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Real-life burden of hospitalizations due to COPD exacerbations in Spain

José Luis Izquierdo, José Miguel Rodríguez, Carlos Almonacid, María Benavent, Ramón Arroyo-Espliguero, Alvar Agustí
ERJ Open Research 2022; DOI: 10.1183/23120541.00141-2022
José Luis Izquierdo
1Department of Medicine and Medical Specialties, University of Alcalá, Alcalá de Henares, Madrid, Spain
2Respiratory Medicine, University Hospital of Guadalajara, Guadalajara, Spain
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José Miguel Rodríguez
1Department of Medicine and Medical Specialties, University of Alcalá, Alcalá de Henares, Madrid, Spain
3Respiratory Medicine, University Hospital Príncipe de Asturias, Alcalá de Henares, Madrid, Spain
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Carlos Almonacid
4Respiratory Medicine, University Hospital of Toledo, Toledo, Spain
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María Benavent
5SAVANA, Spain
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Ramón Arroyo-Espliguero
6Cardiology Medicine, University Hospital, Guadalajara, Spain
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Alvar Agustí
7Respiratory Institute, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERES, Spain
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Abstract

Patients with chronic obstructive pulmonary disease (COPD) often suffer episodes of exacerbation of symptoms (ECOPD) that may eventually require hospitalization due to several, often overlapping, causes. We aimed to analyse the characteristics of patients hospitalized because of ECOPD in a real-life setting using a big-data approach. The study population included all patients older than 40 years with a diagnosis of COPD (n=69.359; prevalence 3.72%) registered since January 1st, 2011, until March 1, 2020, in the database of the public healthcare service (SESCAM) of Castilla-La Mancha (Spain) (n=1.863.759 subjects). We used natural language processing (Savana Manager v3.0) to identify those who were hospitalized during this period for any cause, including ECOPD. During the study 26.453 COPD patients (38.1%) were hospitalized (at least once). Main diagnoses at discharge were respiratory infection (51%), heart failure (38%) or pneumonia (19%). ECOPD was the main diagnosis at discharge (or hospital death) in 8.331 of them (12.0% of the entire COPD population and 31.5% of those hospitalized). In-hospital ECOPD-related mortality rate was 3.1%. These patients were hospitalized 2.36 times per patient, with a mean hospital stay of 6.1 days. Heart failure (HF) was the most frequent comorbidity in patients hospitalized because of ECOPD (52.6%). This analysis shows that, in a real-life setting, ECOPD hospitalizations are prevalent, complex (particularly in relation to HF), repetitive and associated with significant in-hospital mortality.

Footnotes

This manuscript has recently been accepted for publication in the ERJ Open Research. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJOR online. Please open or download the PDF to view this article.

Conflicts of interest: All authors declare no conflicts of interest.

This is a PDF-only article. Please click on the PDF link above to read it.

  • Received March 22, 2022.
  • Accepted June 6, 2022.
  • Copyright ©The authors 2022
http://creativecommons.org/licenses/by-nc/4.0/

This version is distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0. For commercial reproduction rights and permissions contact permissions{at}ersnet.org

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Real-life burden of hospitalizations due to COPD exacerbations in Spain
José Luis Izquierdo, José Miguel Rodríguez, Carlos Almonacid, María Benavent, Ramón Arroyo-Espliguero, Alvar Agustí
ERJ Open Research Jan 2022, 00141-2022; DOI: 10.1183/23120541.00141-2022

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Real-life burden of hospitalizations due to COPD exacerbations in Spain
José Luis Izquierdo, José Miguel Rodríguez, Carlos Almonacid, María Benavent, Ramón Arroyo-Espliguero, Alvar Agustí
ERJ Open Research Jan 2022, 00141-2022; DOI: 10.1183/23120541.00141-2022
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