Reduced immunogenicity of the mRNA vaccine BNT162b2 in patients with idiopathic pulmonary fibrosis

Theodoros Karampitsakos; Ourania Papaioannou; Ilias Dimeas; Panagiota Tsiri; Vasilina Sotiropoulou; Ioannis Tomos; Ilias C. Papanikolaou; Matthaios Katsaras; Paraskevi Kirgou; Zoe Daniil; Konstantinos I. Gourgoulianis; Fotios Sampsonas; Effrosyni Manali; Spyridon Papiris; Demosthenes Bouros; Argyris Tzouvelekis

doi:10.1183/23120541.00082-2022

Reduced immunogenicity of the mRNA vaccine BNT162b2 in patients with idiopathic pulmonary fibrosis

Theodoros Karampitsakos, Ourania Papaioannou, Ilias Dimeas, Panagiota Tsiri, Vasilina Sotiropoulou, Ioannis Tomos, Ilias C. Papanikolaou, Matthaios Katsaras, Paraskevi Kirgou, Zoe Daniil, Konstantinos I. Gourgoulianis, Fotios Sampsonas, Effrosyni Manali, Spyridon Papiris, Demosthenes Bouros, Argyris Tzouvelekis

ERJ Open Research 2022 8: 00082-2022; DOI: 10.1183/23120541.00082-2022

Theodoros Karampitsakos

1Dept of Respiratory Medicine, University Hospital of Patras, Patras, Greece

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Ourania Papaioannou

1Dept of Respiratory Medicine, University Hospital of Patras, Patras, Greece

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Ilias Dimeas

2Dept of Respiratory Medicine, Medical School, University of Thessaly, Larissa, Greece

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Panagiota Tsiri

1Dept of Respiratory Medicine, University Hospital of Patras, Patras, Greece

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Vasilina Sotiropoulou

1Dept of Respiratory Medicine, University Hospital of Patras, Patras, Greece

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Ioannis Tomos

32nd Pulmonary Medicine Dept, ATTIKON University Hospital, Athens Medical School, National and Kapodistrian University of Athens, Athens, Greece

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Ilias C. Papanikolaou

4Respiratory Medicine Dept, Corfu General Hospital, Corfu, Greece

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Matthaios Katsaras

1Dept of Respiratory Medicine, University Hospital of Patras, Patras, Greece

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Paraskevi Kirgou

2Dept of Respiratory Medicine, Medical School, University of Thessaly, Larissa, Greece

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Zoe Daniil

2Dept of Respiratory Medicine, Medical School, University of Thessaly, Larissa, Greece

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Konstantinos I. Gourgoulianis

2Dept of Respiratory Medicine, Medical School, University of Thessaly, Larissa, Greece

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Fotios Sampsonas

1Dept of Respiratory Medicine, University Hospital of Patras, Patras, Greece

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Effrosyni Manali

32nd Pulmonary Medicine Dept, ATTIKON University Hospital, Athens Medical School, National and Kapodistrian University of Athens, Athens, Greece

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Spyridon Papiris

32nd Pulmonary Medicine Dept, ATTIKON University Hospital, Athens Medical School, National and Kapodistrian University of Athens, Athens, Greece

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Demosthenes Bouros

5First Academic Dept of Pneumonology, Hospital for Thoracic Diseases, SOTIRIA, Medical School, National and Kapodistrian University of Athens, Athens, Greece

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Argyris Tzouvelekis

1Dept of Respiratory Medicine, University Hospital of Patras, Patras, Greece

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For correspondence: argyris.tzouvelekis@gmail.com

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FIGURE 1
Both patients with idiopathic pulmonary fibrosis (IPF) receiving antifibrotics and patients with IPF under no treatment had reduced levels of anti-SARS-CoV-2 antibodies after two doses of SARS-CoV-2 mRNA vaccine compared to the general population (Kruskal–Wallis test, p=0.002). *: p<0.05.

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