Curvilinearity provides additional information to lung clearance index only in a minority of children with early cystic fibrosis lung disease

Samantha Irving; Katie Bayfield; Jane C. Davies; Andrew Bush

doi:10.1183/23120541.00582-2021

Curvilinearity provides additional information to lung clearance index only in a minority of children with early cystic fibrosis lung disease

Samantha Irving, Katie Bayfield, Jane C. Davies, Andrew Bush

ERJ Open Research 2022 8: 00582-2021; DOI: 10.1183/23120541.00582-2021

Samantha Irving

1Dept of Paediatric Respiratory Medicine, Royal Brompton Hospital, London, UK

2Faculty of Medicine, National Heart and Lung Institute, Imperial College, London, UK

4These authors contributed equally

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ORCID record for Samantha Irving
For correspondence: s.irving@rbht.nhs.uk

Katie Bayfield

2Faculty of Medicine, National Heart and Lung Institute, Imperial College, London, UK

3Children's Hospital at Westmead, Respiratory, Sydney, Australia

4These authors contributed equally

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ORCID record for Katie Bayfield

Jane C. Davies

1Dept of Paediatric Respiratory Medicine, Royal Brompton Hospital, London, UK

2Faculty of Medicine, National Heart and Lung Institute, Imperial College, London, UK

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Andrew Bush

1Dept of Paediatric Respiratory Medicine, Royal Brompton Hospital, London, UK

2Faculty of Medicine, National Heart and Lung Institute, Imperial College, London, UK

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FIGURE 1
Curvilinearity (Curv) versus lung clearance index (LCI) in patients with cystic fibrosis. a) The overall result is not linear. b) The correlation between LCI and Curv in patients with mild changes (LCI<10 Pearson's r of 0.8, p<0.001). c) There is no correlation between LCI and Curv at higher LCI values. ^#: outliers, shown in both relevant panels. ***: p<0.001.

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