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Monocyte migratory signatures identify acute and convalescent COVID-19 patients, and are associated with long COVID-19 symptoms

Laurence Pearmain, Nicholas Scott, Sean B Knight, Oliver Brand, David J Morgan, Chris Jagger, Saba Khan, Pamela Hackney, Lara Smith, Madhvi Menon, Joanne E Konkel, Halima A Shuwa, Miriam Franklin, Verena Kästele, Sarah Harbach, Seema Brij, Andrew Ustianowski, Alexander G Mathoudiakis, Christopher E Brightling, Pilar Rivera Ortega, Nawar Diar Bakerly, Paul Dark, Kathryn Gray, Graham M Lord, Timothy W Felton, Circo, Karen Piper Hanley, Angela Simpson, John R Grainger, Tracy Hussell, Elizabeth R Mann
ERJ Open Research 2022 8: 172; DOI: 10.1183/23120541.LSC-2022.172
Laurence Pearmain
1Wellcome Centre for Cell-Matrix Research, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Oxford Road, Manchester, United Kingdom
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  • For correspondence: laurencepearmain@nhs.net
Nicholas Scott
2Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Grafton Street, Manchester, United Kingdom
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Sean B Knight
2Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Grafton Street, Manchester, United Kingdom
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Oliver Brand
2Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Grafton Street, Manchester, United Kingdom
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David J Morgan
2Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Grafton Street, Manchester, United Kingdom
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Chris Jagger
2Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Grafton Street, Manchester, United Kingdom
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Saba Khan
2Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Grafton Street, Manchester, United Kingdom
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Pamela Hackney
3Research Innovation, Manchester University NHS Foundation Trust, Manchester, United Kingdom
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Lara Smith
3Research Innovation, Manchester University NHS Foundation Trust, Manchester, United Kingdom
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Madhvi Menon
2Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Grafton Street, Manchester, United Kingdom
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Joanne E Konkel
2Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Grafton Street, Manchester, United Kingdom
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Halima A Shuwa
2Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Grafton Street, Manchester, United Kingdom
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Miriam Franklin
2Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Grafton Street, Manchester, United Kingdom
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Verena Kästele
2Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Grafton Street, Manchester, United Kingdom
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Sarah Harbach
2Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Grafton Street, Manchester, United Kingdom
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Seema Brij
4Department of Respiratory Medicine, Manchester Royal Infirmary, Manchester University NHS Foundation Trust, Manchester, United Kingdom
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Andrew Ustianowski
5Regional Infectious Diseases Unit, North Manchester General Hospital, Manchester, United Kingdom
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Alexander G Mathoudiakis
6North West Lung Centre, Wythenshawe Hospital, Manchester University NHS Foundation Trust, Manchester, United Kingdom
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Christopher E Brightling
7Department of Respiratory Sciences, Leicester NIHR BRC, University of Leicester, Leicester, United Kingdom
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Pilar Rivera Ortega
8Interstitial Lung Disease Unit Wythenshawe Hospital Manchester University NHS Foundation Trust, Manchester, United Kingdom
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Nawar Diar Bakerly
9Department of Respiratory Medicine, Salford Royal NHS Foundation Trust, Stott Lane, Manchester, United Kingdom
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Paul Dark
9Department of Respiratory Medicine, Salford Royal NHS Foundation Trust, Stott Lane, Manchester, United Kingdom
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Kathryn Gray
2Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Grafton Street, Manchester, United Kingdom
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Graham M Lord
2Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Grafton Street, Manchester, United Kingdom
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Timothy W Felton
10Division of Infection, Immunity and Respiratory Medicine, Manchester NIHR BRC, Education and Research Centre, Wythenshawe Hospital, Manchester, United Kingdom
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2Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Grafton Street, Manchester, United Kingdom
Karen Piper Hanley
11Division of Diabetes, Endocrinology and Gastroenterology, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Oxford Road , Manchester, United Kingdom
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Angela Simpson
10Division of Infection, Immunity and Respiratory Medicine, Manchester NIHR BRC, Education and Research Centre, Wythenshawe Hospital, Manchester, United Kingdom
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John R Grainger
2Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Grafton Street, Manchester, United Kingdom
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Tracy Hussell
2Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Grafton Street, Manchester, United Kingdom
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Elizabeth R Mann
2Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Grafton Street, Manchester, United Kingdom
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Article Information

vol. 8 no. suppl 8
DOI 
https://doi.org/10.1183/23120541.LSC-2022.172

Published By 
European Respiratory Society
Online ISSN 
2312-0541
History 
  • Published online May 9, 2022.

Copyright & Usage 
Copyright ©the authors 2022

Author Information

  1. Laurence Pearmain1⇑,
  2. Nicholas Scott2,
  3. Sean B Knight2,
  4. Oliver Brand2,
  5. David J Morgan2,
  6. Chris Jagger2,
  7. Saba Khan2,
  8. Pamela Hackney3,
  9. Lara Smith3,
  10. Madhvi Menon2,
  11. Joanne E Konkel2,
  12. Halima A Shuwa2,
  13. Miriam Franklin2,
  14. Verena Kästele2,
  15. Sarah Harbach2,
  16. Seema Brij4,
  17. Andrew Ustianowski5,
  18. Alexander G Mathoudiakis6,
  19. Christopher E Brightling7,
  20. Pilar Rivera Ortega8,
  21. Nawar Diar Bakerly9,
  22. Paul Dark9,
  23. Kathryn Gray2,
  24. Graham M Lord2,
  25. Timothy W Felton10,
  26. Circo2,
  27. Karen Piper Hanley11,
  28. Angela Simpson10,
  29. John R Grainger2,
  30. Tracy Hussell2 and
  31. Elizabeth R Mann2
  1. 1Wellcome Centre for Cell-Matrix Research, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Oxford Road, Manchester, United Kingdom
  2. 2Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Grafton Street, Manchester, United Kingdom
  3. 3Research Innovation, Manchester University NHS Foundation Trust, Manchester, United Kingdom
  4. 4Department of Respiratory Medicine, Manchester Royal Infirmary, Manchester University NHS Foundation Trust, Manchester, United Kingdom
  5. 5Regional Infectious Diseases Unit, North Manchester General Hospital, Manchester, United Kingdom
  6. 6North West Lung Centre, Wythenshawe Hospital, Manchester University NHS Foundation Trust, Manchester, United Kingdom
  7. 7Department of Respiratory Sciences, Leicester NIHR BRC, University of Leicester, Leicester, United Kingdom
  8. 8Interstitial Lung Disease Unit Wythenshawe Hospital Manchester University NHS Foundation Trust, Manchester, United Kingdom
  9. 9Department of Respiratory Medicine, Salford Royal NHS Foundation Trust, Stott Lane, Manchester, United Kingdom
  10. 10Division of Infection, Immunity and Respiratory Medicine, Manchester NIHR BRC, Education and Research Centre, Wythenshawe Hospital, Manchester, United Kingdom
  11. 11Division of Diabetes, Endocrinology and Gastroenterology, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Oxford Road , Manchester, United Kingdom
  1. Laurence Pearmain, Wellcome Centre for Cell-Matrix Research, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Oxford Road, Manchester, United Kingdom. E-mail: laurencepearmain{at}nhs.net

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Monocyte migratory signatures identify acute and convalescent COVID-19 patients, and are associated with long COVID-19 symptoms
Laurence Pearmain, Nicholas Scott, Sean B Knight, Oliver Brand, David J Morgan, Chris Jagger, Saba Khan, Pamela Hackney, Lara Smith, Madhvi Menon, Joanne E Konkel, Halima A Shuwa, Miriam Franklin, Verena Kästele, Sarah Harbach, Seema Brij, Andrew Ustianowski, Alexander G Mathoudiakis, Christopher E Brightling, Pilar Rivera Ortega, Nawar Diar Bakerly, Paul Dark, Kathryn Gray, Graham M Lord, Timothy W Felton, Circo, Karen Piper Hanley, Angela Simpson, John R Grainger, Tracy Hussell, Elizabeth R Mann
ERJ Open Research Mar 2022, 8 (suppl 8) 172; DOI: 10.1183/23120541.LSC-2022.172

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Monocyte migratory signatures identify acute and convalescent COVID-19 patients, and are associated with long COVID-19 symptoms
Laurence Pearmain, Nicholas Scott, Sean B Knight, Oliver Brand, David J Morgan, Chris Jagger, Saba Khan, Pamela Hackney, Lara Smith, Madhvi Menon, Joanne E Konkel, Halima A Shuwa, Miriam Franklin, Verena Kästele, Sarah Harbach, Seema Brij, Andrew Ustianowski, Alexander G Mathoudiakis, Christopher E Brightling, Pilar Rivera Ortega, Nawar Diar Bakerly, Paul Dark, Kathryn Gray, Graham M Lord, Timothy W Felton, Circo, Karen Piper Hanley, Angela Simpson, John R Grainger, Tracy Hussell, Elizabeth R Mann
ERJ Open Research Mar 2022, 8 (suppl 8) 172; DOI: 10.1183/23120541.LSC-2022.172
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