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Polymeric immunoglobulin receptor and immunoglobulin A system in an eosinophilic mouse model of chronic rhinosinusitis

Alba Sánchez Montalvo, Marylene Lecocq, Thomas Plante-Bordeneuve, Caroline Bouzin, Charles Pilette, Valérie Hox
ERJ Open Research 2022 8: 197; DOI: 10.1183/23120541.LSC-2022.197
Alba Sánchez Montalvo
1Institution of Experimental and Clinical Research, Pole of Pulmonology, ENT and Dermatology, UCLouvain, Brussels, Belgium
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  • For correspondence: alba.sanchez@uclouvain.be
Marylene Lecocq
1Institution of Experimental and Clinical Research, Pole of Pulmonology, ENT and Dermatology, UCLouvain, Brussels, Belgium
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Thomas Plante-Bordeneuve
1Institution of Experimental and Clinical Research, Pole of Pulmonology, ENT and Dermatology, UCLouvain, Brussels, Belgium
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Caroline Bouzin
2Institution of Experimental and Clinical Research, Imaging Platform, UCLouvain, Brussels, Belgium
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Charles Pilette
1Institution of Experimental and Clinical Research, Pole of Pulmonology, ENT and Dermatology, UCLouvain, Brussels, Belgium
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Valérie Hox
3Department of Otorhinolaryngology, Cliniques Universitaires Saint-Luc, Brussels, Belgium
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Abstract

Background: Chronic rhinosinusitis (CRS) is an inflammatory respiratory disease with symptoms of nasal blockade, headache, loss of smell and nasal secretions. It affects 11% of european population and is a global health burden. CRS is classified according to inflammatory profile as Type 2 eosinophilic or non-Type 2 neutrophilic CRS. Currently, the pathogenesis of CRS is not fully understood. Patients with selective IgA-deficiency present more often with CRS and an observational study showed a decreased polymeric immunoglobulin receptor (pIgR) expression and specific IgA response towards relevant antigens, such as Staphylococcus aureus enterotoxin B (SEB).

Aims: We aimed at elucidating the role of the pIgR/IgA pathway by using a mouse model of Type 2 CRS.

Methods: Type 2 CRS mouse model was established by intranasal ovalbumin (OVA) and SEB instillations after i.p. sensitization to OVA. Inflammatory and IgA-related parameters were evaluated on decalcified skulls by means of histology and on serum and nasal lavage by means of ELISA. To test the role of pIgR, we repeated the model in pIgR−/−mice.

Results: Mice with experimental Type 2 CRS showed a significant increase in epithelial thickness, sinus fibrosis, eosinophilic infiltration and IgA levels in nasal lavage compared to controls. Also, a significant increase was seen in IgA and pIgR sinus tissue expression. However, no significant changes were seen in inflammatory markers between pIgR−/− mice and WT controls.

Conclusion: Type 2 CRS is linked to an increased sinonasal pIgR expression with increased IgA production and release in an in vivo mouse model. Lack of pIgR does not seem to affect the induction of Type 2 CRS.

  • Animal models
  • Inflammation
  • Rhinitis

Footnotes

Cite this article as ERJ Open Research 2022; 8: Suppl. 8, 197.

This article was presented at the 2022 ERS Lung Science Conference, in session “Poster Session 2”.

This is an ERS Lung Science Conference abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).

  • Copyright ©the authors 2022
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Polymeric immunoglobulin receptor and immunoglobulin A system in an eosinophilic mouse model of chronic rhinosinusitis
Alba Sánchez Montalvo, Marylene Lecocq, Thomas Plante-Bordeneuve, Caroline Bouzin, Charles Pilette, Valérie Hox
ERJ Open Research Mar 2022, 8 (suppl 8) 197; DOI: 10.1183/23120541.LSC-2022.197

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Polymeric immunoglobulin receptor and immunoglobulin A system in an eosinophilic mouse model of chronic rhinosinusitis
Alba Sánchez Montalvo, Marylene Lecocq, Thomas Plante-Bordeneuve, Caroline Bouzin, Charles Pilette, Valérie Hox
ERJ Open Research Mar 2022, 8 (suppl 8) 197; DOI: 10.1183/23120541.LSC-2022.197
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