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Pulmonary hypertension associated with diazoxide: the SUR1 paradox

David Montani, Fabrice Antigny, Etienne-Marie Jutant, Marie-Camille Chaumais, Hélène Le Ribeuz, Julien Grynblat, Charles Khouri, Marc Humbert
ERJ Open Research 2023 9: 00350-2023; DOI: 10.1183/23120541.00350-2023
David Montani
1Université Paris-Saclay, Faculty of Medicine, Le Kremlin-Bicêtre, France
2INSERM UMR_S 999, Hôpital Marie Lannelongue, Le Plessis Robinson, France
3Assistance Publique-Hôpitaux de Paris (AP-HP), Department of Respiratory and Intensive Care Medicine, Pulmonary Hypertension National Referral Centre, Hôpital Bicêtre, DMU 5 Thorinno, Le Kremlin-Bicêtre, France
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  • ORCID record for David Montani
  • For correspondence: davidmontani@gmail.com
Fabrice Antigny
1Université Paris-Saclay, Faculty of Medicine, Le Kremlin-Bicêtre, France
2INSERM UMR_S 999, Hôpital Marie Lannelongue, Le Plessis Robinson, France
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Etienne-Marie Jutant
4CHU de Poitiers, Respiratory Department, INSERM CIC 1402, IS-ALIVE Research Group, University of Poitiers, Poitiers, France
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Marie-Camille Chaumais
2INSERM UMR_S 999, Hôpital Marie Lannelongue, Le Plessis Robinson, France
5Assistance Publique-Hôpitaux de Paris (AP-HP), Department of Pharmacy, Hôpital Bicêtre, Le Kremlin-Bicêtre, France
6Université Paris-Saclay, Faculty of Pharmacy, Saclay, France
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  • ORCID record for Marie-Camille Chaumais
Hélène Le Ribeuz
1Université Paris-Saclay, Faculty of Medicine, Le Kremlin-Bicêtre, France
2INSERM UMR_S 999, Hôpital Marie Lannelongue, Le Plessis Robinson, France
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Julien Grynblat
1Université Paris-Saclay, Faculty of Medicine, Le Kremlin-Bicêtre, France
2INSERM UMR_S 999, Hôpital Marie Lannelongue, Le Plessis Robinson, France
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Charles Khouri
7Univ. Grenoble Alpes, HP2 Laboratory, Grenoble, France
8Grenoble Alpes University Hospital, Pharmacovigilance Unit, Grenoble, France
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Marc Humbert
1Université Paris-Saclay, Faculty of Medicine, Le Kremlin-Bicêtre, France
2INSERM UMR_S 999, Hôpital Marie Lannelongue, Le Plessis Robinson, France
3Assistance Publique-Hôpitaux de Paris (AP-HP), Department of Respiratory and Intensive Care Medicine, Pulmonary Hypertension National Referral Centre, Hôpital Bicêtre, DMU 5 Thorinno, Le Kremlin-Bicêtre, France
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Article Information

vol. 9 no. 6
DOI 
https://doi.org/10.1183/23120541.00350-2023

Published By 
European Respiratory Society
Online ISSN 
2312-0541
History 
  • Received May 29, 2023
  • Accepted September 4, 2023
  • Published online November 13, 2023.

Article Versions

  • previous version (October 12, 2023 - 08:07).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright ©The authors 2023 This version is distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0. For commercial reproduction rights and permissions contact permissions@ersnet.org

Author Information

  1. David Montani1,2,3⇑,
  2. Fabrice Antigny1,2,
  3. Etienne-Marie Jutant4,
  4. Marie-Camille Chaumais2,5,6,
  5. Hélène Le Ribeuz1,2,
  6. Julien Grynblat1,2,
  7. Charles Khouri7,8 and
  8. Marc Humbert1,2,3
  1. 1Université Paris-Saclay, Faculty of Medicine, Le Kremlin-Bicêtre, France
  2. 2INSERM UMR_S 999, Hôpital Marie Lannelongue, Le Plessis Robinson, France
  3. 3Assistance Publique-Hôpitaux de Paris (AP-HP), Department of Respiratory and Intensive Care Medicine, Pulmonary Hypertension National Referral Centre, Hôpital Bicêtre, DMU 5 Thorinno, Le Kremlin-Bicêtre, France
  4. 4CHU de Poitiers, Respiratory Department, INSERM CIC 1402, IS-ALIVE Research Group, University of Poitiers, Poitiers, France
  5. 5Assistance Publique-Hôpitaux de Paris (AP-HP), Department of Pharmacy, Hôpital Bicêtre, Le Kremlin-Bicêtre, France
  6. 6Université Paris-Saclay, Faculty of Pharmacy, Saclay, France
  7. 7Univ. Grenoble Alpes, HP2 Laboratory, Grenoble, France
  8. 8Grenoble Alpes University Hospital, Pharmacovigilance Unit, Grenoble, France
  1. Corresponding author: David Montani (davidmontani{at}gmail.com)
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Funding

  • French National Agency for Research (ANR)

    ANR-18-CE14-0023

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Article usage: October 2023 to October 2023

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ERJ Open Research: 9 (6)
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Pulmonary hypertension associated with diazoxide: the SUR1 paradox
David Montani, Fabrice Antigny, Etienne-Marie Jutant, Marie-Camille Chaumais, Hélène Le Ribeuz, Julien Grynblat, Charles Khouri, Marc Humbert
ERJ Open Research Nov 2023, 9 (6) 00350-2023; DOI: 10.1183/23120541.00350-2023

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Pulmonary hypertension associated with diazoxide: the SUR1 paradox
David Montani, Fabrice Antigny, Etienne-Marie Jutant, Marie-Camille Chaumais, Hélène Le Ribeuz, Julien Grynblat, Charles Khouri, Marc Humbert
ERJ Open Research Nov 2023, 9 (6) 00350-2023; DOI: 10.1183/23120541.00350-2023
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  • Article
    • Abstract
    • Tweetable abstract
    • Introduction
    • Role of SUR1 and SUR2 in pathophysiology in PAH
    • Pharmacology of diazoxide
    • Beneficial effects of diazoxide in animal models of PH
    • Heritable PAH in ABCC8 pathogenic variant carriers
    • Pulmonary hypertension associated with diazoxide
    • Mechanisms of pulmonary hypertension associated with diazoxide
    • Conclusion
    • Supplementary material
    • Acknowledgements
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • PDF

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  • Paediatric pulmonology
  • Pulmonary vascular disease
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