Figures
- FIGURE 1
Distribution of oxygen desaturation index values in the patient and the control groups.
Tables
- TABLE 1
Distribution of variables
Variables Study group Control group p-value Subjects, n 60 60 Sex, n (%) Female 27 (45) 26 (43) 0.523 Male 33 (55) 34 (57) Age years, mean±sd 50.57±11.49 53.07±11.55 0.237# Pack-years smoking 0.032¶ Mean±sd 10.90±16.37 16.52±21.29 Median (1st–3rd quartile) 0 (0–15) 13.5 (0–25.5) BMI kg·m−2 Mean±sd 31.84±5.65 31.89±7.2 0.914¶ Median (1st–3rd quartile) 31.25 (27.92–36.15) 30.97 (28–34.7) BMI category, n (%) Obese 5 (8) 6 (10) 0.945 Overweight 23 (38) 22 (37) Normal 32 (53) 32 (53) Neck circumference cm Mean±sd 40.04±4.03 40.82±3.77 0.131¶ Median (1st–3rd quartile) 39 (38–42) 41 (38.25–43) Comorbidities, n (%) Hypertension 17 (28) 24 (40) Diabetes mellitus 11 (18) 9 (15) Coronary artery disease 5 (8) 12 (20) Asthma 4 (7) 4 (7) COPD 2 (3) 1 (2) Continuous data were expressed as mean±sd and median (1st–3rd quartile). BMI: body mass index. #: independent samples t-test; ¶: Mann–Whitney U test.
- TABLE 2
Distribution of polysomnography data
Study group# Control group# Variables Mean±sd Median (1st quartile–3rd quartile) Mean±sd Median (1st quartile–3rd quartile) p-value ESS scores 7.4±5.56 6 (3.5–9.5) 7.18±5.19 6 (3–10) 0.837 OSAS categories, n (%) 0.786 Normal 6 (10) 4 (7) Mild 11 (18) 14 (23) Moderate 23 (38) 20 (33) Severe 20 (33) 22 (37) Total sleep time min 349.17±60.58 352 (305.5–397) 345.91±78.13 354 (280–409) 0.021¶ Stage N1% 6.13±4.88 4.4 (2.8–8) 7.62±3.59 7.7 (4.7–9.4) 0.017 Stage N2% 61.42±11.4 59.1 (51.95–67.95) 59.1±11.48 56.6 (49.4–67.5) 0.947¶ Stage N3% 20.63±11.13 19.8 (13.3–26.9) 18.27±9.53 18.65 (12.5–24.5) 0.203 REM sleep time min 46.68±20.9 44 (35–60) 54.4±33.42 45.25 (30–79) 0.397 REM % 13.45±6.02 13.1 (10.2–16.3) 15.43±8.07 15.75 (9.6–21.8) 0.116 Arousal index 15.05±11.63 13.65 (7–20.5) 10.58±9.99 9.3 (2.1–16.7) 0.047 AHI events·h−1 28.18±22.62 23.5 (12.9–34.35) 28.27±20.82 22 (12.25–37.9) 0.908 RDI events·h−1 29.95±24.39 19.8 (11.3–47.8) 40.22±23.14 41.3 (17.6–60.2) 0.053 REM-AHI 30.81±26.85 27 (6.8–53.9) 22.11±22.81 17.9 (0–40) 0.041 Supine-AHI 14.03±20.11 5.6 (1.1–15.3) 10.58±17.42 0.2 (0–20.3) 0.016 ODI events·h−1 26.39±29.23 18.65 (6.65–32.65) 16.52±21.29 6.55 (1.25–22.25) 0.002 Mean Spo2 93.33±4.46 94 (93–95) 93.31±2.67 94 (92–95) 0.359 Minimum Spo2 83±9.41 86 (83–89) 83±9.05 86 (80–89) 0.695 T90% 6.65±14.16 0.85 (0.2–3.6) 9.19±15.28 1.9 (0.2–9.1) 0.320 T80% 2.27±7.72 0 (0–0) 1.65±7.57 0 (0–0) 0.995 Mean apnoea duration s 17.58±7.32 15.4 (13.2–21.35) 18.23±9.74 17.65 (12.8–23.9) 0.615 Mean hypopnoea duration s 29.34±8.7 27.95 (22.25–34.75) 29.1±6.92 28.2 (24.2–32.6) 0.873 MAD s 26.93±7.0 26.7 (20.9–30.85) 30.18±12.97 26.9 (24.2–32.8) 0.347 Continuous data were expressed as mean±sd and median (1st–3rd quartile). ESS: Epworth Sleepiness Scale; OSAS: obstructive sleep apnoea syndrome; N1: non rapid-eye movement sleep stage 1; N2: non rapid-eye movement sleep stage 2; N3: deepest non rapid-eye movement sleep stage 3; REM: rapid eye movement; AHI: apnoea–hypopnoea index; RDI: respiratory disturbance index; ODI: oxygen desaturation index; Spo2: oxygen saturation measured by pulse oximetry; T90: oxygen saturation <90%; T80: oxygen saturation <80%; MAD: mean apnoea–hypopnoea duration. #: n=60; ¶: independent samples t-test was used, Mann-Whitney U test was used in other analyses. Bold font indicates p<0.05.
- TABLE 3
Significant factors of the subclinical hypothyroidism, multiple logistic regression analysis (Backward Stepwise, step 12)
β coefficient Standard error Wald p-value Exp(β) 95% confidence interval for Exp(β) Sex (reference: female) −1.029 0.454 5.136 0.023 0.358 0.147–0.87 Min SpO2 0.105 0.039 7.305 0.007 1.111 1.029–1.199 ODI 0.052 0.018 8.108 0.004 1.053 1.016–1.092 Constant −7.704 3.457 4.966 0.026 0 Dependent variable: subclinical hypothyroidism; Nagelkerke R2=0.288. SpO2: oxygen saturation measured by pulse oximetry; ODI: oxygen desaturation index.
