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Randomised controlled trial of first-line tyrosine-kinase inhibitor (TKI) versus intercalated TKI with chemotherapy for EGFR-mutated nonsmall cell lung cancer

Rolof G.P. Gijtenbeek, Vincent van der Noort, Joachim G.J.V. Aerts, Jeske A. Staal-van den Brekel, Egbert F. Smit, Frans H. Krouwels, Frank A. Wilschut, T. Jeroen N. Hiltermann, Wim Timens, Ed Schuuring, Joost D.J. Janssen, Martijn Goosens, Paul M. van den Berg, A. Joop de Langen, Jos A. Stigt, Ben E.E.M. van den Borne, Harry J.M. Groen, Wouter H. van Geffen, Anthonie J. van der Wekken
ERJ Open Research 2022 8: 00239-2022; DOI: 10.1183/23120541.00239-2022
Rolof G.P. Gijtenbeek
1Dept of Respiratory Medicine, Medical Centre Leeuwarden, Leeuwarden, The Netherlands
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  • ORCID record for Rolof G.P. Gijtenbeek
Vincent van der Noort
2Dept of Biometrics, Netherlands Cancer Institute – Antoni van Leeuwenhoek, Amsterdam, The Netherlands
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Joachim G.J.V. Aerts
3Dept of Pulmonary Diseases, Erasmus University Medical Centre, Rotterdam, The Netherlands
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Jeske A. Staal-van den Brekel
4Dept of Respiratory Medicine, Hospital Group Twente, Almelo/Hengelo, The Netherlands
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Egbert F. Smit
5Dept of Pulmonology, Leiden University Medical Centre, Leiden, The Netherlands
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  • ORCID record for Egbert F. Smit
Frans H. Krouwels
6Dept of Respiratory Medicine, Spaarne Hospital, Hoofddorp, The Netherlands
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Frank A. Wilschut
7Dept of Respiratory Medicine, Gelderse Vallei Hospital, Ede, The Netherlands
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T. Jeroen N. Hiltermann
8Dept of Pulmonary Diseases, University of Groningen and University Medical Centre Groningen, Groningen, The Netherlands
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Wim Timens
9Dept of Pathology and Medical Biology, University of Groningen and University Medical Centre Groningen, Groningen, The Netherlands
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Ed Schuuring
9Dept of Pathology and Medical Biology, University of Groningen and University Medical Centre Groningen, Groningen, The Netherlands
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Joost D.J. Janssen
10Dept of Respiratory Medicine, Máxima Medical Centre, Eindhoven/Veldhoven, The Netherlands
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Martijn Goosens
11Dept of Pulmonary Medicine, Gelre Hospitals, Zutphen, The Netherlands
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Paul M. van den Berg
12Dept of Respiratory Medicine, Maasstad Hospital, Rotterdam, The Netherlands
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A. Joop de Langen
13Dept of Thoracic Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands
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Jos A. Stigt
14Dept of Respiratory Medicine, Isala Hospital, Zwolle, The Netherlands
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Ben E.E.M. van den Borne
15Dept of Pulmonary Diseases, Catharina Hospital, Eindhoven, The Netherlands
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Harry J.M. Groen
8Dept of Pulmonary Diseases, University of Groningen and University Medical Centre Groningen, Groningen, The Netherlands
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Wouter H. van Geffen
1Dept of Respiratory Medicine, Medical Centre Leeuwarden, Leeuwarden, The Netherlands
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  • For correspondence: wouter.van.geffen@mcl.nl
Anthonie J. van der Wekken
8Dept of Pulmonary Diseases, University of Groningen and University Medical Centre Groningen, Groningen, The Netherlands
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Article Information

vol. 8 no. 4
DOI 
https://doi.org/10.1183/23120541.00239-2022

Published By 
European Respiratory Society
Online ISSN 
2312-0541
History 
  • Received May 16, 2022
  • Accepted July 5, 2022
  • Published online October 17, 2022.

Article Versions

  • previous version (August 18, 2022 - 07:22).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright ©The authors 2022 This version is distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0. For commercial reproduction rights and permissions contact permissions@ersnet.org

Author Information

  1. Rolof G.P. Gijtenbeek1,
  2. Vincent van der Noort2,
  3. Joachim G.J.V. Aerts3,
  4. Jeske A. Staal-van den Brekel4,
  5. Egbert F. Smit5,
  6. Frans H. Krouwels6,
  7. Frank A. Wilschut7,
  8. T. Jeroen N. Hiltermann8,
  9. Wim Timens9,
  10. Ed Schuuring9,
  11. Joost D.J. Janssen10,
  12. Martijn Goosens11,
  13. Paul M. van den Berg12,
  14. A. Joop de Langen13,
  15. Jos A. Stigt14,
  16. Ben E.E.M. van den Borne15,
  17. Harry J.M. Groen8,
  18. Wouter H. van Geffen1⇑ and
  19. Anthonie J. van der Wekken8
  1. 1Dept of Respiratory Medicine, Medical Centre Leeuwarden, Leeuwarden, The Netherlands
  2. 2Dept of Biometrics, Netherlands Cancer Institute – Antoni van Leeuwenhoek, Amsterdam, The Netherlands
  3. 3Dept of Pulmonary Diseases, Erasmus University Medical Centre, Rotterdam, The Netherlands
  4. 4Dept of Respiratory Medicine, Hospital Group Twente, Almelo/Hengelo, The Netherlands
  5. 5Dept of Pulmonology, Leiden University Medical Centre, Leiden, The Netherlands
  6. 6Dept of Respiratory Medicine, Spaarne Hospital, Hoofddorp, The Netherlands
  7. 7Dept of Respiratory Medicine, Gelderse Vallei Hospital, Ede, The Netherlands
  8. 8Dept of Pulmonary Diseases, University of Groningen and University Medical Centre Groningen, Groningen, The Netherlands
  9. 9Dept of Pathology and Medical Biology, University of Groningen and University Medical Centre Groningen, Groningen, The Netherlands
  10. 10Dept of Respiratory Medicine, Máxima Medical Centre, Eindhoven/Veldhoven, The Netherlands
  11. 11Dept of Pulmonary Medicine, Gelre Hospitals, Zutphen, The Netherlands
  12. 12Dept of Respiratory Medicine, Maasstad Hospital, Rotterdam, The Netherlands
  13. 13Dept of Thoracic Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands
  14. 14Dept of Respiratory Medicine, Isala Hospital, Zwolle, The Netherlands
  15. 15Dept of Pulmonary Diseases, Catharina Hospital, Eindhoven, The Netherlands
  1. Corresponding author: Wouter H. van Geffen (wouter.van.geffen{at}mcl.nl)
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Funding

  • Roche Nederland

  • Eli Lilly and Company

  • Amgen

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Randomised controlled trial of first-line tyrosine-kinase inhibitor (TKI) versus intercalated TKI with chemotherapy for EGFR-mutated nonsmall cell lung cancer
Rolof G.P. Gijtenbeek, Vincent van der Noort, Joachim G.J.V. Aerts, Jeske A. Staal-van den Brekel, Egbert F. Smit, Frans H. Krouwels, Frank A. Wilschut, T. Jeroen N. Hiltermann, Wim Timens, Ed Schuuring, Joost D.J. Janssen, Martijn Goosens, Paul M. van den Berg, A. Joop de Langen, Jos A. Stigt, Ben E.E.M. van den Borne, Harry J.M. Groen, Wouter H. van Geffen, Anthonie J. van der Wekken
ERJ Open Research Oct 2022, 8 (4) 00239-2022; DOI: 10.1183/23120541.00239-2022

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Randomised controlled trial of first-line tyrosine-kinase inhibitor (TKI) versus intercalated TKI with chemotherapy for EGFR-mutated nonsmall cell lung cancer
Rolof G.P. Gijtenbeek, Vincent van der Noort, Joachim G.J.V. Aerts, Jeske A. Staal-van den Brekel, Egbert F. Smit, Frans H. Krouwels, Frank A. Wilschut, T. Jeroen N. Hiltermann, Wim Timens, Ed Schuuring, Joost D.J. Janssen, Martijn Goosens, Paul M. van den Berg, A. Joop de Langen, Jos A. Stigt, Ben E.E.M. van den Borne, Harry J.M. Groen, Wouter H. van Geffen, Anthonie J. van der Wekken
ERJ Open Research Oct 2022, 8 (4) 00239-2022; DOI: 10.1183/23120541.00239-2022
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