Tables
- TABLE 1
Prevalence of lung cancer (LC) in decedents with and without idiopathic pulmonary fibrosis (IPF)
Variable Decedents without IPF# Decedents with IPF¶ OR+ (95% CI) Total deaths LC present Deaths with LC, % total LC mortality rate, % change 2004–2018 p-value for trend Total deaths LC present Deaths with LC, % total LC mortality rate, % change 2004–2018 p-value for trend Sex Female 18 002 346 1 087 001 6.04 −23.4 <0.001 160 389 3985 2.48 0.30 0.40 (0.38–0.41) Male 17 263 723 1 346 703 7.80 −41.0 <0.001 188 984 7816 4.13 0.32 0.51 (0.50–0.52) Age, years 45–54 2 677 125 164 280 6.14 −48.4 <0.001 10 476 294 2.81 0.26 0.44 (0.39–0.50) 55–64 4 797 685 482 281 10.05 −34.8 <0.001 32 043 1533 4.78 0.12 0.45 (0.43–0.47) 65–74 6 566 472 767 181 11.68 −42.0 <0.001 76 494 4070 5.32 −19.1 0.04 0.42 (0.41–0.44) 75–84 9 574 477 729 948 7.62 −27.4 <0.001 126 992 4327 3.40 +22.3 0.001 0.43 (0.41–0.44) ≥85 11 650 310 290 014 2.49 −9.2 <0.001 103 368 1577 1.53 +21.8 <0.001 0.61 (0.58–0.64) Race Native-American 186 275 11 424 6.13 −12.4 0.02 2775 84 3.03 0.52 0.48 (0.38–0.59) Asian 738 695 49 661 6.72 −17.0 <0.001 8726 214 2.45 0.85 0.35 (0.30–0.40) Black 3 851 698 250 914 6.51 −32.4 <0.001 18 707 642 3.43 0.34 0.51 (0.47–0.55) White 28 498 575 2 039 321 7.16 −23.1 <0.001 291 706 10 302 3.53 0.09 0.47 (0.47–0.48) Hispanic 1 902 714 77 398 4.07 −31.2 <0.001 26 903 538 2.00 +35.0 0.03 0.48 (0.44–0.52) UCD IPF NA NA NA NA NA NA 1863 NA 0.92 NA LC NA 2 292 943 NA −28.7 <0.001 NA 8956 NA 0.40 0.19 (0.18–0.20) Pneumonia NA 1023 NA 0.14 NA 19 NA 1.00 3.83 (2.43–6.04) Place of death Inpatient NA 700 652 NA −45.8 <0.001 NA 5625 NA 0.44 2.25 (2.17–2.33) Home NA 993 905 NA −22.5 <0.001 NA 3687 NA 0.11 0.66 (0.63–0.68) Hospice NA 211 291 NA +1130.2 <0.001 NA 847 NA +8880.0 <0.001 0.81 (0.76–0.87) Nursing home NA 331 624 NA −43.0 <0.001 NA 896 NA 0.55 0.52 (0.49–0.56) International Classification of Diseases (10th Revision) (ICD-10) codes used for underlying cause of death (UCD) were pulmonary fibrosis (J84.1 and J84.9), lung cancer (C34–C34.9) and pneumonia (J09–J18.9). Similar to prior studies, ICD-10 codes were used to identify and exclude patients with underlying connective tissue diseases (M32–M35, M35.1, M35.5, M35.8–M36 and M05–M08.9), radiation fibrosis (J70.1), sarcoidosis (D86–D86.9), pneumoconiosis (J60–J65) and hypersensitivity pneumonitis (J67–J67.9). If no data are shown for % change in rate, the regression analysis of the data did not indicate a significant departure from a linear trend during the analysis period. NA: not applicable. #: n=35 266 069; ¶: n=349 373; +: the overall odds of lung cancer with IPF compared to without IPF.
