ERJ Open Research: 8 (4)

01 October 2022; volume 8, issue 4

Editorials

Open Access
It is time to end our love affair with short-acting β₂-agonists in asthma
Michael G. Crooks, Shoaib Faruqi

ERJ Open Res 8: 00353-2022; DOI: 10.1183/23120541.00353-2022 Published 17 October 2022
Open Access
Dual CFTR modulator therapy efficacy in the real world: lessons for the future
Anna-Maria Dittrich, Sandra Y. Chuang

ERJ Open Res 8: 00464-2022; DOI: 10.1183/23120541.00464-2022 Published 14 November 2022
Open Access
Complex pathways leading to future paediatric asthma exacerbations
Amrita Dosanjh

ERJ Open Res 8: 00322-2022; DOI: 10.1183/23120541.00322-2022 Published 14 November 2022
Open Access
Multidrug-resistant tuberculosis: diagnosis, checklists, adverse events, advice and outcomes
Graham H. Bothamley

ERJ Open Res 8: 00512-2022; DOI: 10.1183/23120541.00512-2022 Published 28 November 2022
Open Access
Airway disease: a confusion inside an enigma
Alyn H. Morice

ERJ Open Res 8: 00519-2022; DOI: 10.1183/23120541.00519-2022 Published 12 December 2022

Reviews

Open Access
Blueprint for harmonising unstandardised disease registries to allow federated data analysis: prepare for the future
Johannes A. Kroes, Aruna T. Bansal, Emmanuelle Berret, Nils Christian, Andreas Kremer, Anna Alloni, Matteo Gabetta, Chris Marshall, Scott Wagers, Ratko Djukanovic, Celeste Porsbjerg, Dominique Hamerlijnck, Olivia Fulton, Anneke ten Brinke, Elisabeth H. Bel, Jacob K. Sont

ERJ Open Res 8: 00168-2022; DOI: 10.1183/23120541.00168-2022 Published 4 October 2022
Open Access
Assessment of factors and interventions towards therapeutic adherence among persons with non-cystic fibrosis bronchiectasis
Christina S. Thornton, Ranjani Somayaji, Rachel K. Lim

ERJ Open Res 8: 00340-2022; DOI: 10.1183/23120541.00340-2022 Published 7 November 2022
Open Access
Pulmonary hypertension in interstitial lung disease: an area of unmet clinical need
Sebastiaan Dhont, Bert Zwaenepoel, Els Vandecasteele, Guy Brusselle, Michel De Pauw

ERJ Open Res 8: 00272-2022; DOI: 10.1183/23120541.00272-2022 Published 14 November 2022
Open Access
COVID-19 therapies for inpatients: a review and quality assessment of clinical guidelines
David A. Wohl, Aprille A. Espinueva, Lauren Dau, Chen-Yu Wang, Alexandra Lachmann, Rujuta A. Bam, Aaditya Rawal, Kerris Chappell-Smith, Juergen K. Rockstroh

ERJ Open Res 8: 00236-2022; DOI: 10.1183/23120541.00236-2022 Published 21 November 2022
Open Access
Clinical assessment of balance and functional impairments in people with stable chronic obstructive pulmonary disease: a systematic review and meta-analysis
Rodrigo Núñez-Cortés, Paloma Padilla-Acevedo, Franchesca Vergara-Peña, Sara Mollà-Casanova, Claudia Espinoza-Bravo, Rodrigo Torres-Castro, Carlos Cruz-Montecinos

ERJ Open Res 8: 00164-2022; DOI: 10.1183/23120541.00164-2022 Published 12 December 2022

Study protocols

Open Access
AROMA: real-world global registry of dupilumab for chronic rhinosinusitis with nasal polyps
Shahid Siddiqui, Claus Bachert, Adam M. Chaker, Joseph K. Han, Peter W. Hellings, Anju T. Peters, Enrico Heffler, Siddhesh Kamat, Haixin Zhang, Scott Nash, Asif H. Khan, Lucia De Prado Gomez, Juby A. Jacob-Nara, Paul J. Rowe, Yamo Deniz

ERJ Open Res 8: 00085-2022; DOI: 10.1183/23120541.00085-2022 Published 28 November 2022
Open Access
Eradication of early MRSA infection in cystic fibrosis: a novel study design for the STAR-ter trial
Fiona Cunningham, Ellen Caldwell, Nicole Mayer-Hamblett, Christopher H. Goss, Marianne S. Muhlebach

ERJ Open Res 8: 00190-2022; DOI: 10.1183/23120541.00190-2022 Published 5 December 2022

Original research articles

Asthma
- Open Access
  Complete response to anti-interleukin-5 biologics in a real-life setting: results from the nationwide Danish Severe Asthma Register
  Marianne Baastrup Soendergaard, Susanne Hansen, Anne-Sofie Bjerrum, Ole Hilberg, Sofie Lock-Johansson, Kjell Erik Julius Håkansson, Truls Sylvan Ingebrigtsen, Claus Rikard Johnsen, Linda Makowska Rasmussen, Anna von Bülow, Karin Dahl Assing, Johannes Martin Schmid, Charlotte Suppli Ulrik, Celeste Porsbjerg
  
  ERJ Open Res 8: 00238-2022; DOI: 10.1183/23120541.00238-2022 Published 4 October 2022
- Open Access
  Heterogeneity in the use of biologics for severe asthma in Europe: a SHARP ERS study
  Anne-Noelle Frix, Liam G. Heaney, Barbro Dahlén, Florin Mihaltan, Svetlana Sergejeva, Sanja Popović-Grle, Vratislav Sedlak, Lauri Lehtimäki, Arnaud Bourdin, Stephanie Korn, Eleftherios Zervas, Zsuzsanna Csoma, Dora Lúðvíksdóttir, Marcus Butler, Giorgio Walter Canonica, Ineta Grisle, Kristina Bieksiene, Anneke Ten Brinke, Piotr Kuna, Claudia Chaves Loureiro, Natalia M. Nenasheva, Zorica Lazic, Sabina Škrgat, David Ramos-Barbon, Joerg Leuppi, Bilun Gemicioglu, Apostolos Bossios, Celeste M. Porsbjerg, Elisabeth H. Bel, Ratko Djukanovic, Renaud Louis
  
  ERJ Open Res 8: 00273-2022; DOI: 10.1183/23120541.00273-2022 Published 24 October 2022
- Open Access
  Past asthma exacerbation in children predicting future exacerbation: a systematic review
  Rachel Lowden, Steve Turner
  
  ERJ Open Res 8: 00174-2022; DOI: 10.1183/23120541.00174-2022 Published 14 November 2022
- Open Access
  Early-life risk factors for development of asthma from 8 to 28 years of age: a prospective cohort study
  Linnéa Hedman, Linnéa Almqvist, Anders Bjerg, Martin Andersson, Helena Backman, Matthew S. Perzanowski, Eva Rönmark
  
  ERJ Open Res 8: 00074-2022; DOI: 10.1183/23120541.00074-2022 Published 12 December 2022
Asthma and COPD
- Open Access
  Treatment with interleukin (IL)-5/IL-5 receptor antibodies in patients with severe eosinophilic asthma and COPD
  Nora Drick, Jan Fuge, Benjamin Seeliger, Milan Speth, Jens Vogel-Claussen, Tobias Welte, Hendrik Suhling
  
  ERJ Open Res 8: 00207-2022; DOI: 10.1183/23120541.00207-2022 Published 24 October 2022
COPD
- Open Access
  Mortality associated with metabolic syndrome in people with COPD managed in primary care
  Urvee Karsanji, Rachael A. Evans, Jennifer K. Quint, Kamlesh Khunti, Claire A. Lawson, Emily Petherick, Neil J. Greening, Sally J. Singh, Matthew Richardson, Michael C. Steiner
  
  ERJ Open Res 8: 00211-2022; DOI: 10.1183/23120541.00211-2022 Published 24 October 2022
- Open Access
  Exercise rehabilitation in COPD and heart failure: comparison of two national audits
  Amy V. Jones, Rachael A. Evans, Alexander S. Harrison, Lauren B. Sherar, Michael C. Steiner, Patrick Doherty, Sally J. Singh
  
  ERJ Open Res 8: 00131-2022; DOI: 10.1183/23120541.00131-2022 Published 28 November 2022
- Open Access
  Arterial remodelling in smokers and in patients with small airway disease and COPD: implications for lung physiology and early origins of pulmonary hypertension
  Prem Bhattarai, Wenying Lu, Archana Vijay Gaikwad, Surajit Dey, Collin Chia, Josie Larby, Greg Haug, Ashutosh Hardikar, Andrew Williams, Gurpreet Kaur Singhera, Tillie-Louise Hackett, Mathew Suji Eapen, Sukhwinder Singh Sohal
  
  ERJ Open Res 8: 00254-2022; DOI: 10.1183/23120541.00254-2022 Published 5 December 2022
- Open Access
  Improving the wellbeing of caregivers of patients with COPD using a home-based pulmonary rehabilitation programme
  Jean-Marie Grosbois, Sarah Gephine, Maeva Kyheng, Olivier Le Rouzic, Cécile Chenivesse
  
  ERJ Open Res 8: 00255-2022; DOI: 10.1183/23120541.00255-2022 Published 12 December 2022
Lung volume reduction
- Open Access
  Long-term follow-up after bronchoscopic lung volume reduction valve treatment for emphysema
  Jorine E. Hartman, Karin Klooster, T. David Koster, Nick H.T. ten Hacken, Marlies van Dijk, Dirk-Jan Slebos
  
  ERJ Open Res 8: 00235-2022; DOI: 10.1183/23120541.00235-2022 Published 21 November 2022
Pulmonary vascular disease in children
- Open Access
  Vasoreactive phenotype in children with pulmonary arterial hypertension and syncope
  Alexandra N. Linder, Jill Hsia, Sheila V. Krishnan, Erika B. Rosenzweig, Usha S. Krishnan
  
  ERJ Open Res 8: 00223-2022; DOI: 10.1183/23120541.00223-2022 Published 10 October 2022
Pulmonary vascular disease
- Open Access
  Haemodynamic effects of initial combination therapy in pulmonary arterial hypertension: a systematic review and meta-analysis
  Ioannis T. Farmakis, Elena Vrana, Sophia-Anastasia Mouratoglou, Stefanos Zafeiropoulos, Stavros Zanos, George Giannakoulas
  
  ERJ Open Res 8: 00313-2022; DOI: 10.1183/23120541.00313-2022 Published 24 October 2022
- Open Access
  Relevance of comorbidities on initial combination therapy in pulmonary arterial hypertension
  Roberto Badagliacca, Michele D'Alto, Stefano Ghio, Paola Argiento, Natale Daniele Brunetti, Gavino Casu, Nadia Cedrone, Marco Confalonieri, Marco Corda, Michele Correale, Carlo D'Agostino, Lucrezia De Michele, Serena Di Marino, Domenico Filomena, Giuseppe Galgano, Alessandra Greco, Carlo Lombardi, Giovanna Manzi, Valentina Mercurio, Massimiliano Mulè, Giuseppe Paciocco, Silvia Papa, Emanuele Romeo, Laura Scelsi, Davide Stolfo, Patrizio Vitulo, Carmine Dario Vizza
  
  ERJ Open Res 8: 00298-2022; DOI: 10.1183/23120541.00298-2022 Published 7 November 2022
Drug delivery
- Open Access
  Evaluation of aerosol drug delivery with concurrent low- and high-flow nasal oxygen
  Barry Murphy, Marc Mac Giolla Eain, Mary Joyce, James B. Fink, Ronan MacLoughlin
  
  ERJ Open Res 8: 00220-2022; DOI: 10.1183/23120541.00220-2022 Published 10 October 2022
Thoracic tumours
- Open Access
  Associations of influenza vaccination with severity of immune-related adverse events in patients with advanced thoracic cancers on immune checkpoint inhibitors
  Emily Pei-Ying Lin, Li-Ching Huang, Jennifer Whisenant, Sally York, Travis Osterman, Jennifer Lewis, Wade Iams, Emily Skotte, Amanda Cass, Chih-Yuan Hsu, Yu Shyr, Leora Horn
  
  ERJ Open Res 8: 00684-2021; DOI: 10.1183/23120541.00684-2021 Published 10 October 2022
- Open Access
  Randomised controlled trial of first-line tyrosine-kinase inhibitor (TKI) versus intercalated TKI with chemotherapy for EGFR-mutated nonsmall cell lung cancer
  Rolof G.P. Gijtenbeek, Vincent van der Noort, Joachim G.J.V. Aerts, Jeske A. Staal-van den Brekel, Egbert F. Smit, Frans H. Krouwels, Frank A. Wilschut, T. Jeroen N. Hiltermann, Wim Timens, Ed Schuuring, Joost D.J. Janssen, Martijn Goosens, Paul M. van den Berg, A. Joop de Langen, Jos A. Stigt, Ben E.E.M. van den Borne, Harry J.M. Groen, Wouter H. van Geffen, Anthonie J. van der Wekken
  
  ERJ Open Res 8: 00239-2022; DOI: 10.1183/23120541.00239-2022 Published 17 October 2022
- Open Access
  1-year mortality in lung cancer in France according to key timepoints of care pathways
  Axelle Rivière, Anne Isabelle Lecuyer, Emeline Laurent, Carole Lefebvre, Thierry Lecomte, Elodie Olivier, Delphine Carmier, Laurent Plantier, Leslie Grammatico-Guillon
  
  ERJ Open Res 8: 00157-2022; DOI: 10.1183/23120541.00157-2022 Published 28 November 2022
Lung function
- Open Access
  Infant tidal flow–volume parameters and arousal state
  Karen Eline Stensby Bains, Martin Färdig, Hrefna Katrín Gudmundsdóttir, Catarina Almqvist, Gunilla Hedlin, Live S. Nordhagen, Eva M. Rehbinder, Håvard O. Skjerven, Cilla Söderhäll, Riyas Vettukattil, Björn Nordlund, Karin C. Lødrup Carlsen
  
  ERJ Open Res 8: 00163-2022; DOI: 10.1183/23120541.00163-2022 Published 17 October 2022
- Open Access
  Clinical application of oscillometry in respiratory diseases: an impulse oscillometry registry
  Xiaolin Liang, Jinping Zheng, Yi Gao, Zhe Zhang, Wen Han, Jing Du, Yong Lu, Li Chen, Tao Wang, Jinming Liu, Gang Huang, Bingrong Zhao, Guihua Zhao, Xuhua Zhang, Yi Peng, Xin Chen, Ning Zhou
  
  ERJ Open Res 8: 00080-2022; DOI: 10.1183/23120541.00080-2022 Published 17 October 2022
- Open Access
  Body mass index increase: a risk factor for forced expiratory volume in 1 s decline for overweight and obese adults with asthma
  Nicolás Bermúdez Barón, Hannu Kankaanranta, Linnea Hedman, Martin Andersson, Caroline Stridsman, Anne Lindberg, Eva Rönmark, Helena Backman
  
  ERJ Open Res 8: 00110-2022; DOI: 10.1183/23120541.00110-2022 Published 24 October 2022
- Open Access
  Infant lung function: criteria for selecting tidal flow–volume loops
  Karen Eline Stensby Bains, Hrefna Katrín Gudmundsdóttir, Martin Färdig, Erik Amnö, Christine M. Jonassen, Björn Nordlund, Eva Maria Rehbinder, Håvard O. Skjerven, Corina Silvia Rueegg, Riyas Vettukattil, Karin C. Lødrup Carlsen
  
  ERJ Open Res 8: 00165-2022; DOI: 10.1183/23120541.00165-2022 Published 24 October 2022
- Open Access
  Infant lung function and maternal physical activity in the first half of pregnancy
  Hrefna Katrín Gudmundsdóttir, Oda C.L. Carlsen, Karen Eline Stensby Bains, Martin Färdig, Guttorm Haugen, Christine M. Jonassen, Marissa LeBlanc, Björn Nordlund, Eva Maria Rehbinder, Håvard O. Skjerven, Anne Cathrine Staff, Riyas Vettukattil, Karin C. Lødrup Carlsen
  
  ERJ Open Res 8: 00172-2022; DOI: 10.1183/23120541.00172-2022 Published 31 October 2022
- Open Access
  Period and cohort effects: consequences on spirometric lung function in Norway during the 20th century
  Lucia Cestelli, Ane Johannessen, Knut Stavem, Amund Gulsvik, Rune Nielsen
  
  ERJ Open Res 8: 00302-2022; DOI: 10.1183/23120541.00302-2022 Published 12 December 2022
Interstitial lung disease
- Open Access
  Corticosteroid-induced remission and mycophenolate maintenance therapy in granulomatous lymphocytic interstitial lung disease: long-term, longitudinal change in lung function in a single-centre cohort
  Heba M. Bintalib, David M. Lowe, Gaia Mancuso, Georgia Gkrepi, Suranjith L. Seneviratne, Siobhan O. Burns, John R. Hurst
  
  ERJ Open Res 8: 00024-2022; DOI: 10.1183/23120541.00024-2022 Published 17 October 2022
- Open Access
  Functional clinical impairments and frailty in interstitial lung disease patients
  Pierre-François Tremblay Labrecque, Geneviève Dion, Didier Saey
  
  ERJ Open Res 8: 00144-2022; DOI: 10.1183/23120541.00144-2022 Published 17 October 2022
- Open Access
  Phase I studies of BI 1015550, a preferential phosphodiesterase 4B inhibitor, in healthy males and patients with idiopathic pulmonary fibrosis
  Toby M. Maher, Christina Schlecker, Doreen Luedtke, Sebastian Bossert, Donald F. Zoz, Armin Schultz
  
  ERJ Open Res 8: 00240-2022; DOI: 10.1183/23120541.00240-2022 Published 24 October 2022
- Open Access
  Neighbourhood disadvantage impacts on pulmonary function in patients with sarcoidosis
  Gillian C. Goobie, Christopher J. Ryerson, Kerri A. Johannson, Spencer Keil, Erin Schikowski, Nasreen Khalil, Veronica Marcoux, Deborah Assayag, Hélène Manganas, Jolene H. Fisher, Martin R.J. Kolb, Xiaoping Chen, Kevin F. Gibson, Daniel J. Kass, Yingze Zhang, Kathleen O. Lindell, S. Mehdi Nouraie
  
  ERJ Open Res 8: 00357-2022; DOI: 10.1183/23120541.00357-2022 Published 24 October 2022
- Open Access
  Matrix metalloproteinase-7 is increased in lung bases but not apices in idiopathic pulmonary fibrosis
  Jade Jaffar, Mae Wong, Gregory A. Fishbein, Monther Alhamdoosh, Laura McMillan, Cristina Gamell-Fulla, Milica Ng, Nick Wilson, Karen Symons, Ian Glaspole, Glen Westall
  
  ERJ Open Res 8: 00191-2022; DOI: 10.1183/23120541.00191-2022 Published 24 October 2022
- Open Access
  Analysis of real-world data and a mouse model indicates that pirfenidone causes pellagra
  Koji Kuronuma, Natsumi Susai, Tomohiro Kuroita, Hiroki Yamamoto, Takeshi Yoshioka, Shuji Kaneko, Hirofumi Chiba
  
  ERJ Open Res 8: 00245-2022; DOI: 10.1183/23120541.00245-2022 Published 24 October 2022
- Open Access
  Effect of nintedanib on acute exacerbations of fibrosing interstitial lung diseases: a national database study in Japan
  Hirokazu Urushiyama, Taisuke Jo, Wakae Hasegawa, Akira Yokoyama, Takahiro Ando, Yukiyo Sakamoto, Ryosuke Kumazawa, Kazuaki Uda, Nobuaki Michihata, Nobuyasu Awano, Matsui Hiroki, Kiyohide Fushimi, Hideo Yasunaga, Takahide Nagase
  
  ERJ Open Res 8: 00209-2022; DOI: 10.1183/23120541.00209-2022 Published 28 November 2022
- Open Access
  Development and validation of an interstitial lung disease exposure questionnaire for sub-Saharan Africa
  Peter Jackson, Roma Padalkar, Winceslaus Katagira, Kevin Mortimer, Natalie A. Rykiel, Nicole M. Robertson, Suzanne L. Pollard, Patricia Alupo, William Checkley, Bruce Kirenga, Trishul Siddharthan
  
  ERJ Open Res 8: 00205-2022; DOI: 10.1183/23120541.00205-2022 Published 19 December 2022
- Open Access
  Developing a self-management package for pulmonary fibrosis: an international Delphi study
  Joanna Y.T. Lee, Gabriella Tikellis, Yet H. Khor, Anne E. Holland
  
  ERJ Open Res 8: 00349-2022; DOI: 10.1183/23120541.00349-2022 Published 27 December 2022
COVID-19
- Open Access
  Focused lung ultrasound to predict respiratory failure in patients with symptoms of COVID-19: a multicentre prospective cohort study
  Søren Helbo Skaarup, Rasmus Aagaard, Stig Holm Ovesen, Jesper Weile, Hans Kirkegaard, Caroline Espersen, Mats Christian Højbjerg Lassen, Kristoffer Grundtvig Skaarup, Stefan Posth, Christian B. Laursen, Ask Bock, Michael Dan Arvig, Tor Biering-Sørensen
  
  ERJ Open Res 8: 00128-2022; DOI: 10.1183/23120541.00128-2022 Published 24 October 2022
- Open Access
  Symptoms persisting after hospitalisation for COVID-19: 12 months interim results of the CO-FLOW study
  L. Martine Bek, Julia C. Berentschot, Majanka H. Heijenbrok-Kal, Susanne Huijts, Michel E. van Genderen, J. Hans Vlake, Jasper van Bommel, Joachim G.J.V. Aerts, Gerard M. Ribbers, Rita J.G. van den Berg-Emons, Merel E. Hellemons
  
  ERJ Open Res 8: 00355-2022; DOI: 10.1183/23120541.00355-2022 Published 24 October 2022
- Open Access
  Characteristics and outcomes of asthmatic outpatients with COVID-19 who receive home telesurveillance
  Antoine Beurnier, Youri Yordanov, Agnès Dechartres, Aurélien Dinh, Erwan Debuc, François-Xavier Lescure, Patrick Jourdain, Luc Jaulmes, Marc Humbert
  
  ERJ Open Res 8: 00012-2022; DOI: 10.1183/23120541.00012-2022 Published 24 October 2022
- Open Access
  Telemedicine home CPAP titration and follow-up in the COVID-19 scenario
  Jaume Bordas-Martinez, Neus Salord, Eva Fontanilles, Eliseo Prado, María Calvo, João Carmezim, Salud Santos, Carmen Monasterio
  
  ERJ Open Res 8: 00084-2022; DOI: 10.1183/23120541.00084-2022 Published 24 October 2022
- Open Access
  A novel infrasound and audible machine-learning approach to the diagnosis of COVID-19
  Guy Dori, Noa Bachner-Hinenzon, Nour Kasim, Haitem Zaidani, Sivan Haia Perl, Shlomo Maayan, Amin Shneifi, Yousef Kian, Tuvia Tiosano, Doron Adler, Yochai Adir
  
  ERJ Open Res 8: 00152-2022; DOI: 10.1183/23120541.00152-2022 Published 24 October 2022
- Open Access
  Immunophenotypes of anti-SARS-CoV-2 responses associated with fatal COVID-19
  Julij Šelb, Barbara Bitežnik, Urška Bidovec Stojković, Boštjan Rituper, Katarina Osolnik, Peter Kopač, Petra Svetina, Kristina Cerk Porenta, Franc Šifrer, Petra Lorber, Darinka Trinkaus Leiler, Tomaž Hafner, Tina Jerič, Robert Marčun, Nika Lalek, Nina Frelih, Mojca Bizjak, Rok Lombar, Vesna Nikolić, Katja Adamič, Katja Mohorčič, Sanja Grm Zupan, Irena Šarc, Jerneja Debeljak, Ana Koren, Ajda Demšar Luzar, Matija Rijavec, Izidor Kern, Matjaž Fležar, Aleš Rozman, Peter Korošec
  
  ERJ Open Res 8: 00216-2022; DOI: 10.1183/23120541.00216-2022 Published 5 December 2022
- Open Access
  The trajectory of COVID-19 cardiopulmonary disease: insights from an autopsy study of community-based, pre-hospital deaths
  Luke Milross, Joaquim Majo, Julian Pulle, Sam Hoggard, Nigel Cooper, Bethany Hunter, Christopher J.A. Duncan, Andrew Filby, Andrew J. Fisher
  
  ERJ Open Res 8: 00303-2022; DOI: 10.1183/23120541.00303-2022 Published 27 December 2022
Tuberculosis
- Open Access
  Prevalence and genetic basis of first-line drug resistance of Mycobacterium tuberculosis in Ca Mau, Vietnam
  Jack Callum, Phuong T.B. Nguyen, Elena Martinez, Van-Anh T. Nguyen, Frances Garden, Nhung V. Nguyen, Thu-Anh Nguyen, Hoa B. Nguyen, Son V. Nguyen, Khanh B. Luu, Jennifer Ho, Nguyen N. Linh, Warwick J. Britton, Vitali Sintchenko, Greg J. Fox, Guy B. Marks
  
  ERJ Open Res 8: 00122-2022; DOI: 10.1183/23120541.00122-2022 Published 24 October 2022
- Open Access
  Interferon-γ release assay screening in biologics: safe and reliable, but not perfect
  John Cafferkey, Yorissa Padayachee, Sophia Kostich, Kartik Kumar, Paul Jewell, Mikin Patel, Aneeka Chavda, Alison Cox, Mirae Park, Georgina Russell, Meg Coleman, Laura Martin, Onn Min Kon
  
  ERJ Open Res 8: 00193-2022; DOI: 10.1183/23120541.00193-2022 Published 28 November 2022
- Open Access
  Multidrug-resistant tuberculosis in Finland: treatment outcome and the role of whole-genome sequencing
  Virve Korhonen, Pia Kivelä, Marjo Haanperä, Hanna Soini, Tuula Vasankari
  
  ERJ Open Res 8: 00214-2022; DOI: 10.1183/23120541.00214-2022 Published 28 November 2022
Nontuberculous mycobacteria
- Open Access
  Nontuberculous mycobacterial infections during cancer therapy with immune checkpoint inhibitors: a systematic review
  Andrea Lombardi, Andrea Gramegna, Margherita Ori, Cecilia Azzarà, Francesco Blasi, Andrea Gori
  
  ERJ Open Res 8: 00364-2022; DOI: 10.1183/23120541.00364-2022 Published 28 November 2022
NTM in bronchiectasis
- Open Access
  Nontuberculous mycobacteria infection and pulmonary disease in bronchiectasis
  Kseniia Suska, Francesco Amati, Giovanni Sotgiu, Andrea Gramegna, Marco Mantero, Margherita Ori, Maurizio Ferrarese, Luigi Ruffo Codecasa, Anna Stainer, Francesco Blasi, Stefano Aliberti
  
  ERJ Open Res 8: 00060-2022; DOI: 10.1183/23120541.00060-2022 Published 12 December 2022
Sleep
- Open Access
  Obstructive sleep apnoea-related respiratory events and desaturation severity are associated with the cardiac response
  Salla Hietakoste, Tuomas Karhu, Saara Sillanmäki, Raquel Bailón, Thomas Penzel, Juha Töyräs, Timo Leppänen, Sami Myllymaa, Samu Kainulainen
  
  ERJ Open Res 8: 00121-2022; DOI: 10.1183/23120541.00121-2022 Published 24 October 2022
- Open Access
  Investigation of the frequency of obstructive sleep apnoea syndrome in patients with subclinical hypothyroidism
  Aysegul Gencer, Ersan Atahan, Pinar Kadioglu, Birsen Mutlu
  
  ERJ Open Res 8: 00186-2022; DOI: 10.1183/23120541.00186-2022 Published 24 October 2022
- Open Access
  Baseline clusters and the response to positive airway pressure treatment in obstructive sleep apnoea patients: longitudinal data from the European Sleep Apnea Database cohort
  Ashraf Yassen, Katrin Coboeken, Sébastien Bailly, Rolf Burghaus, Jitka Buskova, Zoran Dogas, Marta Drummond, Haralampos Gouveris, Pavol Joppa, Joerg Lippert, Carolina Lombardi, Stefan Mihaicuta, Jean Louis Pépin, Ding Zou, Jan Hedner, Ludger Grote, the ESADA collaborators , P. Steiropoulos, J. Verbraecken, E. Petiet, G. Trakada, I. Fietze, T. Penzel, N. Laharnar, O. Ludka, I. Bouloukaki, S. Schiza, W.T. McNicholas, S. Ryan, R.L. Riha, J.A. Kvamme, L. Grote, J. Hedner, D. Zou, D. Pevernagie, S. Bailly, J.L. Pépin, R. Tamisier, H. Hein, O.K. Basoglu, M.S. Tasbakan, J. Buskova, P. Joppa, R. Staats, D. Testelmans, H. Gouveris, K. Ludwig, C. Lombardi, G. Parati, M.R. Bonsignore, F. Fanfulla, M. Petitjean, G. Roisman, M. Drummond, M. van Zeller, M. Treml, W. Randerath, Z. Dogas, R. Pecotic, A. Pataka, S. Mihaicuta, U. Anttalainen, T. Saaresranta, S. Sliwinski
  
  ERJ Open Res 8: 00132-2022; DOI: 10.1183/23120541.00132-2022 Published 31 October 2022
- Open Access
  Performance of cough monitoring by Albus Home, a contactless and automated system for nocturnal respiratory monitoring at home
  William Do, Richard Russell, Christopher Wheeler, Hamza Javed, Cihan Dogan, George Cunningham, Vikaran Khanna, Maarten De Vos, Imran Satia, Mona Bafadhel, Ian Pavord
  
  ERJ Open Res 8: 00265-2022; DOI: 10.1183/23120541.00265-2022 Published 5 December 2022
Cough
- Open Access
  Validation of the cough phenotype TBQ among elderly Finnish subjects
  Heikki O. Koskela, Johanna T. Kaulamo, Tuomas A. Selander, Anne M. Lätti
  
  ERJ Open Res 8: 00284-2022; DOI: 10.1183/23120541.00284-2022 Published 24 October 2022
- Open Access
  The demographics, clinical characteristics and quality of life of patients with chronic cough from the Isala Cough Clinic in the Netherlands
  Jan Willem K. van den Berg, Carl A. Baxter, Mireille A. Edens, Kornelis W. Patberg, Hester van der Velden, Arjan Weijerse, Stina Salomonsson
  
  ERJ Open Res 8: 00232-2022; DOI: 10.1183/23120541.00232-2022 Published 12 December 2022
Cystic fibrosis
- Open Access
  The long-term effects of insulin use in incident cystic fibrosis-related diabetes: a target trial emulated using longitudinal national registry data
  Emily Granger, Ruth H. Keogh, Freddy Frost
  
  ERJ Open Res 8: 00170-2022; DOI: 10.1183/23120541.00170-2022 Published 7 November 2022
- Open Access
  Long-term effectiveness of dual CFTR modulator treatment of cystic fibrosis
  Danya Muilwijk, Domenique D. Zomer-van Ommen, Vincent A.M. Gulmans, Marinus J.C. Eijkemans, Cornelis K. van der Ent, Dutch Cystic Fibrosis Registry (NCFR) Steering Group: , J. Altenburg, S.W.J. Terheggen-Lagro, H.G.M. Heijerman, K.M. de Winter-de Groot, M. Bakker, R.A.S. Hoek, H.M. Janssens, R. van der Meer, M. Nuijsink, H. van der Vaart, G.H. Koppelman, L.H. Conemans, M.A.G.E. Bannier, J.J. Noordhoek
  
  ERJ Open Res 8: 00204-2022; DOI: 10.1183/23120541.00204-2022 Published 14 November 2022
- Open Access
  Diagnostic agreement among experts assessing adults presenting with possible cystic fibrosis: need for improvement and implications for patient care
  Alessandro N. Franciosi, April Tanzler, Jodi Goodwin, Pearce G. Wilcox, George M. Solomon, Albert Faro, Noel G. McElvaney, Damian G. Downey, Bradley S. Quon
  
  ERJ Open Res 8: 00227-2022; DOI: 10.1183/23120541.00227-2022 Published 12 December 2022
- Open Access
  Nasal epithelial cell culture fluorescence recovery after photobleaching predicts cystic fibrosis therapeutic response
  Timothy E. Corcoran, Carol A. Bertrand, Michael M. Myerburg, Daniel J. Weiner, Sheila A. Frizzell, Anna Li, Brittani Agostini, Robert S. Parker, Monica E. Shapiro, Ashok Muthukrishnan, Nicholas D. Hages, Brian P. Mulhern, Joseph M. Pilewski
  
  ERJ Open Res 8: 00382-2022; DOI: 10.1183/23120541.00382-2022 Published 12 December 2022
Epidemiology
- Open Access
  Respiratory symptoms and their determinants in the general Spanish population: changes over 20 years
  Marc Miravitlles, Juan José Soler-Cataluña, Joan B. Soriano, Francisco García-Río, Pilar de Lucas, Inmaculada Alfageme, Ciro Casanova, José Miguel Rodríguez González-Moro, Guadalupe Sánchez, Julio Ancochea, Borja G. Cosío
  
  ERJ Open Res 8: 00067-2022; DOI: 10.1183/23120541.00067-2022 Published 14 November 2022
Dyspnoea
- Open Access
  Mixed-methods feasibility cluster randomised controlled trial of a paramedic-administered breathlessness management intervention for acute-on-chronic breathlessness (BREATHE): study findings
  Ann Hutchinson, Victoria Allgar, Judith Cohen, David C. Currow, Susan Griffin, Simon Hart, Kelly Hird, Andrew Hodge, Suzanne Mason, Matthew Northgraves, Joanne Reeve, Flavia Swan, Miriam J. Johnson
  
  ERJ Open Res 8: 00257-2022; DOI: 10.1183/23120541.00257-2022 Published 21 November 2022
Lung biology
- Open Access
  Sputum neutrophil counts in healthy subjects: relationship with age
  Augusta Beech, Dave Singh
  
  ERJ Open Res 8: 00246-2022; DOI: 10.1183/23120541.00246-2022 Published 28 November 2022
Critical care
- Open Access
  Feasibility of transbronchial lung cryobiopsy in patients with veno-venous extracorporeal membrane oxygenation support
  Shiyao Wang, Guowu Zhou, Yingying Feng, Yi Zhang, Ye Tian, Sichao Gu, Xiaojing Wu, Meiyuan Li, Yiming Feng, Dan Wang, Ying Li, Zheng Tian, Ling Zhao, Min Li, Wenhui Chen, Xu Huang, Qingyuan Zhan
  
  ERJ Open Res 8: 00383-2022; DOI: 10.1183/23120541.00383-2022 Published 19 December 2022

Research letters

Open Access
Respiratory healthcare professionals’ views on long-term recommendations of interventions to prevent acute respiratory illnesses after the COVID-19 pandemic
Karin Yaacoby-Bianu, Galit Livnat, James D. Chalmers, Michal Shteinberg

ERJ Open Res 8: 00114-2022; DOI: 10.1183/23120541.00114-2022 Published 4 October 2022
Open Access
Heightened ventilatory response during stair climbing in individuals with dysfunctional breathing
Karina Siewers, Emil Walsted, Bishmann Manivannan, Christopher Warren, Colm McCabe, James H. Hull

ERJ Open Res 8: 00285-2022; DOI: 10.1183/23120541.00285-2022 Published 10 October 2022
Open Access
Air quality in Mexico City during the COVID-19 lockdown possibly decreased COPD exacerbations
Francisco Montiel-Lopez, Daniela Rodríguez-Ramírez, Maricruz Cassou-Martínez, María Cristina Miranda-Márquez, Claudia González-González, Raúl H. Sansores, María Eugenia Mayar-Maya, Rogelio Pérez-Padilla, Robinson Emmanuel Robles-Hernández, Ireri Thirion-Romero, Oliver Pérez-Bautista, Alejandra Ramírez-Venegas

ERJ Open Res 8: 00183-2022; DOI: 10.1183/23120541.00183-2022 Published 10 October 2022
Open Access
Family case studies: absence of Pseudomonas aeruginosa transmission in bronchiectasis
Ruth Sobala, Kristian Brooks, John Davison, Joanna Lumb, Anthony De Soyza

ERJ Open Res 8: 00280-2022; DOI: 10.1183/23120541.00280-2022 Published 17 October 2022
Open Access
Pathological characteristics of mediastinal masses in Sri Lanka 2017–2021: a retrospective observational study
Yasith Mathangasinghe, Saman Pradeep, Udeshika Perera, Ramani Punchihewa

ERJ Open Res 8: 00256-2022; DOI: 10.1183/23120541.00256-2022 Published 21 November 2022
Open Access
Persistent isolated impairment of gas transfer following COVID-19 pneumonitis relates to perfusion defects on dual-energy computed tomography
Laura C. Price, Benjamin Garfield, Chloe Bloom, Nidhish Jeyin, Daniel Nissan, James H. Hull, Brijesh Patel, Gisli Jenkins, Simon Padley, William Man, Suveer Singh, Carole A. Ridge

ERJ Open Res 8: 00224-2022; DOI: 10.1183/23120541.00224-2022 Published 28 November 2022
Open Access
Is it feasible to perform a continuous laryngoscopy exercise test with a cold air inhalate? A case report
Haakon Kvidaland, Sandra Stadheim, Signe Bø, Hege Clemm, Ola D. Røksund, Maria Vollsæter, Jon Hardie

ERJ Open Res 8: 00222-2022; DOI: 10.1183/23120541.00222-2022 Published 28 November 2022
Open Access
Negative association between fatigue and signs of sleep apnoea in patients after COVID-19
Markus C. Hayden, Gabriele Schwarzl, Matthias Limbach, Sorin Mitrea, Michael Schuler, Dennis Nowak, Konrad Schultz

ERJ Open Res 8: 00289-2022; DOI: 10.1183/23120541.00289-2022 Published 27 December 2022
Open Access
Targeted lung denervation modulates the mucosal epithelial transcriptome in COPD
Karthi Srikanthan, Loes Kistemaker, Dirk-Jan Slebos, Wolfgang Gesierich, Kaid Darwiche, Peter Bonta, Gaetan Deslee, Pallav Shah, Reinoud Gosens

ERJ Open Res 8: 00146-2022; DOI: 10.1183/23120541.00146-2022 Published 27 December 2022
Open Access
Increased protease-activated receptor 1 autoantibodies are associated with severe COVID-19
Florian Tran, Danielle M.M. Harris, Alena Scharmacher, Hanna Graßhoff, Kristina Sterner, Susanne Schinke, Nadja Käding, Jens Y. Humrich, Otávio Cabral-Marques, Joana P. Bernardes, Neha Mishra, Thomas Bahmer, Jeanette Franzenburg, Bimba F. Hoyer, Andreas Glück, Martina Guggeis, Alexander Ossysek, Andre Küller, Derk Frank, Christoph Lange, Jan Rupp, Jan Heyckendorf, Karoline I. Gaede, Howard Amital, Philip Rosenstiel, Yehuda Shoenfeld, Gilad Halpert, Avi Z. Rosenberg, Kai Schulze-Forster, Harald Heidecke, Gabriela Riemekasten, Stefan Schreiber

ERJ Open Res 8: 00379-2022; DOI: 10.1183/23120541.00379-2022 Published 27 December 2022

Correspondence

Open Access
Pharmacotherapy for lung cancer with comorbid interstitial pneumonia: limited evidence requires appropriate evaluation
Yuriko Ishida, Satoshi Ikeda, Akimasa Sekine, Tomohisa Baba, Takashi Ogura

ERJ Open Res 8: 00337-2022; DOI: 10.1183/23120541.00337-2022 Published 12 December 2022
Open Access
Reply to: Pharmacotherapy for lung cancer with comorbid interstitial pneumonia: limited evidence requires appropriate evaluation
Manuela Funke-Chambour, Namrata Kewalramani, Carlos Machahua, Venerino Poletti, Athol U. Wells, Jacques Cadranel

ERJ Open Res 8: 00469-2022; DOI: 10.1183/23120541.00469-2022 Published 12 December 2022
Open Access
Nanopore-based metagenomic sequencing: a diagnostic tool in respiratory tract infection
Robert Chapman, Alberto D'Angelo, Stefan Bagby

ERJ Open Res 8: 00461-2022; DOI: 10.1183/23120541.00461-2022 Published 19 December 2022

Author correction

Open Access
“A double-blind randomised controlled trial of protein supplementation to enhance exercise capacity in COPD during pulmonary rehabilitation: a pilot study”. Abdulelah M. Aldhahir, Yousef S. Aldabayan, Jaber S. Alqahtani, Heidi A. Ridsdale, Colette Smith, John R. Hurst and Swapna Mandal. ERJ Open Res 2021; 7: 00077-2021
ERJ Open Res 8: 50077-2021; DOI: 10.1183/23120541.50077-2021 Published 24 October 2022

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Asthma

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COPD

Lung volume reduction

Pulmonary vascular disease in children

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Lung function

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COVID-19

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NTM in bronchiectasis

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