Next-generation sequencing reveals genetic heterogeneity and resistant mechanisms in patients with EGFR-mutated non-small cell lung cancer treated with afatinib

Sheng-Kai Liang; Pin-Fei Wei; Min-Shu Hsieh; Chia-Ling Wu; Jin-Yuan Shih

doi:10.1183/23120541.00676-2023

Next-generation sequencing reveals genetic heterogeneity and resistant mechanisms in patients with EGFR-mutated non-small cell lung cancer treated with afatinib

Sheng-Kai Liang, Pin-Fei Wei, Min-Shu Hsieh, Chia-Ling Wu, Jin-Yuan Shih

ERJ Open Research 2024; DOI: 10.1183/23120541.00676-2023

Sheng-Kai Liang

1Department of Medicine, National Taiwan University Cancer Center, Taipei, Taiwan

2Department of Internal Medicine, National Taiwan University Hospital Hsinchu Branch, Hsinchu, Taiwan

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ORCID record for Sheng-Kai Liang

Pin-Fei Wei

3Graduate Institute of Medical Genomics and Proteomics, College of Medicine, National Taiwan University, Taipei, Taiwan

4Department of Laboratory Medicine, National Taiwan University Hospital, Taipei, Taiwan

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Min-Shu Hsieh

5Department of Pathology, National Taiwan University Hospital, Taipei, Taiwan

6Department of Pathology, National Taiwan University Cancer Center, Taipei, Taiwan

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Chia-Ling Wu

7Medical Informatics, ACT Genomics Co., Ltd, Taipei, Taiwan

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Jin-Yuan Shih

8Department of Internal Medicine, National Taiwan University Hospital and College of Medicine, National Taiwan University, Taipei, Taiwan

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For correspondence: jyshih@ntu.edu.tw

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Next-generation sequencing reveals genetic heterogeneity and resistant mechanisms in patients with EGFR-mutated non-small cell lung cancer treated with afatinib

Sheng-Kai Liang, Pin-Fei Wei, Min-Shu Hsieh, Chia-Ling Wu, Jin-Yuan Shih

ERJ Open Research Jan 2024, 00676-2023; DOI: 10.1183/23120541.00676-2023

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Next-generation sequencing reveals genetic heterogeneity and resistant mechanisms in patients with EGFR-mutated non-small cell lung cancer treated with afatinib