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Increased protease-activated receptor 1 autoantibodies are associated with severe COVID-19

Florian Tran, Danielle MM Harris, Alena Scharmacher, Hanna Graßhoff, Kristina Sterner, Susanne Schinke, Nadja Käding, Jens Y Humrich, Otávio Cabral-Marques, Joana p Bernardes, Neha Mishra, Thomas Bahmer, Jeanette Franzenburg, Bimba F Hoyer, Andreas Glück, Martina Guggeis, Alexander Ossysek, Andre Küller, Derk Frank, Christoph Lange, Jan Rupp, Jan Heyckendorf, Karoline I Gaede, Howard Amital, Philip Rosenstiel, Yehuda Shoenfeld, Gilad Halpert, Avi Z Rosenberg, Kai Schulze-Forster, Harald Heidecke, Gabriela Riemekasten, Stefan Schreiber
ERJ Open Research 2022; DOI: 10.1183/23120541.00379-2022
Florian Tran
1Institute of Clinical Molecular Biology, Christian-Albrechts-University Kiel and University Medical Center Schleswig-Holstein, Kiel, Germany
2Department of Internal Medicine I, University Medical Center Schleswig-Holstein, Kiel, Germany
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  • ORCID record for Florian Tran
  • For correspondence: f.tran@ikmb.uni-kiel.de
Danielle MM Harris
1Institute of Clinical Molecular Biology, Christian-Albrechts-University Kiel and University Medical Center Schleswig-Holstein, Kiel, Germany
3Institute for Human Nutrition and Food Science, University Medical Center Schleswig-Holstein, Kiel, Germany
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  • ORCID record for Danielle MM Harris
Alena Scharmacher
1Institute of Clinical Molecular Biology, Christian-Albrechts-University Kiel and University Medical Center Schleswig-Holstein, Kiel, Germany
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Hanna Graßhoff
4Department of Rheumatology and Clinical Immunology, University Medical Center Schleswig-Holstein, Lübeck, Germany
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Kristina Sterner
4Department of Rheumatology and Clinical Immunology, University Medical Center Schleswig-Holstein, Lübeck, Germany
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Susanne Schinke
4Department of Rheumatology and Clinical Immunology, University Medical Center Schleswig-Holstein, Lübeck, Germany
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Nadja Käding
5Department of Infectious Diseases and Microbiology, University Medical Center Schleswig-Holstein, Lübeck, Germany
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Jens Y Humrich
4Department of Rheumatology and Clinical Immunology, University Medical Center Schleswig-Holstein, Lübeck, Germany
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Otávio Cabral-Marques
6Departamento of Imunologia, Instituto de Ciencias Biomedicas, Universidade de São Paulo, São Paulo, SP, Brazil
7Departamento of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, SP, Brazil
8Network of Immunity in Infection, Malignancy, and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Sao Paulo, Brazil
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Joana p Bernardes
1Institute of Clinical Molecular Biology, Christian-Albrechts-University Kiel and University Medical Center Schleswig-Holstein, Kiel, Germany
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Neha Mishra
1Institute of Clinical Molecular Biology, Christian-Albrechts-University Kiel and University Medical Center Schleswig-Holstein, Kiel, Germany
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Thomas Bahmer
2Department of Internal Medicine I, University Medical Center Schleswig-Holstein, Kiel, Germany
9LungenClinic Grosshansdorf, Airway Research Center North (ARCN), German Center for Lung Research (DZL), Grosshansdorf, Germany
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Jeanette Franzenburg
1Institute of Clinical Molecular Biology, Christian-Albrechts-University Kiel and University Medical Center Schleswig-Holstein, Kiel, Germany
10Institute of Clinical Chemistry, University Medical Center Schleswig-Holstein, Kiel, Germany
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Bimba F Hoyer
11Section for Rheumatology, Department of Internal Medicine I, University Medical Center Schleswig-Holstein, Kiel, Germany
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Andreas Glück
2Department of Internal Medicine I, University Medical Center Schleswig-Holstein, Kiel, Germany
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Martina Guggeis
1Institute of Clinical Molecular Biology, Christian-Albrechts-University Kiel and University Medical Center Schleswig-Holstein, Kiel, Germany
2Department of Internal Medicine I, University Medical Center Schleswig-Holstein, Kiel, Germany
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Alexander Ossysek
1Institute of Clinical Molecular Biology, Christian-Albrechts-University Kiel and University Medical Center Schleswig-Holstein, Kiel, Germany
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Andre Küller
12Department of Internal Medicine III, University Medical Center Schleswig-Holstein, Kiel, Germany
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Derk Frank
12Department of Internal Medicine III, University Medical Center Schleswig-Holstein, Kiel, Germany
13German Centre for Cardiovascular Research (DZHK), partner site Hamburg, Kiel, Lübeck, Germany
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Christoph Lange
14Research Center Borstel, Borstel, Germany
15German Center for Infection Research (DZIF), Hamburg-Lübeck-Borstel-Riems, Borstel, Germany
16Respiratory Medicine & International Health/ University of Lübeck, Lübeck, Germany
17Baylor College of Medicine and Texas Childreńs Hospital, Houston, TX, USA
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Jan Rupp
5Department of Infectious Diseases and Microbiology, University Medical Center Schleswig-Holstein, Lübeck, Germany
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Jan Heyckendorf
2Department of Internal Medicine I, University Medical Center Schleswig-Holstein, Kiel, Germany
14Research Center Borstel, Borstel, Germany
15German Center for Infection Research (DZIF), Hamburg-Lübeck-Borstel-Riems, Borstel, Germany
18Airway Research Center North (ARCN), Members of the German Center for Lung Research (DZL), Borstel, Gemany
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Karoline I Gaede
15German Center for Infection Research (DZIF), Hamburg-Lübeck-Borstel-Riems, Borstel, Germany
18Airway Research Center North (ARCN), Members of the German Center for Lung Research (DZL), Borstel, Gemany
19Research Center Borstel, Borstel, Germany, BioMaterialBank Nord (BMB Nord), Germany
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Howard Amital
20Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Ramat-Gan, Israel
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Philip Rosenstiel
1Institute of Clinical Molecular Biology, Christian-Albrechts-University Kiel and University Medical Center Schleswig-Holstein, Kiel, Germany
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Yehuda Shoenfeld
20Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Ramat-Gan, Israel
21Ariel University, Ariel, Israel
22Laboratory of the Mosaic of Autoimmunity, Saint Petersburg State University, Saint-Petersburg, Russia
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Gilad Halpert
20Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Ramat-Gan, Israel
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Avi Z Rosenberg
23Department of Pathology, Johns Hopkins University, Baltimore, MD , USA
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Kai Schulze-Forster
24CellTrend GmbH, Im Biotechnologiepark 3, Luckenwalde, Germany
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Harald Heidecke
24CellTrend GmbH, Im Biotechnologiepark 3, Luckenwalde, Germany
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Gabriela Riemekasten
3Institute for Human Nutrition and Food Science, University Medical Center Schleswig-Holstein, Kiel, Germany
25Priority Area Asthma & Allergy, Research Center Borstel, Airway Research Center North (ARCN), Members of the German Center for Lung Research (DZL), Borstel, Germany
26Co-last authors
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Stefan Schreiber
1Institute of Clinical Molecular Biology, Christian-Albrechts-University Kiel and University Medical Center Schleswig-Holstein, Kiel, Germany
2Department of Internal Medicine I, University Medical Center Schleswig-Holstein, Kiel, Germany
26Co-last authors
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Footnotes

This manuscript has recently been accepted for publication in the ERJ Open Research. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJOR online. Please open or download the PDF to view this article.

Conflict of Interest: Thomas Bahmer reports grants from BMBF: Unrestricted research grant for the German Center for Lung Research (DZL), BMBF: National Pandemic Cohort Network (NAPKON) – Coordinating Study Site for population-based cohort platform; lecture fees from Novartis, AstraZeneca, Chiesi; support for attending ATS Congress from Chiesi; advisory board participation at GlaxoSmithKline, Boehringer Ingelheim, Roche, AstraZeneca; outside the submitted work.

Conflict of Interest: Derk Frank reports grants from DFG (467267736), BMBF, DZHK; consulting fees and support for attending meetings from Edwards Lifesciences, Medtronic; lecture honoraria from Edwards Lifesciences, Medtronic, Astra Zeneca, Pfizer, BMS, Novartis, Bayer, Abbott; participation on advisory boards at BMS, Boehringer Ingelheim, Daiichi Sankyo; outside the submitted work.

Conflict of Interest: CellTrend is owned by Kai Schulze-Forster. CellTrend is producing ELISA kits for the determination of Antibodies against GPCR.

Conflict of Interest: Avi Z. Rosenberg reports grants from NIH (NIDDK, NHLBI); outside the submitted work.

Conflict of Interest: Gabriela Riemekasten reports consulting fees from CellTrand GmbH; outside the submitted work.

Conflict of Interest: Stefan Schreiber reports consulting fees from Abbvie, Arena, BMS, Biogen, Celltrion, Celgene, IMAB, Gilead, MSD, Mylan, Pfizer, Fresenius, Janssen, Takeda, Theravance, Prevention Bio, Protagonist, Falk; outside the submitted work.

Conflict of Interest: All other authors have nothing to disclose.

This is a PDF-only article. Please click on the PDF link above to read it.

  • Copyright ©The authors 2022
http://creativecommons.org/licenses/by-nc/4.0/

This version is distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0. For commercial reproduction rights and permissions contact permissions{at}ersnet.org

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Increased protease-activated receptor 1 autoantibodies are associated with severe COVID-19
Florian Tran, Danielle MM Harris, Alena Scharmacher, Hanna Graßhoff, Kristina Sterner, Susanne Schinke, Nadja Käding, Jens Y Humrich, Otávio Cabral-Marques, Joana p Bernardes, Neha Mishra, Thomas Bahmer, Jeanette Franzenburg, Bimba F Hoyer, Andreas Glück, Martina Guggeis, Alexander Ossysek, Andre Küller, Derk Frank, Christoph Lange, Jan Rupp, Jan Heyckendorf, Karoline I Gaede, Howard Amital, Philip Rosenstiel, Yehuda Shoenfeld, Gilad Halpert, Avi Z Rosenberg, Kai Schulze-Forster, Harald Heidecke, Gabriela Riemekasten, Stefan Schreiber
ERJ Open Research Jan 2022, 00379-2022; DOI: 10.1183/23120541.00379-2022

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Increased protease-activated receptor 1 autoantibodies are associated with severe COVID-19
Florian Tran, Danielle MM Harris, Alena Scharmacher, Hanna Graßhoff, Kristina Sterner, Susanne Schinke, Nadja Käding, Jens Y Humrich, Otávio Cabral-Marques, Joana p Bernardes, Neha Mishra, Thomas Bahmer, Jeanette Franzenburg, Bimba F Hoyer, Andreas Glück, Martina Guggeis, Alexander Ossysek, Andre Küller, Derk Frank, Christoph Lange, Jan Rupp, Jan Heyckendorf, Karoline I Gaede, Howard Amital, Philip Rosenstiel, Yehuda Shoenfeld, Gilad Halpert, Avi Z Rosenberg, Kai Schulze-Forster, Harald Heidecke, Gabriela Riemekasten, Stefan Schreiber
ERJ Open Research Jan 2022, 00379-2022; DOI: 10.1183/23120541.00379-2022
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