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A potential harmful effect of dexamethasone in non-severe COVID-19: results from the COPPER-pilot study

Janwillem Kocks, Marjan Kerkhof, Jan Scherpenisse, Aimée van de Maat, Iris van Geer-Postmus, Thomas le Rütte, Jan Schaart, Reinold O.B. Gans, Huib A.M. Kerstjens
ERJ Open Research 2022 8: 00129-2022; DOI: 10.1183/23120541.00129-2022
Janwillem Kocks
1General Practitioners Research Institute, Groningen, The Netherlands
2GRIAC Research Institute, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
3Observational and Pragmatic Research Institute, Singapore
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  • For correspondence: Janwillem@gpri.nl
Marjan Kerkhof
1General Practitioners Research Institute, Groningen, The Netherlands
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Jan Scherpenisse
4General Practice Noorderdokters, Valthermond, The Netherlands
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Aimée van de Maat
1General Practitioners Research Institute, Groningen, The Netherlands
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Iris van Geer-Postmus
1General Practitioners Research Institute, Groningen, The Netherlands
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Thomas le Rütte
1General Practitioners Research Institute, Groningen, The Netherlands
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Jan Schaart
5General Practitioners Care Drenthe, Asssen, The Netherlands
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Reinold O.B. Gans
6Dept of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
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Huib A.M. Kerstjens
2GRIAC Research Institute, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
7Dept of Pulmonary Diseases and Tuberculosis, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
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Tables

  • TABLE 1

    Characteristics of patients who started monitoring in the different study arms

    Characteristics at GP consultationStudy arm
    DexamethasoneControl group
    Subjects, n42
    Male sex3 (75)2 (100)
    Age group
     <65 years2 (50)1 (50)
     ≥65 years2 (50)1 (50)
    Obesity (BMI ≥30 kg·m−2)2 (50)0 (0)
    Asthma2 (50)0 (0)
    COPD1 (25)0 (0)
    Cardiovascular disease1 (25)1 (50)
    Diabetes mellitus1 (25)1 (50)
    Dyspnoea degree
     None or mild2 (50)0 (0)
     Moderate1 (25)2 (100)
     Severe1 (25)0 (0)
    Temperature ≥38.0°C2 (50)0 (0)
    SpO2 at rest#, %99/97/94/9394/92
    SpO2 after STS#, %95/92/90/8988/91
    Outcome
     Time to recovery, days#,¶>28/>28/NA/NA14/8
     Severe COVID-19#Yes/No/Yes/YesNo/No

    Data are presented as n (%), unless otherwise stated. BMI: body mass index; SpO2: peripheral oxygen saturation; STS: sit-to-stand test; NA: not available due to hospital admission. #: individual values; ¶: defined as self-reported recovery for at least 2 consecutive days.

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    A potential harmful effect of dexamethasone in non-severe COVID-19: results from the COPPER-pilot study
    Janwillem Kocks, Marjan Kerkhof, Jan Scherpenisse, Aimée van de Maat, Iris van Geer-Postmus, Thomas le Rütte, Jan Schaart, Reinold O.B. Gans, Huib A.M. Kerstjens
    ERJ Open Research Apr 2022, 8 (2) 00129-2022; DOI: 10.1183/23120541.00129-2022

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    A potential harmful effect of dexamethasone in non-severe COVID-19: results from the COPPER-pilot study
    Janwillem Kocks, Marjan Kerkhof, Jan Scherpenisse, Aimée van de Maat, Iris van Geer-Postmus, Thomas le Rütte, Jan Schaart, Reinold O.B. Gans, Huib A.M. Kerstjens
    ERJ Open Research Apr 2022, 8 (2) 00129-2022; DOI: 10.1183/23120541.00129-2022
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