Skip to main content

Main menu

  • Home
  • Current issue
  • Early View
  • Archive
  • Authors/reviewers
    • Instructions for authors
    • Submit a manuscript
    • COVID-19 submission information
    • Institutional open access agreements
    • Peer reviewer login
  • Alerts
  • Subscriptions
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

User menu

  • Log in
  • Subscribe
  • Contact Us
  • My Cart

Search

  • Advanced search
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

Login

European Respiratory Society

Advanced Search

  • Home
  • Current issue
  • Early View
  • Archive
  • Authors/reviewers
    • Instructions for authors
    • Submit a manuscript
    • COVID-19 submission information
    • Institutional open access agreements
    • Peer reviewer login
  • Alerts
  • Subscriptions

Increased protease-activated receptor 1 autoantibodies are associated with severe COVID-19

Florian Tran, Danielle MM Harris, Alena Scharmacher, Hanna Graßhoff, Kristina Sterner, Susanne Schinke, Nadja Käding, Jens Y Humrich, Otávio Cabral-Marques, Joana p Bernardes, Neha Mishra, Thomas Bahmer, Jeanette Franzenburg, Bimba F Hoyer, Andreas Glück, Martina Guggeis, Alexander Ossysek, Andre Küller, Derk Frank, Christoph Lange, Jan Rupp, Jan Heyckendorf, Karoline I Gaede, Howard Amital, Philip Rosenstiel, Yehuda Shoenfeld, Gilad Halpert, Avi Z Rosenberg, Kai Schulze-Forster, Harald Heidecke, Gabriela Riemekasten, Stefan Schreiber
ERJ Open Research 2022; DOI: 10.1183/23120541.00379-2022
Florian Tran
1Institute of Clinical Molecular Biology, Christian-Albrechts-University Kiel and University Medical Center Schleswig-Holstein, Kiel, Germany
2Department of Internal Medicine I, University Medical Center Schleswig-Holstein, Kiel, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Florian Tran
  • For correspondence: f.tran@ikmb.uni-kiel.de
Danielle MM Harris
1Institute of Clinical Molecular Biology, Christian-Albrechts-University Kiel and University Medical Center Schleswig-Holstein, Kiel, Germany
3Institute for Human Nutrition and Food Science, University Medical Center Schleswig-Holstein, Kiel, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Danielle MM Harris
Alena Scharmacher
1Institute of Clinical Molecular Biology, Christian-Albrechts-University Kiel and University Medical Center Schleswig-Holstein, Kiel, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Hanna Graßhoff
4Department of Rheumatology and Clinical Immunology, University Medical Center Schleswig-Holstein, Lübeck, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Kristina Sterner
4Department of Rheumatology and Clinical Immunology, University Medical Center Schleswig-Holstein, Lübeck, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Susanne Schinke
4Department of Rheumatology and Clinical Immunology, University Medical Center Schleswig-Holstein, Lübeck, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Nadja Käding
5Department of Infectious Diseases and Microbiology, University Medical Center Schleswig-Holstein, Lübeck, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jens Y Humrich
4Department of Rheumatology and Clinical Immunology, University Medical Center Schleswig-Holstein, Lübeck, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Otávio Cabral-Marques
6Departamento of Imunologia, Instituto de Ciencias Biomedicas, Universidade de São Paulo, São Paulo, SP, Brazil
7Departamento of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, SP, Brazil
8Network of Immunity in Infection, Malignancy, and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Sao Paulo, Brazil
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Joana p Bernardes
1Institute of Clinical Molecular Biology, Christian-Albrechts-University Kiel and University Medical Center Schleswig-Holstein, Kiel, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Neha Mishra
1Institute of Clinical Molecular Biology, Christian-Albrechts-University Kiel and University Medical Center Schleswig-Holstein, Kiel, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Thomas Bahmer
2Department of Internal Medicine I, University Medical Center Schleswig-Holstein, Kiel, Germany
9LungenClinic Grosshansdorf, Airway Research Center North (ARCN), German Center for Lung Research (DZL), Grosshansdorf, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jeanette Franzenburg
1Institute of Clinical Molecular Biology, Christian-Albrechts-University Kiel and University Medical Center Schleswig-Holstein, Kiel, Germany
10Institute of Clinical Chemistry, University Medical Center Schleswig-Holstein, Kiel, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Bimba F Hoyer
11Section for Rheumatology, Department of Internal Medicine I, University Medical Center Schleswig-Holstein, Kiel, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Andreas Glück
2Department of Internal Medicine I, University Medical Center Schleswig-Holstein, Kiel, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Martina Guggeis
1Institute of Clinical Molecular Biology, Christian-Albrechts-University Kiel and University Medical Center Schleswig-Holstein, Kiel, Germany
2Department of Internal Medicine I, University Medical Center Schleswig-Holstein, Kiel, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Martina Guggeis
Alexander Ossysek
1Institute of Clinical Molecular Biology, Christian-Albrechts-University Kiel and University Medical Center Schleswig-Holstein, Kiel, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Andre Küller
12Department of Internal Medicine III, University Medical Center Schleswig-Holstein, Kiel, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Derk Frank
12Department of Internal Medicine III, University Medical Center Schleswig-Holstein, Kiel, Germany
13German Centre for Cardiovascular Research (DZHK), partner site Hamburg, Kiel, Lübeck, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Christoph Lange
14Research Center Borstel, Borstel, Germany
15German Center for Infection Research (DZIF), Hamburg-Lübeck-Borstel-Riems, Borstel, Germany
16Respiratory Medicine & International Health/ University of Lübeck, Lübeck, Germany
17Baylor College of Medicine and Texas Childreńs Hospital, Houston, TX, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jan Rupp
5Department of Infectious Diseases and Microbiology, University Medical Center Schleswig-Holstein, Lübeck, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jan Heyckendorf
2Department of Internal Medicine I, University Medical Center Schleswig-Holstein, Kiel, Germany
14Research Center Borstel, Borstel, Germany
15German Center for Infection Research (DZIF), Hamburg-Lübeck-Borstel-Riems, Borstel, Germany
18Airway Research Center North (ARCN), Members of the German Center for Lung Research (DZL), Borstel, Gemany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Jan Heyckendorf
Karoline I Gaede
15German Center for Infection Research (DZIF), Hamburg-Lübeck-Borstel-Riems, Borstel, Germany
18Airway Research Center North (ARCN), Members of the German Center for Lung Research (DZL), Borstel, Gemany
19Research Center Borstel, Borstel, Germany, BioMaterialBank Nord (BMB Nord), Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Howard Amital
20Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Ramat-Gan, Israel
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Philip Rosenstiel
1Institute of Clinical Molecular Biology, Christian-Albrechts-University Kiel and University Medical Center Schleswig-Holstein, Kiel, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Yehuda Shoenfeld
20Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Ramat-Gan, Israel
21Ariel University, Ariel, Israel
22Laboratory of the Mosaic of Autoimmunity, Saint Petersburg State University, Saint-Petersburg, Russia
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Gilad Halpert
20Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Ramat-Gan, Israel
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Avi Z Rosenberg
23Department of Pathology, Johns Hopkins University, Baltimore, MD , USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Kai Schulze-Forster
24CellTrend GmbH, Im Biotechnologiepark 3, Luckenwalde, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Harald Heidecke
24CellTrend GmbH, Im Biotechnologiepark 3, Luckenwalde, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Gabriela Riemekasten
3Institute for Human Nutrition and Food Science, University Medical Center Schleswig-Holstein, Kiel, Germany
25Priority Area Asthma & Allergy, Research Center Borstel, Airway Research Center North (ARCN), Members of the German Center for Lung Research (DZL), Borstel, Germany
26Co-last authors
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Stefan Schreiber
1Institute of Clinical Molecular Biology, Christian-Albrechts-University Kiel and University Medical Center Schleswig-Holstein, Kiel, Germany
2Department of Internal Medicine I, University Medical Center Schleswig-Holstein, Kiel, Germany
26Co-last authors
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & Metrics
  • PDF
Loading

Article Information

DOI 
https://doi.org/10.1183/23120541.00379-2022

Published By 
European Respiratory Society
Online ISSN 
2312-0541
History 
  • Published online October 13, 2022.

Article Versions

  • You are currently viewing a previous version of this article (October 13, 2022 - 06:04).
  • View the most recent version of this article
Copyright & Usage 
Copyright ©The authors 2022 This version is distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0. For commercial reproduction rights and permissions contact permissions@ersnet.org

Author Information

  1. Florian Tran1,2⇑,
  2. Danielle MM Harris1,3,
  3. Alena Scharmacher1,
  4. Hanna Graßhoff4,
  5. Kristina Sterner4,
  6. Susanne Schinke4,
  7. Nadja Käding5,
  8. Jens Y Humrich4,
  9. Otávio Cabral-Marques6,7,8,
  10. Joana p Bernardes1,
  11. Neha Mishra1,
  12. Thomas Bahmer2,9,
  13. Jeanette Franzenburg1,10,
  14. Bimba F Hoyer11,
  15. Andreas Glück2,
  16. Martina Guggeis1,2,
  17. Alexander Ossysek1,
  18. Andre Küller12,
  19. Derk Frank12,13,
  20. Christoph Lange14,15,16,17,
  21. Jan Rupp5,
  22. Jan Heyckendorf2,14,15,18,
  23. Karoline I Gaede15,18,19,
  24. Howard Amital20,
  25. Philip Rosenstiel1,
  26. Yehuda Shoenfeld20,21,22,
  27. Gilad Halpert20,
  28. Avi Z Rosenberg23,
  29. Kai Schulze-Forster24,
  30. Harald Heidecke24,
  31. Gabriela Riemekasten3,25,26 and
  32. Stefan Schreiber1,2,26
  1. 1Institute of Clinical Molecular Biology, Christian-Albrechts-University Kiel and University Medical Center Schleswig-Holstein, Kiel, Germany
  2. 2Department of Internal Medicine I, University Medical Center Schleswig-Holstein, Kiel, Germany
  3. 3Institute for Human Nutrition and Food Science, University Medical Center Schleswig-Holstein, Kiel, Germany
  4. 4Department of Rheumatology and Clinical Immunology, University Medical Center Schleswig-Holstein, Lübeck, Germany
  5. 5Department of Infectious Diseases and Microbiology, University Medical Center Schleswig-Holstein, Lübeck, Germany
  6. 6Departamento of Imunologia, Instituto de Ciencias Biomedicas, Universidade de São Paulo, São Paulo, SP, Brazil
  7. 7Departamento of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, SP, Brazil
  8. 8Network of Immunity in Infection, Malignancy, and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Sao Paulo, Brazil
  9. 9LungenClinic Grosshansdorf, Airway Research Center North (ARCN), German Center for Lung Research (DZL), Grosshansdorf, Germany
  10. 10Institute of Clinical Chemistry, University Medical Center Schleswig-Holstein, Kiel, Germany
  11. 11Section for Rheumatology, Department of Internal Medicine I, University Medical Center Schleswig-Holstein, Kiel, Germany
  12. 12Department of Internal Medicine III, University Medical Center Schleswig-Holstein, Kiel, Germany
  13. 13German Centre for Cardiovascular Research (DZHK), partner site Hamburg, Kiel, Lübeck, Germany
  14. 14Research Center Borstel, Borstel, Germany
  15. 15German Center for Infection Research (DZIF), Hamburg-Lübeck-Borstel-Riems, Borstel, Germany
  16. 16Respiratory Medicine & International Health/ University of Lübeck, Lübeck, Germany
  17. 17Baylor College of Medicine and Texas Childreńs Hospital, Houston, TX, USA
  18. 18Airway Research Center North (ARCN), Members of the German Center for Lung Research (DZL), Borstel, Gemany
  19. 19Research Center Borstel, Borstel, Germany, BioMaterialBank Nord (BMB Nord), Germany
  20. 20Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Ramat-Gan, Israel
  21. 21Ariel University, Ariel, Israel
  22. 22Laboratory of the Mosaic of Autoimmunity, Saint Petersburg State University, Saint-Petersburg, Russia
  23. 23Department of Pathology, Johns Hopkins University, Baltimore, MD , USA
  24. 24CellTrend GmbH, Im Biotechnologiepark 3, Luckenwalde, Germany
  25. 25Priority Area Asthma & Allergy, Research Center Borstel, Airway Research Center North (ARCN), Members of the German Center for Lung Research (DZL), Borstel, Germany
  26. 26Co-last authors
  1. Corresponding author: Florian Tran (f.tran{at}ikmb.uni-kiel.de)
View Full Text

Funding

  • BMBF iTREAT project

  • 3TR (IMI2JU)

  • DFG Research Unit 5042 "miTarget"

  • Cluster of Excellence 2167 "Precision Medicine in Chronic Inflammation"

    RTF-VI
  • State Schleswig-Holstein

    COVID-reponse grant

Article usage

Article usage: October 2022 to December 2022

AbstractFullPdf
Oct 20226712731
Nov 2022663928
Dec 20224110156

Altmetrics

PreviousNext
Back to top
Vol 9 Issue 1 Table of Contents
ERJ Open Research: 9 (1)
  • Table of Contents
  • Index by author
Email

Thank you for your interest in spreading the word on European Respiratory Society .

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Increased protease-activated receptor 1 autoantibodies are associated with severe COVID-19
(Your Name) has sent you a message from European Respiratory Society
(Your Name) thought you would like to see the European Respiratory Society web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Print
Citation Tools
Increased protease-activated receptor 1 autoantibodies are associated with severe COVID-19
Florian Tran, Danielle MM Harris, Alena Scharmacher, Hanna Graßhoff, Kristina Sterner, Susanne Schinke, Nadja Käding, Jens Y Humrich, Otávio Cabral-Marques, Joana p Bernardes, Neha Mishra, Thomas Bahmer, Jeanette Franzenburg, Bimba F Hoyer, Andreas Glück, Martina Guggeis, Alexander Ossysek, Andre Küller, Derk Frank, Christoph Lange, Jan Rupp, Jan Heyckendorf, Karoline I Gaede, Howard Amital, Philip Rosenstiel, Yehuda Shoenfeld, Gilad Halpert, Avi Z Rosenberg, Kai Schulze-Forster, Harald Heidecke, Gabriela Riemekasten, Stefan Schreiber
ERJ Open Research Jan 2022, 00379-2022; DOI: 10.1183/23120541.00379-2022

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Increased protease-activated receptor 1 autoantibodies are associated with severe COVID-19
Florian Tran, Danielle MM Harris, Alena Scharmacher, Hanna Graßhoff, Kristina Sterner, Susanne Schinke, Nadja Käding, Jens Y Humrich, Otávio Cabral-Marques, Joana p Bernardes, Neha Mishra, Thomas Bahmer, Jeanette Franzenburg, Bimba F Hoyer, Andreas Glück, Martina Guggeis, Alexander Ossysek, Andre Küller, Derk Frank, Christoph Lange, Jan Rupp, Jan Heyckendorf, Karoline I Gaede, Howard Amital, Philip Rosenstiel, Yehuda Shoenfeld, Gilad Halpert, Avi Z Rosenberg, Kai Schulze-Forster, Harald Heidecke, Gabriela Riemekasten, Stefan Schreiber
ERJ Open Research Jan 2022, 00379-2022; DOI: 10.1183/23120541.00379-2022
del.icio.us logo Digg logo Reddit logo Technorati logo Twitter logo CiteULike logo Connotea logo Facebook logo Google logo Mendeley logo
Full Text (PDF)

Jump To

  • Article
  • Info & Metrics
  • PDF

Subjects

  • Lung biology and experimental studies
  • Respiratory infections and tuberculosis
  • Tweet Widget
  • Facebook Like
  • Google Plus One

More in this TOC Section

  • Broadening the scope for three dimensional (3D) printed airway stents
  • Tracheal complications of mechanical ventilation for COVID-19: a plot twist for survivors
  • Diffuse panniculitis in a teen male with ZZ alpha1-antitrypsin deficiency
Show more Research letter

Related Articles

Navigate

  • Home
  • Current issue
  • Archive

About ERJ Open Research

  • Editorial board
  • Journal information
  • Press
  • Permissions and reprints
  • Advertising

The European Respiratory Society

  • Society home
  • myERS
  • Privacy policy
  • Accessibility

ERS publications

  • European Respiratory Journal
  • ERJ Open Research
  • European Respiratory Review
  • Breathe
  • ERS books online
  • ERS Bookshop

Help

  • Feedback

For authors

  • Instructions for authors
  • Publication ethics and malpractice
  • Submit a manuscript

For readers

  • Alerts
  • Subjects
  • RSS

Subscriptions

  • Accessing the ERS publications

Contact us

European Respiratory Society
442 Glossop Road
Sheffield S10 2PX
United Kingdom
Tel: +44 114 2672860
Email: journals@ersnet.org

ISSN

Online ISSN: 2312-0541

Copyright © 2023 by the European Respiratory Society