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Global burden of non-tuberculous mycobacteria in the cystic fibrosis population: a systematic review and meta-analysis

Miguel D. Prieto, Mosaab E. Alam, Alessandro N. Franciosi, Bradley S. Quon
ERJ Open Research 2022; DOI: 10.1183/23120541.00336-2022
Miguel D. Prieto
1Centre for Heart and Lung Innovation, Vancouver, BC, Canada
2Department of Medicine, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada
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  • For correspondence: miguel.prieto@hli.ubc.ca
Mosaab E. Alam
3Department of Infectious Diseases, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada
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Alessandro N. Franciosi
1Centre for Heart and Lung Innovation, Vancouver, BC, Canada
2Department of Medicine, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada
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Bradley S. Quon
1Centre for Heart and Lung Innovation, Vancouver, BC, Canada
2Department of Medicine, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada
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Abstract

Background People living with cystic fibrosis have an increased risk of lung infection with non-tuberculous mycobacteria (NTM), which is reportedly increasing. We conducted a systematic review of the literature to estimate the burden (prevalence and incidence) of non-tuberculous mycobacteria in the cystic fibrosis population.

Methods Electronic databases, registries, and grey literature sources were searched for cohort and cross-sectional studies reporting epidemiological measures (incidence and prevalence) of NTM infection or NTM pulmonary disease (NTM-PD) in cystic fibrosis. The last search was conducted in September 2021; we included reports since database creation and registry reports published since 2010. The methodological quality of studies was appraised with the Joanna Briggs Institute tool. A random-effects meta-analysis was conducted to summarize the prevalence of NTM infection, and the remaining results are presented in a narrative synthesis.

Results Ninety-five studies were included in this review. All 95 studies reported on NTM infection, and 14 of these also reported on NTM-PD. The pooled estimate for the point prevalence of NTM infection was 7.9% (CI 95%, 5.1–12.0%). In meta-regression, sample size and geographical location of the study modified the estimate. Longitudinal analysis of registry reports showed an increasing trend in NTM infection prevalence between 2010 and 2019.

Conclusions The overall prevalence of NTM infection in CF is 7.9% and is increasing over time based on international registry reports. Future studies should report screening frequency, microbial identification methods, and incidence rates of progression from NTM infection to pulmonary disease.

Footnotes

This manuscript has recently been accepted for publication in the ERJ Open Research. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJOR online. Please open or download the PDF to view this article.

  • Accepted September 5, 2022.
  • Copyright ©The authors 2022
http://creativecommons.org/licenses/by-nc/4.0/

This version is distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0. For commercial reproduction rights and permissions contact permissions{at}ersnet.org

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Global burden of non-tuberculous mycobacteria in the cystic fibrosis population: a systematic review and meta-analysis
Miguel D. Prieto, Mosaab E. Alam, Alessandro N. Franciosi, Bradley S. Quon
ERJ Open Research Jan 2022, 00336-2022; DOI: 10.1183/23120541.00336-2022

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Global burden of non-tuberculous mycobacteria in the cystic fibrosis population: a systematic review and meta-analysis
Miguel D. Prieto, Mosaab E. Alam, Alessandro N. Franciosi, Bradley S. Quon
ERJ Open Research Jan 2022, 00336-2022; DOI: 10.1183/23120541.00336-2022
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