Tables
- TABLE 1
Baseline patients’ characteristics and outcomes in the total original sample and in the pseudo-population weighted for the propensity score of N-Acetyl-l-cysteine (NAC)
Original data Weighted data NAC commencement SMD NAC commencement SMD No Yes No Yes Subjects, n 321 585 329 572 Males 192 (60) 409 (70) 0.213 209 (64) 381 (67) 0.060 Age, median (IQR) 68 (57–79) 63 (55–72) 0.232 64 (54–75) 64 (55–73) 0.003 Oxygen/ventilatory support 0.736 0.098 None 101 (31) 41 (7) 49 (15) 78 (14) Oxygen therapy alone 168 (52) 379 (65) 193 (59) 354 (62) CPAP 51 (16) 147 (25) 82 (25) 128 (22) ETI and IMV 1 (0) 18 (3) 5 (1) 12 (2) Cardiovascular diseases 187 (58) 319 (55) 0.075 178 (54) 315 (55) 0.016 Hypertension 151 (47) 275 (47) 0.001 151 (46) 270 (47) 0.021 Diabetes 69 (21) 84 (14) 0.187 53 (16) 90 (16) 0.006 Obesity 39 (23) 126 (33) 0.219 53 (26) 117 (33) 0.156 Cerebrovascular diseases 25 (8) 30 (5) 0.108 19 (6) 36 (6) 0.019 COPD 25 (8) 20 (3) 0.191 15 (5) 25 (4) 0.017 Moderate or severe chronic kidney diseases 31 (10) 41 (7) 0.096 26 (8) 43 (7) 0.022 Moderate or severe liver diseases 7 (2) 13 (2) 0.003 6 (2) 16 (3) 0.078 Chronic neurological disorders 60 (19) 52 (9) 0.287 41 (12) 74 (13) 0.014 Cancer 37 (12) 47 (8) 0.118 33 (10) 52 (9) 0.030 Immune system disorder 8 (2) 14 (2) 0.006 7 (2) 12 (2) 0.004 Treatment during hospitalisation Systemic steroid 76 (24) 265 (45) 0.467 122 (37) 217 (38) 0.016 Remdesivir 13 (4) 68 (12) 0.285 34 (10) 52 (9) 0.035 Outcomes ICU admission 20 (7) 134 (23) 46 (15) 107 (19) 0.360# Days to ICU, median (IQR) 4 (1–6) 2 (0–5) 2 (0–4) 2 (0–5) 0.972# Days spent in ICU, median (IQR) 9 (4–19) 14 (9–24) 20 (8–32) 14 (9–23) 0.191# Hospital discharge 0.523# Death 42 (13) 91 (16) 44 (13) 91 (16) Discharged at home 229 (71) 396 (68) 224 (68) 392 (68) Transferred to other facility 50 (16) 98 (17) 61 (19) 89 (16) Length of hospital stay in subjects discharged at home, days, median (IQR) 16 (11–25) 16 (10–25) 17 (12–30) 15 (10–24) 0.013# Atelectasis during hospital stay 3 (1) 14 (2) 7 (2) 11 (2) 0.913# Data are presented as n (%), unless otherwise stated. ICU: intensive care unit; IQR: interquartile range; SMD: standardised mean difference; CPAP: continuous positive airway pressure; ETI: endotracheal intubation; IMV: invasive mechanical ventilation. #: p-values are listed for outcomes data.
Vol 8 Issue 1
Table of Contents
Impact of N-acetyl-l-cysteine on SARS-CoV-2 pneumonia and its sequelae: results from a large cohort study
