Skip to main content

Main menu

  • Home
  • Current issue
  • Early View
  • Archive
  • Authors/reviewers
    • Instructions for authors
    • Submit a manuscript
    • COVID-19 submission information
    • Institutional open access agreements
    • Peer reviewer login
  • Alerts
  • Subscriptions
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

User menu

  • Log in
  • Subscribe
  • Contact Us
  • My Cart

Search

  • Advanced search
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

Login

European Respiratory Society

Advanced Search

  • Home
  • Current issue
  • Early View
  • Archive
  • Authors/reviewers
    • Instructions for authors
    • Submit a manuscript
    • COVID-19 submission information
    • Institutional open access agreements
    • Peer reviewer login
  • Alerts
  • Subscriptions

Breastfeeding and risk of childhood asthma: a systematic review and meta-analysis

Mike Xue, Emily Dehaas, Nagendra Chaudhary, Paul O'Byrne, Imran Satia, Om P. Kurmi
ERJ Open Research 2021; DOI: 10.1183/23120541.00504-2021
Mike Xue
1Department of Family Medicine, Queen's University, Kingston, Canada
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Emily Dehaas
2Department of Medicine, University of Toronto, Toronto, Canada
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Nagendra Chaudhary
3Department of Pediatrics, Universal College of Medical Sciences, Bhairahawa, Nepal
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Nagendra Chaudhary
Paul O'Byrne
4Department of Medicine, Division of Respirology, McMaster University, Hamilton, Canada
5Firestone Institute for Respiratory Health, St Joseph's Healthcare, Hamilton, Canada
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Imran Satia
4Department of Medicine, Division of Respirology, McMaster University, Hamilton, Canada
5Firestone Institute for Respiratory Health, St Joseph's Healthcare, Hamilton, Canada
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Imran Satia
Om P. Kurmi
4Department of Medicine, Division of Respirology, McMaster University, Hamilton, Canada
5Firestone Institute for Respiratory Health, St Joseph's Healthcare, Hamilton, Canada
6Faculty Centre for Intelligent Healthcare, Faculty of Health and Life Sciences, Coventry University, Coventry, UK
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: om.kurmi@coventry.ac.uk
  • Article
  • Info & Metrics
  • PDF
Loading

Abstract

Objective To investigate the relationship between breastfeeding and the development of pediatric asthma.

Methods A systematic review and meta-analysis was conducted with MEDLINE, EMBASE, CINAHL and ProQuest Nursing and Allied Health source databases. Retrospective/prospective cohorts in children <18 years old with breastfeeding exposure reported were included. The primary outcome was a diagnosis of asthma by a physician or using a guideline-based criterion. A secondary outcome was asthma severity.

Results Forty-two studies met inclusion criteria. Thirty-seven studies reported the primary outcome of physician/guideline-diagnosed asthma, and five studies reported effects on asthma severity. Children with longer duration/more breastfeeding compared to less have a lower risk of asthma (OR=0.84; 95% CI: 0.75–0.93, I2=62.4%). Similarly, a lower risk of asthma was found in children who had more exclusive breastfeeding versus less exclusive breastfeeding (0.81; 0.72–0.91, I2=44%). Further stratified analysis of different age groups demonstrated a lower risk of asthma in the 0–2 age group (0.73; 0.63–0.83) and the 3–6 age group (0.69; 0.55–0.87), there was no statistically significant effect on the 7+ age group.

Conclusion The finding suggests that the duration and exclusivity of breastfeeding are associated with a lower risk of asthma in children less than seven years of age.

Footnotes

This manuscript has recently been accepted for publication in the ERJ Open Research. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJOR online. Please open or download the PDF to view this article.

Conflict of interest: Mike Xue has nothing to disclose.

Conflict of interest: Emily Dehaas has nothing to disclose.

Conflict of interest: Nagendra Chaudhary has nothing to disclose.

Conflict of interest: Paul O'Byrne has nothing to disclose.

Conflict of interest: Imran Satia has nothing to disclose.

Conflict of interest: Om P Kurmi has nothing to disclose.

This is a PDF-only article. Please click on the PDF link above to read it.

  • Received August 12, 2021.
  • Accepted August 15, 2021.
  • Copyright ©The authors 2021
http://creativecommons.org/licenses/by-nc/4.0/

This version is distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0. For commercial reproduction rights and permissions contact permissions{at}ersnet.org

PreviousNext
Back to top
Vol 9 Issue 1 Table of Contents
ERJ Open Research: 9 (1)
  • Table of Contents
  • Index by author
Email

Thank you for your interest in spreading the word on European Respiratory Society .

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Breastfeeding and risk of childhood asthma: a systematic review and meta-analysis
(Your Name) has sent you a message from European Respiratory Society
(Your Name) thought you would like to see the European Respiratory Society web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Print
Citation Tools
Breastfeeding and risk of childhood asthma: a systematic review and meta-analysis
Mike Xue, Emily Dehaas, Nagendra Chaudhary, Paul O'Byrne, Imran Satia, Om P. Kurmi
ERJ Open Research Jan 2021, 00504-2021; DOI: 10.1183/23120541.00504-2021

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Breastfeeding and risk of childhood asthma: a systematic review and meta-analysis
Mike Xue, Emily Dehaas, Nagendra Chaudhary, Paul O'Byrne, Imran Satia, Om P. Kurmi
ERJ Open Research Jan 2021, 00504-2021; DOI: 10.1183/23120541.00504-2021
del.icio.us logo Digg logo Reddit logo Technorati logo Twitter logo CiteULike logo Connotea logo Facebook logo Google logo Mendeley logo
Full Text (PDF)

Jump To

  • Article
    • Abstract
  • Info & Metrics
  • PDF

Subjects

  • Asthma and allergy
  • Paediatric pulmonology
  • Tweet Widget
  • Facebook Like
  • Google Plus One

More in this TOC Section

  • Adding a biologic to allergen immunotherapy increases treatment efficacy
  • Modifiable lifestyle risk factors for sarcoidosis: a nested case-control study
  • EBUS-guided transbronchial mediastinal cryobiopsy in the diagnosis of mediastinal lesions: safety, feasibility and diagnostic yield – experience in 50 cases
Show more Original research article

Related Articles

Navigate

  • Home
  • Current issue
  • Archive

About ERJ Open Research

  • Editorial board
  • Journal information
  • Press
  • Permissions and reprints
  • Advertising

The European Respiratory Society

  • Society home
  • myERS
  • Privacy policy
  • Accessibility

ERS publications

  • European Respiratory Journal
  • ERJ Open Research
  • European Respiratory Review
  • Breathe
  • ERS books online
  • ERS Bookshop

Help

  • Feedback

For authors

  • Instructions for authors
  • Publication ethics and malpractice
  • Submit a manuscript

For readers

  • Alerts
  • Subjects
  • RSS

Subscriptions

  • Accessing the ERS publications

Contact us

European Respiratory Society
442 Glossop Road
Sheffield S10 2PX
United Kingdom
Tel: +44 114 2672860
Email: journals@ersnet.org

ISSN

Online ISSN: 2312-0541

Copyright © 2023 by the European Respiratory Society