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Vascular remodelling in IPF patients and its detrimental effect on lung physiology: potential role of endothelial to mesenchymal transition (EndMT)

Archana Vijay Gaikwad, Wenying Lu, Surajit Dey, Prem Bhattarai, Collin Chia, Josie Larby, Greg Haug, Stephen Myers, Jade Jaffar, Glen Westall, Gurpreet Kaur Singhera, Tillie-Louise Hackett, James Markos, Mathew Suji Eapen, Sukhwinder Singh Sohal
ERJ Open Research 2022; DOI: 10.1183/23120541.00571-2021
Archana Vijay Gaikwad
1Respiratory Translational Research Group, Department of Laboratory Medicine, School of Health Sciences, College of Health and Medicine, University of Tasmania, Launceston, Tasmania, Australia
2National Health and Medical Research Council (NHMRC) Centre of Research Excellence (CRE) in Pulmonary Fibrosis, Australia
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Wenying Lu
1Respiratory Translational Research Group, Department of Laboratory Medicine, School of Health Sciences, College of Health and Medicine, University of Tasmania, Launceston, Tasmania, Australia
2National Health and Medical Research Council (NHMRC) Centre of Research Excellence (CRE) in Pulmonary Fibrosis, Australia
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Surajit Dey
1Respiratory Translational Research Group, Department of Laboratory Medicine, School of Health Sciences, College of Health and Medicine, University of Tasmania, Launceston, Tasmania, Australia
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Prem Bhattarai
1Respiratory Translational Research Group, Department of Laboratory Medicine, School of Health Sciences, College of Health and Medicine, University of Tasmania, Launceston, Tasmania, Australia
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Collin Chia
1Respiratory Translational Research Group, Department of Laboratory Medicine, School of Health Sciences, College of Health and Medicine, University of Tasmania, Launceston, Tasmania, Australia
3Department of Respiratory Medicine, Launceston General Hospital, Launceston, Tasmania , Australia
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Josie Larby
1Respiratory Translational Research Group, Department of Laboratory Medicine, School of Health Sciences, College of Health and Medicine, University of Tasmania, Launceston, Tasmania, Australia
3Department of Respiratory Medicine, Launceston General Hospital, Launceston, Tasmania , Australia
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Greg Haug
1Respiratory Translational Research Group, Department of Laboratory Medicine, School of Health Sciences, College of Health and Medicine, University of Tasmania, Launceston, Tasmania, Australia
3Department of Respiratory Medicine, Launceston General Hospital, Launceston, Tasmania , Australia
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Stephen Myers
1Respiratory Translational Research Group, Department of Laboratory Medicine, School of Health Sciences, College of Health and Medicine, University of Tasmania, Launceston, Tasmania, Australia
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Jade Jaffar
4Department of Allergy, Immunology and Respiratory Medicine, The Alfred Hospital, Melbourne, Australia
5Department of Immunology and Pathology, Monash University, Melbourne, Australia
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Glen Westall
4Department of Allergy, Immunology and Respiratory Medicine, The Alfred Hospital, Melbourne, Australia
5Department of Immunology and Pathology, Monash University, Melbourne, Australia
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Gurpreet Kaur Singhera
6Department of Anaesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, BC, Canada
7Centre for Heart Lung Innovation, St. Paul's Hospital, Vancouver, BC, Canada
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Tillie-Louise Hackett
6Department of Anaesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, BC, Canada
7Centre for Heart Lung Innovation, St. Paul's Hospital, Vancouver, BC, Canada
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James Markos
1Respiratory Translational Research Group, Department of Laboratory Medicine, School of Health Sciences, College of Health and Medicine, University of Tasmania, Launceston, Tasmania, Australia
3Department of Respiratory Medicine, Launceston General Hospital, Launceston, Tasmania , Australia
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Mathew Suji Eapen
1Respiratory Translational Research Group, Department of Laboratory Medicine, School of Health Sciences, College of Health and Medicine, University of Tasmania, Launceston, Tasmania, Australia
2National Health and Medical Research Council (NHMRC) Centre of Research Excellence (CRE) in Pulmonary Fibrosis, Australia
8Equal contributors
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Sukhwinder Singh Sohal
1Respiratory Translational Research Group, Department of Laboratory Medicine, School of Health Sciences, College of Health and Medicine, University of Tasmania, Launceston, Tasmania, Australia
8Equal contributors
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  • For correspondence: sssohal@utas.edu.au
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Article Information

DOI 
https://doi.org/10.1183/23120541.00571-2021

Published By 
European Respiratory Society
Online ISSN 
2312-0541
History 
  • Received September 30, 2021
  • Accepted January 10, 2022
  • Published online February 3, 2022.

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  • You are currently viewing a previous version of this article (February 3, 2022 - 08:46).
  • View the most recent version of this article
Copyright & Usage 
Copyright ©The authors 2022 This version is distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0. For commercial reproduction rights and permissions contact permissions@ersnet.org

Author Information

  1. Archana Vijay Gaikwad1,2,
  2. Wenying Lu1,2,
  3. Surajit Dey1,
  4. Prem Bhattarai1,
  5. Collin Chia1,3,
  6. Josie Larby1,3,
  7. Greg Haug1,3,
  8. Stephen Myers1,
  9. Jade Jaffar4,5,
  10. Glen Westall4,5,
  11. Gurpreet Kaur Singhera6,7,
  12. Tillie-Louise Hackett6,7,
  13. James Markos1,3,
  14. Mathew Suji Eapen1,2,8 and
  15. Sukhwinder Singh Sohal1,8⇑
  1. 1Respiratory Translational Research Group, Department of Laboratory Medicine, School of Health Sciences, College of Health and Medicine, University of Tasmania, Launceston, Tasmania, Australia
  2. 2National Health and Medical Research Council (NHMRC) Centre of Research Excellence (CRE) in Pulmonary Fibrosis, Australia
  3. 3Department of Respiratory Medicine, Launceston General Hospital, Launceston, Tasmania , Australia
  4. 4Department of Allergy, Immunology and Respiratory Medicine, The Alfred Hospital, Melbourne, Australia
  5. 5Department of Immunology and Pathology, Monash University, Melbourne, Australia
  6. 6Department of Anaesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, BC, Canada
  7. 7Centre for Heart Lung Innovation, St. Paul's Hospital, Vancouver, BC, Canada
  8. 8Equal contributors
  1. Corresponding author: Sukhwinder Sohal (sssohal{at}utas.edu.au)
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Funding

  • Lung Foundation Australia

  • Clifford Craig Foundation Launceston General Hospital

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Vascular remodelling in IPF patients and its detrimental effect on lung physiology: potential role of endothelial to mesenchymal transition (EndMT)
Archana Vijay Gaikwad, Wenying Lu, Surajit Dey, Prem Bhattarai, Collin Chia, Josie Larby, Greg Haug, Stephen Myers, Jade Jaffar, Glen Westall, Gurpreet Kaur Singhera, Tillie-Louise Hackett, James Markos, Mathew Suji Eapen, Sukhwinder Singh Sohal
ERJ Open Research Jan 2022, 00571-2021; DOI: 10.1183/23120541.00571-2021

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Vascular remodelling in IPF patients and its detrimental effect on lung physiology: potential role of endothelial to mesenchymal transition (EndMT)
Archana Vijay Gaikwad, Wenying Lu, Surajit Dey, Prem Bhattarai, Collin Chia, Josie Larby, Greg Haug, Stephen Myers, Jade Jaffar, Glen Westall, Gurpreet Kaur Singhera, Tillie-Louise Hackett, James Markos, Mathew Suji Eapen, Sukhwinder Singh Sohal
ERJ Open Research Jan 2022, 00571-2021; DOI: 10.1183/23120541.00571-2021
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