe as we think? A multicentre historical cohort study
  Sacha C. Rowling, Marianne Fløjstrup, Daniel Pilsgaard Henriksen, Bjarke Viberg, Christian Hallenberg, Jes Sanddal Lindholt, Andreas Alberg-Fløjborg, Prabath W.B. Nanayakkara, Mikkel Brabrand
  
  ERJ Open Res 8: 00535-2021; DOI: 10.1183/23120541.00535-2021 Published 28 February 2022
Lung function
- Open Access
  Does DNA methylation mediate the association of age at puberty with forced vital capacity or forced expiratory volume in 1 s?
  Liang Li, Hongmei Zhang, John W. Holloway, Susan Ewart, Caroline L. Relton, S. Hasan Arshad, Wilfried Karmaus
  
  ERJ Open Res 8: 00476-2021; DOI: 10.1183/23120541.00476-2021 Published 28 February 2022
Cystic fibrosis
- Open Access
  Novel volumetric capnography indices measure ventilation inhomogeneity in cystic fibrosis
  Sotirios Fouzas, Anne-Christianne Kentgens, Olga Lagiou, Bettina Sarah Frauchiger, Florian Wyler, Ilias Theodorakopoulos, Sophie Yammine, Philipp Latzin
  
  ERJ Open Res 8: 00440-2021; DOI: 10.1183/23120541.00440-2021 Published 14 March 2022
Exercise testing
- Open Access
  Reliability of translaryngeal airway resistance measurements during maximal exercise
  Zoe Fretheim-Kelly, Mette Engan, Hege Clemm, Tiina Andersen, John-Helge Heimdal, Eric Strand, Thomas Halvorsen, Ola Røksund, Maria Vollsæter
  
  ERJ Open Res 8: 00581-2021; DOI: 10.1183/23120541.00581-2021 Published 14 March 2022
Paediatric pulmonology
- Open Access
  Childhood lung function following perinatal HIV infection and early antiretroviral therapy initiation: a cross-sectional study
  Andre Gie, Julie Morrison, David Maree, Barbara Laughton, Sara H. Browne, Mark F. Cotton, Pierre Goussard, Steve Innes
  
  ERJ Open Res 8: 00691-2021; DOI: 10.1183/23120541.00691-2021 Published 24 March 2022

Research letters

Open Access
The association of lung cancer with pulmonary fibrosis
Niranjan Jeganathan, Derrick Cleland, Matheni Sathananthan

ERJ Open Res 8: 00505-2021; DOI: 10.1183/23120541.00505-2021 Published 12 January 2022
Open Access
Impact of N-acetyl-l-cysteine on SARS-CoV-2 pneumonia and its sequelae: results from a large cohort study
Paola Faverio, Paola Rebora, Emanuela Rossi, Savino Del Giudice, Filippo Montanelli, Laura Garzillo, Sara Busnelli, Fabrizio Luppi, Maria Grazia Valsecchi, Alberto Pesci

ERJ Open Res 8: 00542-2021; DOI: 10.1183/23120541.00542-2021 Published 7 February 2022
Open Access
The prevalence and burden of interstitial lung diseases in the USA
Niranjan Jeganathan, Matheni Sathananthan

ERJ Open Res 8: 00630-2021; DOI: 10.1183/23120541.00630-2021 Published 7 February 2022
Open Access
Observational study of inhaled corticosteroid treatment for improved expiratory variability index in steroid-naïve asthmatic children
Janne Burman, Pekka Malmberg, Ville-Pekka Seppä, Tuomas Jartti, Sami Remes, Ove Mickelsson, Anna S. Pelkonen, Mika J. Mäkelä

ERJ Open Res 8: 00499-2021; DOI: 10.1183/23120541.00499-2021 Published 7 February 2022
Open Access
Recommended respiratory tests are not routinely performed for mucopolysaccharidosis patients
Sophie Denamur, Guy Touati, Stéphane Debelleix, Léna Damaj, Magalie Barth, Marine Tardieu, Magali Gorce, Pierre Broué, Didier Lacombe, François Labarthe

ERJ Open Res 8: 00567-2021; DOI: 10.1183/23120541.00567-2021 Published 7 February 2022
Open Access
Predicting the benefits of type-2 targeted anti-inflammatory treatment with the prototype Oxford Asthma Attack Risk Scale (ORACLE)
Simon Couillard, William Il Hoon Do, Richard Beasley, Timothy S.C. Hinks, Ian D. Pavord

ERJ Open Res 8: 00570-2021; DOI: 10.1183/23120541.00570-2021 Published 7 February 2022
Open Access
Missing sputum samples are common in asthma intervention studies and successful collection at follow-up is related to improvement in clinical outcomes
Laurits Frøssing, Morten Hvidtfeldt, Alexander Silberbrandt, Asger Sverrild, Celeste Porsbjerg

ERJ Open Res 8: 00612-2021; DOI: 10.1183/23120541.00612-2021 Published 7 February 2022
Open Access
De-labelling severe asthma diagnosis: the challenge of DIPNECH
Caroline Hurabielle, Camille Taillé, Grégoire Prévot, Maud Russier, Alain Didier, Pierre-Olivier Girodet, Magali Colombat, Julien Mazières, Laurent Guilleminault

ERJ Open Res 8: 00485-2021; DOI: 10.1183/23120541.00485-2021 Published 7 February 2022
Open Access
Continuous positive airway pressure for moderate to severe COVID-19 acute respiratory distress syndrome in a resource-limited setting
Anbesan Hoole, Sahar Qamar, Ayesha Khan, Mariam Ejaz

ERJ Open Res 8: 00536-2021; DOI: 10.1183/23120541.00536-2021 Published 7 February 2022
Open Access
Language and geographical location influence the incidence of chronic cough in the Canadian Longitudinal Study on Aging
Imran Satia, Alexandra J. Mayhew, Nazmul Sohel, Om Kurmi, Kieran J. Killian, Megan E. O'Connell, Paul M. O'Byrne, Parminder Raina

ERJ Open Res 8: 00721-2021; DOI: 10.1183/23120541.00721-2021 Published 21 February 2022
Open Access
Treatment outcomes among childhood extensively drug-resistant tuberculosis patients in Pakistan
Muhammad Abubakar, Nafees Ahmad, Muhammad Atif, Amer Hayat Khan, Abdul Ghafoor

ERJ Open Res 8: 00551-2021; DOI: 10.1183/23120541.00551-2021 Published 21 February 2022
Open Access
Human bronchial epithelial cells from patients with asthma have an altered gene expression profile
Sangita Bhaker, Michael A. Portelli, Kamini Rakkar, Dominick Shaw, Simon Johnson, Christopher Brightling, Ian Sayers

ERJ Open Res 8: 00625-2021; DOI: 10.1183/23120541.00625-2021 Published 21 February 2022
Open Access
The landscape of transcriptomic and proteomic studies in sarcoidosis
Maneesh Bhargava, Shu-Yi Liao, Elliott D. Crouser, Lisa A. Maier, Sonia M. Leach

ERJ Open Res 8: 00621-2021; DOI: 10.1183/23120541.00621-2021 Published 28 February 2022
Open Access
Inhaled corticosteroids and COVID-19 outcomes in asthma: the Israeli experience
Yochai Adir, Einat Fireman Klein, Walid Saliba

ERJ Open Res 8: 00014-2022; DOI: 10.1183/23120541.00014-2022 Published 7 March 2022
Open Access
SARS-CoV-2 T-cell response in COVID-19 convalescent patients with and without lung sequelae
Tamara Cruz, Núria Mendoza, Lídia Perea, Núria Albacar, Azucena Gonzalez, Fernanda Hernandez-Gonzalez, Manel Juan, Alvar Agustí, Jacobo Sellares, Oriol Sibila, Rosa Faner

ERJ Open Res 8: 00706-2021; DOI: 10.1183/23120541.00706-2021 Published 7 March 2022
Open Access
Impact of lockdown during the COVID-19 pandemic on health status in patients with cystic fibrosis: a mono-centre observational study
Stephanie Thee, Leonie Marie Busack, Marcus A. Mall, Mirjam Stahl

ERJ Open Res 8: 00588-2021; DOI: 10.1183/23120541.00588-2021 Published 14 March 2022
Open Access
Facemasks do not lead to abnormal gas exchange during treadmill exercise testing in children
Maria Christina Mallet, Michael Hitzler, Marco Lurà, Claudia E. Kuehni, Nicolas Regamey

ERJ Open Res 8: 00613-2021; DOI: 10.1183/23120541.00613-2021 Published 24 March 2022

Correspondence

Open Access
External validation of the OPALS prediction model for in-hospital mortality in patients with acute decompensated pulmonary hypertension
Marcos V.F. Garcia, Rogerio Souza, Pedro Caruso

ERJ Open Res 8: 00006-2022; DOI: 10.1183/23120541.00006-2022 Published 7 March 2022
Open Access
Reply: External validation of the OPALS prediction model for in-hospital mortality in patients with acute decompensated pulmonary hypertension
Robin Condliffe, Kris Bauchmuller, Jennifer Southern, David G. Kiely, Gary H. Mills

ERJ Open Res 8: 00066-2022; DOI: 10.1183/23120541.00066-2022 Published 7 March 2022
Open Access
Quality assessment pathway for respiratory oscillometry
Alice M. Cottee, Cindy Thamrin, Claude S. Farah, Leigh M. Seccombe

ERJ Open Res 8: 00569-2021; DOI: 10.1183/23120541.00569-2021 Published 7 March 2022

Acknowledgement

Open Access
ERJ Open Research, list of peer reviewers 2021
ERJ Open Res 8: 10801-2022; DOI: 10.1183/23120541.10801-2022 Published 12 January 2022

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Table of Contents

Editorials

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Study protocols

Original research articles

COPD

Asthma

COPD and asthma

COPD and pulmonary hypertension

COVID-19

Respiratory infections

Tuberculosis

Cough

Aspiration

Interstitial lung disease

Dyspnoea

Lung cancer

Pulmonary pharmacology

Pulmonary vascular disease

Sleep

Breath analysis

ARDS

Bronchiectasis

Lung imaging

Arterial blood gases

Lung function

Cystic fibrosis

Exercise testing

Paediatric pulmonology

Research letters

Correspondence

Acknowledgement

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