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Asthma Innovations from the First International Collaborative Asthma Network (ICAN) Forum

Benjamin Gaston, Donna D. Gardner, Kenzie Mahan, Praveen Akuthota, Eneida A. Mendonca, Hannah Durrington, Nadzeya Marozkina, Rocio T. Martinez-Nunez, Dawn Newcomb, Benjamin Ainsworth, Arthur H. Owora, Kian Fan Chung, Samantha Walker, Stephen J. Fowler, Salman Siddiqui, Tonya Winders, Joe Zein, Nizar Jarjour, Yvonne J. Huang, Katherine N. Cahill, Ratko Djukanovic
ERJ Open Research 2023; DOI: 10.1183/23120541.00090-2023
Benjamin Gaston
1Indiana University, Indianapolis, IN, USA
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Donna D. Gardner
2Allergy & Asthma Network, Vienna, VA, USA
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  • For correspondence: dgardner@allergyasthmanetwork.org
Kenzie Mahan
1Indiana University, Indianapolis, IN, USA
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Praveen Akuthota
3University of California San Diego, La Jolla, CA, USA
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Eneida A. Mendonca
1Indiana University, Indianapolis, IN, USA
4Cincinnati Children's Hospital Medical Center and University of Cincinnati, Cincinnati, OH, USA
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Hannah Durrington
5Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK
6NIHR Manchester Biomedical Research Centre, Manchester University Hospitals NHS Foundation Trust, Manchester, UK
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Nadzeya Marozkina
1Indiana University, Indianapolis, IN, USA
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Rocio T. Martinez-Nunez
7King's College London, London, UK
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Dawn Newcomb
8Vanderbilt University Medical Center, Nashville, TN, USA
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Benjamin Ainsworth
9University of Southampton, Southampton, UK
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Arthur H. Owora
1Indiana University, Indianapolis, IN, USA
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Kian Fan Chung
10National Heart and Lung Institute, Imperial College London, London, UK
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Samantha Walker
11Asthma and Lung UK, London, UK
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Stephen J. Fowler
5Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK
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Salman Siddiqui
10National Heart and Lung Institute, Imperial College London, London, UK
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Tonya Winders
2Allergy & Asthma Network, Vienna, VA, USA
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Joe Zein
12Cleveland Clinic, Cleveland, OH, USA
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Nizar Jarjour
13University of Wisconsin, Madison, WI, USA
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Yvonne J. Huang
14University of Michigan, Ann Arbor, MI, USA
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Katherine N. Cahill
8Vanderbilt University Medical Center, Nashville, TN, USA
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Ratko Djukanovic
9University of Southampton, Southampton, UK
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Abstract

Many patients have uncontrolled asthma despite available treatments. Most of the new asthma therapies have focused on Type-2 (T2) inflammation, leaving an unmet need for innovative research into mechanisms of asthma beyond T2 and immunity. An international group of investigators developed the International Collaborative Asthma Network (ICAN) with the goal of sharing innovative research on disease mechanisms, developing new technologies and therapies, organising pilot studies, and engaging early-stage career investigators from across the world. This report describes the purpose, development, and outcomes of the first ICAN forum.

Abstracts were solicited from interdisciplinary early-stage career investigators with innovative ideas beyond T2 inflammation for asthma and were selected for presentation at the forum. Breakout sessions were conducted to discuss innovation, collaboration, and research translation.

The abstracts were categorised into 1) general omics and big data analysis; 2) lung-brain axis and airway neurology; 3) sex differences; 4) paediatric asthma; 5) new therapeutic targets inspired by airway epithelial biology; 6) new therapeutics targeting airway and circulating immune mediators; and 7) lung anatomy, physiology, and imaging. Discussions revealed that research groups are looking for opportunities to further their findings using larger scale collaboration and the ability to translate their in vitro findings into clinical treatment.

Through ICAN, teams that included interdisciplinary early-stage career investigators discussed innovation, collaboration, and translation in asthma and severe asthma research. With a combination of fresh ideas and energetic, collaborative, global participation, ICAN has laid a firm foundation and model for future collaborative global asthma research.

Footnotes

This manuscript has recently been accepted for publication in the ERJ Open Research. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJOR online. Please open or download the PDF to view this article.

Conflict of interest: B. Gaston is a founder and equity holder in Respiratory Research, Inc. and Airbase Breathing Company.

Conflict of interest: D.D. Gardner has nothing to disclose. K. Mahan is an equity holder of Atelerix Life Sciences, Inc.

Conflict of interest: P. Akuthota reports consultancy fees and research funding from GlaxoSmithKline, AstraZeneca, and Sanofi and research funding from Regeneron.

Conflict of interest: E.A. Mendonca has no conflict of interest to report.

Conflict of interest: H. Durrington has provided paid consultancy work for Chiesi.

Conflict of interest: N. Marozkina has nothing to disclose.

Conflict of interest: R.T. Martinez-Nunez is funded by AstraZeneca and GlaxoSmithKline who had no input on this work.

Conflict of interest: D. Newcomb has nothing to disclose.

Conflict of interest: B. Ainsworth has received honoraria from AstraZeneca and Roche Ltd.

Conflict of interest: A.H. Owora has nothing to disclose.

Conflict of interest: K. F. Chung has received honoraria for participation on advisory board meetings of AstraZeneca, Roche, Merck, Novartis, GlaxoSmithKline, Nocion, Shionogi, and Rickett-Beckinson and has also been renumerated for speaking engagements for Sanofi, Novartis and AstraZeneca.

Conflict of interest: S. Walker has no direct conflicts of interest regarding this work.

Conflict of interest: S.J. Fowler has no direct conflicts of interest regarding this work.

Conflict of interest: S. Siddiqui has no direct conflicts of interest regarding this work.

Conflict of interest: T. Winders has no direct conflicts of interest regarding this work; however, her institution has received funding for unbranded disease awareness and education from the following: AbbVie, ALK, Amgen, AstraZeneca, Incyte, Lilly, GlaxoSmithKline, Novartis, Pfizer, Sanofi/Regeneron, and TEVA.

Conflict of interest: J. Zein has nothing to disclose.

Conflict of interest: N. Jarjour has received consulting fees from GlaxoSmithKline.

Conflict of interest: Y.J. Huang has received payments for participating on advisory board meetings for Alveolus Bio.

Conflict of interest: K.N. Cahill is an advisory board member for AstraZeneca, Regeneron, and GlaxoSmithKline, a consultant for Ribon Therapeutics, Third Harmonic Bio, and Verantos, and receives investigational product support from NovoNordisk and royalties from UpToDate. R. Djukanovic has received payments for advisory boards and consulting of Sanofi, Kymab Cambridge and Synairen and he is the co-founder of Synairgen where he also has shares.

This is a PDF-only article. Please click on the PDF link above to read it.

  • Received February 10, 2023.
  • Accepted April 9, 2023.
  • Copyright ©The authors 2023
http://creativecommons.org/licenses/by-nc/4.0/

This version is distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0. For commercial reproduction rights and permissions contact permissions{at}ersnet.org

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Asthma Innovations from the First International Collaborative Asthma Network (ICAN) Forum
Benjamin Gaston, Donna D. Gardner, Kenzie Mahan, Praveen Akuthota, Eneida A. Mendonca, Hannah Durrington, Nadzeya Marozkina, Rocio T. Martinez-Nunez, Dawn Newcomb, Benjamin Ainsworth, Arthur H. Owora, Kian Fan Chung, Samantha Walker, Stephen J. Fowler, Salman Siddiqui, Tonya Winders, Joe Zein, Nizar Jarjour, Yvonne J. Huang, Katherine N. Cahill, Ratko Djukanovic
ERJ Open Research Jan 2023, 00090-2023; DOI: 10.1183/23120541.00090-2023

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Asthma Innovations from the First International Collaborative Asthma Network (ICAN) Forum
Benjamin Gaston, Donna D. Gardner, Kenzie Mahan, Praveen Akuthota, Eneida A. Mendonca, Hannah Durrington, Nadzeya Marozkina, Rocio T. Martinez-Nunez, Dawn Newcomb, Benjamin Ainsworth, Arthur H. Owora, Kian Fan Chung, Samantha Walker, Stephen J. Fowler, Salman Siddiqui, Tonya Winders, Joe Zein, Nizar Jarjour, Yvonne J. Huang, Katherine N. Cahill, Ratko Djukanovic
ERJ Open Research Jan 2023, 00090-2023; DOI: 10.1183/23120541.00090-2023
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