Predicting the benefits of type-2 targeted anti-inflammatory treatment with the prototype OxfoRd Asthma attaCk risk scaLE (ORACLE)

Footnotes

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Conflict of interest: Simon Couillard received a non-restricted research grant from Sanofi-Genzyme for investigator-initiated type 2 innovation research and received speaker honoraria from GlaxoSmithKline, Sanofi-Regeneron and AstraZeneca; outside the submitted work.

Conflict of interest: William Il Hoon Do is co-founder and sharehold of the Albus Health company; outside the submitted work.

Conflict of interest: Richard Beasley has received honoraria for presentations or consulting in Adboards from AstraZeneca, Asthma and Respiratory Foundation of New Zealand, Avillion, Cipla and Theravance; and research grants from AstraZeneca, CureKids (NZ), Genentech, and the Health Research Council of New Zealand.

Conflict of interest: Timothy S. C. Hinks has received grants from the Wellcome Trust, The Guardians of the Beit Fellowship, Pfizer Inc., Kymab Ltd, University of Oxford, Sensyne Health and Sanofi Genzyme; outside the submitted work. He has received personal fees from Astra Zeneca, personal fees from TEVA, personal fees from Omniprex and personal fees from Peer Voice outside the submitted work.

Conflict of interest: Ian D. Pavord In the last 5 years, IP has received speaker's honoraria for speaking at sponsored meetings from AstraZeneca, Boehringer Ingelheim, Aerocrine AB, Almirall, Novartis, Teva, Chiesi, Sanofi/Regeneron, Menarini, and GSK, and payments for organising educational events from AstraZeneca, GSK, Sanofi/Regeneron, and Teva. He has received honoraria for attending advisory panels with Genentech, Sanofi/Regeneron, AstraZeneca, Boehringer Ingelheim, GSK, Novartis, Teva, Merck, Circassia, Chiesi, and Knopp, and payments to support FDA approval meetings from GSK. He has received sponsorship to attend international scientific meetings from Boehringer Ingelheim, GSK, AstraZeneca, Teva, and Chiesi. He has received grants from Chiesi and Sanofi Genzyme. He is co-patent holder of the rights to the Leicester Cough Questionnaire and has received payments for its use in clinical trials from Merck, Bayer, and Insmed. In 2014-2015 he was an expert witness for a patent dispute involving AstraZeneca and Teva.