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Multiomics links global surfactant dysregulation with airflow obstruction and emphysema in COPD

Ventzislava A. Hristova, Alastair Watson, Raghothama Chaerkady, Matthew S. Glover, Jodie Ackland, Bastian Angerman, Graham Belfield, Maria G. Belvisi, Hannah Burke, Doriana Cellura, Howard W. Clark, Damla Etal, Anna Freeman, Ashley I Heinson, Sonja Hess, Michael Hühn, Emily Hall, Alex Mackay, Jens Madsen, Christopher McCrae, Daniel Muthas, Steven Novick, Kristoffer Ostridge, Lisa Öberg, Adam Platt, Anthony D. Postle, C. Mirella Spalluto, Outi Vaarala, Junmin Wang, Karl J. Staples, Tom M.A Wilkinson on behalf of the MICA II Study group
ERJ Open Research 2022; DOI: 10.1183/23120541.00378-2022
Ventzislava A. Hristova
1Dynamic Omics, Centre for Genomics Research (CGR), Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, USA
15These authors contributed equally to this work
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Alastair Watson
2Faculty of Medicine, University of Southampton, Southampton, UK
3School of Clinical Medicine, University of Cambridge, Cambridge, UK
15These authors contributed equally to this work
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  • ORCID record for Alastair Watson
Raghothama Chaerkady
1Dynamic Omics, Centre for Genomics Research (CGR), Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, USA
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Matthew S. Glover
1Dynamic Omics, Centre for Genomics Research (CGR), Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, USA
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Jodie Ackland
2Faculty of Medicine, University of Southampton, Southampton, UK
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Bastian Angerman
4Translational Science and Experimental Medicine, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden
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Graham Belfield
5Translational Genomics, Discovery Biology, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden
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Maria G. Belvisi
6Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden
7NHLI, Imperial College, London, UK
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  • ORCID record for Maria G. Belvisi
Hannah Burke
2Faculty of Medicine, University of Southampton, Southampton, UK
8NIHR Southampton Biomedical Research Centre, University Hospital, Southampton, UK
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Doriana Cellura
2Faculty of Medicine, University of Southampton, Southampton, UK
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  • ORCID record for Doriana Cellura
Howard W. Clark
9Neonatology, Faculty of Population Health Sciences, EGA Institute for Women's Health, University College London, London, UK
10NIHR University College London Hospital Biomedical Research, University College London Hospital, London, UK
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Damla Etal
5Translational Genomics, Discovery Biology, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden
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Anna Freeman
2Faculty of Medicine, University of Southampton, Southampton, UK
8NIHR Southampton Biomedical Research Centre, University Hospital, Southampton, UK
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Ashley I Heinson
2Faculty of Medicine, University of Southampton, Southampton, UK
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Sonja Hess
1Dynamic Omics, Centre for Genomics Research (CGR), Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, USA
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Michael Hühn
4Translational Science and Experimental Medicine, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden
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Emily Hall
2Faculty of Medicine, University of Southampton, Southampton, UK
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Alex Mackay
4Translational Science and Experimental Medicine, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden
7NHLI, Imperial College, London, UK
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Jens Madsen
2Faculty of Medicine, University of Southampton, Southampton, UK
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Christopher McCrae
11Translational Science and Experimental Medicine, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, USA
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Daniel Muthas
4Translational Science and Experimental Medicine, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden
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Steven Novick
12Data Sciences & Quantitative Biology, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, USA
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Kristoffer Ostridge
2Faculty of Medicine, University of Southampton, Southampton, UK
4Translational Science and Experimental Medicine, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden
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Lisa Öberg
4Translational Science and Experimental Medicine, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden
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Adam Platt
13Translational Science and Experimental Medicine, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK
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Anthony D. Postle
2Faculty of Medicine, University of Southampton, Southampton, UK
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C. Mirella Spalluto
2Faculty of Medicine, University of Southampton, Southampton, UK
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Outi Vaarala
14Faculty of Medicine, University of Helsinki, Helsinki, Finland
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Junmin Wang
1Dynamic Omics, Centre for Genomics Research (CGR), Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, USA
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Karl J. Staples
2Faculty of Medicine, University of Southampton, Southampton, UK
8NIHR Southampton Biomedical Research Centre, University Hospital, Southampton, UK
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Tom M.A Wilkinson
2Faculty of Medicine, University of Southampton, Southampton, UK
8NIHR Southampton Biomedical Research Centre, University Hospital, Southampton, UK
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  • For correspondence: T.Wilkinson@soton.ac.uk
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Article Information

DOI 
https://doi.org/10.1183/23120541.00378-2022
PubMed 
37228288

Published By 
European Respiratory Society
Online ISSN 
2312-0541
History 
  • Received July 26, 2022
  • Accepted October 16, 2022
  • Published online December 1, 2022.

Article Versions

  • You are currently viewing a previous version of this article (December 1, 2022 - 07:51).
  • View the most recent version of this article
Copyright & Usage 
Copyright ©The authors 2022 This version is distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0. For commercial reproduction rights and permissions contact permissions@ersnet.org

Author Information

  1. Ventzislava A. Hristova1,15,
  2. Alastair Watson2,3,15,
  3. Raghothama Chaerkady1,
  4. Matthew S. Glover1,
  5. Jodie Ackland2,
  6. Bastian Angerman4,
  7. Graham Belfield5,
  8. Maria G. Belvisi6,7,
  9. Hannah Burke2,8,
  10. Doriana Cellura2,
  11. Howard W. Clark9,10,
  12. Damla Etal5,
  13. Anna Freeman2,8,
  14. Ashley I Heinson2,
  15. Sonja Hess1,
  16. Michael Hühn4,
  17. Emily Hall2,
  18. Alex Mackay4,7,
  19. Jens Madsen2,
  20. Christopher McCrae11,
  21. Daniel Muthas4,
  22. Steven Novick12,
  23. Kristoffer Ostridge2,4,
  24. Lisa Öberg4,
  25. Adam Platt13,
  26. Anthony D. Postle2,
  27. C. Mirella Spalluto2,
  28. Outi Vaarala14,
  29. Junmin Wang1,
  30. Karl J. Staples2,8 and
  31. Tom M.A Wilkinson2,8⇑
  32. on behalf of the MICA II Study group16
  1. 1Dynamic Omics, Centre for Genomics Research (CGR), Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, USA
  2. 2Faculty of Medicine, University of Southampton, Southampton, UK
  3. 3School of Clinical Medicine, University of Cambridge, Cambridge, UK
  4. 4Translational Science and Experimental Medicine, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden
  5. 5Translational Genomics, Discovery Biology, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden
  6. 6Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden
  7. 7NHLI, Imperial College, London, UK
  8. 8NIHR Southampton Biomedical Research Centre, University Hospital, Southampton, UK
  9. 9Neonatology, Faculty of Population Health Sciences, EGA Institute for Women's Health, University College London, London, UK
  10. 10NIHR University College London Hospital Biomedical Research, University College London Hospital, London, UK
  11. 11Translational Science and Experimental Medicine, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, USA
  12. 12Data Sciences & Quantitative Biology, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, USA
  13. 13Translational Science and Experimental Medicine, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK
  14. 14Faculty of Medicine, University of Helsinki, Helsinki, Finland
  15. 15These authors contributed equally to this work
  16. 16For MICAII study group see end of manuscript
  1. Corresponding author: Tom Wilkinson (T.Wilkinson{at}soton.ac.uk)
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  • AstraZeneca

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Multiomics links global surfactant dysregulation with airflow obstruction and emphysema in COPD
Ventzislava A. Hristova, Alastair Watson, Raghothama Chaerkady, Matthew S. Glover, Jodie Ackland, Bastian Angerman, Graham Belfield, Maria G. Belvisi, Hannah Burke, Doriana Cellura, Howard W. Clark, Damla Etal, Anna Freeman, Ashley I Heinson, Sonja Hess, Michael Hühn, Emily Hall, Alex Mackay, Jens Madsen, Christopher McCrae, Daniel Muthas, Steven Novick, Kristoffer Ostridge, Lisa Öberg, Adam Platt, Anthony D. Postle, C. Mirella Spalluto, Outi Vaarala, Junmin Wang, Karl J. Staples, Tom M.A Wilkinson
ERJ Open Research Jan 2022, 00378-2022; DOI: 10.1183/23120541.00378-2022

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Multiomics links global surfactant dysregulation with airflow obstruction and emphysema in COPD
Ventzislava A. Hristova, Alastair Watson, Raghothama Chaerkady, Matthew S. Glover, Jodie Ackland, Bastian Angerman, Graham Belfield, Maria G. Belvisi, Hannah Burke, Doriana Cellura, Howard W. Clark, Damla Etal, Anna Freeman, Ashley I Heinson, Sonja Hess, Michael Hühn, Emily Hall, Alex Mackay, Jens Madsen, Christopher McCrae, Daniel Muthas, Steven Novick, Kristoffer Ostridge, Lisa Öberg, Adam Platt, Anthony D. Postle, C. Mirella Spalluto, Outi Vaarala, Junmin Wang, Karl J. Staples, Tom M.A Wilkinson
ERJ Open Research Jan 2022, 00378-2022; DOI: 10.1183/23120541.00378-2022
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