Table of Contents

Original research articles

• COVID-19

  • Open Access

    Enhanced neutrophil extracellular trap formation in COVID-19 is inhibited by the protein kinase C inhibitor ruboxistaurin

    Rebecca Dowey, Joby Cole, A.A. Roger Thompson, Rebecca C. Hull, Chenghao Huang, Jacob Whatmore, Ahmed Iqbal, Kirsty L. Bradley, Joanne McKenzie, Allan Lawrie, Alison M. Condliffe, Endre Kiss-Toth, Ian Sabroe, Lynne R. Prince

    ERJ Open Res 8: 00596-2021; DOI: 10.1183/23120541.00596-2021 Published 4 April 2022
  • Open Access

    Prospective longitudinal evaluation of hospitalised COVID-19 survivors 3 and 12 months after discharge

    Natalie Lorent, Yannick Vande Weygaerde, Eveline Claeys, Ipek Guler Caamano Fajardo, Nicolas De Vos, Walter De Wever, Bihiyga Salhi, Iwein Gyselinck, Cedric Bosteels, Bart N. Lambrecht, Stephanie Everaerts, Sven Verschraegen, Christophe Schepers, Heleen Demeyer, Arne Heyns, Pieter Depuydt, Sandra Oeyen, Pascal Van Bleyenbergh, Laurent Godinas, Lieven Dupont, Greet Hermans, Eric Derom, Rik Gosselink, Wim Janssens, Eva Van Braeckel

    ERJ Open Res 8: 00004-2022; DOI: 10.1183/23120541.00004-2022 Published 11 April 2022
  • Open Access

    Respiratory symptoms and radiological findings in post-acute COVID-19 syndrome

    Etienne-Marie Jutant, Olivier Meyrignac, Antoine Beurnier, Xavier Jaïs, Tai Pham, Luc Morin, Athénaïs Boucly, Sophie Bulifon, Samy Figueiredo, Anatole Harrois, Mitja Jevnikar, Nicolas Noël, Jérémie Pichon, Anne Roche, Andrei Seferian, Samer Soliman, Jacques Duranteau, Laurent Becquemont, Xavier Monnet, Olivier Sitbon, Marie-France Bellin, Marc Humbert, Laurent Savale, David Montani

    ERJ Open Res 8: 00479-2021; DOI: 10.1183/23120541.00479-2021 Published 19 April 2022
  • Open Access

    Heparan sulfate mimetic fucoidan restores the endothelial glycocalyx and protects against dysfunction induced by serum of COVID-19 patients in the intensive care unit

    Lushun Yuan, Shuzhen Cheng, Wendy M.P.J. Sol, Anouk I.M. van der Velden, Hans Vink, Ton J. Rabelink, Bernard M. van den Berg

    ERJ Open Res 8: 00652-2021; DOI: 10.1183/23120541.00652-2021 Published 3 May 2022
  • Open Access

    An externally validated fully automated deep learning algorithm to classify COVID-19 and other pneumonias on chest computed tomography

    Akshayaa Vaidyanathan, Julien Guiot, Fadila Zerka, Flore Belmans, Ingrid Van Peufflik, Louis Deprez, Denis Danthine, Gregory Canivet, Philippe Lambin, Sean Walsh, Mariaelena Occhipinti, Paul Meunier, Wim Vos, Pierre Lovinfosse, Ralph T.H. Leijenaar

    ERJ Open Res 8: 00579-2021; DOI: 10.1183/23120541.00579-2021 Published 3 May 2022

• Tuberculosis

  • Open Access

    Latent tuberculosis screening and treatment in HIV: highly acceptable in a prospective cohort study

    Helena A. White, Hajra Okhai, Amandip Sahota, John Maltby, Iain Stephenson, Hemu Patel, Philip M. Hefford, Martin J. Wiselka, Manish Pareek

    ERJ Open Res 8: 00442-2021; DOI: 10.1183/23120541.00442-2021 Published 25 April 2022
  • Open Access

    Safety of prolonged treatment with bedaquiline in programmatic conditions

    Dzmitriy Zhurkin, Elmira Gurbanova, Jonathon R. Campbell, Dick Menzies, Svetlana Setkina, Hennadz Hurevich, Varvara Solodovnikova, Dzmitry Viatushka, Alan Altraja, Alena Skrahina

    ERJ Open Res 8: 00685-2021; DOI: 10.1183/23120541.00685-2021 Published 16 May 2022

• Respiratory infections

  • Open Access

    Influence of sex, season and environmental air quality on experimental human pneumococcal carriage acquisition: a retrospective cohort analysis

    Katerina S. Cheliotis, Christopher P. Jewell, Carla Solórzano, Britta Urban, Andrea M. Collins, Elena Mitsi, Sherin Pojar, Elissavet Nikolaou, Esther L. German, Jesús Reiné, Stephen B. Gordon, Simon P. Jochems, Jamie Rylance, Daniela M. Ferreira

    ERJ Open Res 8: 00586-2021; DOI: 10.1183/23120541.00586-2021 Published 11 April 2022
  • Open Access

    An observational study of Pseudomonas aeruginosa in adult long-term ventilation

    Ruth Sobala, Hannah Carlin, Thomas Fretwell, Sufyan Shakir, Katie Cattermole, Amy Royston, Paul McCallion, John Davison, Joanna Lumb, Hilary Tedd, Ben Messer, Anthony De Soyza

    ERJ Open Res 8: 00687-2021; DOI: 10.1183/23120541.00687-2021 Published 19 April 2022
  • Open Access

    Multiplex bacterial PCR in the bronchoalveolar lavage fluid of non-intubated patients with suspected pulmonary infection: a quasi-experimental study

    Anna Salina, Desiree M. Schumann, Léo Franchetti, Kathleen Jahn, Kurosch Purkabiri, Raphael Müller, Werner Strobel, Nina Khanna, Michael Tamm, Daiana Stolz

    ERJ Open Res 8: 00595-2021; DOI: 10.1183/23120541.00595-2021 Published 25 April 2022

• Respiratory infections and asthma

  • Open Access

    Imprinting of bronchial epithelial cells upon in vivo rhinovirus infection in people with asthma

    Abilash Ravi, Saheli Chowdhury, Annemiek Dijkhuis, Barbara S. Dierdorp, Tamara Dekker, Rianne Kruize, Yanaika S. Sabogal Piñeros, Christof J. Majoor, Peter J. Sterk, René Lutter

    ERJ Open Res 8: 00522-2021; DOI: 10.1183/23120541.00522-2021 Published 19 April 2022

• Asthma

  • Open Access

    Plethysmography-derived gas trapping lacks utility in predicting response to bronchial thermoplasty

    Ashwin Rajan, Kim Bennetts, David Langton

    ERJ Open Res 8: 00690-2021; DOI: 10.1183/23120541.00690-2021 Published 9 May 2022
  • Open Access

    The effect of the COVID-19 pandemic on severe asthma care in Europe: will care change for good?

    Katrien Eger, Dora Paroczai, Alison Bacon, Florence Schleich, Svetlana Sergejeva, Arnaud Bourdin, Isabelle Vachier, Eleftherios Zervas, Konstantinos Katsoulis, Dimosthenis Papapetrou, Konstantinos Kostikas, Zsuzsanna Csoma, Enrico Heffler, Giorgio Walter Canonica, Ineta Grisle, Kristina Bieksiene, Jolita Palacionyte, Anneke ten Brinke, Simone Hashimoto, Frank W.J.M. Smeenk, Gert-Jan Braunstahl, Simone van der Sar, Florin Mihălţan, Natalia Nenasheva, Marina Peredelskaya, Biljana Zvezdin, Ivan Čekerevac, Sanja Hromiš, Vojislav Ćupurdija, Zorica Lazic, Branislava Milenkovic, Sanja Dimic-Janjic, Valentyna Yasinska, Barbro Dahlén, Apostolos Bossios, Nikolaos Lazarinis, David Aronsson, Arne Egesten, Abul Kashem Mohammad Munir, Lars Ahlbeck, Christer Janson, Sabina Škrgat, Natalija Edelbaher, Joerg Leuppi, Fabienne Jaun, Jochen Rüdiger, Nikolay Pavlov, Pietro Gianella, Reta Fischer, Florian Charbonnier, Rekha Chaudhuri, Steven James Smith, Simon Doe, Michelle Fawdon, Matthew Masoli, Liam Heaney, Hans Michael Haitchi, Ramesh Kurukulaaratchy, Olivia Fulton, Betty Frankemölle, Toni Gibson, Karen Needham, Peter Howarth, Ratko Djukanovic, Elisabeth Bel, Michael Hyland

    ERJ Open Res 8: 00065-2022; DOI: 10.1183/23120541.00065-2022 Published 16 May 2022

• COPD

  • Open Access

    Expiratory flow limitation in a cohort of highly symptomatic COPD patients

    Augusta Beech, Natalie Jackson, James Dean, Dave Singh

    ERJ Open Res 8: 00680-2021; DOI: 10.1183/23120541.00680-2021 Published 4 April 2022
  • Open Access

    Single-nucleotide polymorphisms in the sulfatase-modifying factor 1 gene are associated with lung function and COPD

    Linnea Jarenbäck, Sophia Frantz, Julie Weidner, Jaro Ankerst, Ulf Nihlén, Leif Bjermer, Per Wollmer, Ellen Tufvesson

    ERJ Open Res 8: 00668-2021; DOI: 10.1183/23120541.00668-2021 Published 16 May 2022
  • Open Access

    Predictors of chronic obstructive pulmonary disease in women who have never smoked: a cohort study

    Roger M. Engel, Katie de Luca, Petra L. Graham, Masoumeh Kaboli Farshchi, Subramanyam Vemulpad, Julie Byles

    ERJ Open Res 8: 00532-2021; DOI: 10.1183/23120541.00532-2021 Published 16 May 2022

• Cough

  • Open Access

    The interrelationship of chronic cough and depression: a prospective population-based study

    Johnmary T. Arinze, Amy Hofman, Emmely W. de Roos, Maria A.J. de Ridder, Katia M.C. Verhamme, Bruno Stricker, Guy G. Brusselle, Annemarie I. Luik

    ERJ Open Res 8: 00069-2022; DOI: 10.1183/23120541.00069-2022 Published 4 April 2022
  • Open Access

    Longitudinal passive cough monitoring and its implications for detecting changes in clinical status

    Juan C. Gabaldón-Figueira, Eric Keen, Matthew Rudd, Virginia Orrilo, Isabel Blavia, Juliane Chaccour, Mindaugas Galvosas, Peter Small, Simon Grandjean Lapierre, Carlos Chaccour

    ERJ Open Res 8: 00001-2022; DOI: 10.1183/23120541.00001-2022 Published 16 May 2022

• E-cigarettes and vaping

  • Open Access

    Noninvasive systemic biomarkers of e-cigarette or vaping use-associated lung injury: a pilot study

    Stephanie Podguski, Gagandeep Kaur, Thivanka Muthumalage, Matthew D. McGraw, Irfan Rahman

    ERJ Open Res 8: 00639-2021; DOI: 10.1183/23120541.00639-2021 Published 4 April 2022

• Cannabis

  • Open Access

    Lifetime cannabis exposure and small airway function in a population-based cohort study

    Hua Shin Tan, Helena M. McAnally, Jack Dummer, Robert J. Hancox

    ERJ Open Res 8: 00688-2021; DOI: 10.1183/23120541.00688-2021 Published 3 May 2022

• Primary ciliary dyskinesia

  • Open Access

    An international survey on nasal nitric oxide measurement practices for the diagnosis of primary ciliary dyskinesia

    Nicole Beydon, Thomas Ferkol, Amanda Lea Harris, Murielle Colas, Stephanie D. Davis, Eric Haarman, Claire Hogg, Emma Kilbride, Panayotis Kouis, Claudia E. Kuehni, Philipp Latzin, Diana Marangu, June Marthin, Kim G. Nielsen, Phil Robinson, Nisreen Rumman, Matthew Rutter, Woolf Walker, Jane S. Lucas

    ERJ Open Res 8: 00708-2021; DOI: 10.1183/23120541.00708-2021 Published 4 April 2022
  • Open Access

    Respiratory symptoms of Swiss people with primary ciliary dyskinesia

    Myrofora Goutaki, Leonie Hüsler, Yin Ting Lam, Helena M. Koppe, Andreas Jung, Romain Lazor, Loretta Müller, Swiss PCD Research Group, Eva S.L. Pedersen, Claudia E. Kuehni

    ERJ Open Res 8: 00673-2021; DOI: 10.1183/23120541.00673-2021 Published 11 April 2022

• Cystic fibrosis

  • Open Access

    CFTR modulator use and risk of nontuberculous mycobacteria positivity in cystic fibrosis, 2011–2018

    Emily E. Ricotta, D. Rebecca Prevots, Kenneth N. Olivier

    ERJ Open Res 8: 00724-2021; DOI: 10.1183/23120541.00724-2021 Published 11 April 2022
  • Open Access

    Novel CFTR modulator combinations maximise rescue of G85E and N1303K in rectal organoids

    Marjolein M. Ensinck, Liesbeth De Keersmaecker, Anabela S. Ramalho, Senne Cuyx, Stephanie Van Biervliet, Lieven Dupont, Frauke Christ, Zeger Debyser, François Vermeulen, Marianne S. Carlon

    ERJ Open Res 8: 00716-2021; DOI: 10.1183/23120541.00716-2021 Published 19 April 2022

• Pleural effusion

  • Open Access

    Predictors of outcome of chest tube drainage of nonpurulent exudative pleural effusions

    Chimaobi Ikechukwu Nwagboso, Chidiebere Peter Echieh, John Nkemakolam Eze, Stephen Omirigbe Ogbudu, Chibueze Haggai Njoku, Anietimfon Umoh Etiuma, Okokon Odonkwo Bassey

    ERJ Open Res 8: 00604-2021; DOI: 10.1183/23120541.00604-2021 Published 4 April 2022

• Interstitial lung disease

  • Open Access

    Serum autotaxin levels in chronic disease and acute exacerbation of fibrosing interstitial lung disease

    Takuma Isshiki, Hiroshige Shimizu, Susumu Sakamoto, Akira Yamasaki, Shion Miyoshi, Yasuhiko Nakamura, Sakae Homma, Kazuma Kishi

    ERJ Open Res 8: 00683-2021; DOI: 10.1183/23120541.00683-2021 Published 11 April 2022
  • Open Access

    Developing a conceptual model of symptoms and impacts in progressive fibrosing interstitial lung disease to evaluate patient-reported outcome measures

    Marlies Wijsenbeek, Maria Molina-Molina, Olivier Chassany, John Fox, Liam Galvin, Klaus Geissler, Katherine M. Hammitt, Michael Kreuter, Teng Moua, Emily C. O'Brien, Ashley F. Slagle, Anna Krasnow, Matthew Reaney, Michael Baldwin, Natalia Male, Klaus B. Rohr, Jeff Swigris, Katerina Antoniou

    ERJ Open Res 8: 00681-2021; DOI: 10.1183/23120541.00681-2021 Published 3 May 2022
  • Open Access

    Underdiagnosis of cardiac sarcoidosis by ECG and echocardiography in cases of extracardiac sarcoidosis

    Hiroshi Ohira, Takahiro Sato, Osamu Manabe, Noriko Oyama-Manabe, Akiko Hayashishita, Toshitaka Nakaya, Junichi Nakamura, Naoko Suzuki, Ayako Sugimoto, Sho Furuya, Satonori Tsuneta, Taku Watanabe, Ichizo Tsujino, Satoshi Konno

    ERJ Open Res 8: 00516-2021; DOI: 10.1183/23120541.00516-2021 Published 9 May 2022

• Paediatric lung function

  • Open Access

    Age and body mass index affect fit of spirometry Global Lung Function Initiative references in schoolchildren

    Rebeca Mozun, Cristina Ardura-Garcia, Eva S.L. Pedersen, Jakob Usemann, Florian Singer, Philipp Latzin, Alexander Moeller, Claudia E. Kuehni

    ERJ Open Res 8: 00618-2021; DOI: 10.1183/23120541.00618-2021 Published 19 April 2022
  • Open Access

    Breathing pattern and muscle activity using different inspiratory resistance devices in children with mouth breathing syndrome

    Jéssica Danielle Medeiros da Fonsêca, Andrea Aliverti, Kadja Benício, Valéria Soraya de Farias Sales, Luciana Fontes Silva da Cunha Lima, Vanessa Regiane Resqueti, Guilherme Augusto de Freitas Fregonezi

    ERJ Open Res 8: 00480-2021; DOI: 10.1183/23120541.00480-2021 Published 9 May 2022

• Pulmonary vascular disease

  • Open Access

    Noninvasive diagnosis of pulmonary hypertension with hyperpolarised ¹²⁹Xe magnetic resonance imaging and spectroscopy

    Elianna A. Bier, Fawaz Alenezi, Junlan Lu, Ziyi Wang, Joseph G. Mammarappallil, Bryan O'Sullivan-Murphy, Alaattin Erkanli, Bastiaan Driehuys, Sudarshan Rajagopal

    ERJ Open Res 8: 00035-2022; DOI: 10.1183/23120541.00035-2022 Published 16 May 2022
  • Open Access

    Causes and outcomes of ICU hospitalisations in patients with pulmonary arterial hypertension

    Mario Naranjo, Valentina Mercurio, Hussein Hassan, Noura Alturaif, Alessandra Cuomo, Umberto Attanasio, Nermin Diab, Sarina K. Sahetya, Monica Mukherjee, Steven Hsu, Aparna Balasubramanian, Catherine E. Simpson, Rachel Damico, Todd M. Kolb, Stephen C. Mathai, Paul M. Hassoun

    ERJ Open Res 8: 00002-2022; DOI: 10.1183/23120541.00002-2022 Published 16 May 2022
  • Open Access

    Severe pulmonary hypertension associated with lung disease is characterised by a loss of small pulmonary vessels on quantitative computed tomography

    Dheyaa Alkhanfar, Yousef Shahin, Faisal Alandejani, Krit Dwivedi, Samer Alabed, Chris Johns, Allan Lawrie, A.A. Roger Thompson, Alexander M.K. Rothman, Juerg Tschirren, Johanna M. Uthoff, Eric Hoffman, Robin Condliffe, Jim M. Wild, David G. Kiely, Andrew J. Swift

    ERJ Open Res 8: 00503-2021; DOI: 10.1183/23120541.00503-2021 Published 16 May 2022
  • Open Access

    Noninvasive follow-up strategy after pulmonary endarterectomy for chronic thromboembolic pulmonary hypertension

    Dieuwertje Ruigrok, M. Louis Handoko, Lilian J. Meijboom, Esther J. Nossent, Anco Boonstra, Natalia J. Braams, Jessie van Wezenbeek, Robert Tepaske, Pieter Roel Tuinman, Leo M.A. Heunks, Anton Vonk Noordegraaf, Frances S. de Man, Petr Symersky, Harm-Jan Bogaard

    ERJ Open Res 8: 00564-2021; DOI: 10.1183/23120541.00564-2021 Published 16 May 2022