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Sputum neutrophil counts in healthy subjects: relationship with age

Augusta Beech, Dave Singh
ERJ Open Research 2022 8: 00246-2022; DOI: 10.1183/23120541.00246-2022
Augusta Beech
1Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK
2Medicines Evaluation Unit, Manchester University NHS Foundation Trust, Manchester, UK
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  • For correspondence: augusta.beech@manchester.ac.uk
Dave Singh
1Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK
2Medicines Evaluation Unit, Manchester University NHS Foundation Trust, Manchester, UK
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  • FIGURE 1
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    FIGURE 1

    Association between a) sputum neutrophil % and age, and b) sputum neutrophil % for different age groups in healthy non-smoking subjects. a) n=121 and b) n=26, 17, 30, 21, 17 and 10 for age groups 18–29, 30–39, 40–49, 50–59, 60–69 and 70+ respectively. *: p<0.05.

  • FIGURE 2
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    FIGURE 2

    a) Sputum neutrophil % at baseline and long-term follow-up visits, and b) Bland–Altman plot of the difference versus the mean of two repeat measurements of sputum neutrophil % over time for healthy non-smoking subjects. n=29. Long-term defined as >6 months from baseline.

Tables

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  • TABLE 1

    Baseline demographics for the entire cohort (n=121) #

    Characteristic% or mean±sd
    Sex, % male70.3
    Age years46.0±15.7
    Smoking status, current %0.0
    BMI kg·m−226.7±3.7
    FEV1 L3.5±1.0
    FEV1 % predicted104.8±15.7
    FEV1/FVC %78.0±6.4
    Sputum characteristicsMedian (range)Mean±sdPercentile95% CI
    10th90th
    Sputum total cell count ×106·g−15.64 (0.99–37.00)8.68±7.992.0721.966.66–10.69
    Sputum neutrophil %62.00 (4.00–97.25)55.20±24.4716.3082.5050.79–59.60
    Sputum eosinophil %0.00 (0.00–3.50)0.43±0.790.001.450.27–0.60
    Sputum lymphocyte %0.50 (0.00–3.75)0.85±0.880.002.000.67–1.03
    Sputum macrophage %35.00 (0.25–91.50)39.37±22.6712.8573.4034.65–44.10
    Sputum epithelial cells %3.25 (0.00–3.75)6.21±8.460.5015.254.45–7.97
    Sputum neutrophil cell count ×106·g−13.11 (0.14–30.53)5.79±15.400.7215.404.16–7.43
    Sputum eosinophil cell count ×106·g−10.00 (0.00–0.75)0.05±0.130.000.090.02–0.08
    Sputum lymphocyte cell count ×106·g−10.04 (0.00–0.75)0.07±0.120.000.170.04–0.10
    Sputum macrophage cell count ×106·g−11.72 (0.19–8.25)2.43±1.870.595.421.95–2.90
    Sputum epithelial cell count ×106·g−10.24 (0.00–1.40)0.34±0.310.040.770.26–0.42

    Data presented as mean±sd or median (range) unless specified otherwise. BMI: body mass index; FEV1: forced expiratory volume in 1 s; FVC: forced vital capacity. #: 30 subjects did not have full differential cell counts data available aside from neutrophil %; 58 subjects did not have absolute sputum counts available.

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    Sputum neutrophil counts in healthy subjects: relationship with age
    Augusta Beech, Dave Singh
    ERJ Open Research Oct 2022, 8 (4) 00246-2022; DOI: 10.1183/23120541.00246-2022

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    Sputum neutrophil counts in healthy subjects: relationship with age
    Augusta Beech, Dave Singh
    ERJ Open Research Oct 2022, 8 (4) 00246-2022; DOI: 10.1183/23120541.00246-2022
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