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Interstitial lung disease incidence and mortality in the United Kingdom and the European Union: an observational study, 2001–2017

Justin D. Salciccioli, Dominic C. Marshall, Richard Goodall, Conor Crowley, Joseph Shalhoub, Preya Patel, Philip L. Molyneaux
ERJ Open Research 2022; DOI: 10.1183/23120541.00058-2022
Justin D. Salciccioli
1Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
2Honorary Clinical Research Fellow, Department of Surgery and Cancer, Imperial College London, UK
3Medical Data Research Collaborative
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  • ORCID record for Justin D. Salciccioli
  • For correspondence: jsalciccioli@bwh.harvard.edu
Dominic C. Marshall
2Honorary Clinical Research Fellow, Department of Surgery and Cancer, Imperial College London, UK
3Medical Data Research Collaborative
4Guy's and St Thomas’ NHS Foundation Trust, London, UK
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Richard Goodall
2Honorary Clinical Research Fellow, Department of Surgery and Cancer, Imperial College London, UK
3Medical Data Research Collaborative
5Oxford University Hospitals NHS Foundation Trust, Oxford, UK
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Conor Crowley
6Department of Critical Care, Lahey Hospital and Medical Center, Burlington, MA, USA
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Joseph Shalhoub
3Medical Data Research Collaborative
7Imperial College Healthcare NHS Trust & Honorary Clinical Senior Lecturer, Imperial College London, UK
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Preya Patel
8Department of Internal Medicine, The Wright Center, Scranton, PA, USA
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Philip L. Molyneaux
2Honorary Clinical Research Fellow, Department of Surgery and Cancer, Imperial College London, UK
9Royal Brompton and Harefield Hospitals, Guy's and St Thomas’ NHS Foundation Trust London, UK
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Abstract

Objective To compare the trends in age-standardised incidence and mortality from interstitial lung diseases (ILD) in the United Kingdom (UK) and the European Union (EU).

Design Observational study using data obtained from the Global Burden of Disease Study.

Setting and Participants Residents of the UK and of the twenty-seven EU countries.

Main outcome measures ILD age-standardised incidence rates per 100 000 (ASIR), age-standardised death rates per 100 000 (ASDR), and mortality-to-incidence ratio (MIRs) are presented for males and females separately for each country, for the years 2001–2017. Trends were analysed using Joinpoint regression analysis.

Results For men, in 2017, the median incidence of ILD was 7.22 (IQR 5.57–8.96) per 100 000 population. For women, in 2017, the median incidence of ILD was 4.34 (IQR 3.36–6.29) per 100 000 population. For men, in 2017, the median ASDR attributed to ILD was 2.04 (IQR 1.13–2.71) per 100 000 population. For women, the median ASDR in 2017 for ILD was 1.02 (0.68–1.37) per 100 000 population. There was an overall increase in ASDR during the observation period with a median change of +20.42% (IQR 5.44–31.40) for men and an increase of +15.44% (IQR −1.01–31.52) for women. Despite increases in mortality over the entire observation period, there were decreasing mortality trends in the majority of countries at the end of the observation period (75% for men and 86% for women).

Conclusion Over the past two decades, there have been increases in the incidence and mortality of interstitial lung diseases in Europe. The most recent trends, however, demonstrate decreases in mortality from ILD in the majority of European countries for both men and women. These data support the ongoing improvements in the diagnosis and management of ILD.

Footnotes

This manuscript has recently been accepted for publication in the ERJ Open Research. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJOR online. Please open or download the PDF to view this article.

Conflict of interest: Dr. Salciccioli has nothing to disclose.

Conflict of interest: Dr. Marshall has nothing to disclose.

Conflict of interest: Dr. Goodall has nothing to disclose.

Conflict of interest: Conor Crowley has nothing to disclose.

Conflict of interest: Dr. Shalhoub reports grants from UK National Institute for Health Research, outside the submitted work.

Conflict of interest:

Conflict of interest: Dr. Molyneaux, via his institution received industry-academic funding from AstraZeneca and has received speaker and consultancy fees from Boehringer Ingelheim and Hoffman-La Roche outside the submitted work.

This is a PDF-only article. Please click on the PDF link above to read it.

  • Received January 31, 2022.
  • Accepted April 6, 2022.
  • Copyright ©The authors 2022
http://creativecommons.org/licenses/by-nc/4.0/

This version is distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0. For commercial reproduction rights and permissions contact permissions{at}ersnet.org

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Interstitial lung disease incidence and mortality in the United Kingdom and the European Union: an observational study, 2001–2017
Justin D. Salciccioli, Dominic C. Marshall, Richard Goodall, Conor Crowley, Joseph Shalhoub, Preya Patel, Philip L. Molyneaux
ERJ Open Research Jan 2022, 00058-2022; DOI: 10.1183/23120541.00058-2022

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Interstitial lung disease incidence and mortality in the United Kingdom and the European Union: an observational study, 2001–2017
Justin D. Salciccioli, Dominic C. Marshall, Richard Goodall, Conor Crowley, Joseph Shalhoub, Preya Patel, Philip L. Molyneaux
ERJ Open Research Jan 2022, 00058-2022; DOI: 10.1183/23120541.00058-2022
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