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COVID-19 in patients with Pulmonary Alveolar Proteinosis A European multicenter study

Spyros A. Papiris, Ilaria Campo, Francesca Mariani, Maria Kallieri, Lykourgos Kolilekas, Andriana I Papaioannou, Efsun Gonca Chousein, Erdogan Cetinkaya, Francesco Bonella, Raphael Borie, Maria Kokosi, Thomas Pickworth, Maria Molina-Molina, Mercè Gasa, Elżbieta Radzikowska, Justyna Fijolek, Stéphane Jouneau, Emmanuel Gomez, Cormac McCarthy, Elisabeth Bendstrup, Wojciech J. Piotrowski, Rishi Pabary, Alice Hadchouel, Nathalie Coolen-Allou, Tiago Alfaro, Carlos Robalo Cordeiro, Elvira-Markela Antonogiannaki, Ioannis P. Tomos, Despoina Papakosta, Theodoros Kontakiotis, Panagiota Panagiotou, Konstantinos Douros, Andrea Schams, Sara Lettieri, Vassiliki Papaevangelou, Christina Kanaka-Gantenbein, Anna Karakatsani, Stelios Loukides, Ulrich Costabel, Bruno Crestani, Cliff Morgan, Ryushi Tazawa, Andrew Bush, Matthias Griese, Effrosyni D. Manali
ERJ Open Research 2022; DOI: 10.1183/23120541.00199-2022
Spyros A. Papiris
1General University Hospital “Attikon”, Medical School, National and Kapodistrian University of Athens, Greece.
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Ilaria Campo
2Laboratorio di Biochimica e Genetica, U.O.C. Pneumologia, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
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Francesca Mariani
2Laboratorio di Biochimica e Genetica, U.O.C. Pneumologia, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
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Maria Kallieri
1General University Hospital “Attikon”, Medical School, National and Kapodistrian University of Athens, Greece.
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Lykourgos Kolilekas
3Dr Lykourgos Kolilekas, 7th Pulmonary Department, Athens Chest Hospital “Sotiria”, Athens Greece
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Andriana I Papaioannou
1General University Hospital “Attikon”, Medical School, National and Kapodistrian University of Athens, Greece.
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Efsun Gonca Chousein
4University of Health Sciences Turkey, Yedikule Chest Diseases and Thoracic Surgery Research and Training Hospital, İstanbul, Turkey
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Erdogan Cetinkaya
4University of Health Sciences Turkey, Yedikule Chest Diseases and Thoracic Surgery Research and Training Hospital, İstanbul, Turkey
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Francesco Bonella
5Center for Interstitial and Rare Lung Diseases, Pneumology Department, Ruhrlandklinik, University Hospital, University of Essen, Essen, Germany; European Reference Network (ERN)-LUNG, ILD Core Net, Francesco
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Raphael Borie
6Université de Paris, INSERM UMR 1152, Paris, France, APHP, Hôpital Bichat, Service de Pneumologie A, FHU APOLLO, Centre de référence des maladies pulmonaires rares, Paris, France
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Maria Kokosi
7Interstitial Lung Disease Unit, Royal Brompton Hospital & Harefield NHS Foundation Trust, London, UK; Interstitial Lung Disease Unit, Guy's and St Thomas’ Hospital NHS Foundation Trust, Great Maze Pond, London, UK
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Thomas Pickworth
8Department of Anaesthesia, Royal Brompton Hospital, London, UK
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Maria Molina-Molina
9ILD Multidisciplinary Unit Hospital Universitari de Bellvitge-IDIBELL, L'Hospitalet del Llobregat, Barcelona, Spain
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Mercè Gasa
9ILD Multidisciplinary Unit Hospital Universitari de Bellvitge-IDIBELL, L'Hospitalet del Llobregat, Barcelona, Spain
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Elżbieta Radzikowska
103rd Department of Lung Diseases and Oncology, National Tuberculosis and Lung Diseases Research Institute, Warsaw, Poland
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Justyna Fijolek
103rd Department of Lung Diseases and Oncology, National Tuberculosis and Lung Diseases Research Institute, Warsaw, Poland
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Stéphane Jouneau
11IRSET UMR 1085, Université de Rennes Service de Pneumologie, CHU de Rennes, France
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Emmanuel Gomez
12Pneumologie, CHU de Nancy
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Cormac McCarthy
13University College Dublin School of Medicine Education and Research Centre, St. Vincent's University Hospital, Dublin 4, Ireland
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Elisabeth Bendstrup
14Center for Rare Lung diseases, Department of Respiratory Diseases and Allergy, Aarhus University Hospital, Denmark
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Wojciech J. Piotrowski
15Department of Pneumonology, 2nd Chair of Internal Medicine, Medical University of Lodz, Lodz
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Rishi Pabary
16Paediatrics and Paediatric Respirology, Imperial College, UK; Imperial Centre for Paediatrics and Child Health, UK, Royal Brompton Harefield NHS Foundation Trust, London, UK
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Alice Hadchouel
17AP-HP, Hôpital Necker-Enfants Malades, Service de Pneumologie Pédiatrique, Centre de Référence pour les Maladies Respiratoires Rares de l'Enfant, Paris, France, INSERM U1151, Institut Necker Enfants Malades, Paris, France, Université de Paris, Faculté de Médecine, Paris, France
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Nathalie Coolen-Allou
18Service de Pneumologie Hôpital Félix Guyon, CHU Réunion
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Tiago Alfaro
19Department of Pulmonology, Coimbra Univesrity Hospital, Univesrity of Coimbra, Portugal
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Carlos Robalo Cordeiro
19Department of Pulmonology, Coimbra Univesrity Hospital, Univesrity of Coimbra, Portugal
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Elvira-Markela Antonogiannaki
1General University Hospital “Attikon”, Medical School, National and Kapodistrian University of Athens, Greece.
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Ioannis P. Tomos
1General University Hospital “Attikon”, Medical School, National and Kapodistrian University of Athens, Greece.
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Despoina Papakosta
20A Department of Pulmonary Medicine, Aristotle University of Thessaloniki, “G. Papanikolaou” Hospital, Exochi, Thessaloniki, Greece
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Theodoros Kontakiotis
20A Department of Pulmonary Medicine, Aristotle University of Thessaloniki, “G. Papanikolaou” Hospital, Exochi, Thessaloniki, Greece
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Panagiota Panagiotou
21First Department of Paediatrics, Agia Sophia Children's Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece
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Konstantinos Douros
22Third Department of Pediatrics “Attikon” University Hospital, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece
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Andrea Schams
23Department of Pediatric Pneumology, Dr von Hauner Children's Hospital, Ludwig-Maximilians-University, German Center for Lung Research, Munich, Germany
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Sara Lettieri
2Laboratorio di Biochimica e Genetica, U.O.C. Pneumologia, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
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Vassiliki Papaevangelou
22Third Department of Pediatrics “Attikon” University Hospital, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece
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Christina Kanaka-Gantenbein
21First Department of Paediatrics, Agia Sophia Children's Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece
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Anna Karakatsani
1General University Hospital “Attikon”, Medical School, National and Kapodistrian University of Athens, Greece.
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Stelios Loukides
1General University Hospital “Attikon”, Medical School, National and Kapodistrian University of Athens, Greece.
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Ulrich Costabel
5Center for Interstitial and Rare Lung Diseases, Pneumology Department, Ruhrlandklinik, University Hospital, University of Essen, Essen, Germany; European Reference Network (ERN)-LUNG, ILD Core Net, Francesco
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Bruno Crestani
6Université de Paris, INSERM UMR 1152, Paris, France, APHP, Hôpital Bichat, Service de Pneumologie A, FHU APOLLO, Centre de référence des maladies pulmonaires rares, Paris, France
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Cliff Morgan
7Interstitial Lung Disease Unit, Royal Brompton Hospital & Harefield NHS Foundation Trust, London, UK; Interstitial Lung Disease Unit, Guy's and St Thomas’ Hospital NHS Foundation Trust, Great Maze Pond, London, UK
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Ryushi Tazawa
24Health Administration Center, Tokyo Medical and Dental University, Tokyo, Japan
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Andrew Bush
16Paediatrics and Paediatric Respirology, Imperial College, UK; Imperial Centre for Paediatrics and Child Health, UK, Royal Brompton Harefield NHS Foundation Trust, London, UK
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Matthias Griese
23Department of Pediatric Pneumology, Dr von Hauner Children's Hospital, Ludwig-Maximilians-University, German Center for Lung Research, Munich, Germany
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Effrosyni D. Manali
1General University Hospital “Attikon”, Medical School, National and Kapodistrian University of Athens, Greece.
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  • For correspondence: fmanali@otenet.gr
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Footnotes

This manuscript has recently been accepted for publication in the ERJ Open Research. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJOR online. Please open or download the PDF to view this article.

Conflict of interest: Dr. Papiris reports grants, personal fees and non-financial support from La Roche Hoffman , grants, personal fees and non-financial support from Boehringer Ingelheim , other from SAVARA , outside the submitted work.

Conflict of interest: Dr. Bonella reports grants and personal fees from Savara Pharma, outside the submitted work.

Conflict of interest: Raphael Borie has received consulting fees from Boerhinger Ingelheim, Roche, and Sanofi, outside the submitted work. Payment or honoraria for lectures, presentations, speakers bureaus, manuscript writing or educational events received from Boerhinger Ingelheim and Roche, outside the submitted work. Support for attending meetings and/or travel received from Boerhinger Ingelheim, Roche, and Chiesim outside the submitted work. Participation on a Data Safety Monitoring Board or Advisory Board for SAvara, outside the submitted work.

Conflict of interest: Dr. MOLINA MOLINA reports personal fees and grants from Esteve-Teijin, Roche, and Boehringer Ing., outside the submitted work.

Conflict of interest: Dr. Bendstrup reports grants and personal fees from Boehringer Ingelheim, grants and personal fees from Hofmann la Roche, personal fees from Galapagos, outside the submitted work.

Conflict of interest: Dr. Jouneau reports personal fees and other from Actelion, personal fees and other from AIRB, personal fees and other from AstraZeneca, personal fees and other from Bellerophon Therapeutics, personal fees and other from Biogen, personal fees and other from BMS, personal fees and other from Boehringer Ingelheim, personal fees and other from Chiesi, personal fees and other from FibroGen, personal fees and other from Galecto Biotech, personal fees and other from Genzyme, personal fees and other from Gilead, personal fees and other from GlaxoSmithKline, personal fees and other from LVL, personal fees and other from Mundipharma, personal fees and other from Novartis, personal fees and other from Pharm-Olam, personal fees and other from Pfizer, personal fees and other from Pliant Therapeutics, personal fees and other from F. Hoffmann-La Roche, Ltd., personal fees and other from Sanofi, personal fees and other from Savara-Serendex, outside the submitted work.

Conflict of interest: Dr. McCarthy reports and Scientific advisory board member of Savara Inc. Unrelated to this work and have not received any payment from Savara Inc for any work to date.

Conflict of interest: Matthias Griese has received grants or contracts from Böhringer Ingelheim, outside the submitted work. Participation on a Data Safety Monitoring Board or Advisory Board for Böhringer Ingelheim, outside the submitted work. Leadership or fiduciary role in other board, society, committee or advocacy group, unpaid for Head chILD-EU, outsde the submitted work.

Conflict of interest: Dr. MANALI reports personal fees and non-financial support from La Roche Hoffman , grants, personal fees and non-financial support from Boehringer Ingelheim , other from SAVARA , outside the submitted work.

Conflict of interest: The remaining authors have nothing to disclose.

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COVID-19 in patients with Pulmonary Alveolar Proteinosis A European multicenter study
Spyros A. Papiris, Ilaria Campo, Francesca Mariani, Maria Kallieri, Lykourgos Kolilekas, Andriana I Papaioannou, Efsun Gonca Chousein, Erdogan Cetinkaya, Francesco Bonella, Raphael Borie, Maria Kokosi, Thomas Pickworth, Maria Molina-Molina, Mercè Gasa, Elżbieta Radzikowska, Justyna Fijolek, Stéphane Jouneau, Emmanuel Gomez, Cormac McCarthy, Elisabeth Bendstrup, Wojciech J. Piotrowski, Rishi Pabary, Alice Hadchouel, Nathalie Coolen-Allou, Tiago Alfaro, Carlos Robalo Cordeiro, Elvira-Markela Antonogiannaki, Ioannis P. Tomos, Despoina Papakosta, Theodoros Kontakiotis, Panagiota Panagiotou, Konstantinos Douros, Andrea Schams, Sara Lettieri, Vassiliki Papaevangelou, Christina Kanaka-Gantenbein, Anna Karakatsani, Stelios Loukides, Ulrich Costabel, Bruno Crestani, Cliff Morgan, Ryushi Tazawa, Andrew Bush, Matthias Griese, Effrosyni D. Manali
ERJ Open Research Jan 2022, 00199-2022; DOI: 10.1183/23120541.00199-2022

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COVID-19 in patients with Pulmonary Alveolar Proteinosis A European multicenter study
Spyros A. Papiris, Ilaria Campo, Francesca Mariani, Maria Kallieri, Lykourgos Kolilekas, Andriana I Papaioannou, Efsun Gonca Chousein, Erdogan Cetinkaya, Francesco Bonella, Raphael Borie, Maria Kokosi, Thomas Pickworth, Maria Molina-Molina, Mercè Gasa, Elżbieta Radzikowska, Justyna Fijolek, Stéphane Jouneau, Emmanuel Gomez, Cormac McCarthy, Elisabeth Bendstrup, Wojciech J. Piotrowski, Rishi Pabary, Alice Hadchouel, Nathalie Coolen-Allou, Tiago Alfaro, Carlos Robalo Cordeiro, Elvira-Markela Antonogiannaki, Ioannis P. Tomos, Despoina Papakosta, Theodoros Kontakiotis, Panagiota Panagiotou, Konstantinos Douros, Andrea Schams, Sara Lettieri, Vassiliki Papaevangelou, Christina Kanaka-Gantenbein, Anna Karakatsani, Stelios Loukides, Ulrich Costabel, Bruno Crestani, Cliff Morgan, Ryushi Tazawa, Andrew Bush, Matthias Griese, Effrosyni D. Manali
ERJ Open Research Jan 2022, 00199-2022; DOI: 10.1183/23120541.00199-2022
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