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COL18A1 genotypic associations with endostatin levels and clinical features in pulmonary arterial hypertension: a quantitative trait association study

Catherine E. Simpson, Megan Griffiths, Jun Yang, Melanie K. Nies, R. Dhananjay Vaidya, Stephanie Brandal, Lisa J. Martin, Michael W. Pauciulo, Katie A. Lutz, Anna W. Coleman, Eric D. Austin, D. Dunbar Ivy, William C. Nichols, Allen D. Everett, Paul M. Hassoun, Rachel L. Damico
ERJ Open Research 2022; DOI: 10.1183/23120541.00725-2021
Catherine E. Simpson
1Johns Hopkins University, Department of Medicine, Division of Pulmonary and Critical Care Medicine, Baltimore, Maryland, United States
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  • ORCID record for Catherine E. Simpson
  • For correspondence: catherine.simpson@jhmi.edu
Megan Griffiths
2Johns Hopkins University, Department of Pediatrics, Division of Pediatric Cardiology, Baltimore, Maryland, United States
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Jun Yang
2Johns Hopkins University, Department of Pediatrics, Division of Pediatric Cardiology, Baltimore, Maryland, United States
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Melanie K. Nies
2Johns Hopkins University, Department of Pediatrics, Division of Pediatric Cardiology, Baltimore, Maryland, United States
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R. Dhananjay Vaidya
3Johns Hopkins University, Department of Medicine, Division of General Internal Medicine, Baltimore, Maryland, United States
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Stephanie Brandal
2Johns Hopkins University, Department of Pediatrics, Division of Pediatric Cardiology, Baltimore, Maryland, United States
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Lisa J. Martin
4Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine, Department of Pediatrics, Division of Human Genetics, Cincinnati, Ohio, Unites States
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Michael W. Pauciulo
4Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine, Department of Pediatrics, Division of Human Genetics, Cincinnati, Ohio, Unites States
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Katie A. Lutz
4Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine, Department of Pediatrics, Division of Human Genetics, Cincinnati, Ohio, Unites States
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Anna W. Coleman
4Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine, Department of Pediatrics, Division of Human Genetics, Cincinnati, Ohio, Unites States
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Eric D. Austin
5Vanderbilt University, Department of Pediatrics, Division of Allergy, Immunology, and Pulmonary Medicine
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D. Dunbar Ivy
6Children's Hospital Colorado, Department of Pediatric Cardiology
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William C. Nichols
4Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine, Department of Pediatrics, Division of Human Genetics, Cincinnati, Ohio, Unites States
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Allen D. Everett
2Johns Hopkins University, Department of Pediatrics, Division of Pediatric Cardiology, Baltimore, Maryland, United States
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Paul M. Hassoun
1Johns Hopkins University, Department of Medicine, Division of Pulmonary and Critical Care Medicine, Baltimore, Maryland, United States
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Rachel L. Damico
1Johns Hopkins University, Department of Medicine, Division of Pulmonary and Critical Care Medicine, Baltimore, Maryland, United States
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Footnotes

This manuscript has recently been accepted for publication in the ERJ Open Research. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJOR online. Please open or download the PDF to view this article.

Conflict of interest: Catherine E. Simpson reports support for the present manuscript received from NIH/NHLBI grants.

Conflict of interest: Megan Griffiths reports support for the present manuscript received from NIH/NHLBI grants.

Conflict of interest: Jun Yang has nothing to disclose.

Conflict of interest: Melanie K. Nies has nothing to disclose.

Conflict of interest: Dhananjay Vaidya reports receiving grants or contacts outside the submitted work from National Institutes of Health.

Conflict of interest: Stephanie Brandal has nothing to disclose.

Conflict of interest: Lisa J. Martin reports support for the present manuscript received from NIH/NHLBI grants.

Conflict of interest: Michael W. Pauciulo has nothing to disclose.

Conflict of interest: Katie A. Lutz has nothing to disclose.

Conflict of interest: Anna W. Coleman has nothing to disclose.

Conflict of interest: Eric D. Austin reports support for the present manuscript received from NIH/NHLBI grants. Grants or contracts received from CMREF, outside the submitted work.

Conflict of interest: D. Dunbar Ivy reports support for the present manuscript received from NIH/NHLBI grants. Consulting fees received from The University of Colorado contracts with Actelion, Altavant, Bayer, and Gossamer Bio, outside the submitted work.

Conflict of interest: William C. Nichols reports support for the present manuscript received from NIH/NHLBI grants.

Conflict of interest: Allen D. Everett reports support for the present manuscript received from NIH/NHLBI grants.

Conflict of interest: Paul M. Hassoun reports receiving grants or contacts outside the submitted work from NIH/NHLBI. Participation on a Data Safety Monitoring Board or Advisory Board for PMH serves on a scientific Advisory Board for MSD. This activity is unrelated to the current work.

Conflict of interest: Rachel L. Damico reports support for the present manuscript received from NIH/NHLBI grants.

This is a PDF-only article. Please click on the PDF link above to read it.

  • Received December 28, 2021.
  • Accepted April 29, 2022.
  • Copyright ©The authors 2022
http://creativecommons.org/licenses/by-nc/4.0/

This version is distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0. For commercial reproduction rights and permissions contact permissions{at}ersnet.org

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COL18A1 genotypic associations with endostatin levels and clinical features in pulmonary arterial hypertension: a quantitative trait association study
Catherine E. Simpson, Megan Griffiths, Jun Yang, Melanie K. Nies, R. Dhananjay Vaidya, Stephanie Brandal, Lisa J. Martin, Michael W. Pauciulo, Katie A. Lutz, Anna W. Coleman, Eric D. Austin, D. Dunbar Ivy, William C. Nichols, Allen D. Everett, Paul M. Hassoun, Rachel L. Damico
ERJ Open Research Jan 2022, 00725-2021; DOI: 10.1183/23120541.00725-2021

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COL18A1 genotypic associations with endostatin levels and clinical features in pulmonary arterial hypertension: a quantitative trait association study
Catherine E. Simpson, Megan Griffiths, Jun Yang, Melanie K. Nies, R. Dhananjay Vaidya, Stephanie Brandal, Lisa J. Martin, Michael W. Pauciulo, Katie A. Lutz, Anna W. Coleman, Eric D. Austin, D. Dunbar Ivy, William C. Nichols, Allen D. Everett, Paul M. Hassoun, Rachel L. Damico
ERJ Open Research Jan 2022, 00725-2021; DOI: 10.1183/23120541.00725-2021
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