Skip to main content

Main menu

  • Home
  • Current issue
  • Early View
  • Archive
  • Authors/reviewers
    • Instructions for authors
    • Submit a manuscript
    • COVID-19 submission information
    • Institutional open access agreements
    • Peer reviewer login
  • Alerts
  • Subscriptions
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

User menu

  • Log in
  • Subscribe
  • Contact Us
  • My Cart

Search

  • Advanced search
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

Login

European Respiratory Society

Advanced Search

  • Home
  • Current issue
  • Early View
  • Archive
  • Authors/reviewers
    • Instructions for authors
    • Submit a manuscript
    • COVID-19 submission information
    • Institutional open access agreements
    • Peer reviewer login
  • Alerts
  • Subscriptions

All-cause admissions following a first-ever exacerbation-related hospitalization in COPD

Kiki Waeijen-Smit, Peter A. Jacobsen, Sarah Houben-Wilke, Sami O. Simons, Frits M. E. Franssen, Martijn A. Spruit, Christian T. Pedersen, Kristian H. Kragholm, Ulla M. Weinreich
ERJ Open Research 2022; DOI: 10.1183/23120541.00217-2022
Kiki Waeijen-Smit
1Department of Research and Education, Ciro, Horn, the Netherlands
2Department of Respiratory Medicine, NUTRIM School of Nutrition and Translational Research in Metabolism, Faculty of Health Medicine and Life Sciences, Maastricht University Medical Centre+, Maastricht, The Netherlands
8shared first author
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: kikismit@ciro-horn.nl
Peter A. Jacobsen
3Department of Respiratory Diseases, Aalborg University Hospital, Aalborg, Denmark
4The Clinical Institute, The Faculty of Health, Aalborg University, Aalborg, Denmark
8shared first author
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Sarah Houben-Wilke
1Department of Research and Education, Ciro, Horn, the Netherlands
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Sami O. Simons
2Department of Respiratory Medicine, NUTRIM School of Nutrition and Translational Research in Metabolism, Faculty of Health Medicine and Life Sciences, Maastricht University Medical Centre+, Maastricht, The Netherlands
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Sami O. Simons
Frits M. E. Franssen
1Department of Research and Education, Ciro, Horn, the Netherlands
2Department of Respiratory Medicine, NUTRIM School of Nutrition and Translational Research in Metabolism, Faculty of Health Medicine and Life Sciences, Maastricht University Medical Centre+, Maastricht, The Netherlands
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Martijn A. Spruit
1Department of Research and Education, Ciro, Horn, the Netherlands
2Department of Respiratory Medicine, NUTRIM School of Nutrition and Translational Research in Metabolism, Faculty of Health Medicine and Life Sciences, Maastricht University Medical Centre+, Maastricht, The Netherlands
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Martijn A. Spruit
Christian T. Pedersen
5Department of Cardiology, Nordsjællands Hospital, Hillerød, Denmark
6Department of Biostatistics, University of Copenhagen, Copenhagen, Denmark
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Kristian H. Kragholm
7Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ulla M. Weinreich
3Department of Respiratory Diseases, Aalborg University Hospital, Aalborg, Denmark
4The Clinical Institute, The Faculty of Health, Aalborg University, Aalborg, Denmark
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & Metrics
  • PDF
Loading

Abstract

Background Hospital admissions are important contributors to the overall burden of chronic obstructive pulmonary disease (COPD). Understanding the patterns and causes of hospital admissions will help to identify targets for preventive interventions. This study aimed to determine the five-year all-cause hospital admission trajectories of patients with COPD following their first-ever exacerbation-related hospitalization.

Methods Patients with COPD were identified from the Danish national registries. Patients experiencing their first-ever exacerbation-related hospitalization, defined as the index event, between 2000 and 2014 were included. All-cause hospital admissions were examined during a subsequent five-year follow-up period, and categorized using the International Classification of Diseases, 10th revision (ICD-10).

Results In total, 82 964 patients with COPD were included. The average age was 72 (sd 10) years and 48% was male. Comorbidities were present in 58%, and 65% of the patients collected inhalation medication ≤6 months prior to the index event. In total, 337 066 all-cause hospital admissions were identified, resulting in a five-year admission rate of 82%. Most admissions were due to non-respiratory causes (59%), amongst which cardiac events were most common (19%).

Conclusion Hospital admissions following a first exacerbation-related hospitalization are common, non-respiratory events constitute the majority of admissions. Besides the respiratory causes, treatment targeting the non-respiratory causes of hospital admission should be considered to effectively decrease the burden of hospitalization in COPD.

Footnotes

This manuscript has recently been accepted for publication in the ERJ Open Research. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJOR online. Please open or download the PDF to view this article.

Conflict of interest: S.O. Simons has received grants and personal fees from AstraZeneca, Boehringer Ingelheim, GlaxoSmithKline and Chiesi outside the submitted work. F.M.E. Franssen has received grants and personal fees from AstraZeneca, Chiesi, Boehringer Ingelheim, Glaxosmithkline, Novartis and MSD outside the submitted work. M.A. Spruit has received grants and personal fees from the Netherlands Lung Foundation, Stichting Asthma Bestrijding, AstraZeneca, Boehringer Ingeheim, TEVA and CHIESI outside the submitted work. C.T. Pedersen has received grants from Bayer and Novo Nordisk outside the submitted work.

All authors declare no conflicts of interest in relation to the present study.

This is a PDF-only article. Please click on the PDF link above to read it.

  • Received May 4, 2022.
  • Accepted June 29, 2022.
  • Copyright ©The authors 2022
http://creativecommons.org/licenses/by-nc/4.0/

This version is distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0. For commercial reproduction rights and permissions contact permissions{at}ersnet.org

PreviousNext
Back to top
Vol 9 Issue 2 Table of Contents
ERJ Open Research: 9 (2)
  • Table of Contents
  • Index by author
Email

Thank you for your interest in spreading the word on European Respiratory Society .

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
All-cause admissions following a first-ever exacerbation-related hospitalization in COPD
(Your Name) has sent you a message from European Respiratory Society
(Your Name) thought you would like to see the European Respiratory Society web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Print
Citation Tools
All-cause admissions following a first-ever exacerbation-related hospitalization in COPD
Kiki Waeijen-Smit, Peter A. Jacobsen, Sarah Houben-Wilke, Sami O. Simons, Frits M. E. Franssen, Martijn A. Spruit, Christian T. Pedersen, Kristian H. Kragholm, Ulla M. Weinreich
ERJ Open Research Jan 2022, 00217-2022; DOI: 10.1183/23120541.00217-2022

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
All-cause admissions following a first-ever exacerbation-related hospitalization in COPD
Kiki Waeijen-Smit, Peter A. Jacobsen, Sarah Houben-Wilke, Sami O. Simons, Frits M. E. Franssen, Martijn A. Spruit, Christian T. Pedersen, Kristian H. Kragholm, Ulla M. Weinreich
ERJ Open Research Jan 2022, 00217-2022; DOI: 10.1183/23120541.00217-2022
Reddit logo Technorati logo Twitter logo Connotea logo Facebook logo Mendeley logo
Full Text (PDF)

Jump To

  • Article
    • Abstract
  • Info & Metrics
  • PDF

Subjects

  • COPD and smoking
  • Tweet Widget
  • Facebook Like
  • Google Plus One

More in this TOC Section

  • Application of the Rome severity classification of COPD exacerbations in a real-world cohort of hospitalized patients
  • The detection, assessment and clinical evolution of interstitial lung abnormalities identified through lung cancer screening
  • The Bronchiectasis Exacerbation Diary: A Novel PRO for Non-Cystic Fibrosis Bronchiectasis
Show more Original research article

Related Articles

Navigate

  • Home
  • Current issue
  • Archive

About ERJ Open Research

  • Editorial board
  • Journal information
  • Press
  • Permissions and reprints
  • Advertising

The European Respiratory Society

  • Society home
  • myERS
  • Privacy policy
  • Accessibility

ERS publications

  • European Respiratory Journal
  • ERJ Open Research
  • European Respiratory Review
  • Breathe
  • ERS books online
  • ERS Bookshop

Help

  • Feedback

For authors

  • Instructions for authors
  • Publication ethics and malpractice
  • Submit a manuscript

For readers

  • Alerts
  • Subjects
  • RSS

Subscriptions

  • Accessing the ERS publications

Contact us

European Respiratory Society
442 Glossop Road
Sheffield S10 2PX
United Kingdom
Tel: +44 114 2672860
Email: journals@ersnet.org

ISSN

Online ISSN: 2312-0541

Copyright © 2023 by the European Respiratory Society