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Airway wall splice-QTL analysis reveals novel downstream mechanisms for known asthma-SNPs

Tessa M. Kole, Simon D. Pouwels, Rene Bults, Marlies E. Ketelaar, Victor Guryev, Lisanne Koll, Huib A.M. Kerstjens, Martijn C. Nawijn, Alen Faiz, Maarten van den Berge
ERJ Open Research 2023; DOI: 10.1183/23120541.00413-2022
Tessa M. Kole
1Groningen Research Institute for Asthma and COPD (GRIAC), Groningen, the Netherlands
2Department of Pulmonology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands
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  • ORCID record for Tessa M. Kole
  • For correspondence: t.m.kole@umcg.nl
Simon D. Pouwels
1Groningen Research Institute for Asthma and COPD (GRIAC), Groningen, the Netherlands
2Department of Pulmonology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands
3Department of Medical Biology and Pathology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands
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Rene Bults
1Groningen Research Institute for Asthma and COPD (GRIAC), Groningen, the Netherlands
2Department of Pulmonology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands
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Marlies E. Ketelaar
1Groningen Research Institute for Asthma and COPD (GRIAC), Groningen, the Netherlands
3Department of Medical Biology and Pathology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands
4Department of Pediatrics, division of Pediatric Pulmonology and Pediatric Allergology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands
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Victor Guryev
1Groningen Research Institute for Asthma and COPD (GRIAC), Groningen, the Netherlands
5University of Groningen, European Research Institute for the Biology of Ageing, Groningen, the Netherlands
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Lisanne Koll
1Groningen Research Institute for Asthma and COPD (GRIAC), Groningen, the Netherlands
3Department of Medical Biology and Pathology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands
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Huib A.M. Kerstjens
1Groningen Research Institute for Asthma and COPD (GRIAC), Groningen, the Netherlands
2Department of Pulmonology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands
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Martijn C. Nawijn
1Groningen Research Institute for Asthma and COPD (GRIAC), Groningen, the Netherlands
3Department of Medical Biology and Pathology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands
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Alen Faiz
1Groningen Research Institute for Asthma and COPD (GRIAC), Groningen, the Netherlands
2Department of Pulmonology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands
6Respiratory Bioinformatics and Molecular Biology, University of Technology Sydney, Sydney, New South Wales, Australia
7Shared last author
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Maarten van den Berge
1Groningen Research Institute for Asthma and COPD (GRIAC), Groningen, the Netherlands
2Department of Pulmonology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands
7Shared last author
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Footnotes

This manuscript has recently been accepted for publication in the ERJ Open Research. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJOR online. Please open or download the PDF to view this article.

Conflict of interest: T.M. Kole has nothing to disclose.

Conflict of interest: S.D. Pouwels has nothing to disclose.

Conflict of interest: R. Bults has nothing to disclose.

Conflict of interest: M.E. Ketelaar has nothing to disclose.

Conflict of interest: V. Guryev has nothing to disclose.

Conflict of interest: L. Koll has nothing to disclose.

Conflict of interest: H.A.M. Kerstjens has nothing to disclose.

Conflict of interest: M.C. Nawijn has nothing to disclose.

Conflict of interest: A. Faiz is a member of TSANZ special interest group.

Conflict of interest: M. van den Berge reports research grants paid to institution by GlaxoSmithKline, Novartis, Astra Zeneca, Roche, Genentech. The submitted work is cofinanced by the Ministry of Economic Affairs and Climate Policy by means of the PPP.

This is a PDF-only article. Please click on the PDF link above to read it.

  • Received August 24, 2022.
  • Accepted January 9, 2023.
  • Copyright ©The authors 2023
http://creativecommons.org/licenses/by-nc/4.0/

This version is distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0. For commercial reproduction rights and permissions contact permissions{at}ersnet.org

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Airway wall splice-QTL analysis reveals novel downstream mechanisms for known asthma-SNPs
Tessa M. Kole, Simon D. Pouwels, Rene Bults, Marlies E. Ketelaar, Victor Guryev, Lisanne Koll, Huib A.M. Kerstjens, Martijn C. Nawijn, Alen Faiz, Maarten van den Berge
ERJ Open Research Jan 2023, 00413-2022; DOI: 10.1183/23120541.00413-2022

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Airway wall splice-QTL analysis reveals novel downstream mechanisms for known asthma-SNPs
Tessa M. Kole, Simon D. Pouwels, Rene Bults, Marlies E. Ketelaar, Victor Guryev, Lisanne Koll, Huib A.M. Kerstjens, Martijn C. Nawijn, Alen Faiz, Maarten van den Berge
ERJ Open Research Jan 2023, 00413-2022; DOI: 10.1183/23120541.00413-2022
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