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Monocyte migratory signatures identify acute and convalescent COVID-19 patients, and are associated with long COVID-19 symptoms

Laurence Pearmain, Nicholas Scott, Sean B Knight, Oliver Brand, David J Morgan, Chris Jagger, Saba Khan, Pamela Hackney, Lara Smith, Madhvi Menon, Joanne E Konkel, Halima A Shuwa, Miriam Franklin, Verena Kästele, Sarah Harbach, Seema Brij, Andrew Ustianowski, Alexander G Mathoudiakis, Christopher E Brightling, Pilar Rivera Ortega, Nawar Diar Bakerly, Paul Dark, Kathryn Gray, Graham M Lord, Timothy W Felton, Circo, Karen Piper Hanley, Angela Simpson, John R Grainger, Tracy Hussell, Elizabeth R Mann
ERJ Open Research 2022 8: 172; DOI: 10.1183/23120541.LSC-2022.172
Laurence Pearmain
1Wellcome Centre for Cell-Matrix Research, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Oxford Road, Manchester, United Kingdom
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  • For correspondence: laurencepearmain@nhs.net
Nicholas Scott
2Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Grafton Street, Manchester, United Kingdom
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Sean B Knight
2Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Grafton Street, Manchester, United Kingdom
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Oliver Brand
2Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Grafton Street, Manchester, United Kingdom
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David J Morgan
2Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Grafton Street, Manchester, United Kingdom
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Chris Jagger
2Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Grafton Street, Manchester, United Kingdom
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Saba Khan
2Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Grafton Street, Manchester, United Kingdom
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Pamela Hackney
3Research Innovation, Manchester University NHS Foundation Trust, Manchester, United Kingdom
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Lara Smith
3Research Innovation, Manchester University NHS Foundation Trust, Manchester, United Kingdom
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Madhvi Menon
2Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Grafton Street, Manchester, United Kingdom
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Joanne E Konkel
2Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Grafton Street, Manchester, United Kingdom
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Halima A Shuwa
2Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Grafton Street, Manchester, United Kingdom
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Miriam Franklin
2Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Grafton Street, Manchester, United Kingdom
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Verena Kästele
2Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Grafton Street, Manchester, United Kingdom
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Sarah Harbach
2Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Grafton Street, Manchester, United Kingdom
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Seema Brij
4Department of Respiratory Medicine, Manchester Royal Infirmary, Manchester University NHS Foundation Trust, Manchester, United Kingdom
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Andrew Ustianowski
5Regional Infectious Diseases Unit, North Manchester General Hospital, Manchester, United Kingdom
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Alexander G Mathoudiakis
6North West Lung Centre, Wythenshawe Hospital, Manchester University NHS Foundation Trust, Manchester, United Kingdom
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Christopher E Brightling
7Department of Respiratory Sciences, Leicester NIHR BRC, University of Leicester, Leicester, United Kingdom
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Pilar Rivera Ortega
8Interstitial Lung Disease Unit Wythenshawe Hospital Manchester University NHS Foundation Trust, Manchester, United Kingdom
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Nawar Diar Bakerly
9Department of Respiratory Medicine, Salford Royal NHS Foundation Trust, Stott Lane, Manchester, United Kingdom
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Paul Dark
9Department of Respiratory Medicine, Salford Royal NHS Foundation Trust, Stott Lane, Manchester, United Kingdom
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Kathryn Gray
2Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Grafton Street, Manchester, United Kingdom
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Graham M Lord
2Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Grafton Street, Manchester, United Kingdom
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Timothy W Felton
10Division of Infection, Immunity and Respiratory Medicine, Manchester NIHR BRC, Education and Research Centre, Wythenshawe Hospital, Manchester, United Kingdom
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2Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Grafton Street, Manchester, United Kingdom
Karen Piper Hanley
11Division of Diabetes, Endocrinology and Gastroenterology, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Oxford Road , Manchester, United Kingdom
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Angela Simpson
10Division of Infection, Immunity and Respiratory Medicine, Manchester NIHR BRC, Education and Research Centre, Wythenshawe Hospital, Manchester, United Kingdom
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John R Grainger
2Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Grafton Street, Manchester, United Kingdom
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Tracy Hussell
2Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Grafton Street, Manchester, United Kingdom
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Elizabeth R Mann
2Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Grafton Street, Manchester, United Kingdom
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Abstract

Background: Monocytes regulate the development and resolution of lung injury. We previously demonstrated dysregulation of blood monocytes in hospitalised COVID-19 patients. It is unknown whether monocyte abnormalities persist after discharge and their clinical significance to long COVID symptoms

Aims: We aimed to assess if monocyte dysfunction in COVID-19 is associated with long COVID symptoms.

Methods: Clinical data were collected from 72 patients with acute COVID-19 pneumonitis, 147 COVID-19 convalescent patients (range 8-36 weeks), and 38 healthy controls. Blood monocytes were characterised by flow cytometry.

Results: Monocytes from hospitalised, acute COVID-19 patients aberrantly expressed adhesion/migration molecules, including increased monocyte chemoattractant protein 1, chemokine receptor CXCR6 and adhesion molecules integrinβ7, PSGL-1. Notably chemokine receptor CXCR2 (decreased) and CD62L (increased) expression stratified with acute COVID-19 severity. In convalescence, increased monocyte CXCR6 and PSGL1 persisted; associating with patient breathlessness. Cyclo-oxygenase 2 expression was decreased on monocytes during acute COVID-19, stratifying with disease severity, and remained low during convalescence in patients with persistent fatigue. TNFα monocyte production was enhanced in patients with mild disease during the acute phase, and in patients without long COVID symptoms.

Conlusions: Persistent changes in monocytes during COVID-19 convalescence are associated with long COVID symptoms, where traditional tests of lung recovery are not. Targeting aberrant monocyte phenotypes throughout the COVID-19 time-course has biomarker & immunomodulatory therapy promise.

  • Immunology
  • Monocyte / Macrophage
  • Covid-19

Footnotes

Cite this article as ERJ Open Research 2022; 8: Suppl. 8, 172.

This article was presented at the 2022 ERS Lung Science Conference, in session “Poster Session 2”.

This is an ERS Lung Science Conference abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).

  • Copyright ©the authors 2022
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Monocyte migratory signatures identify acute and convalescent COVID-19 patients, and are associated with long COVID-19 symptoms
Laurence Pearmain, Nicholas Scott, Sean B Knight, Oliver Brand, David J Morgan, Chris Jagger, Saba Khan, Pamela Hackney, Lara Smith, Madhvi Menon, Joanne E Konkel, Halima A Shuwa, Miriam Franklin, Verena Kästele, Sarah Harbach, Seema Brij, Andrew Ustianowski, Alexander G Mathoudiakis, Christopher E Brightling, Pilar Rivera Ortega, Nawar Diar Bakerly, Paul Dark, Kathryn Gray, Graham M Lord, Timothy W Felton, Circo, Karen Piper Hanley, Angela Simpson, John R Grainger, Tracy Hussell, Elizabeth R Mann
ERJ Open Research Mar 2022, 8 (suppl 8) 172; DOI: 10.1183/23120541.LSC-2022.172

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Monocyte migratory signatures identify acute and convalescent COVID-19 patients, and are associated with long COVID-19 symptoms
Laurence Pearmain, Nicholas Scott, Sean B Knight, Oliver Brand, David J Morgan, Chris Jagger, Saba Khan, Pamela Hackney, Lara Smith, Madhvi Menon, Joanne E Konkel, Halima A Shuwa, Miriam Franklin, Verena Kästele, Sarah Harbach, Seema Brij, Andrew Ustianowski, Alexander G Mathoudiakis, Christopher E Brightling, Pilar Rivera Ortega, Nawar Diar Bakerly, Paul Dark, Kathryn Gray, Graham M Lord, Timothy W Felton, Circo, Karen Piper Hanley, Angela Simpson, John R Grainger, Tracy Hussell, Elizabeth R Mann
ERJ Open Research Mar 2022, 8 (suppl 8) 172; DOI: 10.1183/23120541.LSC-2022.172
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