Vitamin D replacement in children with acute wheeze: a dose-escalation study

Christos Stefanidis; Andrew Bush; Christopher Newby; Chinedu Nwokoro; Susan Liebeschuetz; Imogen P. Skene; Christopher J. Griffiths; Adrian R. Martineau

doi:10.1183/23120541.00609-2021

Vitamin D replacement in children with acute wheeze: a dose-escalation study

Christos Stefanidis, Andrew Bush, Christopher Newby, Chinedu Nwokoro, Susan Liebeschuetz, Imogen P. Skene, Christopher J. Griffiths, Adrian R. Martineau

ERJ Open Research 2022 8: 00609-2021; DOI: 10.1183/23120541.00609-2021

Christos Stefanidis

1Asthma UK Centre for Applied Research; Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK

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For correspondence: c.stefanidis@outlook.com

Andrew Bush

2Asthma UK Centre for Applied Research; Imperial College and Royal Brompton Hospital, Biomedical Research Unit at the Royal Brompton and Harefield NHS Foundation Trust and Imperial College London, London, UK

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Christopher Newby

1Asthma UK Centre for Applied Research; Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK

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Chinedu Nwokoro

1Asthma UK Centre for Applied Research; Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK

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Susan Liebeschuetz

3Dept of Paediatrics, Newham University Hospital, London, UK

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Imogen P. Skene

4Emergency Department Research Office, Royal London Hospital, Whitechapel, London, UK

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Christopher J. Griffiths

1Asthma UK Centre for Applied Research; Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK

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Adrian R. Martineau

1Asthma UK Centre for Applied Research; Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK

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FIGURE 1
25-hydroxyvitamin D (25(OH)D) concentrations by study time-point in a) all participants (n=31), b) the subset of participants with preschool wheeze (n=15) and c) the subset of participants with school-age asthma (n=16). The dotted line represents the threshold denoting optimal 25(OH)D concentration (>75 nmol·L⁻¹). p-values from paired t-tests.

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Vitamin D replacement in children with acute wheeze: a dose-escalation study

Christos Stefanidis, Andrew Bush, Christopher Newby, Chinedu Nwokoro, Susan Liebeschuetz, Imogen P. Skene, Christopher J. Griffiths, Adrian R. Martineau

ERJ Open Research Apr 2022, 8 (2) 00609-2021; DOI: 10.1183/23120541.00609-2021

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Vitamin D replacement in children with acute wheeze: a dose-escalation study

Christos Stefanidis, Andrew Bush, Christopher Newby, Chinedu Nwokoro, Susan Liebeschuetz, Imogen P. Skene, Christopher J. Griffiths, Adrian R. Martineau

ERJ Open Research Apr 2022, 8 (2) 00609-2021; DOI: 10.1183/23120541.00609-2021

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