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High-dose glucocorticoid treatment of near-fatal Bocavirus lung infection results in rapid recovery

Matthias Obenaus, Oliver Schildgen, Dirk Schürmann, Ann-Christin von Brünneck, Martin Janz, Ulrich Keller, Bernhard Gebauer, Johannes Schilling, Stefan Schwartz, Benedikt Weissbrich, Thomas Schneider, Jörg Hofmann, Stephan Mathas
ERJ Open Research 2021; DOI: 10.1183/23120541.00060-2021
Matthias Obenaus
1Hematology, Oncology and Tumor Immunology, Charité – Universitätsmedizin Berlin, Berlin, Germany
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  • ORCID record for Matthias Obenaus
Oliver Schildgen
2Institute of Pathology, Kliniken der Stadt Köln gGmbH, Kliniken der Privaten Universität Witten/Herdecke mit Sitz in Köln, Köln, Germany
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Dirk Schürmann
3Infectious Diseases and Respiratory Medicine, Charité – Universitätsmedizin Berlin, Berlin, Germany
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Ann-Christin von Brünneck
4Pathology, Charité – Universitätsmedizin Berlin, Berlin, Germany
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Martin Janz
1Hematology, Oncology and Tumor Immunology, Charité – Universitätsmedizin Berlin, Berlin, Germany
5Experimental and Clinical Research Center, a cooperation between the Charité and the Max-Delbrück-Center for Molecular Medicine, Berlin, Germany
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Ulrich Keller
1Hematology, Oncology and Tumor Immunology, Charité – Universitätsmedizin Berlin, Berlin, Germany
5Experimental and Clinical Research Center, a cooperation between the Charité and the Max-Delbrück-Center for Molecular Medicine, Berlin, Germany
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Bernhard Gebauer
6Radiology, Charité – Universitätsmedizin Berlin, Berlin, Germany
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Johannes Schilling
7Nephrology and Medical Intensive Care, Charité – Universitätsmedizin Berlin, Berlin, Germany
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Stefan Schwartz
1Hematology, Oncology and Tumor Immunology, Charité – Universitätsmedizin Berlin, Berlin, Germany
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  • ORCID record for Stefan Schwartz
Benedikt Weissbrich
8Institute for Virology and Immunbiology, University Würzburg, Würzburg, Germany
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Thomas Schneider
9Gastroenterology, Infectious Diseases and Rheumatology, Charité – Universitätsmedizin Berlin, Berlin, Germany
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Jörg Hofmann
10Institute of Virology, Charité – Universitätsmedizin Berlin, Berlin, Germany
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Stephan Mathas
1Hematology, Oncology and Tumor Immunology, Charité – Universitätsmedizin Berlin, Berlin, Germany
5Experimental and Clinical Research Center, a cooperation between the Charité and the Max-Delbrück-Center for Molecular Medicine, Berlin, Germany
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Footnotes

This manuscript has recently been accepted for publication in the ERJ Open Research. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJOR online. Please open or download the PDF to view this article.

Conflict of interest: Dr Obenaus reports personal fees from Novartis, during the conduct of this study.

Conflict of interest: Dr Schildgen has nothing to disclose.

Conflict of interest: Dr Schürmann has nothing to disclose.

Conflict of interest: Dr von Brünneck has nothing to disclose.

Conflict of interest: Dr Janz has nothing to disclose.

Conflict of interest: Dr Keller reportrs personal fees from Takeda, personal fees and other from Roche, personal fees and other from Janssen-Cilag, personal fees from Hexal, personal fees from Abbvie, personal fees and other from Pfizer, personal fees from Pentixapharm, personal fees and other from BMS, personal fees from Astra Zeneca, outside the submitted work.

Conflict of interest: Dr Gebauer reports personal fees from Parexek/CALYX, personal feels from ICON, personal fees from Bayer, personal fees from Siemens, personal fees from Roche, personal fees from Merck, personal fees from IPSEN, personal fees from Pfizer, personal fees from Elsai, personal fees from MSD, personal fees from Pharmcept, personal fees from Guerbet, personal fees from Ewimed, personal fees from Sirtex Medicalm outside the submitted work.

Conflict of interest: Dr Schilling has nothing to disclose.

Conflict of interest: Dr Schwartz reports personal fees from Pfizer, personal feels from BTG Intl Inc, personal fees and non-financial support from Gilead Sciences, personal fees from MSD Sharp & Dohme, non-financial support from Basilea, personal fees and non-financial support from AMGEN, personal fees from Novartis, personal fees and non-financial support from Jazz Pharmaceu9ticals, outside the submitted work.

Conflict of interest: Dr Weissbrich has nothing to disclose.

Conflict of interest: Dr Schneider has nothing to disclose.

Conflict of interest: Dr Hofmann has nothing to disclose.

Conflict of interest: Dr Mathas has nothing to disclose.

This is a PDF-only article. Please click on the PDF link above to read it.

  • Received February 12, 2021.
  • Accepted February 27, 2021.
  • Copyright ©The authors 2021
http://creativecommons.org/licenses/by-nc/4.0/

This version is distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0. For commercial reproduction rights and permissions contact permissions{at}ersnet.org

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High-dose glucocorticoid treatment of near-fatal Bocavirus lung infection results in rapid recovery
Matthias Obenaus, Oliver Schildgen, Dirk Schürmann, Ann-Christin von Brünneck, Martin Janz, Ulrich Keller, Bernhard Gebauer, Johannes Schilling, Stefan Schwartz, Benedikt Weissbrich, Thomas Schneider, Jörg Hofmann, Stephan Mathas
ERJ Open Research Jan 2021, 00060-2021; DOI: 10.1183/23120541.00060-2021

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High-dose glucocorticoid treatment of near-fatal Bocavirus lung infection results in rapid recovery
Matthias Obenaus, Oliver Schildgen, Dirk Schürmann, Ann-Christin von Brünneck, Martin Janz, Ulrich Keller, Bernhard Gebauer, Johannes Schilling, Stefan Schwartz, Benedikt Weissbrich, Thomas Schneider, Jörg Hofmann, Stephan Mathas
ERJ Open Research Jan 2021, 00060-2021; DOI: 10.1183/23120541.00060-2021
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