Skip to main content

Main menu

  • Home
  • Current issue
  • Early View
  • Archive
  • For authors
    • Instructions for authors
    • Submit a manuscript
    • ERS Author FAQs
    • COVID-19 submission information
  • Alerts
  • Subscriptions
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

User menu

  • Log in
  • Subscribe
  • Contact Us
  • My Cart

Search

  • Advanced search
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

Login

European Respiratory Society

Advanced Search

  • Home
  • Current issue
  • Early View
  • Archive
  • For authors
    • Instructions for authors
    • Submit a manuscript
    • ERS Author FAQs
    • COVID-19 submission information
  • Alerts
  • Subscriptions

Endoscopic lung volume reduction with endobronchial valves in very low DLCO patients: results from the German Registry (Lungenemphysemregister e.V.)

Pavlina Lenga, Christoph Ruwwe-Glösenkamp, Christian Grah, Joachim Pfannschmidt, Jens Rückert, Stephan Eggeling, Sven Gläser, Bernd Schmidt, Paul Schneider, Sylke Kurz, Gunda Leschber, Andreas Gebhardt, Birgit Becke, Olaf Schega, Jakob Borchardt, Ralf-Harto Hübner
ERJ Open Research 2020; DOI: 10.1183/23120541.00449-2020
Pavlina Lenga
1Department of Infectious Diseases and Respiratory Medicine, Charité - Universitätsmedizin Berlin, Berlin, Germany
15shared authorship
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Christoph Ruwwe-Glösenkamp
1Department of Infectious Diseases and Respiratory Medicine, Charité - Universitätsmedizin Berlin, Berlin, Germany
15shared authorship
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Christian Grah
2Department of Internal Medicine and Respiratory Medicine, Clinic Havelhöhe Berlin, Berlin, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Joachim Pfannschmidt
3Department of Thoracic Surgery, Heckeshorn Lung Clinic, Berlin, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jens Rückert
4Department of Surgery, Competence Center of Thoracic Surgery, Berlin, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Stephan Eggeling
5Department of Thoracic Surgery, Vivantes Netzwerk für Gesundheit, Klinikum Neukölln, Berlin, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Sven Gläser
6Department of Pulmonary Medicine and Infectious Diseases, Vivantes-Klinikum Neukölln, Berlin, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Bernd Schmidt
7Department of Respiratory Medicine, DRK Kliniken Berlin Mitte, Berlin, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Paul Schneider
8Department of Thoracic Surgery, DRK Kliniken Berlin Mitte, Berlin, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Sylke Kurz
9Department of Respiratory Medicine, ELK Berlin Chest Hospital, Berlin, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Gunda Leschber
10Department of Thoracic Surgery, ELK Berlin Chest Hospital, Berlin, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Andreas Gebhardt
11Department of Internal Medicine and Respiratory Medicine, Helios Hospital Emil von Behring, Berlin, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Birgit Becke
12Department of Respiratory Medicine, Johanniter-Krankenhaus, Treuenbrietzen, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Olaf Schega
13Department of Thoracic Surgery, Johanniter-Krankenhaus, Treuenbrietzen, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jakob Borchardt
14Department of Pulmonary Medicine and Infectious Diseases, Vivantes-Klinikum Friedrichshain, Berlin, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ralf-Harto Hübner
1Department of Infectious Diseases and Respiratory Medicine, Charité - Universitätsmedizin Berlin, Berlin, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & Metrics
  • PDF
Loading

Abstract

Background Endoscopic lung volume reduction (ELVR) with valves has been suggested to be the key strategy for patients with severe emphysema and concomitant low diffusion capacity of the lung for carbon monoxide (DLCO). However, robust evidence is still missing. We therefore aim to compare clinical outcomes in relation to DLCO for patients treated with ELVR.

Methods We assessed DLCO at baseline and 3-months follow-up and compared pre- and postprocedural pulmonary function test (PFT), quality of life, exercise capacity and adverse events. This is a retrospective subanalysis of prospectively collected data from the German Lung Emphysema Registry.

Results 121 patients treated with ELVR were analysed. 34 patients with a DLCO ≤20% and 87 patients with a DLCO >20% showed similar baseline characteristics. After ELVR, there was a decrease of residual volume (both p<0.001 to baseline) in both groups and both demonstrated better quality of life (p<0.01 to baseline). Forced expiratory volume in 1 s (FEV1) improved significantly only in patients with a DLCO >20% (p<0.001 to baseline). Exercise capacity remained almost unchanged in both groups (p=0.3). The most frequent complication for both groups was a pneumothorax (DLCO ≤20%: 17.6% versus DLCO >20%: 16.1%; p=0.728). However, there were no significant differences in other adverse events between both groups.

Conclusions ELVR improves lung function as well as quality of life in patients with DLCO >20% and DLCO ≤20%. Adverse events did not differ between groups. Therefore, ELVR should be considered as a treatment option, even in patients with a very low DLCO.

Footnotes

This manuscript has recently been accepted for publication in the ERJ Open Research. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJOR online. Please open or download the PDF to view this article.

Conflict of interest: Dr. Lenga has nothing to disclose.

Conflict of interest: Dr. Ruwwe-Glösenkamp has nothing do disclose

Conflict of interest: Dr. Grah has nothing to disclose.

Conflict of interest: Dr. Pfannschmidt has nothing to disclose.

Conflict of interest: Prof. Rückert has nothing to disclose.

Conflict of interest: Dr. Eggeling has nothing to disclose.

Conflict of interest: Dr. Schmidt has nothing to disclose.

Conflict of interest: Dr. Schneider has nothing to disclose.

Conflict of interest: Dr. Sven has nothing to disclose.Dr. Kurz has nothing to disclose.

Conflict of interest: Dr. Leschber has nothing to disclose.

Conflict of interest: Dr. Gebhardt has nothing to disclose.

Conflict of interest: Dr. Schega has nothing to disclose.

Conflict of interest: Dr. Borchardt has nothing to disclose.

Conflict of interest: Dr. Hübner reports personal fees and non-financial support from Pulmonx, from null, from null, from null, from null, from null, from null, from null, outside the submitted work; .Dr. Hübner reports personal fees and non-financial support from Pulmonx, outside the submitted work.

Conflict of interest: Dr. Birgit has nothing to disclose.

Conflict of interest: Dr. Glaeser reports personal fees from Boehringer Ingelheim, grants and personal fees from Novartis Pharma, personal fees from Roche Pharma, personal fees from Berlin Chemie, personal fees from PneumRx, personal fees from PulmonX, personal fees from Actelion Pharma, personal fees from Bayer Healthcare, outside the submitted work.

This is a PDF-only article. Please click on the PDF link above to read it.

  • Received June 30, 2020.
  • Accepted September 23, 2020.
  • Copyright ©ERS 2020
http://creativecommons.org/licenses/by-nc/4.0/

This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0.

PreviousNext
Back to top
Vol 7 Issue 1 Table of Contents
ERJ Open Research: 7 (1)
  • Table of Contents
  • Index by author
Email

Thank you for your interest in spreading the word on European Respiratory Society .

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Endoscopic lung volume reduction with endobronchial valves in very low DLCO patients: results from the German Registry (Lungenemphysemregister e.V.)
(Your Name) has sent you a message from European Respiratory Society
(Your Name) thought you would like to see the European Respiratory Society web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Print
Alerts
Sign In to Email Alerts with your Email Address
Citation Tools
Endoscopic lung volume reduction with endobronchial valves in very low DLCO patients: results from the German Registry (Lungenemphysemregister e.V.)
Pavlina Lenga, Christoph Ruwwe-Glösenkamp, Christian Grah, Joachim Pfannschmidt, Jens Rückert, Stephan Eggeling, Sven Gläser, Bernd Schmidt, Paul Schneider, Sylke Kurz, Gunda Leschber, Andreas Gebhardt, Birgit Becke, Olaf Schega, Jakob Borchardt, Ralf-Harto Hübner
ERJ Open Research Jan 2020, 00449-2020; DOI: 10.1183/23120541.00449-2020

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Endoscopic lung volume reduction with endobronchial valves in very low DLCO patients: results from the German Registry (Lungenemphysemregister e.V.)
Pavlina Lenga, Christoph Ruwwe-Glösenkamp, Christian Grah, Joachim Pfannschmidt, Jens Rückert, Stephan Eggeling, Sven Gläser, Bernd Schmidt, Paul Schneider, Sylke Kurz, Gunda Leschber, Andreas Gebhardt, Birgit Becke, Olaf Schega, Jakob Borchardt, Ralf-Harto Hübner
ERJ Open Research Jan 2020, 00449-2020; DOI: 10.1183/23120541.00449-2020
del.icio.us logo Digg logo Reddit logo Technorati logo Twitter logo CiteULike logo Connotea logo Facebook logo Google logo Mendeley logo
Full Text (PDF)

Jump To

  • Article
    • Abstract
  • Info & Metrics
  • PDF

Subjects

  • Lung structure and function
  • COPD and smoking
  • Tweet Widget
  • Facebook Like
  • Google Plus One

More in this TOC Section

  • Microbial and clinical factors are related to recurrence of symptoms after childhood lower respiratory tract infection
  • Participation in physical activity is associated with reduced nocturnal hypoxaemia in males
  • Chest computed tomography and alveolar-arterial oxygen gradient as rapid tools to diagnose and triage mildly symptomatic COVID-19 pneumonia patients
Show more Original article

Related Articles

Navigate

  • Home
  • Current issue
  • Archive

About ERJ Open Research

  • Editorial board
  • Journal information
  • Press
  • Permissions and reprints
  • Advertising

The European Respiratory Society

  • Society home
  • myERS
  • Privacy policy
  • Accessibility

ERS publications

  • European Respiratory Journal
  • ERJ Open Research
  • European Respiratory Review
  • Breathe
  • ERS books online
  • ERS Bookshop

Help

  • Feedback

For authors

  • Instructions for authors
  • Submit a manuscript
  • ERS author centre

For readers

  • Alerts
  • Subjects
  • RSS

Subscriptions

  • Accessing the ERS publications

Contact us

European Respiratory Society
442 Glossop Road
Sheffield S10 2PX
United Kingdom
Tel: +44 114 2672860
Email: journals@ersnet.org

ISSN

Online ISSN: 2312-0541

Copyright © 2021 by the European Respiratory Society